Breaking News
December 14, 2018 - Researchers discover Ebola-fighting protein in human cells
December 14, 2018 - Fentanyl surpasses heroin in cause of U.S. drug overdose deaths
December 14, 2018 - When Heart Attack Strikes, Women Often Hesitate to Call for Help
December 14, 2018 - A warning about costume contacts
December 14, 2018 - Study examines link between peripheral artery disease and heart attack
December 14, 2018 - Researchers develop biotechnological tool to produce antifungal proteins in plants
December 14, 2018 - 3D-printed adaptive aids can benefit patients with arthritis
December 14, 2018 - Chronic bullying during adolescence impacts mental health
December 14, 2018 - Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics
December 13, 2018 - Importance of cell cycle and cellular senescence in the placenta discovered
December 13, 2018 - Gold “nanoprisms” open new window into vessels and single cells
December 13, 2018 - Research findings could lead to new targets for cancer-fighting therapeutics
December 13, 2018 - Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines
December 13, 2018 - Study explores how patients want to discuss symptoms with doctors
December 13, 2018 - RUDN medics first to gather scattered data on hepatitis morbidity in Somalia
December 13, 2018 - Age and gender disparities found in use of bed nets to prevent malaria in sub-Saharan Africa
December 13, 2018 - Caffeine therapy benefits developing brains of premature babies
December 13, 2018 - New review focuses on electrospinning techniques used in musculoskeletal tissue engineering
December 13, 2018 - A new division focused on human immune system
December 13, 2018 - Zogenix Announces Positive Phase 3 Trial Results on the Efficacy and Safety of Fintepla (ZX008) in Dravet Syndrome
December 13, 2018 - BCR ABL Genetic Test: MedlinePlus Lab Test Information
December 13, 2018 - Caffeinated beverages during pregnancy linked to lower birth weight babies
December 13, 2018 - Stanford Medicine Health Trends Report examines opportunity to democratize health care
December 13, 2018 - Obsessive-compulsive disorder may protect individuals from obesity
December 13, 2018 - Scientists investigate how a painful event is processed in the brain
December 13, 2018 - Genetic study reveals new insights into underlying causes of moderate-to-severe asthma
December 13, 2018 - Vitamin C supplementation for pregnant smokers may reduce harm to infants’ lungs
December 13, 2018 - New study reveals yin-yang personality of dopamine
December 13, 2018 - Research identifies nerve-signaling pathway behind sustained pain after injury
December 13, 2018 - Children with high levels of callous traits show widespread differences in brain structure
December 13, 2018 - Long-term Benefit of Steroid Injections for Knee Osteoarthritis Challenged
December 13, 2018 - Adding new channels to the brain remote control
December 13, 2018 - In the Spotlight: A different side of neuroscience
December 13, 2018 - Medical Marvels: Using immunotherapy for melanoma that spread to the brain
December 13, 2018 - Puzzles do not keep dementia away finds study
December 13, 2018 - New mouse model shows potential for rapid identification of promising muscular dystrophy therapies
December 13, 2018 - Study reveals urban and rural differences in prenatal exposure to essential and toxic elements
December 13, 2018 - New collaborative partnership in quest of novel antibiotics
December 13, 2018 - Single tau molecule holds clues to help diagnose neurodegeneration in its earliest stages
December 13, 2018 - AHA Scientific Statement: Low Risk of Side Effects for Statins
December 13, 2018 - What Is Acute Flaccid Myelitis?
December 13, 2018 - How bereaved people control their thoughts without knowing it
December 13, 2018 - Health care democratization underway, according to 2nd annual Stanford Medicine Health Trends Report | News Center
December 13, 2018 - Going Beyond a Single Color
December 13, 2018 - London-based startup launches ‘’ aiming to clean up CBD industry
December 13, 2018 - Loss of tight junction barrier protein results in gastric cancer development
December 13, 2018 - Novel way to efficiently deliver anti-parasitic medicines
December 13, 2018 - RKI publishes new data on disease prevention and utilization of medical services
December 13, 2018 - High-tech, flexible patches sewn into clothes could help to stay warm
December 13, 2018 - The CCA releases three reports on requests for medical assistance in dying
December 13, 2018 - Restoring Hair Growth on Scarred Skin? Mouse Study Could Show the Way
December 13, 2018 - Probiotic use may reduce antibiotic prescriptions, researchers say
December 13, 2018 - Drug repositioning strategy identifies potential new treatments for epilepsy
December 13, 2018 - Chronic rhinitis associated with hospital readmissions for asthma and COPD patients
December 13, 2018 - Food poisoning discovery could save lives
December 13, 2018 - Cloned antibodies show potential to treat, diagnose life-threatening fungal infections
December 13, 2018 - Exercise may reduce colorectal cancer risk after weight loss
December 13, 2018 - Russian scientists create hardware-information system for brain disorders treatment
December 13, 2018 - Moderate alcohol consumption linked with lower risk of hospitalization
December 13, 2018 - Nurturing Healthy Neighborhoods | NIH News in Health
December 13, 2018 - Rise in meth and opioid use during pregnancy
December 13, 2018 - Researchers gain new insights into pediatric tumors
December 13, 2018 - FSU study finds racial disparity among adolescents receiving flu vaccine
December 13, 2018 - Study investigates attitudes toward implementation of ‘sex as a biological variable’ policy
December 13, 2018 - Drug cocktail induces cancer cell death by switching off energy supply
December 13, 2018 - Baculovirus virion completely eliminates liver-stage parasites in mouse model
December 13, 2018 - Researchers create noninvasive technology that detects when nerve cells fire
December 13, 2018 - Allen Institute for Immunology to partner with CU Anschutz to understand dynamics of human immune system
December 13, 2018 - Inability to do daily living tasks delays discharge of mental health patients
December 13, 2018 - Treating patients with hypertension induced albuminuria
December 13, 2018 - New substance could improve efficacy of established breast cancer treatments
December 13, 2018 - Scientists develop new stem cell line to study conversion of stem cells into muscle
December 13, 2018 - Re-programming the body’s energy pathway boosts kidney self-repair
December 13, 2018 - Research findings could help improve treatment of anxiety and post-traumatic stress disorders
December 13, 2018 - The Microbiome Movement announce Microbiotica as official industry partner
December 13, 2018 - New study reveals potential benefits of cEEG monitoring for infant ICU patients
December 13, 2018 - Whole-body imaging PET/MRI offers information to guide treatment options for prostate cancer
December 13, 2018 - International investigators fight against the negative campaign on benzodiazepines
December 13, 2018 - Targeting biochemical pathway may lead to new therapies for alleviating symptoms of anxiety disorders
December 13, 2018 - FDA Approves Tolsura (SUBA®-itraconazole capsules) for the Treatment of Certain Fungal Infections
Staff eradicates hepatitis C in 10 sufferers following lifesaving transplants from contaminated donors

