Breaking News
January 21, 2019 - How Much Caffeine is Too Much?
January 21, 2019 - Take a timeout before you force your child to apologize
January 21, 2019 - Scientists design two AI algorithms to improve early detection of cognitive impairment
January 21, 2019 - Novel therapy for children with chronic hormone deficiency provides lifeline for parents
January 21, 2019 - Bioethicists call for oversight of poorly regulated, consumer-grade neurotechnology products
January 21, 2019 - Study shows hereditary hemochromatosis behind many cancers and joint diseases
January 21, 2019 - Short bouts of stairclimbing throughout the day can improve cardiovascular health
January 20, 2019 - Liver Transplant Survival May Improve With Race Matching
January 20, 2019 - Study implicates hyperactive immune system in aging brain disorders
January 20, 2019 - Cancer Diagnosis May Quadruple Suicide Risk
January 20, 2019 - Parkinson’s disease experts devise a roadmap
January 20, 2019 - Research brings new hope to treating degenerative brain diseases
January 20, 2019 - Scientists pinpoint a set of molecules that wire the body weight center of the brain
January 20, 2019 - Researchers get close to developing elusive blood test for Alzheimer’s disease
January 20, 2019 - UCLA researchers demonstrate new technique to develop cancer-fighting T cells
January 20, 2019 - Researchers discover how cancer cells avoid genetic meltdown
January 20, 2019 - Exercise makes even the ‘still overweight’ healthier: study
January 20, 2019 - University of Utah to establish first-of-its-kind dark sky studies minor in the US
January 20, 2019 - School-based nutritional programs reduce student obesity
January 20, 2019 - Improved maternity care practices in the southern U.S. reduce racial inequities in breastfeeding
January 20, 2019 - New enzyme biomarker test indicates diseases and bacterial contamination
January 20, 2019 - Republican and Democratic governors have different visions to transform health care, say researchers
January 20, 2019 - Researchers discover that spin flips happen in only half a picosecond in the course of a chemical reaction
January 20, 2019 - Suicide Risk Up More Than Fourfold for Cancer Patients
January 20, 2019 - Doctors find 122 nails in Ethiopian’s stomach
January 20, 2019 - UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms
January 20, 2019 - Researchers discover mechanism which drives leukemia cell growth
January 20, 2019 - AHA: Infection as a Baby Led to Heart Valve Surgery for Teen
January 20, 2019 - Injection improves vision in a form of childhood blindness
January 20, 2019 - Multiple sclerosis therapies delay progression of disability
January 20, 2019 - New study finds infrequent helmet use among bike share riders
January 20, 2019 - Clearing up information about corneal dystrophies
January 20, 2019 - Researchers describe new behavior in energy metabolism that refutes existing evidence
January 20, 2019 - New study takes first step toward treating endometriosis
January 20, 2019 - Researchers find how GREB1 gene promotes resistance to prostate cancer treatments
January 20, 2019 - Replacing Sitting Time With Activity Lowers Mortality Risk
January 20, 2019 - A simple, inexpensive intervention makes birth safer for moms and babies in parts of Africa
January 19, 2019 - New anti-inflammatory compound acts as ‘surge protector’ to reduce cancer growth
January 19, 2019 - Significant flaws found in recently released forensic software
January 19, 2019 - New Leash on Life? Staying Slim Keeps Pooches Happy, Healthy
January 19, 2019 - Men and women remember pain differently
January 19, 2019 - Rising air pollution linked with increased ER visits for breathing problems
