Breaking News
November 24, 2017 - Video game improves balance in youth with autism
November 24, 2017 - Chromatrap introduces easy-to-use range of DNA kits for molecular biology applications
November 24, 2017 - Bacteria in the intestine can play important pacemaker role in peristalsis
November 24, 2017 - Resistance training promotes environmental quality of life and sense of coherence in older people
November 24, 2017 - Research suggests genome’s spatial organization as important switch for defining cell types
November 24, 2017 - Study highlights need for more clinical trials to improve treatment of children with heart disease
November 24, 2017 - Quickly Treating Mini-Stroke Can Cut Risk for Future Stroke
November 24, 2017 - Inclusion in mainstream school can exacerbate feelings of being ‘different’ in pupils with autism spectrum conditions
November 24, 2017 - Fat-busting ingredients in cinnamon
November 24, 2017 - IMeasureU introduces IMU Step for tracking movements of professional, amateur athletes
November 24, 2017 - Study uncovers key mechanism by which tumors develop resistance to radiation therapy
November 24, 2017 - This Thanksgiving, carve out time for lively discourse on end-of-life wishes
November 24, 2017 - Creutzfeldt-Jakob disease patients harbor infectious prions in their skin
November 24, 2017 - Call for ‘renewed focus’ on deadly threat from antibiotic resistance
November 24, 2017 - 14 signs your daughter may have ADHD
November 24, 2017 - ACA appears to have encouraged more people to use preventive care for heart health
November 23, 2017 - UVA researchers developing new tool to help cancer patients make complex care decisions
November 23, 2017 - SITC releases first consensus recommendations on managing immunotherapy side effects
November 23, 2017 - Research shows major shift in eye surgeries from hospitals to ambulatory surgery centers
November 23, 2017 - Multiple sclerosis drug can beat obstinate bacteria
November 23, 2017 - Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis
November 23, 2017 - Heart disease risk factors linked to walking difficulties in people under age of 78
November 23, 2017 - UVA scientists working to find end-around method to stop triple-negative breast cancer
November 23, 2017 - Researchers develop new tool to share clinico-genomic data
November 23, 2017 - New analysis identifies five distinct patient clusters that may need different approaches to manage asthma
November 23, 2017 - Study shows education and poverty affect outcomes of total knee replacement
November 23, 2017 - Research paves way for development of vaccines against mycoplasma bacteria
November 23, 2017 - Season of festivities can increase opportunities to overindulge in alcohol
November 23, 2017 - Methotrexate drug holiday improves flu vaccine efficacy in rheumatoid arthritis patients
November 23, 2017 - Study identifies signaling pathway essential for growth of new blood vessels
November 23, 2017 - OBD presents results of immunotherapy studies at FNIH Biomarker Consortium Cancer Steering Committee’s annual meeting
November 23, 2017 - New study shows how SNO reaction may contribute to Parkinson’s disease
November 23, 2017 - Study highlights need to improve quality of cardiovascular care for HIV-positive adults
November 23, 2017 - New intelligence tool provides clarity to scientists in booming immuno-oncology field
November 23, 2017 - Cancer Survivors Can Develop PTSD, Too
November 23, 2017 - One step closer toward a treatment for Alzheimer’s disease?
November 23, 2017 - Scientists detect pathological prion protein in skin of CJD patients
November 23, 2017 - Bacterial colonization can function as a pacemaker for the intestine, study reveals
November 23, 2017 - Preclinical study shows clear path toward effective treatment for rare bone disease
November 23, 2017 - Displaced Puerto Ricans face obstacles getting health care
November 23, 2017 - High-intensity exercise improves memory, study finds
November 23, 2017 - Researchers compare shunts and stents to maintain blood flow in infants with heart disease
November 23, 2017 - Gold nanoparticles could potentially help in more effective drug delivery
November 23, 2017 - Moderate coffee consumption more likely to provide beneficial health outcomes
November 23, 2017 - ESMO Consortium Study advocates for equal access to quality cancer treatment across Asia
November 23, 2017 - Gut bacteria at young age can contribute to MS onset and progression, study suggests
November 23, 2017 - Australian government urged to sue tobacco companies
November 23, 2017 - OB/GYN vs PCP: Who Should Handle Sexual Health?
November 23, 2017 - A Teen Mom’s Stress May Harm Her Heart: MedlinePlus Health News
November 23, 2017 - How SORLA protects against Alzheimer’s disease
November 23, 2017 - Newly discovered drug-like compound may revolutionize treatment of autoimmune diseases
November 23, 2017 - Comprehensive review finds increasing number of new heart failure cases in the UK
November 23, 2017 - Leishmania adaptation to environmental changes results from frequent chromosomal amplifications
November 23, 2017 - People who use indoor firing ranges at risk of lead poisoning
November 23, 2017 - Tiny robots could pave way for treating illness in hard-to-reach areas of the body
November 23, 2017 - Study finds smokers wrongly believe Natural American Spirit cigarettes are healthier
November 23, 2017 - Cancer patients willing to swap drug efficacy for reduced risk of adverse events
November 23, 2017 - Oncologists find new biomarker for breast cancer having poor prognosis
November 23, 2017 - Scientists show how diaper phantoms can improve tumor measurements
November 23, 2017 - Metabolites significantly affected in chronic kidney disease, study finds
November 23, 2017 - AR and VR technologies hold potential to increase attractiveness of healthy foods
November 23, 2017 - Amazon Filters offers SupaPore H0P filters for fermentation applications
November 23, 2017 - FDA Approves Genentech’s Gazyva for Previously Untreated Advanced Follicular Lymphoma
November 23, 2017 - Does Sex Really Trigger Cardiac Arrest?: MedlinePlus Health News
November 23, 2017 - Baby-boomers and millennials more afflicted by the opioid epidemic
November 23, 2017 - UNC Lineberger professor receives The Leukemia & Lymphoma Society grant for immunotherapy research
November 23, 2017 - Researchers question exclusion of people with prior cancer history from clinical trials
November 23, 2017 - New mechanism in cancer cells to disarm attacking immune cells, study reveals
November 23, 2017 - Most U.S. Parents Can’t Find Good Childcare: Survey
November 23, 2017 - Alpha-fetoprotein (AFP) Test: MedlinePlus Lab Test Information
November 23, 2017 - Opening windows and doors may improve sleep
November 23, 2017 - Research shows how HLF gene affects blood cell development
November 23, 2017 - Deaths due to diabetes higher than expected in Germany
November 23, 2017 - Study finds improvement in men’s health and negative health trend among women
November 23, 2017 - Study finds specific tumor environment that stimulates cancer cells to metastasize
November 23, 2017 - Problems with your hospital care? Speak up!
November 23, 2017 - Thyroid cancer survivors have higher risk for aging-related diseases
November 23, 2017 - Is a common shoulder surgery useless?
November 23, 2017 - Palliative care services help cancer patients
November 23, 2017 - Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’
New study shows link between gut bacteria and age-related chronic inflammation

