Breaking News
April 20, 2018 - NovaDigm Therapeutics initiates NDV-3A Phase 2a study for reduction of S. aureus in military trainees
April 20, 2018 - Experimental compound reduces destructive inflammation to improve stroke outcome
April 20, 2018 - The May issue of Drug Discovery Today is a Special Issue and will be published very soon
April 20, 2018 - Larger families linked to heightened tooth loss risk for moms
April 20, 2018 - Scientists develop tiny fluorescent probe that seeks out GLUT5 and detects cancer cells
April 20, 2018 - The Swedish Childhood Cancer Foundation awards grant to KI researchers
April 20, 2018 - AMSBIO’s MC-Easy minicircle technology allows sustained transgene expression in quiescent cells and tissues
April 20, 2018 - Researchers use optogenetics to treat chronic pain
April 20, 2018 - Discovery of 100 new genes may aid research into pigmentation
April 20, 2018 - AYOXXA introduces new LUNARIS Mouse 12-Plex Th17 Kit for quantitative analysis of Th17 cell biology
April 20, 2018 - Compound derived from immune cells treats psoriasis in mice
April 20, 2018 - GABA-transaminase deficiency – Genetics Home Reference
April 20, 2018 - Key heart risks decline for older Americans
April 20, 2018 - UD professor wins $2.3 million grant from NIH for research on Achilles tendinopathy
April 20, 2018 - Researchers discover unique protein in malaria parasite that could be new drug target
April 20, 2018 - Bio-Techne expands automation capabilities of popular RNAscope ISH technology
April 20, 2018 - Smartphone app effective in promoting proper child car seat practices
April 20, 2018 - Nutraceuticals could play an important role in preventing heart disease
April 20, 2018 - FDA Alert: Certain Kratom-Containing Powder Products by Viable Solutions: Recall -Possible Salmonella Contamination
April 20, 2018 - What is heart failure?
April 20, 2018 - TIP Biosystems introduces handheld UV-Visible spectrophotometer for photometric measurements
April 20, 2018 - Inactivity of astronauts during spaceflights may have more pronounced effect on skeletal muscle than hypoxia
April 20, 2018 - New SIDS Info app seeks to reduce infant sleep-related deaths
April 20, 2018 - Wide-scale distribution of naloxone effectively prevents overdose deaths, study finds
April 20, 2018 - Triple-negative breast cancer found to be chemoresistant prior to treatment
April 20, 2018 - ACL tears occur the same way in women and men, study finds
April 20, 2018 - UT Southwestern researchers identify 170 potential therapeutic targets for lung cancer
April 20, 2018 - Finding the ‘keyhole’ to beat obesity at the cellular level
April 20, 2018 - Long-term exposure to cold temperatures reduces diabetes and obesity, shows study
April 20, 2018 - Metabolic Syndrome Common With Chronic Hep B Infection
April 20, 2018 - Tracking quality of life during prostate cancer treatment
April 20, 2018 - Study shows presence of beta-amyloid dimers in the brains of Alzheimer’s patients
April 20, 2018 - Researchers identify link between physical inactivity and increased risk of dying from cancer
April 20, 2018 - Breathtaking evolution amongst Indonesian tribe
April 20, 2018 - Study shows testosterone deficiency in men is associated with chronic diseases
April 20, 2018 - Simple one-page form helps improve satisfaction of patients with care
April 20, 2018 - Researchers evaluate accuracy of simple blood test to predict lung cancer
April 20, 2018 - Study looks at sperm producing ability in testicular cancer patients
April 20, 2018 - Exercise In, Vitamin D Out for Preventing Falls: U.S. Panel
April 20, 2018 - Skin cancers associated with decreased risk of developing AD
April 20, 2018 - Preserving fertility during chemotherapy
April 20, 2018 - Teva and Procter & Gamble Company terminate PGT Healthcare partnership
April 20, 2018 - People diagnosed with traumatic brain injury may have increased risk of Parkinson’s disease, shows study
April 20, 2018 - Researchers use smartphone to diagnose people infected with Loa loa worm
April 20, 2018 - College students with autism have high rate of suicidal thoughts
April 20, 2018 - Study sheds light on how the HSC niche is maintained
April 20, 2018 - Drug test spurs frank talk between hypertension patients and doctors
April 19, 2018 - Low-cost deworming drug improves female farmers’ physical fitness
April 19, 2018 - Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects
April 19, 2018 - Many European countries lack comprehensive policy to eliminate viral hepatitis
April 19, 2018 - Young people with ADHD ‘more likely’ to come from deprived neighbourhoods
April 19, 2018 - SLU professor discovers new biomarkers for chlorine gas exposure
April 19, 2018 - Study proposes new mechanism that may contribute to gender differences in weight control
April 19, 2018 - Sleep restriction therapy does not interfere with insomnia patient’s driving ability, research shows
April 19, 2018 - Deep brain stimulation offers relief to UTHealth patient with treatment-resistant depression
April 19, 2018 - Study shows fatty fish and camelina oil boost HDL and IDL cholesterol
April 19, 2018 - FDA Alert: Euphoric Capsules by Epic Products: Recall
April 19, 2018 - Researchers identify peptide produced during cartilage deterioration as a potential source of osteoarthritis pain
April 19, 2018 - New breakthrough may allow scientists to orchestrate tissue regeneration in humans
April 19, 2018 - SYGNIS AG introduces new TruePrime apoptotic cell free DNA amplification kit
April 19, 2018 - Innovative device shows promise in capturing and releasing circulating tumor cells
April 19, 2018 - Researchers shed light on role of striosomal neurons in reinforcement learning
April 19, 2018 - Genetic make-up impacts long-term effectiveness of phobia treatment
April 19, 2018 - Novel biomarker can distinguish malignant lung nodules
April 19, 2018 - Study reports promising novel approach to treat therapy resistant pediatric brain tumors
April 19, 2018 - One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy
April 19, 2018 - Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain
April 19, 2018 - Transplanted livers have a protective effect and reduce potential for organ rejection
April 19, 2018 - Researchers develop new method to study activity of inflammatory cells
April 19, 2018 - Researchers discover highly antibiotic resistant superbugs in Gulf States
April 19, 2018 - Smart-tooth technology shows promise in detecting certain diseases in high-risk patients
April 19, 2018 - Interaction between dioxin and HLA gene variant activates events associated with rheumatoid arthritis
April 19, 2018 - Eyes of adolescents could be associated with increased risk of cardiovascular disease in later life
April 19, 2018 - U.S. Women Less Likely Than Men to Get Statins After Heart Attack
April 19, 2018 - Health Canada grants cannabis cultivation license to High Park Farms
April 19, 2018 - Atypical brain development observed in preschoolers with ADHD symptoms
April 19, 2018 - SC Johnson releases annual Sustainability Report
April 19, 2018 - Positive attitudes about aging reduce risk of dementia in older adults
April 19, 2018 - Environmental pollutants found to worsen rheumatoid arthritis
April 19, 2018 - UT Southwestern scientists discover protein linked to metastatic breast cancer
Staff eradicates hepatitis C in 10 sufferers following lifesaving transplants from contaminated donors

