Breaking News
March 19, 2019 - Heart attack patients who are taken to heart care centres directly survive longer
March 19, 2019 - IVF babies have increased in birthweight over the past 25 years, study reveals
March 19, 2019 - Study highlights the need for psychiatric care to be integrated into cancer treatment
March 19, 2019 - Testosterone treatment lowers recurrence rates in low-risk prostate cancer patients
March 19, 2019 - Caterpillars could hold the secret to new treatment for Osteoarthritis
March 19, 2019 - Parkinson’s treatment delivers a power-up to brain cell ‘batteries’
March 19, 2019 - Stanford launches new Institute for Human-Centered Artificial Intelligence
March 19, 2019 - Wireless earphones may cause cancer
March 18, 2019 - ACC/AHA guideline for prevention of cardiovascular disease released
March 18, 2019 - UTA nursing professor receives $6.575 million to attack musculoskeletal diseases
March 18, 2019 - Gene medication shows promise to treat spinal cord injuries
March 18, 2019 - First Human Study of “Robotic” RaniPill™ Capsule to Replace Injections Announced by Rani Therapeutics
March 18, 2019 - Food Allergy Testing: MedlinePlus Lab Test Information
March 18, 2019 - Altered brain activity patterns of Parkinson’s captured in mice
March 18, 2019 - Apple Heart Study demonstrates ability of wearable technology to detect atrial fibrillation | News Center
March 18, 2019 - Cardiovascular benefits of diabetes drug extend across a wide spectrum of patients, shows study
March 18, 2019 - Novel cardiac pump shows superior outcomes in patients with advanced heart failure
March 18, 2019 - U.S. FDA Grants Priority Review for Fedratinib New Drug Application in Myelofibrosis
March 18, 2019 - Living like a caveman won’t make you thin—but it might make you healthy
March 18, 2019 - Modified immune cells issue alert when detecting cancer in mice | News Center
March 18, 2019 - Dementia caregivers design robots for alleviating stress and increasing joyful moments
March 18, 2019 - VR technology could help improve balance in humans
March 18, 2019 - Study demonstrates effective way to slow progression of cerebrovascular disease in older adults
March 18, 2019 - Premature babies also have protective anti-viral antibodies
March 18, 2019 - Painkillers taken by pregnant mothers unlikely to cause asthma in the child
March 18, 2019 - Fibromyalgia can be reliably detected in blood samples
March 18, 2019 - Marijuana use has dropped among most teens after legalization
March 18, 2019 - Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25mg, 50mg, And 100mg Due to The Detection of Trace Amounts Of N-Nitroso N-Methyl 4-Amino Butyric Acid (NMBA) Impurity Found in The Active Pharmaceutical Ingredient (API)
March 18, 2019 - Researchers identify early home and family factors that contribute to obesity
March 18, 2019 - Fate and festivity: Match Day 2019
March 18, 2019 - Study finds TAVR to be as good as open-heart surgery for patients at low surgical risk
March 18, 2019 - EU-funded project is developing new tools for diagnosing cancer
March 18, 2019 - Gluten, lactose, food dyes in pills could be causing side effects finds study
March 18, 2019 - Taking painkillers during pregnancy is not responsible for asthma risk in children, study shows
March 18, 2019 - Prediagnosis Psychiatric Care Linked to Worse Cancer Mortality
March 18, 2019 - Paris hospital halts stool study after donor deluge
March 18, 2019 - Partial oral antibiotic therapy shows efficacy and safety in patients with infectious endocarditis
March 18, 2019 - Olympus improves access to science education through BioBus collaboration
March 18, 2019 - Depression screening does not improve quality of life in heart attack patients
March 18, 2019 - Echocardiography may aid in patient selection for TMVR
March 18, 2019 - Are ‘Inactive’ Ingredients in Your Drugs Really So Harmless?
March 18, 2019 - Wearable technology can safely identify atrial fibrillation
March 18, 2019 - Scientists tackle rare retinal disease in unique research project
March 18, 2019 - Death By A Thousand Clicks
March 18, 2019 - Absorbable, antibiotic-eluting envelope can reduce rate of cardiac device infections
March 18, 2019 - Hormonal treatment associated with depression in men with prostate cancer
March 18, 2019 - Porvair Sciences launches reinforced 96-well deep round microplate
March 18, 2019 - Simplified catheter ablation could slash waiting lists for atrial fibrillation patients
March 18, 2019 - BFR therapy as part of rehabilitation following ACL surgery may slow bone loss
March 18, 2019 - A human model to test implants for cataract surgery
March 18, 2019 - New risk adjustment model could reduce financial penalty for safety net hospitals
March 18, 2019 - NHS cancer patients’ wait to start treatment worrying
March 18, 2019 - Inventiva Announces Results from Phase IIb Clinical Trial with Lanifibranor in Systemic Sclerosis
March 18, 2019 - Cologuard
March 18, 2019 - Researchers find evidence of prenatal environment tuning genomic imprinting
March 18, 2019 - Dolomite Bio launches novel Nadia product family for single-cell research
March 18, 2019 - Intellipharmaceutics Announces Resubmission of New Drug Application to the U.S. FDA for its Oxycodone ER
March 18, 2019 - Excessive gestational weight gain tied to maternal morbidity
March 18, 2019 - RCEM issues position statement on metrics to supplement four-hour standard target
March 17, 2019 - Noncontrast Brain MRI Effective for Monitoring Multiple Sclerosis
March 17, 2019 - Brain region plays key role in regulation of parenting behavior, study finds
March 17, 2019 - Natural speed limit on DNA replication sets pace for life’s first steps
March 17, 2019 - New research reveals overlooked impact of herbicide glyphosate on the environment
March 17, 2019 - Molecular patterns could help predict relapse risk in breast cancer patients
March 17, 2019 - Study confirms sensitivity of microbiological cultures for detecting cholera
March 17, 2019 - Scientists Spot Clues to Predicting Breast Cancer’s Return
March 17, 2019 - Scientists identify gene that keeps PTSD-like behavior at bay in female mice
March 17, 2019 - New method would allow doctors to detect earliest stages of cancers in the lymph nodes
March 17, 2019 - Cholesterol protein discovery raises hope for smarter drugs
March 17, 2019 - New insect medium delivers high viable cell density growth and protein yield
March 17, 2019 - Opioid crisis brings concerns about heart dangers
March 17, 2019 - Resistance Training May Prevent Type 2 Diabetes Progression
March 17, 2019 - Bioluminescence sensors make new approaches to drug discovery possible
March 17, 2019 - New FDA Rules Aim to Keep Kids From Flavored E-Cigarettes
March 17, 2019 - Vitamin B3 analogue boosts production of blood cells
March 17, 2019 - Government cuts to stop smoking services have detrimental impact on public health
March 17, 2019 - Common tool to assess potential adoptive parents lags behind societal changes
March 17, 2019 - Patients’ own cells could be the key to treating Crohn’s disease
March 17, 2019 - Diagnostic delays common in inflammatory bowel disease
March 17, 2019 - Study uncovers dramatic differences in the brains of Hispanics with dementia
Analysis supplies new insights into how telomeres keep an eye on cell senescence

