Breaking News
September 24, 2018 - Transcatheter mitral-valve repair in patients with heart failure
September 24, 2018 - Study opens new avenues for treatment of Laing distal myopathy
September 24, 2018 - Stroke Facts | cdc.gov
September 24, 2018 - Sarcolipin tricks muscle cells into using more energy, burning fat
September 24, 2018 - Enrollment in opioid controlled substance agreement reduces primary care visits
September 24, 2018 - UTA researchers patent new smart seat cushion technology that helps prevent painful ulcers
September 24, 2018 - Second HPV-Related Primary Cancers Common in Survivors
September 24, 2018 - How a virus destabilizes the genome
September 24, 2018 - Old letters provide insight into Spanish flu pandemic horror
September 23, 2018 - Smart textile-based soft robotic exosuit helps wearers save energy and traverse difficult terrain
September 23, 2018 - New research hub to drive radical change in development and manufacturing of vaccines
September 23, 2018 - AHA: For Hispanics, Neighborhood May Be Key Factor in Heart Disease Risk
September 23, 2018 - Excessive airway nerves tied to more severe asthma symptoms, study finds
September 23, 2018 - Study highlights need to remain vigilant in maintaining key infection control processes
September 23, 2018 - Novel therapeutic strategy for blood vessel related disorders, such as cancer and retinopathy
September 23, 2018 - New naturally occurring antibiotic found effective against Mycobacterium tuberculosis
September 23, 2018 - First-in-human phase 0 study shows clinically-relevant activity of new drug in glioblastoma
September 23, 2018 - Removing tobacco product display from shops reduced number of children buying cigarettes
September 23, 2018 - Random fraction of specialized immune cells leads the charge in battling invaders
September 23, 2018 - Few minutes of sprinting exercise may be as effective as longer exercise sessions
September 23, 2018 - Researchers use neutrons to make first direct observations of water in lipid bilayers
September 23, 2018 - Researchers demonstrate pre-clinical success for universal flu vaccine in new paper
September 23, 2018 - Study reveals surprising gaps in some HIV medical providers’ knowledge of ACA
September 23, 2018 - Oxehealth secures European medical device accreditation for vital signs measurement software
September 23, 2018 - HTN Tx Intensification Common Upon Discharge in U.S. Vets
September 23, 2018 - Fibre can strengthen the intestinal barrier
September 23, 2018 - New platform examines infectious pathogens that may spread from animals to humans
September 23, 2018 - Demographers create detailed color map of population aging in Europe
September 23, 2018 - New type of fatty acid can slow down overreactive immune system
September 23, 2018 - Innovative procedure could provide breakthrough in treating early-stage lung cancer
September 23, 2018 - Research finds drop in number of measles cases in the EU/EEA since March 2018
September 23, 2018 - Researchers acquire new insights into DNA polymerases
September 23, 2018 - Alzheimer’s diagnosis might become simpler with new brain imaging method
September 23, 2018 - Reports Warn of Growing Opioid Crisis Among Seniors
September 23, 2018 - Researchers unravel why people with HIV suffer from more neurologic diseases
September 23, 2018 - Human brain structured to make best possible decision with limited resources
September 23, 2018 - KHN’s ‘What the Health?’ Health on the hill
September 23, 2018 - Bad air and inadequate data prove an unhealthy mix
September 23, 2018 - Regular bedtime and wake time important for heart, metabolic health even among adults
September 23, 2018 - HIV and a tale of a few cities
September 23, 2018 - NIH launches clinical trial to test infusions of combination antibodies in people with HIV
September 23, 2018 - Researchers develop new system to detect consumption of synthetic cannabinoids
September 23, 2018 - Vax-Hub to influenze radical change in development and manufacturing of vaccines
September 23, 2018 - People who have slept lesser than seven hours have higher risks of car crashes
September 23, 2018 - an ancient art may work best to prevent falls in old age
September 23, 2018 - Consumption of foods with lower nutritional quality related to increased cancer risk
September 23, 2018 - Patient Health Information Often Shared Electronically
September 23, 2018 - Can machine learning bring more humanity to health care?
September 23, 2018 - Body organs undergo structural changes in response to diet
September 23, 2018 - Genetic polymorphisms linked with muscle injury and stiffness
September 23, 2018 - As states try to rein in drug spending, feds slap down one bold Medicaid move
September 22, 2018 - Why Eczema Is Tougher to Treat for Black Patients
September 22, 2018 - Team reveals that human genome could contain up to 20 percent fewer genes
September 22, 2018 - USC research uncovers previously unknown genetic risk factor for Alzheimer’s disease
September 22, 2018 - Novel method achieves accurate and precise temperature estimation in fat-containing tissues
September 22, 2018 - BSI accredits Oxehealth’s vital signs measurement software as Class IIa medical device
September 22, 2018 - Evolution of psychiatric disorders and human personality traits
September 22, 2018 - Obesity in early puberty doubles asthma risk for boy’s future offspring
September 22, 2018 - World’s most advanced real-time patient monitoring platform receives key US patent
September 22, 2018 - Study explores connection between sexuality and cognitive status in older adults
September 22, 2018 - LSTM partners with TB Alliance to develop novel TB drug regimens
September 22, 2018 - Annual wellness visits improve delivery of preventive services in elderly population
September 22, 2018 - CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma
September 22, 2018 - Hispanic communities with high proportions of Hispanics face more cardiovascular-related death
September 22, 2018 - Vici syndrome – Genetics Home Reference
September 22, 2018 - Single-dose drug can shorten flu symptoms by about a day, studies suggest
September 22, 2018 - AMSBIO launches circulating tumor DNA Reference Standards
September 22, 2018 - Sandalwood mimicking odorant could stimulate hair growth in humans
September 22, 2018 - Overlooked immune cells could play a key role in cancer immunotherapy, claims new study
September 22, 2018 - Study reveals prevalence of diagnosed type 1 and type 2 diabetes among American adults
September 22, 2018 - Researchers develop fast detection strategy to know type of virus acquired by patients
September 22, 2018 - Global Prevalence of Insufficient Activity 27.5 Percent
September 22, 2018 - Strategies to protect bone health in hematologic stem cell transplant recipients
September 22, 2018 - Brigham Genomic Medicine program unravels 30 medical mysteries
September 22, 2018 - New system harnesses power of bubbles to destroy dangerous biofilms
September 22, 2018 - Inflammation plays crucial role in preventing heart attacks and strokes, study reveals
September 22, 2018 - Calorie dense, nutrient deficient meals common across the world
September 22, 2018 - Researchers develop technology to study behavior of implants without animal testing
September 22, 2018 - First gut bacteria in newborns may have lasting effect on ability to ward off chronic diseases
September 22, 2018 - Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species
Scientists release new digital platform to assist international seek for remedy of leukemia

