Breaking News
June 22, 2018 - State opioid monitoring programs are not created equal
June 22, 2018 - Autistic teens who are bullied have higher rates of depression
June 22, 2018 - Penn Medicine team launches universal stroke awareness program
June 22, 2018 - Scientists discover the molecular trigger of necroptosis
June 22, 2018 - Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer’s disease
June 22, 2018 - Theoretical models predict how juveniles evolve to be more susceptible than adults to infection
June 22, 2018 - USC study reveals how the cell launches emergency response to repair damaged DNA
June 22, 2018 - $1.9 million grant aims to enhance behavioral health services in community-based settings
June 22, 2018 - New 3D imaging technique could improve arthritis treatment
June 22, 2018 - Cytokinetics Announces Data From Phase 2 Clinical Study of Reldesemtiv in Patients With Spinal Muscular Atrophy
June 22, 2018 - Polarized cells give the heart its fully developed form
June 21, 2018 - Stem cells appear to help fight obesity in animal models
June 21, 2018 - Harnessing Pediatric Cancer Genomic Data in the Cloud
June 21, 2018 - Training nursing students with cost-effective 3D-printed task trainers
June 21, 2018 - Study provides insight into how planned and spontaneous movements are processed in the brain
June 21, 2018 - Suicide Prevention | SAMHSA – Substance Abuse and Mental Health Services Administration
June 21, 2018 - From designer microbes to stem cells, researchers are investigating new strategies to treat bowel disease
June 21, 2018 - Study suggests state-of-the-art genomic testing for routine autopsy of stillbirths
June 21, 2018 - Christiana Care Health System opens first Epilepsy Monitoring Unit in Delaware
June 21, 2018 - CDC: Obesity Prevalence Higher in Non-Metropolitan Counties
June 21, 2018 - Youths Treated for Non-Suicidal Self Harm at Increased Risk of Suicide Within a Year
June 21, 2018 - Pediatric kidney recipients often have subclinical inflammation
June 21, 2018 - OHSU Knight Cancer Institute Director wins 2018 Tang Prize in Biopharmaceutical Science
June 21, 2018 - Researchers study broader effects of neonics on wildlife
June 21, 2018 - Study provides new insight on how antibiotics affect the gut microbiome
June 21, 2018 - InHealth Technologies becomes exclusive distributor of RENÚ Voice, RENÚ Gel in the United States
June 21, 2018 - New analysis links higher BMI to lower breast cancer risk for younger women
June 21, 2018 - Interactive preclinical PET-MR workshop demonstrates benefits of multi-modality imaging
June 21, 2018 - Gene signature could improve early diagnosis of TB
June 21, 2018 - Psychiatric Drug Lithium Tied to Birth Defect Risk
June 21, 2018 - Preclinical study suggests ARID1a may be useful biomarker for immunotherapy
June 21, 2018 - Risks of cancer and mortality found to be lowest in light drinkers
June 21, 2018 - Fetal immune cells are fast-acting first responders to microbes in adulthood
June 21, 2018 - Researchers invent medical device for proliferation, differentiation of neural stem cells
June 21, 2018 - Study explores current understanding of human physiology, pathology, trauma and surgery in space
June 21, 2018 - Scientists explore interactions between chromosomes 12 and 17
June 21, 2018 - People with severe obesity constantly try to reduce or control their weight
June 21, 2018 - Relaxing ‘brain tingles’ may have benefits for both mental and physical health
June 21, 2018 - Breakthrough discovery reveals brain metals that may drive progression of Alzheimer’s disease
June 21, 2018 - New methods of fragment-based lead discovery to identify potential antibiotics
June 21, 2018 - Recovery and Treatment | NIH MedlinePlus the Magazine
June 21, 2018 - Study finds cell-free DNA profiling as versatile method to monitor UTIs
June 21, 2018 - ‘Hidden’ driver discovered that helps prime the anti-tumor immune response
June 21, 2018 - Groundbreaking discovery could be key to preventing cancer metastasis
June 21, 2018 - Impulse control disorders found to be more common in people taking Parkinson’s drugs
June 21, 2018 - Study finds possible link between Type 2 diabetes and common white pigment
June 21, 2018 - Most emergency department patients wish to be involved in medical decision-making
June 21, 2018 - Study highlights growing problem of ‘iPad neck’ among young adults and women
June 21, 2018 - UT Southwestern scientists identify gene mutation linked with perplexing brain condition
June 21, 2018 - Probiotics could cut age-related bone loss in elderly women
June 21, 2018 - New study sheds light on role of vitamin D in healthy pregnancy
June 21, 2018 - Teva Provides Update on Clinical Trial of Fremanezumab for Use in Chronic Cluster Headache
June 21, 2018 - Unlocking the secrets of HIV’s persistence
June 21, 2018 - New guidelines recommend newborns with Down’s syndrome to receive leukemia test
June 21, 2018 - BetterYou’s new Magnesium Bone Lotion helps maximize bone health
June 21, 2018 - UH scientist receives grant to examine understudied part of glaucoma
June 21, 2018 - Lifestyle intervention could normalize unhealthy behaviors that lead to cancer, chronic disease
June 21, 2018 - Combining two anti-malarial vaccines could greatly reduce number of infections
June 21, 2018 - By 2030, prostate and lung cancers expected to be most common cancers among HIV population
June 21, 2018 - Researchers evaluate patient satisfaction and well-being after breast reconstruction
June 21, 2018 - Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases
June 21, 2018 - Monash study reveals why older people have reduced immune responses to cancer therapy
June 21, 2018 - Researchers develop new microscope system that can image living tissue in real time
June 21, 2018 - Long-term estrogen therapy alters microbial composition and activity in the gut
June 21, 2018 - Study points to dangers of feeding non-dairy drink to infants
June 21, 2018 - Cannabis Use Linked to Psychosis Symptoms in Adolescents
June 21, 2018 - Inadequate sleep could cost countries billions
June 21, 2018 - Inhibiting epigenetic proteins with drugs could prevent development of breast cancer
June 21, 2018 - Study identifies factors that contribute to vaginal dryness
June 21, 2018 - Researchers employ nucleotide-based gene silencing to mitigate common ataxia
June 21, 2018 - New tool determines best treatment plan for adults with severe asthma
June 21, 2018 - Identifying gene variants that contribute to ovarian reserve may improve female fertility
June 21, 2018 - Religious involvement has no significant effect on misuse of prescription opioids, study finds
June 21, 2018 - Researchers characterize key signaling network that drives growth of triple negative breast cancers
June 21, 2018 - AHA: Big Weight Gain in 1st Pregnancy Could Boost Preeclampsia Risk
June 21, 2018 - How vaping helps even hardened smokers quit
June 21, 2018 - Gaming disorder an official disease condition says WHO
June 21, 2018 - Oxygen consumption in human BAT increases after a meal, shows research
June 21, 2018 - Research finds addictions to be diseases of the brain, not criminal behavior or personality disorders
June 21, 2018 - New study is testing safety and efficacy of glycoside in breaking up kidney stones
When It Comes to Obesity, Genes Just Partly to Blame

