Breaking News
April 19, 2018 - Transplanted livers have a protective effect and reduce potential for organ rejection
April 19, 2018 - Researchers develop new method to study activity of inflammatory cells
April 19, 2018 - Researchers discover highly antibiotic resistant superbugs in Gulf States
April 19, 2018 - U.S. Women Less Likely Than Men to Get Statins After Heart Attack
April 19, 2018 - Atypical brain development observed in preschoolers with ADHD symptoms
April 19, 2018 - Positive attitudes about aging reduce risk of dementia in older adults
April 19, 2018 - Environmental pollutants found to worsen rheumatoid arthritis
April 19, 2018 - UT Southwestern scientists discover protein linked to metastatic breast cancer
April 19, 2018 - Study highlights need for further evidence to improve symptom management in end of life care
April 19, 2018 - Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer’s
April 19, 2018 - Uniqsis offers high-power LED light unit for scalable flow photochemistry reactions
April 19, 2018 - Case study shows how intravascular ultrasound imaging helps detect acute aortic syndrome
April 19, 2018 - Research reveals new mechanism by which HIV evades the immune system
April 19, 2018 - Nanodisc-delivered cancer treatment helps eliminate tumors
April 19, 2018 - Functional connectivity MRI could help detect brain disorders and diseases
April 19, 2018 - Finding better way to quantify neuropathy symptoms and treatment efficacy
April 19, 2018 - Study examines effectiveness of caregiver education about sickle cell trait
April 19, 2018 - High-resolution images of tumor vasculature using new technology
April 19, 2018 - Lack of sleep may be linked to risk factor for Alzheimer’s disease
April 19, 2018 - Study finds neurotransmitter may play a role in alcohol relapse, addiction
April 19, 2018 - Researchers build molecular networks of calcific aortic valve disease
April 19, 2018 - Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens
April 19, 2018 - Scientists decipher mechanism of chemotherapy induced female infertility
April 19, 2018 - New insight may allow researchers to design drugs that improve immune responses to vaccines
April 19, 2018 - FDA Approves Crysvita (burosumab-twza) for X-Linked Hypophosphatemia
April 19, 2018 - Researchers uncover origin of virus-fighting plasma B cells
April 19, 2018 - Study finds no evidence of lower intelligence in young children who had anesthesia
April 19, 2018 - Baboons break out of research facility briefly
April 19, 2018 - Study shows how deployment time increases risk of suicide attempt in soldiers
April 19, 2018 - Specific odors from malaria infected individuals attract more mosquitoes
April 19, 2018 - FDA Alert: Rhino 69 Extreme 50000 by AMA Wholesale: Recall
April 19, 2018 - Top HIV cure research team refutes major recent results on how to identify HIV persistence
April 19, 2018 - Experts propose new solutions to increase benefit, affordability of targeted cancer medicines
April 19, 2018 - Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice
April 19, 2018 - New machine learning method offers better way to detect heart disease
April 19, 2018 - CNIO researchers determine structure of protein complex related to cell survival
April 19, 2018 - Faith-based diabetes support program launched by UTSA research team
April 19, 2018 - Volumetric Laser Endomicroscopy Helps ID Barrett’s Regions
April 19, 2018 - Engineered cartilage template to heal broken bones
April 19, 2018 - New computational framework accurately predicts drug-drug and drug-food interactions
April 18, 2018 - Some human cancers may be result of evolutionary accidents, research finds
April 18, 2018 - Higher levels of education linked to lower dementia risk in older African Americans
April 18, 2018 - Smoking Puts Blacks at Higher Risk for Heart Failure
April 18, 2018 - Physiotherapist contributes to guidelines for knee cartilage treatment
April 18, 2018 - Researchers use ‘top-down proteomics’ strategy to get new insights into cancer
April 18, 2018 - Physician assistants less likely to accurately diagnose early stage skin cancers
April 18, 2018 - New faster, streamlined method for bowel cancer detection and treatment
April 18, 2018 - Researchers identify new Listeria species in Costa Rica
April 18, 2018 - Novel interactive diagram shows many facets of mild traumatic brain injury
April 18, 2018 - Short sleep linked to obesity in children and adolescents
April 18, 2018 - When weight loss helps with sleep
April 18, 2018 - New mathematical model can predict efficiency of microbiome therapies
April 18, 2018 - People with high LDL cholesterol levels likely to get greater benefits from statins
April 18, 2018 - Listening to music enhances effect of anti-hypertensive drugs
April 18, 2018 - New method could help treat severe epilepsy in the future
April 18, 2018 - Study reveals increased risks for Alzheimer’s, suicide among youth in polluted cities
April 18, 2018 - Obese patients more likely to develop rapid and irregular heart rate
April 18, 2018 - Study may change global guidelines for managing children with uncomplicated fever
April 18, 2018 - Researchers find letter we’ve seen millions of times, yet can’t write
April 18, 2018 - Roswell Park researchers identify driver of cancer-promoting metabolic changes
April 18, 2018 - Study shows connection between early life stress, depression and sleep disturbances
April 18, 2018 - New tool developed to protect women from HIV infection
April 18, 2018 - Tradeshow Talks with HealthSapiens
April 18, 2018 - NYC mice carry deadly bacteria and viruses
April 18, 2018 - FDA Approves Tavalisse (fostamatinib disodium hexahydrate) for Chronic Immune Thrombocytopenia
April 18, 2018 - Doctors curbing first-time prescriptions for opioids
April 18, 2018 - Scientists analyze nanostructure of chicken eggshells
April 18, 2018 - Study finds muscle complications among active young adults with Type 1 diabetes
April 18, 2018 - Young children should be priority for snail fever treatment
April 18, 2018 - One class of diabetes drug not associated with reduced risk of death
April 18, 2018 - Breakthrough microscope revolutionizes live cell imaging of stem cells
April 18, 2018 - Study on arthritis prevalence and trends reveals unexpected findings
April 18, 2018 - Low-Vision Rehab Improves Several Elements of Visual Function
April 18, 2018 - Babies who look like their father at birth are healthier one year later: study
April 18, 2018 - New drug for migraine in the pipeline
April 18, 2018 - Precancerous colon polyps in Lynch syndrome patients display immune activation
April 18, 2018 - Mouse study shows how tungsten accumulates in the bones
April 18, 2018 - Scientists provide insight into how gene associated with autoimmunity contributes to disease
April 18, 2018 - AHA: Rx for Sedentary Kids — Friends and the Great Outdoors
April 18, 2018 - Expert panel reliable and accurate in identifying injuries in young children
'Remarkable' effects introduced from new blood most cancers find out about