Staff eradicates hepatitis C in 10 sufferers following lifesaving transplants from contaminated donors

image_pdfDownload PDFimage_print
Electron micrographs of hepatitis C virus purified from mobile tradition. Scale bar is 50 nanometers. Credit score: Heart for the Find out about of Hepatitis C, The Rockefeller College.

Ten sufferers at Penn Medication were cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who had been contaminated with the illness. The findings level to new methods for expanding the availability of organs for the country’s greater than 97,000 sufferers who’re waiting for kidney transplants – incessantly for as many as 5 or extra years.

In 2016, Penn Medication introduced an leading edge scientific trial to check the impact of transplanting kidneys from donors with HCV into sufferers these days at the kidney transplant waitlist who would not have the virus, and who choose in to obtain those another way unused organs. Recipients had been then handled with an antiviral treatment so that you could remedy the virus. Early knowledge from the learn about had been introduced as of late by means of David S. Goldberg, MD, MSCE, an assistant professor of Medication and Epidemiology within the Perelman Faculty of Medication on the College of Pennsylvania, on the 2017 American Transplant Congress in Chicago, and had been concurrently revealed within the New England Magazine of Medication.

“We began this trial within the hopes that, if a hit, lets open up a completely new pool of donor organs, and successfully transplant loads, if no longer 1000’s, extra sufferers who’re waiting for a lifesaving organ,” Goldberg mentioned. “Traditionally, Hepatitis C-infected kidneys had been incessantly discarded, and had been regarded as broken or too ‘high-risk.’ Our pilot knowledge show the facility to remedy the reduced in size virus following transplantation on this affected person inhabitants. If long term research are a hit, this can be a viable choice for sufferers who might another way by no means see a transplant.”

Goldberg, who co-led the learn about with Peter Reese, MD, MSCE, an assistant professor of Medication and Epidemiology at Penn and chair of the Ethics Committee for the United Community of Organ Sharing (UNOS), approached and enrolled members who trusted dialysis therapies to face in for his or her broken kidneys. Members had been between 40 and 65 years of age and have been looking forward to a transplant for no less than a yr and a part. A 3-step means of training and consent was once used right through pre-enrollment to verify sufferers, and their family members had been supplied with a complete working out of the dangers. As soon as enrolled, and as organs changed into to be had, the workforce carried out HCV donor genotyping right through the allocation procedure, settling on best kidneys that had been thought to be “prime quality.”

Within the first section of the learn about, up to now, 10 sufferers have won transplants the use of the protocol. On reasonable, sufferers won a transplant 58 days after enrolling within the trial—some in as temporarily as 11 days, whilst others waited for over 100 days. At 3 days after surgical procedure, sufferers had been examined for HCV, and all 10 examined wonderful for the illness. Subsequent, the members had been handled with the usual 12-week process elbasvir/grazoprevir, repeatedly referred to as Zepatier, a recently-approved and extremely efficient oral medicine prescribed to get rid of HCV. All 10 sufferers were cured in their reduced in size HCV.

“For see you later, HCV was once an endemic with an excessively detrimental stigma related to it, particularly amongst physicians. So it was once attention-grabbing to look that sufferers had been fast to leap on the likelihood to get this transplant, regardless of the chance that they may get Hepatitis C completely,” Reese mentioned. “Going into the learn about, we knew it was once an opportunity that some or all the sufferers would contract HCV, and that they may have the illness for the remainder of their lives if we had been unsuccessful. However for those sufferers, getting off of dialysis and getting again to their standard lives was once very a lot definitely worth the menace.”

Following the early wonderful effects, the analysis workforce was once granted an extension in their learn about, which can let them transplant and deal with an extra 10 sufferers—20 sufferers in general.

The analysis workforce is designing a brand new scientific trial that may learn about this identical way in sufferers who’re center transplant recipients, and sooner or later they hope to inspect the efficacy of this way in liver and lung transplants. Researchers word there’s a want for longer and bigger trials to proceed comparing the effectiveness of HCV-positive to HCV-negative transplantation adopted by means of antiviral treatment in a broader inhabitants.


Discover additional:
Increasing get entry to: First scientific trial transplants hepatitis C-infected kidneys at Penn Medication

Magazine reference:
New England Magazine of Medication

Equipped by means of:
Perelman Faculty of Medication on the College of Pennsylvania

Tagged with:

About author

Related Articles