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GW-led network will receive NIH grant to follow children with autism transition into adulthood

GW-led network will receive NIH grant to follow children with autism transition into adulthood

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A George Washington University-led national collaborative network aimed at improving outcomes for children diagnosed with autism spectrum disorder (ASD) will receive more than $11.7 million from the National Institutes of Health (NIH) over the next five years to help propel innovative research in the field.

Kevin Pelphrey, director of the GW Autism and Neurodevelopmental Disorders Institute and his colleagues will follow children through adolescence and into adulthood to understand differences in ASD risk between boys and girls and in how they each respond to interventions. Although boys may be more at risk, the symptoms of autism materialize differently and sometimes less severely in girls, Dr. Pelphrey said. Because of these differences, many girls go undiagnosed and miss a significant window for impactful treatments.

“No one has focused on the [adolescence] period of development or focused on it in autism before, so we’re very excited about that,” he said. “If we understand something about brain development during adolescence, that could tell us what to predict in young adulthood, including outcomes in terms of happiness, job placement, educational outcomes, health and well being of our participants and their families.”

Experts have typically focused on early development and infancy as the primary time for treatment intervention for individuals with ASD. Many children, however, are not diagnosed until they are a few years older. Teenage years, he said, present a “second major opportunity” that to date has not been a research focus.

Dr. Pelphrey is also one of the first researchers in this field to focus heavily on girls with ASD. As part of this evolving research, the team has for the first time enlisted women and girls with ASD to be researchers as part of a self-advocacy initiative through a key collaboration with Children’s National Health System.

Participants will help examine brain data and talk about the diagnosis process. The advocates also will interact with the research team to provide information about how the lab’s results match up with their diagnosis experience. Dr. Pelphrey expects this process to generate interesting insights on how to further explore the data and make it more useful going forward.

“We’ve been hearing from a lot of families that they feel the work is really meaningful and they’re excited that we’re studying girls,” he said. “They’re hopeful that future families won’t have the type of trouble getting a diagnosis and getting help that they had.”

GW leads an NIH-designated Autism Center of Excellence (ACE) network. The ACE program was created in 2007 from the consolidation of previous programs. The NIH has awarded ACE grants every five years, and 2017 marks the third grant cycle. Dr. Pelphrey first received part of the grant funding in 2012 before coming to GW.

The ACE collaborators are the first group that he knows of to seriously look at how hormone levels in adolescence interact with brain and genetic differences to produce differences in the expression of autism. They will look at both boys and girls and the differences between them on an individual level.

Building on the research initially funded in 2012, Dr. Pelphrey and ACE network collaborators from Harvard University/Boston Children’s Hospital, Children’s National Health System, Seattle Children’s Hospital/University of Washington, Johns Hopkins University, the University of California-Los Angeles, the University of Southern California, the University of California-San Francisco, University of Colorado-Denver and Yale University will continue to follow subjects who were studied in the first phase through adolescence.

Over the past five years the collaborating institutions collected information on an unparalleled study sample, gathering genetic, brain imaging and behavioral data on 250 girls and 250 boys with autism, 200 siblings of people with autism, and 200 typically developing girls and boys, all within the range of 6 to 17 years old.

“That allowed us to start to try to understand the relationship among genes and brain behavior in those kids and look for biomarkers of developmental pathways that might differ for boys and girls,” Dr. Pelphrey said.

Researchers will collect the same data on the participants in this second phase, Dr. Pelphrey said. This will allow them to start charting differing developmental trajectories as the study participants get older and move through key developmental transitions, through puberty and into young adulthood.


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