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Signal flare – how heart muscle cells protect themselves from viral invaders

Signal flare – how heart muscle cells protect themselves from viral invaders

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Cardiac myocyte with nucleus (blue). Yellow indicates active MAVS pathway. Credit: North Carolina State University

The human heart is particularly vulnerable to viruses. That’s because cardiac myocytes, the heart muscle cells that give your heart its ability to “beat,” have one major weakness – they don’t reproduce themselves to repair the heart in the same way that cells in other organs do. So damage to these cells from viruses or bacteria is a really big deal.

And viruses can and do invade the heart. In fact, 5 to 20 percent of people will have a viral infection in the heart at some point in their lives. Viral myocarditis, inflammation and damage to the heart due to viral infection, ranks as the second leading cause of sudden death in young adults.

Fortunately, the heart has a unique way to protect itself from viral invasion – a first alert system managed by the MAVS signaling pathway, named for the protein that triggers the pathway to become active. The MAVS pathway is responsible for letting cells know when to produce interferon beta, a natural antiviral.

Every cell in our body contains MAVS. Normally when a virus attacks a cell, sensors on the surface of the cell detect the invader and activate the MAVS pathway. Then the cell begins to produce interferon beta, which can help destroy the virus.

Cardiac myocytes, however, are special. Barbara Sherry, a virologist at NC State, recently found that in cardiac myocytes the MAVS pathway is always active, and that these cells are constantly producing small amounts of interferon beta. What does this mean?

“Interferon beta isn’t like a sledgehammer that’s being produced to destroy a virus. It’s a signal flare that tells a cell to arm itself against virus infection,” Sherry says. “Thanks to the constantly active MAVS pathway, cardiac myocytes are always making a little interferon beta and so they are always pre-arming themselves. When myocytes see a virus, that just kicks their interferon beta production into overdrive so they can tell other cells in the heart to arm themselves, too.”

That interferon beta and pre-arming won’t completely stop the virus, but it can keep it under control until the body’s regular (or adaptive) immune system can mobilize to clear it, minimizing damage to vulnerable myocytes.

“Cardiac myocytes are particularly vulnerable, not because it’s somehow easier for them to become infected by viruses, but because they don’t reproduce well,” Sherry says. “In the other type of heart cell we looked at – cardiac fibroblasts – the MAVS pathway isn’t always active. That’s because these cells can reproduce quickly and don’t need the same type of protective perimeter that myocytes do.

“Cardiac myocytes are not only different from other heart cells in this respect, but they’re different from all of the other muscle cells in your body,” Sherry adds. “And that’s a good thing. Myocytes don’t come back when they die. Without this constantly active pathway, many more people would die of heart infections. Understanding how the body protects itself from infection can help us design therapeutics for the future.”

Sherry’s work appears in the Journal of Molecular and Cellular Cardiology.

Explore further:
Scientists identify early impact of Ebola virus on immune system

More information:
Efraín E. Rivera-Serrano et al. Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes, Journal of Molecular and Cellular Cardiology (2017). DOI: 10.1016/j.yjmcc.2017.08.008

Journal reference:
Journal of Molecular and Cellular Cardiology

Provided by:
North Carolina State University

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