Breaking News
January 17, 2018 - Raw Meat Not the Safest Choice for Your Dog or for You
January 17, 2018 - High-Dose Aspirin Preferred for Kawasaki’s
January 17, 2018 - Study suggests risk management approach to combat EMS fatigue
January 17, 2018 - A new therapy against obesity
January 17, 2018 - Doctors warn against holding your nose and closing your mouth to contain a sneeze
January 17, 2018 - Measles outbreak alarms public health officials
January 17, 2018 - FDA Slaps Class Warning on Gadolinium Contrast Agents
January 17, 2018 - Distinct human mutations can alter the effect of medicine
January 17, 2018 - ASIT biotech’s new article presents clinical results of gp
January 17, 2018 - Alternative tobacco use by adolescents associated with greater odds of future cigarette smoking
January 17, 2018 - A High-Salt Diet Produces Dementia In Mice
January 17, 2018 - Scientists provide insights into crucial interaction for DNA repair
January 17, 2018 - Sanofi and Regeneron Announce Positive Topline Pivotal Results for PD-1 Antibody Cemiplimab in Advanced Cutaneous Squamous Cell Carcinoma
January 17, 2018 - Morning Break: Pfizer Kills AD/PD Pipeline; Trump Affirms His Mental Health; Humira Pricing Strategy
January 17, 2018 - Researchers see gene influencing performance of sleep-deprived people
January 17, 2018 - Fast food triggers the immune system making it hyperactive
January 17, 2018 - Scientists find increased risk of HIV outbreaks in Ukraine due to war-related migration
January 17, 2018 - New universal flu vaccine moves to clinical trial phase and could be a reality soon
January 17, 2018 - Cocaine de-addiction breakthrough shows promise
January 17, 2018 - FDA Accepts New Drug Application for Seysara (sarecycline) for the Treatment of Moderate to Severe Acne
January 17, 2018 - Robotic Telestenting; BP Cuff Smartwatch; Medicare Bundled Care
January 17, 2018 - New cellular approach found to control progression of chronic kidney disease
January 17, 2018 - Lamprey genes provide clues to repair spinal cord damage, finds study
January 17, 2018 - Tissue-based soft robot could lead to advances in bio-inspired robotics
January 17, 2018 - Mostly the healthy and wealthy Americans use mobile phone apps to track sleep habits
January 17, 2018 - FDA Alert: Varubi (rolapitant) Injectable Emulsion: Health Care Provider Letter
January 16, 2018 - NeuroBreak: Rough Days for Neuroscience Research; Another Migraine Drug Advances
January 16, 2018 - The ‘greatest pandemic in history’ was 100 years ago – but many of us still get the basic facts wrong
January 16, 2018 - Serena Williams Shares Childbirth Ordeal
January 16, 2018 - The Artificial Brain as Doctor
January 16, 2018 - Type 2 diabetes has hepatic origins
January 16, 2018 - Expert discusses how to identify, support individuals with drug or alcohol addiction in workplace
January 16, 2018 - Starting menstruation early increases risk of cardiovascular disease and stroke in later life
January 16, 2018 - CapsoVision receives CE Mark approval for use of CapsoCam Plus System in pediatric patients
January 16, 2018 - Researchers develop new dynamic statistical model to follow gene expressions over time
January 16, 2018 - Alzheimer’s ‘looks like me, it looks like you’
January 16, 2018 - By the Numbers: Physicians’ Economic Impact
January 16, 2018 - Sound Health | NIH News in Health
January 16, 2018 - Modifying baby formula doesn’t prevent type 1 diabetes in children
January 16, 2018 - Energy drinks dangerous for kids
January 16, 2018 - When you need a breast screening, should you get a 3-D mammogram?
January 16, 2018 - Johns Hopkins gets approval to perform HIV positive to HIV positive living donor kidney transplants