New study shows link between gut bacteria and age-related chronic inflammation

image_pdfDownload PDFimage_print

A new study shows for the first time that gut bacteria from old mice induce age-related chronic inflammation when transplanted into young mice. Called “inflammaging”, this low-grade chronic inflammation is linked to life-limiting conditions such as stroke, dementia and cardiovasuclar disease. The research, published today in open-access journal Frontiers in Immunology, brings the hope of a potentially simple strategy to contribute to healthy ageing, as the composition of bacteria in the gut is, at least in part, controlled by diet.

“Since inflammaging is thought to contribute to many diseases associated with ageing, and we now find that the gut microbiota plays a role in this process, strategies that alter the gut microbiota composition in the elderly could reduce inflammaging and promote healthy ageing,” explains Dr Floris Fransen, who performed the research at the University Medical Center Groningen, The Netherlands. “Strategies that are known to alter gut microbiota composition include changes in diet, probiotics, and prebiotics”.

Previous research shows that the elderly tend to have a different composition of gut bacteria than younger people. Immune responses also tend to be compromised in the elderly, resulting in inflammaging. Knowing this, Fransen and his team set out to investigate a potential link.

The scientists transferred gut microbiota from old and young conventional mice to young germ-free mice, and analysed immune responses in their spleen, lymph nodes and tissues in the small intestine. They also analysed whole-genome gene expression in the small intestine. All results showed an immune response to bacteria transferred from the old mice but not from the young mice.

The results suggest that an imbalance of the bacterial composition in the gut may be the cause of inflammaging in the elderly. Imbalances, or “dysbiosis” of gut bacteria results in “bad” bacteria being more dominant than “good” bacteria. An overgrowth of bad bacteria can make the lining of the gut become more permeable, allowing toxins to enter the bloodstream where they can travel around the body with various negative effects. Dysbiosis can have serious health implications: several disorders, such as inflammatory bowel disease, obesity, diabetes, cancer, anxiety and autism are already linked to the condition.

“Our gut is inhabited by a huge number of bacteria” explains Fransen. “Moreover, there are many different kinds of bacterial species, and the bacterial species that are present can vary a lot from person to person”.

Maintaining a healthy gut microbiota is clearly important to a healthy body and healthy ageing, but why the gut microbiota is different in the elderly is not fully understood. Many people are aware of the effect a course of antibiotics can have on the digestive system for example, but as Fransen explains, it may not be down to just one thing: “It is likely a combination of factors such as reduced physical activity, changes in diet, but also as part of a natural process”.

Most, if not all, age-related diseases can be linked back to inflammaging. Despite the fact that this particular study was conducted on mice, it is clear that maintaining a healthy gut microbiota is key to a healthy lifestyle. However, more research is needed to confirm that the human body mirrors the mice in this study.

“Both in humans and mice there is a correlation between altered gut microbiota composition and inflammaging, but the link between the two remains to be proven in humans” concludes Fransen.

Source:

https://www.frontiersin.org/

Tagged with:

About author

Related Articles