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Novel technique to hit upon poisonous results of chemical compounds may cut back want for animal checking out

Novel technique to hit upon poisonous results of chemical compounds may cut back want for animal checking out

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A fluorescence microscopy symbol of neurons derived from mouse embryonal carcinoma P19 cells. Credit score: Dina Popova

Conventional toxicological investigations carried out on animals (in vivo) are dear, time-consuming and would possibly purpose animal struggling. However analysis from Umeå College demonstrates neuronal mobile style, derived from mouse, can be utilized to guage the neurotoxic impact of chemical compounds. The other toxicity possibility evaluation may cut back reliance on animal checking out whilst additionally permit fast massive scale toxicity reviews.

“Easy and powerful cell fashions are vital as a result of they enable us to display numerous chemical compounds together with environmental pollution, cosmetics, meals preservatives and medicine for attainable toxicity. Additionally, they enable us to analyze mechanisms of toxicity at the cell degree,” says Dina Popova, doctoral scholar on the Division of Pharmacology and Medical Neuroscience at Umeå College and creator of the doctoral thesis.

The total intention of Dina Popova’s analysis has been to guage the usefulness of neuronally differentiated mouse embryonal carcinoma P19 cells (P19 neurons) as a style for toxicity checking out. P19 cells are a most often to be had tumour mobile line which may also be simply cultured in vitro. What makes the cells fascinating is their talent to tell apart into other mobile varieties relying at the remedy. Dina Popova differentiated P19 cells into neurons with a variety of traits which can be conventional of mammalian mind cells.

The use of those differentiated cells, Dina Popova discovered that P19 neurons can hit upon toxicity of identified neurotoxic compounds together with the environmental toxicant methylmercury, the marine biotoxin okadaic acid and acrylamide, which is a chemical utilized in other industries. The style will also be used to check the toxicity of leisure medication akin to methylenedioxymethamphetamine (referred to as MDMA or ecstasy) and a gaggle of piperazine derivatives.

When in comparison to the opposite two cell fashions continuously used for neurotoxicity research, the P19 neurons have been generally extra delicate to the poisonous results of the compounds examined. As well as, the P19 neurons might be used to spot mechanisms of toxicity.

Dina Popova has additionally advanced a easy technique to measure neurite outgrowth in P19 neurons. Neurite outgrowth, i.e. projections from the mobile our bodies, is crucial parameter in neurotoxicity evaluation of chemical compounds since disruptions in neurite community would possibly result in cognitive abnormalities.


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