Breaking News
August 19, 2018 - HPV Legislation Doesn’t Impact Teen Sexual Behaviors
August 19, 2018 - Exenatide treatment alleviated symptoms of depression in patients
August 19, 2018 - Tufts researchers win grant to study integration of genomic sequencing into neonatal care
August 19, 2018 - Novel finger-prick test can help prevent toxoplasmosis
August 19, 2018 - Cosmetic Procedures Boost Well-Being, Poll Shows
August 19, 2018 - Responsive parenting intervention results in lower BMIs through age three
August 19, 2018 - Anticancer drugs can help plants to battle infection
August 19, 2018 - Sunscreen from bathers releases significant quantities of polluting titanium dioxide into the sea
August 19, 2018 - Case Western Reserve gets three-year grant to enhance food systems in Cleveland neighborhoods
August 19, 2018 - Teenagers can thank their parents’ positive attitude for avoiding obesity
August 19, 2018 - Body mass index positively linked with blood pressure
August 19, 2018 - New tool fills gap in Small Molecules market
August 19, 2018 - Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials
August 19, 2018 - Researchers develop molecular matrix that delivers healing stem cells to injured elderly muscles
August 19, 2018 - Teva and Regeneron Announce Positive Topline Phase 3 Fasinumab Results in Patients with Chronic Pain from Osteoarthritis of the Knee or Hip
August 19, 2018 - New study pinpoints ways to improve quality of food and nutrition research
August 19, 2018 - Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody
August 19, 2018 - New CRISPR technology may help eliminate mutated gene sequence
August 19, 2018 - “Zombie gene” protects elephants from cancer finds study
August 19, 2018 - Study explores how many American cities protect the rights of employed breastfeeding mothers
August 19, 2018 - FDA Approves Lenvima (lenvatinib) for First-line Treatment of Unresectable Hepatocellular Carcinoma (HCC)
August 19, 2018 - Pain: Considering Complementary Approaches (eBook)
August 19, 2018 - Autoimmune response drives vision loss in glaucoma
August 19, 2018 - Tandem Diabetes Care introduces t:slim X2 Insulin Pump with Basal-IQ Technology in the US
August 19, 2018 - Innovative platform developed to destroy cancer cells
August 19, 2018 - Lowering pH inside tumor cells can slow down spread of cancer
August 19, 2018 - Biomarker predicts kidney cancer risk years before diagnosis
August 19, 2018 - Consequences of healthcare-associated infections go beyond patients’ physical health
August 19, 2018 - New drug- free, nanotechnology-based method detects and treats oral plaque
August 19, 2018 - Integration of Opioid, Infectious Disease Treatment Needed
August 19, 2018 - How eye disorders may have influenced the work of famous painters
August 18, 2018 - Blood biomarker could help predict kidney cancer up to five years prior to diagnosis
August 18, 2018 - Dartmouth scientists create more sustainable feed for aquaculture
August 18, 2018 - Immigrants Not a Burden on U.S. Health Care: Study
August 18, 2018 - Women who eat fast food take longer to become pregnant
August 18, 2018 - Most YouTube videos on plastic surgery are misleading marketing campaigns
August 18, 2018 - The essential guide to make your laboratory more sustainable
August 18, 2018 - Loyola Medicine offers scalp cooling treatment to reduce risk of chemotherapy hair loss
August 18, 2018 - Researchers describe promising strategy to remove melanoma’s most powerful defenses
August 18, 2018 - Women with polycystic ovary syndrome dissatisfied with medical care
August 18, 2018 - Research discoveries reveal insights behind neurological degeneration
August 18, 2018 - Researchers win multi-million Euro award to conduct research into liver disease
August 18, 2018 - Survey highlights variations in practice of airway management in pediatric intensive care units
August 18, 2018 - UK students win sponsorship from Promega Corporation
August 18, 2018 - Janssen Reports Positive Topline Results for ATLAS Phase III Study of a Novel, Long Acting Injectable Two-Drug Regimen for the treatment of HIV-1
August 18, 2018 - PSD as a molecular platform for understanding synapse formation and plasticity
August 18, 2018 - Improved visual communication could help patients to make informed health-care decisions
August 18, 2018 - New algorithm helps identify and manage diabetic patients at increased fracture risk
August 18, 2018 - Microscopic insect odour detecting mechanisms discovered
August 18, 2018 - Researchers develop new approach to study how tuberculosis infects people
August 18, 2018 - FDA Approves Kalydeco (ivacaftor) for Cystic Fibrosis in Children Ages 12 to
August 18, 2018 - An ion channel differentiates newborn and mature neurons in the adult brain
August 18, 2018 - Conditions of first sexual encounter can be indicators of future HIV risk and gender-based violence
August 18, 2018 - Socio-economic position associated with pregnant women’s exposure to environmental hazards
August 18, 2018 - Study evaluates how students change their breakfast consumption when given extra time
August 18, 2018 - Chronic perinatal hypoxia linked to locomotor miscoordination, long-term cerebellar learning deficits
August 18, 2018 - Voters to settle dispute over ambulance employee break times
August 18, 2018 - AGA urges policymakers and stakeholders to improve affordability of drugs
August 18, 2018 - Increasing dietary protein may lower risk of diabetes in people with NAFLD
August 18, 2018 - New HIV therapy suppresses viral replication and increases immune cells in drug-resistant patients
August 18, 2018 - Broad Genetic Testing for NSCLC May Not Improve Survival
August 18, 2018 - Discovery opens door for synthetic opioids with less addictive qualities
August 18, 2018 - Transgenic rice plant extracts could help stop the spread of HIV
August 18, 2018 - Hologic’s Cynosure division partners with Porter Instrument to distribute nitrous oxide and oxygen system
August 18, 2018 - Two thyroid medications recalled by FDA
August 18, 2018 - Forecast Sees Abnormal Heat Worldwide Through 2022
August 18, 2018 - Childhood absence epilepsy – Genetics Home Reference
August 18, 2018 - Fearing hard Brexit, UK drugmakers stockpile to protect lives
August 18, 2018 - Discovery may help broaden the scope of defenses against HPV
August 18, 2018 - When they start thinking green, they see green
August 18, 2018 - Scientists introduce microfluidics-based chip for manipulation and analysis of single cells
August 18, 2018 - Researchers design new way to grow nose cells for treating spinal cord injuries
August 18, 2018 - New light shed on relationship between calorie-burning fat and muscle function
August 18, 2018 - Surgery Saturday Instagram series takes you inside Stanford’s OR
August 18, 2018 - Researchers uncover surprising new role for inhibition in the cerebellum
August 18, 2018 - Children have better nutrition when they live near forests, global study shows
August 18, 2018 - OHSU professor conducts clinical trial with artificial pancreas using Xeris’ liquid glucagon
August 18, 2018 - HSS takes young patients with physical challenges on a surfing trip
August 18, 2018 - Study shows electronic health records leave doctors and patients unsatisfied
August 18, 2018 - Study uncovers mechanism that affects multiplication of dengue virus lineage
Fecal microbiota transplant is protected and efficient for sufferers with ulcerative colitis