January 16, 2018 - The Salk Institute and Indivumed collaborate for cutting-edge cancer research
January 16, 2018 - Study reveals negative long-term effects of heavy cannabis use on brain function and behavior
January 16, 2018 - Many gym-goers injure themselves by pushing harder to be better than friends
January 16, 2018 - Risankizumab Meets All Primary Endpoints Reporting Positive Results in Fourth Pivotal Phase 3 Psoriasis Study
January 16, 2018 - Federal Junk Food Tax Feasible, Study Says
January 16, 2018 - Do girls have stronger teeth than boys?
January 16, 2018 - New high-sensitivity blood tests could aid faster diagnosis and treatment for heart attack
January 16, 2018 - How fatal mitochondrial diseases may strike offspring of families with no history of the conditions
January 16, 2018 - TherapeuticsMD Announces FDA Acceptance of New Drug Application and Prescription Drug User Fee Act (PDUFA) Date for TX-004HR
January 16, 2018 - Morning Break: Food Pharmacies; Obamacare Sign-ups Dip; Top Pot Studies
January 16, 2018 - Blood pressure declines 14 to 18 years before death
January 16, 2018 - ViLim Ball technology helps reduce uncontrollable shaking hands
January 16, 2018 - Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies
January 16, 2018 - In Wisconsin, hopes rise for production of a lifesaving radioactive isotope
January 16, 2018 - Researchers develop software to better predict risk of leakage around aortic stents
January 16, 2018 - Bile acids could directly burn away lipids in the fat depots
January 16, 2018 - Cycling does not negatively impact sexual and urinary health finds study
January 16, 2018 - Severe peer victimization in childhood may contribute to mental health issues in adolescence
January 16, 2018 - Exelixis Announces U.S. FDA Approval of Cabometyx (cabozantinib) Tablets for Previously Untreated Advanced Renal Cell Carcinoma
January 16, 2018 - Just How Often Do Patients Turn Post-Surgical Opioids Into a Habit?
January 16, 2018 - Opioid addiction – Genetics Home Reference
January 16, 2018 - Incomplete revascularization in PCI linked to higher mortality
January 16, 2018 - Machine learning algorithm uses brain scans to predict language ability in deaf children
January 16, 2018 - Penn scientists identify new therapeutic target for treatment of melanoma
January 16, 2018 - The London Clinic exhibits innovative technology to treat Parkinson’s disease at Arab Health
January 16, 2018 - Early influenza testing is critical to prevent serious complications
January 16, 2018 - Study Gets to the Core of Back Pain in Runners
January 16, 2018 - Year in Review: Ophthalmology | Medpage Today
January 16, 2018 - ClinicalTrials.gov: Marijuana Use
January 16, 2018 - Researchers create novel compound targeting melanoma cells
January 16, 2018 - FDA grants approval for first drug to treat inherited breast cancer
January 16, 2018 - Researchers develop remote-controlled mechanogenetics system to target and kill cancer cells
January 16, 2018 - Fresh, Frozen Embryos Equal in IVF
January 16, 2018 - Research shows biological clocks could improve brain cancer treatment
January 16, 2018 - Dire view from within accident and emergency wards of England and Wales
January 16, 2018 - Study reveals how devastating mitochondrial diseases strike families without any previous history
January 16, 2018 - Experts look for ways to standardize treatments for pediatric rheumatic diseases
January 16, 2018 - Teens who watch TV shows with ads likely to eat more junk food
UC San Diego Health scientists help create ‘dream team’ to prevent pancreatic cancer

