Breaking News
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
October 19, 2018 - Juul e-cigarettes pose addiction risk for young users | News Center
October 19, 2018 - Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei
October 19, 2018 - New DNA vaccine strategy protects mice against lethal challenge by multiple H3N2 viruses
October 19, 2018 - Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
October 19, 2018 - Muscle mass plays a critical role in health, shows research
October 19, 2018 - Study finds undiagnosed prediabetes in many infertile men
October 19, 2018 - The Current issue of “The view from here” is concerned with Nanotherapeutic strategies
October 19, 2018 - Delay in replacing the Pap smear with HPV screening is costing lives
October 19, 2018 - Physicians battle pediatric diseases of ear, nose, throat in Zimbabwe | News Center
October 19, 2018 - Researchers investigate why some cancers affect only young women
October 19, 2018 - Drugmakers funnel millions to lawmakers; a few dozen get $100,000-plus
October 19, 2018 - Unselfish people tend to have more children and receive higher salaries
October 19, 2018 - New findings reveal potential cellular players in tumor microenvironment
October 19, 2018 - Some countries take more time for reimbursement decisions on new cancer drugs
October 19, 2018 - Human brain cell transplant offers insights into neurological conditions
October 19, 2018 - Parental education associated with increased family health care spending
October 19, 2018 - New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women
October 19, 2018 - Father’s exposure to nicotine may cause cognitive deficits in descendants
October 19, 2018 - Could we prevent Alzheimer’s disease by treating herpes?
October 19, 2018 - Nurse-led care can be more successful in managing gout
October 19, 2018 - Trump administration, pharma exchange verbal volleys on drug-price transparency
October 19, 2018 - Duke researchers find way to detect blood doping in athletes
October 19, 2018 - Many primary care doctors are still prescribing sedative drugs for older adults
October 19, 2018 - Finger length can predict sexuality in women say researchers
October 19, 2018 - Study finds differences in side-effects experienced by male and female OG cancer patients
October 19, 2018 - Dysfunction of single gene leads to miscarriages
October 19, 2018 - Few Seniors Who Self-Harm Referred for Mental Health Care
October 19, 2018 - Don’t sweat the sweet stuff
October 19, 2018 - URMC researchers discover new approach to deliver therapeutics to the brain
October 19, 2018 - Speech Pathology Australia raises awareness about Developmental Language Disorder
October 19, 2018 - Middlemen suppliers can increase drug prices and hospital bills, say Johns Hopkins researchers
October 19, 2018 - Survey finds high prevalence of HTLV-1 infection among teens and adults in Gabon
October 19, 2018 - Bliss funds research to find whether parental touch can help alleviate pain in premature infants
October 19, 2018 - Human neurons employ highly compartmentalized signaling, study shows
October 19, 2018 - Ultromics expands multiple clinical trials for coronary heart disease to the U.S.
October 19, 2018 - $11 million NIH grant for Clemson University helps launch new center for musculoskeletal research
October 19, 2018 - A new approach identified to control Zika virus, dengue fever
October 19, 2018 - Head Blows Without Concussion May Not Damage Brain, Study Claims
October 19, 2018 - US opioid use not declined, despite focus on abuse and awareness of risk
October 19, 2018 - Next-generation RNA sequencing technology sheds new light on human mitochondrial diseases
October 19, 2018 - UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery
October 19, 2018 - The immune system also plays a key role in day-to-day function of healthy organs
October 19, 2018 - New tool may reveal how the brain structure impacts brain activity, human behavior
October 19, 2018 - Trump Administration announces ‘Winning on Reducing Food Waste’ initiative
October 19, 2018 - For-profit nursing home residents more likely to experience health issues caused by substandard care
October 19, 2018 - Incidence of stroke has risen steadily among marijuana users, show studies
October 19, 2018 - Conceptual framework proposed to examine role of exercise in multiple sclerosis
October 19, 2018 - Near infrared spectroscopy technique for accurate evaluation of chondral injuries
October 19, 2018 - Scientists receive $5.1 million grant to develop stem cell-based therapy for blinding retinal conditions
October 19, 2018 - Shorter physician encounters associated with antibiotic prescribing
Alkaline Phosphatase: MedlinePlus Lab Test Information

Alkaline Phosphatase: MedlinePlus Lab Test Information

image_pdfDownload PDFimage_print

What is an Alkaline Phosphatase Test?

An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. ALP is an enzyme found throughout the body, but it is mostly found in the liver, bones, kidneys, and digestive system. When the liver is damaged, ALP may leak into the bloodstream. High levels of ALP can indicate liver disease or bone disorders.

Other names: ALP, ALK, PHOS, Alkp, ALK PHOS

What is it used for?

An alkaline phosphatase test is used to detect diseases of the liver or bones.

Why do I need an alkaline phosphatase test?

Your health care provider may have ordered an alkaline phosphatase test as part of a routine checkup or if you have symptoms of liver damage or a bone disorder. Symptoms of liver disease include:

  • Nausea and vomiting
  • Weight loss
  • Tiredness
  • Weakness
  • Jaundice, a condition that causes your skin and eyes to turn yellow
  • Swelling and/or pain in your abdomen
  • Dark-colored urine and/or light-colored stool
  • Frequent Itching

Symptoms of bone disorders include:

  • Pain in the bones and/or joints
  • Enlarged and/or abnormally shaped bones
  • Increased frequency of bone fractures

What happens during an alkaline phosphatase test?

An alkaline phosphatase test is a type of blood test. During the test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

Will I need to do anything to prepare for the test?