Fecal microbiota transplant is protected and efficient for sufferers with ulcerative colitis

image_pdfDownload PDFimage_print
Intestine micro organism microbiome. 3-d representation. Illustration. Picture via Anatomy Insider. Credit score: Weill Cornell Clinical School

A unmarried transplant of microbes contained within the stool of a wholesome donor is a protected and efficient solution to build up variety of fine micro organism within the guts of sufferers with ulcerative colitis, in line with new analysis from Weill Cornell Medication and NewYork-Presbyterian. The findings counsel that fecal microbiota transplantation (FMT) could be an efficient remedy for the illness, which reasons irritation and ulcers within the digestive tract.

Fecal microbiota transplantation is a process by which fecal topic—which is stuffed with micro organism from the intestine—is amassed from a wholesome donor, strained and positioned within the colon of a affected person with inflammatory bowel illness. “The theory is that you’ll exchange any person’s microbiome, the organisms that colonize the intestine,” mentioned Dr. Randy Longman, an assistant professor of medication at Weill Cornell Medication and a gastroenterologist at NewYork-Presbyterian/Weill Cornell Clinical Middle. “We introduce excellent micro organism into the intestines of any person with the illness and hope that it encourages therapeutic.”

FMT has been confirmed efficient for sufferers with Clostridium difficile, a major bacterial an infection of the intestines, however questions stay about its effectiveness as a remedy for different illnesses. In a learn about revealed April 26 in Inflammatory Bowel Illness, a group of gastroenterologists and researchers from Weill Cornell Medication and NewYork-Presbyterian led via Drs. Vinita Jacob, Carl Crawford and Longman provide knowledge suggesting that FMT is protected and will increase the variety of microbes in sufferers with lively ulcerative colitis.

“Sufferers with ulcerative colitis generally have a decrease variety of microbes of their guts,” mentioned Dr. Longman, who could also be a scientist within the Jill Roberts Institute for Analysis in Inflammatory Bowel Illness and a clinician within the Jill Roberts Middle for Inflammatory Bowel Illness at NewYork-Presbyterian/Weill Cornell and Weill Cornell Medication. “We all know extra numerous microbiota is correlated with higher well being, so expanding that variety is also a key issue within the healing efficacy of FMT for ulcerative colitis.”

The researchers used a fecal microbiota preparation (FMP) consisting of stool from two other wholesome donors that have been screened and purified. This two-donor preparation was once used in an effort to maximize the variety of micro organism within the transplant. They then used a colonoscopy to transplant the FMP into the colons of 20 ulcerative colitis sufferers. After 4 weeks, the investigators amassed fecal samples from the sufferers and carried out rectal biopsies in an effort to measure the fecal microbiome and immune reaction after remedy.

The researchers discovered that when 4 weeks, the bacterial populations within the intestines of the sufferers extra carefully resembled the ones of the wholesome donors than the sufferers’ authentic microbiomes. As well as, the remedy additionally ended in a discount within the inflammatory reaction that drives ulcerative colitis. Total, 35 p.c of sufferers confirmed a scientific growth of their signs and 15 p.c of sufferers completed scientific remission (entire loss of signs) via the tip of the four-week learn about.

“We nonetheless wish to know why this remedy is helping some sufferers and no longer others in order that we will discover a more secure and extra reproducible remedy choice for a better majority of sufferers affected by ulcerative colitis,” mentioned Dr. Crawford, an assistant professor of scientific medication.

Additional research are essential to decide how lengthy those certain results might final in ulcerative colitis sufferers, the precise micro organism that could be most efficient for FMP and among the finest supply manner. This learn about supplies promising effects for the rising function for FMT in ulcerative, Dr. Longman mentioned.

“We noticed transparent certain results, each with regards to higher bacterial inhabitants and in scientific reaction. This issues to FMT as an exhilarating conceivable treatment for folks with ulcerative colitis.”

Discover additional:
Yoga is helping sufferers with ulcerative colitis

Additional information:
Vinita Jacob et al. Unmarried Supply of Top-Range Fecal Microbiota Preparation via Colonoscopy Is Protected and Efficient in Expanding Microbial Range in Energetic Ulcerative Colitis, Inflammatory Bowel Sicknesses (2017). DOI: 10.1097/MIB.0000000000001132

Magazine reference:
Inflammatory Bowel Sicknesses

Supplied via:
Weill Cornell Clinical School

Tagged with:

About author

Related Articles