January 19, 2019 - Study uses local data to model food consumption patterns among Seattle residents
January 19, 2019 - The brain’s cerebellum plays role in controlling reward and social behaviors, study shows
January 19, 2019 - Relationship between nurse work environment and patient safety
January 19, 2019 - Pioneering surgery restores movement to children paralyzed by acute flaccid myelitis
January 19, 2019 - Genetic variants linked with risk tolerance and risky behaviors
January 19, 2019 - New research provides better understanding of our early human ancestors
January 19, 2019 - First-ever tailored reporting guidance to improve patient care and outcomes
January 19, 2019 - 4.6 percent of Massachusetts residents have opioid use disorder
January 19, 2019 - New study suggests vital exhaustion as risk factor for dementia
January 19, 2019 - New antibiotic discovery heralds breakthrough in the fight against drug-resistant bacteria
January 19, 2019 - Ural Federal University scientists synthesize a group of multi-purpose fluorophores
January 19, 2019 - Researchers identify new therapeutic target in the fight against chronic liver diseases
January 19, 2019 - Preparation, characterization of Soyasapogenol B loaded onto functionalized MWCNTs
January 19, 2019 - FDA Approves Ontruzant (trastuzumab-dttb), a Biosimilar to Herceptin
January 19, 2019 - Tobacco use linked with higher use of opioids and sedatives
January 19, 2019 - Study delves deeper into developmental dyslexia
January 19, 2019 - Anti-vaccination movement one of the top health threats in 2019 says WHO
January 19, 2019 - Newly developed risk score more effective at identifying type 1 diabetes
January 19, 2019 - Highly effective protocol to prepare cannabis samples for THC/CBD analysis
January 19, 2019 - Prinston Pharmaceutical Inc. Issues Voluntary Nationwide Recall of Irbesartan and Irbesartan HCTZ Tablets Due to Detection of a Trace Amount of Unexpected Impurity, N-Nitrosodiethylamine (NDEA) in the Products
January 19, 2019 - How does solid stress from brain tumors cause neuronal loss, neurologic dysfunction?
January 19, 2019 - $14.7 million partnership to supercharge vaccine development
January 19, 2019 - Ian Fotheringham receives Charles Tennant Memorial Lecture award
January 19, 2019 - Brain vital signs detect neurophysiological impairments in players with concussions
January 19, 2019 - Lack of job and poor housing conditions increased likelihood of people attending A&E
January 19, 2019 - Novel targeted drug delivery system improves conventional cancer treatments
January 19, 2019 - Rutgers study finds gene responsible for spread of prostate cancer
January 19, 2019 - Complications Higher Than Expected for Invasive Lung Tests
January 19, 2019 - 3-D printed implant promotes nerve cell growth to treat spinal cord injury
January 19, 2019 - Automated texts lead to improved outcomes after total knee or hip replacement surgery
January 19, 2019 - Poor cardiorespiratory fitness could increase risk of future heart attack, finds new study
January 19, 2019 - Drinking soft drinks while exercising in hot weather may increase risk of kidney disease
January 19, 2019 - Formlabs 3D prints anatomical models
January 19, 2019 - Heart-Healthy Living Also Wards Off Type 2 Diabetes
January 19, 2019 - Teaching Kids to Be Smart About Social Media (for Parents)
January 19, 2019 - Metabolite produced by gut microbiota from pomegranates reduces inflammatory bowel disease
January 19, 2019 - Researchers examine how spray from showers and toilets expose us to disease causing bacteria
January 19, 2019 - Behavioral experiments confirm that additional neurons improve brain function
Data, technology drive new approaches to Parkinson's care

