Breaking News
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
December 18, 2018 - New battery-free, implantable device aids weight loss
December 18, 2018 - Parental alcohol use disorder associated with offspring marital outcomes
December 18, 2018 - Novel Breast Imaging Technique Might Cut Unnecessary Biopsies
December 18, 2018 - What can a snowflake teach us about how cancer spreads in the body?
December 18, 2018 - Management of nausea and vomiting in pregnancy costs the NHS more than previously thought
December 18, 2018 - Green leafy vegetables may reduce risk of developing liver steatosis
December 18, 2018 - Veganism linked to nutrient deficiencies and malnutrition if not planned correctly
December 18, 2018 - Coming Soon: A Tiny Robot You Swallow to Help You Stay Healthy
December 18, 2018 - Modified malaria drug proven effective at inhibiting Ebola
December 18, 2018 - Study finds epigenetic differences in the brains of individuals with schizophrenia
December 18, 2018 - Fitness instructors’ motivational comments influence women’s body satisfaction
December 18, 2018 - Study focuses on modification of lipid nanoparticles for successful brain cell targeting
December 18, 2018 - New gut bacteria may be effective against obesity, metabolic and mental disorders
December 18, 2018 - New two-in-one powder aerosol to upgrade fight against deadly superbugs in lungs
December 18, 2018 - Biofilms feed with swirling flows
December 17, 2018 - Study identifies specific neurological changes related to traumatic brain injury
December 17, 2018 - New study confirms geographic bias in lung allocation for transplant
December 17, 2018 - Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate
December 17, 2018 - Carpal tunnel syndrome – Genetics Home Reference
December 17, 2018 - A novel insulin accelerant
December 17, 2018 - Tips for caring for patients with disabilities, from a mother and physician
December 17, 2018 - Menopause-related sexual, urinary problems tied to worse quality of life
December 17, 2018 - In-school nutrition programs among students limit increases in BMI, finds study
December 17, 2018 - Risk for Hospitalization for Heart Failure Greater With Diabetes
December 17, 2018 - Food assistance may help older adults adhere to diabetes meds
New blood check might higher are expecting gestational diabetes

New blood check might higher are expecting gestational diabetes

image_pdfDownload PDFimage_print
Credit score: public area

A brand new find out about led by way of researchers at Brigham and Girls’s Clinic has discovered unmarried size of plasma glycated CD59 (GCD59), a singular biomarker for diabetes, at weeks 24-28 of gestation recognized, with prime sensitivity and specificity, ladies who failed the glucose problem check in addition to ladies with gestational diabetes. Plasma ranges of GCD59 have been additionally related to the likelihood of handing over a large-for-gestational-age new child. Those findings are revealed in Diabetes Care.

Gestational diabetes is a kind of diabetes that happens all over a girl’s being pregnant, expanding the mum’s possibility of handing over a large-for-gestational-age child, which can result in pre-term beginning, fetal damage, perinatal mortality and cesarean supply. Gestational diabetes could also be a possibility issue for preeclampsia and gestational high blood pressure. Since remedy of gestational diabetes can reduce the danger of difficult being pregnant results, follow tips suggest screening all non-diabetic, pregnant ladies for the illness. The present usual of care to each display screen and diagnose gestational diabetes predominantly comes to a two-step means. Step one, referred to as the glucose problem check, comprises management of a sugary drink adopted by way of a blood sugar size one hour later. Girls who fail this screening are then despatched for an extended check, referred to as the oral glucose tolerance check, which calls for fasting in a single day, ingesting a extra concentrated sugar resolution and present process baseline and hourly blood attracts for 3 hours. Those glucose exams, or permutations thereof, are recently the one strategies used to display screen pregnant ladies for or diagnose gestational diabetes. They’re time eating, bulky, uncomfortable for moms and feature deficient reported reproducibility.

The analysis crew’s number one function was once to evaluate the accuracy of the diabetes biomarker, GCD59, in predicting the result of the usual of care glucose problem check used to display screen for gestational diabetes. The crew carried out a case-control find out about of one,000 pregnant ladies who have been receiving usual prenatal care at BWH: 500 ladies who had a typical glucose problem check (management topics) and 500 ladies who failed the glucose problem check and required a next oral glucose tolerance check (case sufferers). Researchers discovered that, when put next with the management topics, the median plasma GCD59 price was once eight.Five-fold upper within the sufferers who failed the glucose problem check and 10-fold upper within the subset of those sufferers who met diagnostic standards for gestational diabetes within the next oral glucose tolerance check.

“That is the primary find out about to display unmarried size of plasma GCD59 can be utilized as a simplified solution to establish ladies who’re in danger for failing the glucose problem check and are at upper possibility for growing gestational diabetes,” says Jose Halperin, MD, a doctor and researcher, Director of the Hematology Laboratory for Translational Analysis at BWH and senior writer of the newsletter.

The researchers additionally discovered that upper plasma GCD59 ranges at gestational week 24-28 have been related to upper occurrence of large-for-gestational-age newborns, with the upper the extent, the upper the danger (four % upper possibility for sufferers within the lowest quartile of GCD59 plasma ranges, and 14 % within the best possible quartile). Out of the 58 large-for-gestational-age young children born to moms that failed the glucose problem check on this find out about, 80 % have been born to moms who didn’t meet oral glucose tolerance check standards for gestational diabetes, however had median plasma GCD59 ranges 7-fold upper than management ladies with a typical glucose problem check. Those findings are in step with different research appearing that ladies who fail the glucose problem check, however don’t meet standards for gestational diabetes, are nonetheless at the next possibility of atypical being pregnant results, together with handing over vast for gestational age young children. Lately there aren’t any follow tips for the control of ladies who fall between commonplace and atypical glucose tolerance ranges, and, subsequently, their control is equal to that for ladies with a typical glucose problem check effects.

“Those effects recommend unmarried size of plasma GCD59 all over weeks 24-28 might also assist stratify the danger for handing over higher babies amongst ladies with gestational glucose intolerance.” says Halperin. “Our research opened an street for higher multicenter research to additional assess the medical application of plasma GCD59 for screening and analysis of gestational diabetes some of the common inhabitants of the USA. If our effects are showed, we are hopeful that the GCD59 check might be to be had in medical practices inside of the following couple of years.”


Discover additional:
Maternal hyperglycemia united states of americaoffspring cardiometabolic possibility

Additional information:
Halperin et al. “Plasma Glycated CD59, a Novel Biomarker for Detection of Being pregnant-Brought on Glucose Intolerance.” Diabetes Care DOI: 10.2337/dc16-2598

Magazine reference:
Diabetes Care

Supplied by way of:
Brigham and Girls’s Clinic

Tagged with:

About author

Related Articles