'Remarkable' effects introduced from new blood most cancers find out about

image_pdfDownload PDFimage_print
Electron microscopic symbol of a unmarried human lymphocyte. Credit score: Dr. Triche Nationwide Most cancers Institute

Scientists have described new result of a blood most cancers find out about as ‘exceptional’ in tackling up to now untreatable kinds of power lymphocytic leukaemia (CLL).

The development led through a crew from the College of Leicester and College Hospitals of Leicester NHS Agree with, inside the Hope Medical Trials Facility, concerned about treating sufferers with CLL.

It follows on from a world-first scientific trial of a brand new drug to regard explicit blood cancers. Result of that global scientific trial, led through Dr Harriet Walter and Professor Martin Dyer have been revealed within the magazine Blood in November 2015 and appeared on the efficacy of a brand new inhibitor, ONO/GS-4059, within the remedy of CLL and Non-Hodgkin Lymphoma sufferers, refractory or proof against present chemotherapies.

ONO/GS-4059 goals BTK, a protein crucial for the survival and proliferation of the tumour cells.

The find out about opened in January 2012 and 90 sufferers have been enrolled in several centres in the United Kingdom and in France, with 28 coming from Leicester. Sufferers with CLL confirmed the most efficient reaction and maximum of them have been nonetheless at the find out about after three years, and remarkably with out notable toxicities.

Within the new paper, the researchers are reporting for the long-term follow-up effects. Their paintings, revealed within the magazine Blood, was once funded through the Ernest and Helen Scott Haematological Analysis Institute, ONO Prescription drugs, Gilead Prescription drugs and the Most cancers Analysis UK Leicester Experimental Most cancers Drugs Centre. Native charity Hope Towards Most cancers fund the Medical Trials Facility based totally on the Leicester Royal Infirmary.

Professor Martin Dyer is Professor of Haemato-Oncology within the Division of Most cancers Research on the College of Leicester and Honorary Guide Doctor within the Division of Haematology at Leicester Royal Infirmary.

He mentioned: “This present paper describes the longer term keep on with up and presentations that during sufferers with CLL the remissions are sturdy and related with out a new toxicities. Moreover, in collaboration with Sistemas Genomicos, an organization in Valencia, we have now proven that mutations related to competitive illness reply neatly to remedy with ONO/GS-4059.

“Our long run keep on with up presentations maintained efficacy with out toxicity. This find out about is the primary document of long run follow-up of a selective BTK inhibitor – and it is superb information for sufferers.

“The consequences we’re presenting are according to a global scientific find out about involving the United Kingdom, France, Japan and US – and led through Leicester.

This was once a Section 1 scientific find out about because of this the researchers are within the early levels of trying out the drug’s effectiveness.

“We are actually doing research of ONO/GS-4059 together with different precision medications to evaluate whether or not those effects will also be enhanced in sufferers with CLL and different B cellular malignancies.”

Native most cancers analysis charity, Hope Towards Most cancers, has been investment a few of Professor Dyer’s paintings. Leader Govt of the charity, Nigel Rose mentioned: “Professor Dyer is a long-standing collaborator and recipient of Hope’s investment. We’re overjoyed that that is being put to such extraordinarily vital use in assembly our charity’s undertaking of bettering the lives of most cancers sufferers in the community.”

Discover additional:
Global-first blood most cancers drug trial finds life-changing effects

Additional info:
Harriet S. Walter et al. Lengthy-term follow-up of sufferers with CLL handled with the selective Bruton’s tyrosine kinase inhibitor ONO/GS-4059, Blood (2017). DOI: 10.1182/blood-2017-02-765115

Magazine reference:

Equipped through:
College of Leicester

Tagged with:

About author

Related Articles