Breaking News
December 19, 2018 - New $1.6 million NIH grant supports study on a gene vital to circadian rhythms
December 19, 2018 - Racial Disparities Seen Among Teens Undergoing Flu Vaccination
December 19, 2018 - To resolve inflammation, location matters
December 19, 2018 - Research identifies new therapeutic target for cancer treatment and tissue regeneration
December 19, 2018 - Energy costs, social isolation contribute to health risk of older adults in extreme weather
December 19, 2018 - Potential combination therapy against rare disease of the bone marrow could improve treatment
December 19, 2018 - Researchers aim to improve cognition, reverse weight gain in schizophrenia
December 19, 2018 - UC San Diego Health offers new DRG stimulation device for phantom limb pain
December 19, 2018 - Study examines relationship between growth restriction and risk of childhood mortality
December 19, 2018 - New study provides insights on increased risk of suicide in young patients visiting ED
December 19, 2018 - AHA: Thyroid Problems Linked to Worsening Heart Failure
December 19, 2018 - World-first coeliac disease vaccine enters Phase 2 trials
December 19, 2018 - RNA sequencing offers novel insights into the microbiome
December 19, 2018 - A promising, effective vaccine for common respiratory disease
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - ‘Little Foot’ endocast reveals a small brain combining ape-like and human-like features
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
December 18, 2018 - New battery-free, implantable device aids weight loss
December 18, 2018 - Parental alcohol use disorder associated with offspring marital outcomes
December 18, 2018 - Novel Breast Imaging Technique Might Cut Unnecessary Biopsies
December 18, 2018 - What can a snowflake teach us about how cancer spreads in the body?
December 18, 2018 - Management of nausea and vomiting in pregnancy costs the NHS more than previously thought
December 18, 2018 - Green leafy vegetables may reduce risk of developing liver steatosis
December 18, 2018 - Veganism linked to nutrient deficiencies and malnutrition if not planned correctly
December 18, 2018 - Coming Soon: A Tiny Robot You Swallow to Help You Stay Healthy
December 18, 2018 - Modified malaria drug proven effective at inhibiting Ebola
December 18, 2018 - Study finds epigenetic differences in the brains of individuals with schizophrenia
MDI Organic Laboratory investigator awarded NIH grant for analysis on peripheral neuropathy

MDI Organic Laboratory investigator awarded NIH grant for analysis on peripheral neuropathy

image_pdfDownload PDFimage_print

The MDI Organic Laboratory has introduced that Sandra Rieger, Ph.D., has been awarded a extremely aggressive grant from the Nationwide Most cancers Institute, an institute of the Nationwide Institutes of Well being (NIH), to check the molecular mechanisms underlying chemotherapy-induced peripheral neuropathy, a facet impact of most cancers chemotherapy inflicting signs akin to ache, tingling, temperature sensitivity and numbness within the extremities.

The grant will permit Rieger to proceed her analysis on peripheral neuropathy brought about through Taxol (paclitaxel), a chemotherapy agent used within the remedy of ovarian, breast, lung, pancreatic and different cancers. About 60 to 70 p.c of sufferers receiving Taxol revel in peripheral neuropathy. In serious instances, sufferers is also pressured to scale back or curtail remedy, which deprives them of most cancers remedy and might lower possibilities of survival.

Rieger’s analysis additionally has doable programs within the remedy of peripheral neuropathies brought about through different prerequisites, together with diabetes, getting old and antibiotic remedy. Neuropathy is a normal time period for peripheral nerve degeneration, which is assumed to have an effect on no less than 20 million American citizens, with some estimates as prime as 40 million. No therapies are lately to be had, as opposed to for signs akin to ache.

“This grant is an acknowledgment of the significance of Dr. Rieger’s analysis,” stated Kevin Bizarre, Ph.D. president of the MDI Organic Laboratory. “Peripheral neuropathy is a lot more not unusual than most often believed. Her analysis at the underlying molecular mechanisms of nerve regeneration opens the door to the improvement of latest drug treatments to lend a hand the hundreds of thousands who be afflicted by this doubtlessly debilitating situation.”

The five-year grant, which takes impact July 1, totals roughly $1.eight million over 5 years, with further investment for amenities and administrative prices. The grant will fund Rieger’s proceeding analysis within the zebrafish and analysis with neurologist Nathan P. Personnel, M.D., Ph.D. on pores and skin samples from breast most cancers sufferers present process Taxol remedy on the Mayo Health facility in Rochester, Minn.

The analysis on the Mayo Health facility, which is able to happen over the primary two years of the grant, will search to resolve if the similar mechanisms that underlie Taxol-induced peripheral neuropathy in zebrafish also are related to the situation in people.

“The analysis with Dr. Personnel on the Mayo Health facility is step one to growing a drug treatment to regard peripheral neuropathy in people,” Rieger stated. “That is my primary passion — discovering a treatment to treatment this situation.”

The grant will permit Rieger to construct on previous analysis appearing that Taxol-induced peripheral neuropathy is related to the higher task of a matrix-degrading enzyme, matrix metalloproteinase-13, or MMP-13, within the pores and skin. The rise in MMP-13 task results in diminished pores and skin resistance and the degeneration of sensory nerve endings, which in flip reasons the indicators of peripheral neuropathy.

Rieger has additionally came upon two compounds that save you or opposite chemotherapy-induced peripheral neuropathy in zebrafish through inhibiting the task of MMP-13. The compounds are the topic of a provisional patent filed closing yr through the MDI Organic Laboratory for his or her use within the remedy of chemotherapy- and diabetes-induced peripheral neuropathy. The compounds have not begun to be examined in people.

The power presented through the grant to realize a deeper working out of the mechanisms underlying peripheral neuropathy raises the chance that different MMP-inhibiting medication can also be advanced to regard peripheral neuropathy.

Supply:

https://mdibl.org/press-release/mdi-biological-laboratory-scientist-receives-grant-to-study-peripheral-neuropathy/

About author

Related Articles