Breaking News
April 19, 2018 - Transplanted livers have a protective effect and reduce potential for organ rejection
April 19, 2018 - Researchers develop new method to study activity of inflammatory cells
April 19, 2018 - Researchers discover highly antibiotic resistant superbugs in Gulf States
April 19, 2018 - U.S. Women Less Likely Than Men to Get Statins After Heart Attack
April 19, 2018 - Atypical brain development observed in preschoolers with ADHD symptoms
April 19, 2018 - Positive attitudes about aging reduce risk of dementia in older adults
April 19, 2018 - Environmental pollutants found to worsen rheumatoid arthritis
April 19, 2018 - UT Southwestern scientists discover protein linked to metastatic breast cancer
April 19, 2018 - Study highlights need for further evidence to improve symptom management in end of life care
April 19, 2018 - Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer’s
April 19, 2018 - Uniqsis offers high-power LED light unit for scalable flow photochemistry reactions
April 19, 2018 - Case study shows how intravascular ultrasound imaging helps detect acute aortic syndrome
April 19, 2018 - Research reveals new mechanism by which HIV evades the immune system
April 19, 2018 - Nanodisc-delivered cancer treatment helps eliminate tumors
April 19, 2018 - Functional connectivity MRI could help detect brain disorders and diseases
April 19, 2018 - Finding better way to quantify neuropathy symptoms and treatment efficacy
April 19, 2018 - Study examines effectiveness of caregiver education about sickle cell trait
April 19, 2018 - High-resolution images of tumor vasculature using new technology
April 19, 2018 - Lack of sleep may be linked to risk factor for Alzheimer’s disease
April 19, 2018 - Study finds neurotransmitter may play a role in alcohol relapse, addiction
April 19, 2018 - Researchers build molecular networks of calcific aortic valve disease
April 19, 2018 - Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens
April 19, 2018 - Scientists decipher mechanism of chemotherapy induced female infertility
April 19, 2018 - New insight may allow researchers to design drugs that improve immune responses to vaccines
April 19, 2018 - FDA Approves Crysvita (burosumab-twza) for X-Linked Hypophosphatemia
April 19, 2018 - Researchers uncover origin of virus-fighting plasma B cells
April 19, 2018 - Study finds no evidence of lower intelligence in young children who had anesthesia
April 19, 2018 - Baboons break out of research facility briefly
April 19, 2018 - Study shows how deployment time increases risk of suicide attempt in soldiers
April 19, 2018 - Specific odors from malaria infected individuals attract more mosquitoes
April 19, 2018 - FDA Alert: Rhino 69 Extreme 50000 by AMA Wholesale: Recall
April 19, 2018 - Top HIV cure research team refutes major recent results on how to identify HIV persistence
April 19, 2018 - Experts propose new solutions to increase benefit, affordability of targeted cancer medicines
April 19, 2018 - Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice
April 19, 2018 - New machine learning method offers better way to detect heart disease
April 19, 2018 - CNIO researchers determine structure of protein complex related to cell survival
April 19, 2018 - Faith-based diabetes support program launched by UTSA research team
April 19, 2018 - Volumetric Laser Endomicroscopy Helps ID Barrett’s Regions
April 19, 2018 - Engineered cartilage template to heal broken bones
April 19, 2018 - New computational framework accurately predicts drug-drug and drug-food interactions
April 18, 2018 - Some human cancers may be result of evolutionary accidents, research finds
April 18, 2018 - Higher levels of education linked to lower dementia risk in older African Americans
April 18, 2018 - Smoking Puts Blacks at Higher Risk for Heart Failure
April 18, 2018 - Physiotherapist contributes to guidelines for knee cartilage treatment
April 18, 2018 - Researchers use ‘top-down proteomics’ strategy to get new insights into cancer
April 18, 2018 - Physician assistants less likely to accurately diagnose early stage skin cancers
April 18, 2018 - New faster, streamlined method for bowel cancer detection and treatment
April 18, 2018 - Researchers identify new Listeria species in Costa Rica
April 18, 2018 - Novel interactive diagram shows many facets of mild traumatic brain injury
April 18, 2018 - Short sleep linked to obesity in children and adolescents
April 18, 2018 - When weight loss helps with sleep
April 18, 2018 - New mathematical model can predict efficiency of microbiome therapies
April 18, 2018 - People with high LDL cholesterol levels likely to get greater benefits from statins
April 18, 2018 - Listening to music enhances effect of anti-hypertensive drugs
April 18, 2018 - New method could help treat severe epilepsy in the future
April 18, 2018 - Study reveals increased risks for Alzheimer’s, suicide among youth in polluted cities
April 18, 2018 - Obese patients more likely to develop rapid and irregular heart rate
April 18, 2018 - Study may change global guidelines for managing children with uncomplicated fever
April 18, 2018 - Researchers find letter we’ve seen millions of times, yet can’t write
April 18, 2018 - Roswell Park researchers identify driver of cancer-promoting metabolic changes
April 18, 2018 - Study shows connection between early life stress, depression and sleep disturbances
April 18, 2018 - New tool developed to protect women from HIV infection
April 18, 2018 - Tradeshow Talks with HealthSapiens
April 18, 2018 - NYC mice carry deadly bacteria and viruses
April 18, 2018 - FDA Approves Tavalisse (fostamatinib disodium hexahydrate) for Chronic Immune Thrombocytopenia
April 18, 2018 - Doctors curbing first-time prescriptions for opioids
April 18, 2018 - Scientists analyze nanostructure of chicken eggshells
April 18, 2018 - Study finds muscle complications among active young adults with Type 1 diabetes
April 18, 2018 - Young children should be priority for snail fever treatment
April 18, 2018 - One class of diabetes drug not associated with reduced risk of death
April 18, 2018 - Breakthrough microscope revolutionizes live cell imaging of stem cells
April 18, 2018 - Study on arthritis prevalence and trends reveals unexpected findings
April 18, 2018 - Low-Vision Rehab Improves Several Elements of Visual Function
April 18, 2018 - Babies who look like their father at birth are healthier one year later: study
April 18, 2018 - New drug for migraine in the pipeline
April 18, 2018 - Precancerous colon polyps in Lynch syndrome patients display immune activation
April 18, 2018 - Mouse study shows how tungsten accumulates in the bones
April 18, 2018 - Scientists provide insight into how gene associated with autoimmunity contributes to disease
April 18, 2018 - AHA: Rx for Sedentary Kids — Friends and the Great Outdoors
April 18, 2018 - Expert panel reliable and accurate in identifying injuries in young children
Low cost drug for serious bleeding may just save lives of moms after childbirth