When It Comes to Obesity, Genes Just Partly to Blame

image_pdfDownload PDFimage_print

THURSDAY, Oct. 26, 2017 (HealthDay News) — If you have trouble keeping slim, don’t put all the blame on your DNA.

People carrying so-called “obesity” genes tend to gain more weight if they don’t work out or don’t get enough sleep, said Timothy Frayling, a professor with the University of Exeter Medical School in England.

“You can’t change your genes — but they only explain part of your weight,” Frayling said. This means that even people genetically inclined to pile on pounds can curb it by eating right and exercising.

Frayling and his fellow researchers tracked physical activity and sleep patterns for about 85,000 people in England, aged 40 to 70. The participants wore accelerometers that allowed researchers to estimate their amount of exercise and quality of sleep.

The team also computed a genetic risk score for each person based on 76 common variants known to be associated with increased risk for obesity.

Genetics accounted for some, but not all, of a person’s obesity risk, the researchers concluded.

For example, a person of average height who had 10 genetic risk factors for obesity gained an average of 8 pounds during the course of their life if they tended to be couch potatoes, but only about 6 pounds if they were more physically active, the study authors said.

The results were similar regarding sleeplessness. People with some genetic risk for obesity tended to have a higher body mass index (BMI) if they woke frequently or slept more restlessly, the study findings showed. BMI is a measurement of body fat based on height and weight.

“For public health and diet and exercise interventions, our study suggests there will be ‘bigger bang for the buck’ by focusing limited resources on people who are most susceptible due to their genes and their lifestyles,” Frayling said.

Obesity experts said the study results make sense, given what’s known about the factors that contribute to excess weight.

“Obesity is an energy storage disease that is caused by hormonal imbalances,” said Dr. Mitchell Roslin, chief of obesity surgery at Lenox Hill Hospital in New York City. “Your genetic makeup plays a role, but your activity and the environment also influence your genetic expression,” he explained.

“Many believe that obesity is an epigenetic disease, meaning it is not the genes themselves but how the environment changes their shape,” Roslin continued. “Think of genes as pieces in a jigsaw puzzle. The environment puts the puzzle together. Our actions matter, and while our genes influence our behavior, our behavior influences how genes work and their effect on the body.”

Dr. Jamie Kane, chairman of the Center for Weight Management at Northwell Health’s Syosset Hospital in Syosset, N.Y., said the study “seems to ring true based on the research that’s out there to date, and based on my clinical experience as well.”

Kane and his staff try “to look at the lifestyle, and work at the most stringent level with patients because we don’t know who has what genetics,” he said.

It might require more dedication, but a person can overcome genetics that might otherwise lead to obesity, Kane concluded.

“There are a very small number of people who suffer from morbid obesity where it’s purely genetic,” he said. “In most of these cases, people might need to exercise way more than the average person, and they might need to change their diet dramatically.”

Frayling and his colleagues presented their findings this week at the annual meeting of the American Society of Human Genetics, in Orlando, Fla. Research presented at meetings should be viewed as preliminary until published in a peer-reviewed journal.

SOURCES: Timothy Frayling, Ph.D., professor, University of Exeter Medical School, Exeter, England; Mitchell Roslin, M.D., chief, obesity surgery, Lenox Hill Hospital, New York City; Jamie Kane, M.D., chairman, Center for Weight Management, Syosset Hospital, Syosset, N.Y.; presentation, Oct. 20, 2017, annual meeting, American Society of Human Genetics, Orlando

News stories are written and provided by HealthDay and do not reflect federal policy, the views of MedlinePlus, the National Library of Medicine, the National Institutes of Health, or the U.S. Department of Health and Human Services.

Tagged with:

About author

Related Articles