Analysis supplies new insights into how telomeres keep an eye on cell senescence

image_pdfDownload PDFimage_print

Researchers on the Institute of Molecular Biology (IMB) and Johannes Gutenberg College Mainz (JGU) have additional exposed the secrets and techniques of telomeres, the caps that offer protection to the ends of our chromosomes. They found out that an RNA molecule referred to as TERRA is helping to make certain that very brief (or damaged) telomeres get fastened once more. The paintings, which used to be just lately printed within the magazine Mobile, supplies new insights into cell processes that keep an eye on cellular senescence and survival in growing older and most cancers.

Telomeres offer protection to the ends of our chromosomes, similar to the plastic cap on the finish of a shoelace that stops the lace from unravelling. Over a cellular’s lifetime, telomeres get progressively shorter with every cellular department and due to this fact the protecting cap turns into much less and no more efficient. In the event that they get too brief, this can be a sign for the cellular that its genetic subject matter is compromised and the cellular stops dividing. Telomere shortening and lowered cellular department are thought to be a trademark of growing older and most probably give a contribution to the growing older procedure. Alternatively, telomere shortening may be a protection mechanism in opposition to most cancers as a result of extremely proliferative cells can handiest divide when their telomeres don’t shorten. Subsequently, telomere shortening is a double-edged sword and must be in moderation regulated to strike a steadiness between growing older and most cancers prevention. When a telomere by chance will get minimize brief early in a cellular’s lifetime, it must be fastened in order that the cellular does not grow to be senescent too early.

“Within the lifetime of a cellular, you must in finding some form of steadiness between most cancers prevention and growing older. Telomeres are on the nexus between the 2, so working out how they’re maintained is actually vital”, stated Brian Luke, Professor on the JGU Institute for Developmental Biology and Neurobiology and Adjunct Director at IMB.

Luke and his lab have been concerned about working out how the cellular acknowledges those shortened and broken telomeres that experience misplaced their caps. Moreover, they sought after to resolve which elements have been vital for selling the restore of brief telomeres. This knowledge may assist in working out why cells both decide to senescence or keep growing.

Of their contemporary paper, printed within the prestigious magazine Mobile, Luke and his staff have proven that some of the keys to working out this downside is TERRA. TERRA is an RNA species that accumulates in particular on the ends of severely brief telomeres through binding immediately to the DNA and indicators to the cellular that those telomeres will have to be repaired, permitting the cellular to hold on dividing.

“We already knew that brief telomeres play a key function in figuring out the onset of cell senescence, however we did not actually perceive which options of brief telomeres have been vital. What we’ve discovered with TERRA is an intricate regulatory device that explains how brief telomeres are known through the cellular”, stated Luke.

The paper is in fact the results of two other analysis tasks on telomeres within the Luke lab. Diego Bonetti used to be taking a look into the law of TERRA within the cellular cycle and located that TERRA ranges have been other at other levels of the cellular cycle. In the meantime, Arianna Lockhart and Marco Graf have been investigating the buildup of TERRA at brief telomeres. Once they found out that the development of cyclic TERRA accumulation used to be other between brief and lengthy telomeres, they knew they have been directly to one thing and joined forces for this venture.

Their joint paintings led them to appreciate that TERRA in fact accumulates in any respect telomeres, however at lengthy telomeres it’s abruptly got rid of with the assistance of proteins Rat1 and RNase H2. Those proteins bind preferentially to the lengthy telomeres and make certain that TERRA is got rid of, however they don’t seem to be provide on the severely brief telomeres, this means that that TERRA stays for an extended time. This mechanism guarantees the next restore of the quick telomere, which is the most important for the cellular to continue to exist and stay dividing.

Luke’s paintings used to be performed in yeast; alternatively, telomeres and TERRA are discovered throughout all organisms with linear chromosomes. The researchers be expecting their paintings to be appropriate to people as smartly. Their subsequent step shall be to appear into those processes in human cells and interrogate their implications for growing older and most cancers.

Supply:

http://www.uni-mainz.de/presse/aktuell/2048_ENG_HTML.php

Tagged with:

About author

Related Articles