You don’t need any special preparations for an alkaline phosphatase test. If your health care provider has ordered other blood tests, you may need to fast (not eat or drink) for several hours before the test. Your health care provider will let you know if there are any special instructions to follow.

Are there any risks to the test?

There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.

What do the results mean?

High alkaline phosphatase levels may mean there is damage to your liver or that you have a type of bone disorder. Liver damage creates a different type of ALP than bone disorders do. If the test results show high alkaline phosphatase levels, your health care provider may order additional tests to find out where the extra ALP is coming from. High alkaline phosphatase levels in the liver can indicate:

There are several other types of blood tests that check your liver function. These include bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) tests. If these results are normal and your alkaline phosphatase levels are high, it may mean the problem is not in your liver. Instead, it can indicate a bone disorder, such as Paget’s Disease of Bone, a condition that causes your bones to become abnormally large, weak, and prone to fractures.

Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection.

Low levels of alkaline phosphatase may indicate hypophosphatasia, a rare genetic disease that affects bones and teeth. Low levels may also be due to a deficiency of zinc or malnutrition. To learn what your results mean, talk to your health care provider.

Is there anything else I need to know about alkaline phosphatase test?

ALP levels can vary for different groups. Pregnancy can cause higher than normal ALP levels. Children and teens may have high levels of ALP because their bones are growing. Certain drugs, such as birth control pills, may lower ALP levels, while other medicines can cause the levels to increase.

References

  1. American Liver Foundation. [Internet]. New York: American Liver Foundation; c2017. Liver Function Tests; [updated 2016 Jan 25; cited 2017 Mar 13]; [about 3 screens]. Available from: http://www.liverfoundation.org/abouttheliver/info/liverfunctiontests/
  2. Centers for Disease Control and Prevention [Internet]. Atlanta: U.S. Department of Health and Human Services; Epstein-Barr Virus and Infectious Mononucleosis; [updated 2016 Sep 14; cited 2017 Mar 13]; [about 2 screens]. Available from: https://www.cdc.gov/epstein-barr/about-mono.html
  3. Hinkle J, Cheever K. Brunner & Suddarth’s Handbook of Laboratory and Diagnostic Tests. 2nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Alkaline Phosphate; p. 35–6.
  4. Johns Hopkins Medicine [Internet]. The Johns Hopkins University; Paget Disease of the Bone; [cited 2017 Mar 13]; [about 2 screens]. Available from: http://www.hopkinsmedicine.org/healthlibrary/conditions/orthopaedic_disorders/paget_disease_of_the_bone_85,P00128/
  5. Josse RG, Hanley DA, Kendler D, Ste Marie LG, Adachi, JD, Brown J. Diagnosis and treatment of Paget disease of bone. Clin Invest Med [Internet] 2007 [cited 2017 Mar 13]; 30(5):E210–23. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17892763/–weakened%20deformed%20bones
  6. Lab Tests Online [Internet]. Washington D.C.: American Association for Clinical Chemistry; c2001–2017. ALP: The Test; [updated 2016 Oct 5; cited 2017 Mar 13]; [about 4 screens]. Available from: https://labtestsonline.org/understanding/analytes/alp/tab/test
  7. Lab Tests Online [Internet]. Washington D.C.: American Association for Clinical Chemistry; c2001–2017. ALP: The Test Sample; [updated 2016 Oct 5; cited 2017 Mar 13]; [about 3 screens]. Available from: https://labtestsonline.org/understanding/analytes/alp/tab/sample/
  8. Merck Manual Professional Version [Internet]. Kenilworth (NJ): Merck & Co. Inc.; c2017. Laboratory Tests of the Liver and Gall Bladder; [cited 2017 Mar 13]; [about 3 screens]. Available from: https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/testing-for-hepatic-and-biliary-disorders/laboratory-tests-of-the-liver-and-gallbladder
  9. National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; What Are the Risks of Blood Tests?; [updated 2012 Jan 6; cited 2017 Mar 13]; [about 6 screens]. Available from: https://www.nhlbi.nih.gov/health/health-topics/topics/bdt/risks
  10. National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; What To Expect with Blood Tests; [updated 2012 Jan 6; cited 2017 Mar 13]; [about 5 screens]. Available from: https://www.nhlbi.nih.gov/health/health-topics/topics/bdt/with
  11. NIH U.S. National Library of Medicine: Genetics Home Reference [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; hypophosphatasia; 2017 Mar 7 [cited 2017 Mar 13]; [about 2 screens]. Available from: https://ghr.nlm.nih.gov/condition/hypophosphatasia
  12. NIH National Osteoporosis and Related Bone Diseases National Resource Center [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Questions and Answers about Paget’s Disease of Bone; 2014 Jun [cited 2017 Mar 13]; [about 2 screens]. Available from: https://www.niams.nih.gov/Health_Info/Bone/Pagets/qa_pagets.asp
  13. NIH National Osteoporosis and Related Bone Diseases National Resource Center [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; What Is Paget’s Disease of Bone? Fast Facts: An Easy-to-Read Series of Publications for the Public; 2014 Nov [cited 2017 Mar 13]; [about 2 screens]. Available from: https://www.niams.nih.gov/Health_Info/Bone/Pagets/pagets_disease_ff.asp
  14. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c2017. Health Encyclopedia: Alkaline Phosphate; [cited 2017 Mar 13]; [about 2 screens]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=alkaline_phosphatase
Tagged with:

About author

Related Articles