Staff eradicates hepatitis C in 10 sufferers following lifesaving transplants from contaminated donors

image_pdfDownload PDFimage_print
Electron micrographs of hepatitis C virus purified from mobile tradition. Scale bar is 50 nanometers. Credit score: Heart for the Find out about of Hepatitis C, The Rockefeller College.

Ten sufferers at Penn Medication were cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who had been contaminated with the illness. The findings level to new methods for expanding the availability of organs for the country’s greater than 97,000 sufferers who’re waiting for kidney transplants – incessantly for as many as 5 or extra years.

In 2016, Penn Medication introduced an leading edge scientific trial to check the impact of transplanting kidneys from donors with HCV into sufferers these days at the kidney transplant waitlist who would not have the virus, and who choose in to obtain those another way unused organs. Recipients had been then handled with an antiviral treatment so that you could remedy the virus. Early knowledge from the learn about had been introduced as of late by means of David S. Goldberg, MD, MSCE, an assistant professor of Medication and Epidemiology within the Perelman Faculty of Medication on the College of Pennsylvania, on the 2017 American Transplant Congress in Chicago, and had been concurrently revealed within the New England Magazine of Medication.

“We began this trial within the hopes that, if a hit, lets open up a completely new pool of donor organs, and successfully transplant loads, if no longer 1000’s, extra sufferers who’re waiting for a lifesaving organ,” Goldberg mentioned. “Traditionally, Hepatitis C-infected kidneys had been incessantly discarded, and had been regarded as broken or too ‘high-risk.’ Our pilot knowledge show the facility to remedy the reduced in size virus following transplantation on this affected person inhabitants. If long term research are a hit, this can be a viable choice for sufferers who might another way by no means see a transplant.”

Goldberg, who co-led the learn about with Peter Reese, MD, MSCE, an assistant professor of Medication and Epidemiology at Penn and chair of the Ethics Committee for the United Community of Organ Sharing (UNOS), approached and enrolled members who trusted dialysis therapies to face in for his or her broken kidneys. Members had been between 40 and 65 years of age and have been looking forward to a transplant for no less than a yr and a part. A 3-step means of training and consent was once used right through pre-enrollment to verify sufferers, and their family members had been supplied with a complete working out of the dangers. As soon as enrolled, and as organs changed into to be had, the workforce carried out HCV donor genotyping right through the allocation procedure, settling on best kidneys that had been thought to be “prime quality.”

Within the first section of the learn about, up to now, 10 sufferers have won transplants the use of the protocol. On reasonable, sufferers won a transplant 58 days after enrolling within the trial—some in as temporarily as 11 days, whilst others waited for over 100 days. At 3 days after surgical procedure, sufferers had been examined for HCV, and all 10 examined wonderful for the illness. Subsequent, the members had been handled with the usual 12-week process elbasvir/grazoprevir, repeatedly referred to as Zepatier, a recently-approved and extremely efficient oral medicine prescribed to get rid of HCV. All 10 sufferers were cured in their reduced in size HCV.

“For see you later, HCV was once an endemic with an excessively detrimental stigma related to it, particularly amongst physicians. So it was once attention-grabbing to look that sufferers had been fast to leap on the likelihood to get this transplant, regardless of the chance that they may get Hepatitis C completely,” Reese mentioned. “Going into the learn about, we knew it was once an opportunity that some or all the sufferers would contract HCV, and that they may have the illness for the remainder of their lives if we had been unsuccessful. However for those sufferers, getting off of dialysis and getting again to their standard lives was once very a lot definitely worth the menace.”

Following the early wonderful effects, the analysis workforce was once granted an extension in their learn about, which can let them transplant and deal with an extra 10 sufferers—20 sufferers in general.

The analysis workforce is designing a brand new scientific trial that may learn about this identical way in sufferers who’re center transplant recipients, and sooner or later they hope to inspect the efficacy of this way in liver and lung transplants. Researchers word there’s a want for longer and bigger trials to proceed comparing the effectiveness of HCV-positive to HCV-negative transplantation adopted by means of antiviral treatment in a broader inhabitants.

Discover additional:
Increasing get entry to: First scientific trial transplants hepatitis C-infected kidneys at Penn Medication

Magazine reference:
New England Magazine of Medication

Equipped by means of:
Perelman Faculty of Medication on the College of Pennsylvania

Tagged with:

About author

Related Articles