Low cost drug for serious bleeding may just save lives of moms after childbirth

image_pdfDownload PDFimage_print

An affordable and extensively to be had drug may just save the lives of 1 in 3 moms who would another way bleed to demise after childbirth, in step with a significant learn about printed in The Lancet. The worldwide trial of 20,000 girls discovered that demise because of bleeding was once lowered via 31% if the remedy was once given inside 3 hours.

The drug, known as tranexamic acid (TXA), works via preventing blood clots from breaking down. The findings additionally display it lowered the desire for pressing surgical operation to keep watch over bleeding (laparotomy) via greater than a 3rd (36%).

Serious bleeding after childbirth (referred to as post-partum haemorrhage or PPH) is the main reason for maternal demise international. Greater than 100,000 girls globally die every 12 months from the situation, however this clot-stabilising drug has the possible to cut back the quantity considerably.

The WOMAN (International Maternal Antifibrinolytic) Trial recruited moms from 193 hospitals in 21 international locations, basically in Africa and Asia, but additionally in the United Kingdom and somewhere else. The London College of Hygiene & Tropical Drugs coordinated the trial. It was once funded via The Wellcome Accept as true with and UK Division of Well being during the Well being Innovation Problem Fund, and the Invoice & Melinda Gates Basis.

The effects display that of the ladies given tranexamic acid inside 3 hours, 89 died from bleeding when compared with 127 given placebo (along with usual care). The researchers discovered no unintended effects from the drug for both moms or small children. Those findings give you the first complete proof on the usage of tranexamic acid for post-partum haemorrhage and recommend it will have to be used as a frontline remedy.

Haleema Shakur, Affiliate Professor of Medical Trials on the London College of Hygiene & Tropical Drugs and Venture Director at the WOMAN Trial, stated:

We’ve got necessary proof that the early use of tranexamic acid can save girls’s lives and make sure extra youngsters develop up with a mom. It’s secure, inexpensive and simple to manage, and we are hoping that medical doctors will use it as early as conceivable following the onset of serious bleeding after childbirth.

Tranexamic acid was once invented within the 1960s via a Jap husband and spouse analysis staff, Shosuke and Utako Okamoto.

Ian Roberts, Professor of Medical Trials on the London College of Hygiene & Tropical Drugs, who co-led the learn about, stated:

The researchers who invented tranexamic acid greater than 50 years in the past was hoping it will cut back deaths from post-partum haemorrhage, however they couldn’t convince obstetricians on the time to habits an ordeal. Now we in the end have those effects that we are hoping can assist save girls’s lives world wide.

Virtually all the deaths from post-partum haemorrhage are in low- and middle-income international locations. Even though giving delivery in a well being facility will increase the risk of surviving post-partum haemorrhage, girls nonetheless die from the situation even inside hospitals.

Tim Knott, Senior Spouse in Inventions at Wellcome Accept as true with, stated:

Globally, serious bleeding in childbirth stays one of the most major reasons of maternal demise – with alarming numbers of girls loss of life in lots of low- and middle-income international locations. The WOMAN Trial staff undertook a vastly necessary and extremely bold learn about. Their paintings stands to make a essential distinction in combating girls loss of life after childbirth.

Whilst the WOMAN Trial discovered that tranexamic acid considerably lowered demise because of bleeding, it didn’t save you hysterectomy. The researchers say it is because in low- and middle-income international locations the place blood provides are restricted, a hysterectomy is every now and then performed instantly after the onset of very serious post-partum haemorrhage to avoid wasting the mummy’s existence. This implies there’s no time for tranexamic acid to have an impact.

The learn about builds on earlier analysis involving 20,000 trauma sufferers, which confirmed that tranexamic acid lowered deaths because of bleeding via virtually a 3rd if given inside 3 hours.

Present International Well being Group pointers, in response to the former trauma analysis, suggest the usage of tranexamic acid in post-partum haemorrhage as a next remedy possibility if uterotonics (medicine to urge contractions) fail to keep watch over the bleeding, or if the bleeding is considered because of trauma.

Publish-partum haemorrhage is outlined as a blood lack of greater than 500ml inside 24 hours of giving delivery.

Supply:

http://www.lshtm.ac.united kingdom/newsevents/information/2017/woman_trial_results.html

Tagged with:

About author

Related Articles