Data, technology drive new approaches to Parkinson's care

image_pdfDownload PDFimage_print
Data, technology drive new approaches to Parkinson’s care
Credit: University of Rochester

Complex, multi-system diseases like Parkinson’s have long posed challenges to both scientists and physicians. University of Rochester Medical Center (URMC) researchers are now reaching for new tools, such as algorithms, machine learning, computer simulations, and mobile technologies, to both improve care and identify new therapies.

Parkinson’s disease is a progressive neurological disorder that erodes an individual’s control over their movements and speech. While many of the recent advances in treatment have transformed Parkinson’s into a manageable chronic illness, the individual patient experience can vary widely in both the onset and progression of the symptoms of the disease. This creates problems for clinicians who must constantly tweak the combination and doses of medications to effectively manage symptoms and researchers who are often confronted with a range of responses to experimental treatments.

The advent and spread of new technologies – such as to broadband internet, smartphones, and remote monitoring and wearable sensors – coupled with growing investments in computational resources and expertise in fields such as bioinformatics and data science have the potential to provide researchers with unprecedented insight into the complex variations of diseases like Parkinson’s.

An example of this approach is new research out in the journal The Lancet Neurology. The study sought to identify genetic markers that may explain why motor symptoms –stiffness or rigidity of the arms and legs, slowness or lack of movement, tremors, and walking difficulties – come on more rapidly for some patients with the disease.

The research involved Charles Venuto, Pharm.D., an assistant professor in the URMC Department of Neurology and the Center for Health + Technology (CHeT), and GNS Healthcare, and was funded by the Michael J. Fox Foundation for Parkinson’s Research and the National Institute of Neurological Disorders and Stroke.

The researchers tapped into huge data sets compiled by the Parkinson’s Progression Markers Initiative (PPMI) which has collected biological samples and clinical data from hundreds of individuals with the disease.

“We have access to more information about diseases like Parkinson’s than ever before,” said Venuto. “But all of that data has created a scientific conundrum akin to losing sight of the forest for the trees. In order to unlock the potential of this information we need to harness more sophisticated ways to understand what we are seeing.”

In a departure from traditional research approaches, the team turned over the vast quantities of genetic, clinical, and imaging profiles compiled by the PPMI study to a machine learning and simulation program. As the computer program analyzed the data, it was also “learning” by constantly refining and modifying its criteria and algorithms as it sifted through the information looking for patterns and associations.

The study identified a mutation in the LINGO2 gene that, together with a second gene and demographic factors, could identify patients with faster motor progression of Parkinson’s. The finding, if confirmed, could ultimately help clinicians refine care and help researchers more precisely understand how individual patients may respond to experimental therapies.

The application of data-driven technologies to biomedical research has exploded in the last several years. URMC neurologist Ray Dorsey, M.D., M.B.A., who is also the director of CHeT, has been at the forefront of this transformation. Dorsey has long been a pioneer in expanding access to Parkinson’s care via telemedicine. In 2015, Dorsey – in collaboration with Sage Bionetworks – helped develop an iPhone app which allows patients with Parkinson’s disease to track their symptoms in real time and share this information with researchers. Dorsey has become a national figure in this field and has organized an annual conference – the dhealth Summit – that brings together thought leaders from industry, academia, health care, and government to discuss the application of technology to improve the delivery and access to care.

Several additional research programs at the intersection of technology and disease have emerged in Rochester in recent years. Gaurav Sharma, Ph.D., a professor in the University of Rochester Department of Electrical and Computer Engineering, is working with wearable sensors to track the progression of Parkinson’s and Huntington’s diseases. M. Eshan Hoque, Ph.D., an assistant professor in the Department of Computer Science, is developing analytical tools that scan videos of patients to help diagnose early stage Parkinson’s.

“The volume of data we are now generating is astronomical,” said Dorsey. “In the past we would collect data from a patient once every six months, now we have sensors that are sampling data 10 times per second. So as opposed to spending a lot of effort to gather a small amount of data, now with very little effort we are generating huge amounts of data.”

The challenge for researchers is to both transform the vast amount of data that is being collected into a usable format – a process referred to as data wrangling – and then ultimately extract valuable scientific and clinical conclusions. To accomplish this, new tools and methods to collect, store, organize, and analyze data are being developed. In recent years, the Medical Center and the University have made significant new investments in state-of-the-art computational resources, recruited new faculty, and started new degree programs in the fields of bioinformatics, computer science, and data science.

The data revolution in medicine has created a wave of new scholarship. Dorsey also serves as editor-in-chief of Digital Biomarkers, a new journal that launched this month in recognition that emerging technologies hold the potential to transform research and the delivery of care.

“Just as imaging and genetics have revolutionized our understanding of health, altered our definition of disease, revealed our ignorance, and changed therapeutic development, new digital biomarkers can do the same,” said Dorsey. “Digital Biomarkers was created to foster this emerging field by disseminating the best ideas and supporting the international community of scientists working on novel ways to advance research.”


Explore further:
Telemedicine as effective as in-person care for Parkinson’s disease

More information:
Jeanne C Latourelle et al. Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation, The Lancet Neurology (2017). DOI: 10.1016/S1474-4422(17)30328-9

Journal reference:
Lancet Neurology

Provided by:
University of Rochester

Tagged with:

About author

Related Articles