Scientists release new digital platform to assist international seek for remedy of leukemia

image_pdfDownload PDFimage_print

Discovering a remedy for an extraordinary form of blood most cancers may well be speeded up by way of a brand new digital platform that permits researchers simple get right of entry to to knowledge from affected person samples generated by way of laboratories world wide.

LEUKomics, which has been introduced by way of scientists on the College of Glasgow and the College of Melbourne, is a complete database describing over 100 continual myeloid leukemia (CML) samples. It’s totally loose for researchers to make use of and percentage.

CML signs regularly come with critical fatigue and weight reduction, and even if it develops slowly, it is going to in the end development and end up deadly if untreated.  Not like many different cancers, a unmarried genetic mutation underlies the biology of CML. The fault happens early on within the construction of a kind of white blood mobile referred to as myeloid cells.

Scientists hope LEUKomics will building up working out of CML, and result in new focused medication and in the long run a remedy. The website online has been constructed as a part of the stem mobile database Stemformatics, with investment from the charities Bloodwise and the Scottish Most cancers Basis.

Medicine referred to as tyrosine kinase inhibitors, or TKIs, had been presented within the early 2000s, and are designed to focus on the genetic mutation that drives CML. Maximum sufferers can take a day by day tablet and are living an ordinary lifestyles, however some folks revel in insupportable unintended effects from TKIs or expand resistance.

One of the most primary goals of present analysis is to design therapies that may goal the underlying leukaemic stem cells that may evade TKIs, providing hope of an enduring remedy. To do that, researchers wish to know extra about those elusive leukemic stem cells, they usually consider that the solutions lie within the research of enormous scale organic knowledge.

Advanced by way of the groups of Professor Christine Wells at The College of Melbourne and Professor Tessa Holyoake at The College of Glasgow, the LEUKomics database curates prime quality knowledge at the gene job of various CML stem mobile samples.

Because of the expense of producing this knowledge and difficulties acquiring those uncommon CML cells from affected person subject matter, unmarried datasets have a tendency to have small pattern numbers, which limits their doable to turn small adjustments within the leukemic samples.  With the higher samples measurement that comes from combining more than one knowledge units, researchers have the facility to come across extra delicate adjustments that can be a very powerful to the biology of the leukemic stem cells.

Professor Jeff Evans, Director of the Institute of Most cancers Sciences on the College of Glasgow stated:

LEUKomics is an excessively treasured useful resource and may lend a hand us to show new underlying mechanisms that pressure CML. It has the possible to turn into CML analysis on a world degree, because the findings will also be downloaded and shared with different researchers internationally.  We additionally hope it evokes new analysis concepts, and in the long run fuels a world seek into discovering remedies for CML.

The knowledge lets in researchers to discover how lively other genes are in leukemic stem cells and the way those have interaction with each and every different to have an effect on the blood most cancers’s conduct. The net portal additionally accommodates samples of wholesome blood stem cells, permitting researchers to at once examine the gene job with leukemic stem cells.

Dr Alasdair Rankin, Director of Analysis at Bloodwise, stated:

Thank you to analyze, maximum sufferers with CML will now are living an ordinary lifestyles by way of taking a unmarried tablet. However remedy is life-long and no longer everybody can tolerate the unintended effects from their remedy, or won’t reply and spot their CML go back. There stays a wish to expand an enduring remedy for all folks with this blood most cancers. LEUKomics is a extremely leading edge solution to accelerate this seek for a remedy, and will have to be a treasured asset for the worldwide blood most cancers analysis neighborhood. We look ahead to seeing its have an effect on within the months to return.

Supply:

https://bloodwise.org.united kingdom/weblog/scientists-create-leukaemia-online-tool-aid-global-search-cure

Tagged with:

About author

Related Articles