UC San Diego Health scientists help create ‘dream team’ to prevent pancreatic cancer

image_pdfDownload PDFimage_print

Scientists and physicians at Moores Cancer Center at UC San Diego Health, in partnership with colleagues at MD Anderson Cancer Center in Texas, Johns Hopkins University in Maryland and elsewhere, have been awarded a $7 million grant over four years by Stand Up to Cancer (SU2C) to create a “dream team” to develop new ways to prevent pancreatic cancer — one of the nation’s deadliest malignancies.

The grant, sponsored and administered by SU2C, the Lustgarten Foundation and the American Association for Cancer Research, was accepted by Scott Lippman, MD, director of Moores Cancer Center, and his two co-leaders at an international cancer conference in Philadelphia earlier today.

Pancreatic cancer is among the most devastating and lethal of all cancers. It comprises just 3 percent of all cancer cases in the United States — the average lifetime risk of developing it is roughly one in 67 or 1.5 percent, according to the National Cancer Institute — but it is the fourth leading cause of cancer death, after lung, prostate and colon.

More than 53,000 American men and women (evenly split) will be diagnosed this year with pancreatic cancer; more than 43,000 will die from the disease (7 percent of all cancer deaths). For all stages of the disease combined, the 5-year relative survival rate is just 8 percent (a 6 percent increase since 1940).

“Because pancreatic cancer occurs deep within the body, it’s hard to detect early. Doctors can’t see or feel tumors during routine physical exams,” said Lippman. “There is no simple blood test for persons without symptoms. By the time symptoms appear, such as weight loss or abdominal discomfort, the disease has likely progressed and metastasized, which of course makes it deadlier.”

Lippman is co-leader and a principal investigator in the new “Pancreatic Cancer Interception Dream Team.” He is a recognized advocate and leader for developing cancer prevention strategies. Other key members of the team include Anirban Maitra, MBBS, professor of pathology at the University of Texas MD Anderson Cancer Center; Michael G. Goggins, MD, professor of pathology, medicine and oncology at Johns Hopkins University; Elizabeth Jaffee, MD, deputy director of the Sidney Kimmel Comprehensive Cancer Center, also at Johns Hopkins; Bert Vogelstein, MD, director of the Ludwig Center for Cancer Genetics and Therapeutics at Sidney Kimmel; Tyler Jacks, PhD, director of the Koch Institute for Integrative Cancer Research at MIT; Jim Allison, PhD, chair of the Department of Immunology at MD Anderson Cancer Center; Karen E. Nelson, PhD, director of the J. Craig Venter Institute campus in Rockville, MD; and J. Craig Venter, PhD, founder, chairman and CEO of the J. Craig Venter Institute.

The grant is the second specifically targeting pancreatic cancer to be awarded to Moores Cancer Center researchers. A first pancreatic cancer “dream team” with Andrew Lowy, MD, and Tannishtha Reya PhD, as members was announced in 2015 with a three-year, $12-million grant. Their goal focuses on finding new ways to treat the disease or render it less lethal.

“The idea is that you can reprogram pancreatic cancer cells to a different state so they can be less aggressive or you can create new vulnerabilities that can be exploited with combination drug therapies,” said Lowy.

Lowy will also be part of the new dream team, focusing on the identification and management of patients at high risk for development of pancreatic cancer.

Lippman said the new grant seeks to find ways of fending off disease before treatment is required. “Before there is cancer, there are often red flags, such as lesions or bits of abnormal tissue. Sometimes these lesions don’t change and remain benignly abnormal. They may even regress. But sometimes they transform into cancer,” he said.

“The best remedy for cancer is to avoid having to treat it at all. That’s what prevention is all about — better understanding cancers before they actually become cancers, before they harm health or threaten life.

“Unfortunately, typical lifestyle changes, such as diet and smoking, have little effect on pancreatic cancer compared to the beneficial effects on other cancer types. Our SU2C dream team is and will be assessing new risk biomarkers and immune interception with cancer vaccines, which hold tremendous promise.”

Lippman’s co-investigator Stephen Schoenberger, PhD, at La Jolla Institute for Allergy and Immunology and an adjunct professor at UC San Diego, will lead efforts to develop personalized cancer prevention vaccines.

Source:

https://health.ucsd.edu/news/releases/Pages/2017-10-26-uc-san-diego-health-researchers-launch-second-pancreas-cancer-dream-team.aspx

Tagged with:

About author

Related Articles