Breaking News
March 24, 2018 - Foil-based measuring chip rapidly detects Legionella
March 24, 2018 - Bariatric surgery linked to positive outcomes in very obese adolescents with type 2 diabetes
March 24, 2018 - Are there risks from secondhand marijuana smoke? Early science says yes.
March 24, 2018 - Researchers examine link between knee pain and depression in older adults
March 24, 2018 - FDA Alert: BD Vacutainer Blood Collection Tubes by Becton, Dickinson and Company (BD): Class I Recall
March 24, 2018 - Daytime Sleepiness Linked to Amyloid Accumulation Without Dementia
March 24, 2018 - Energy storehouses in the brain may be source of Alzheimer’s, targets of new therapy
March 24, 2018 - Praising people with autism shows promise for producing more exercise
March 24, 2018 - Using harmless red or infrared light to diagnose breast cancer
March 24, 2018 - Clash over abortion hobbles a health bill. Again. Here’s how.
March 23, 2018 - Virtual nature environment could be new way to recover from stress
March 23, 2018 - New study identifies key cellular mechanisms behind vascular aging in mice
March 23, 2018 - Nightmares Common Among U.S. Troops, But Seldom Reported
March 23, 2018 - Another Record Low for Tuberculosis in U.S.
March 23, 2018 - Changes in the eye connected to a decline in memory
March 23, 2018 - Radiologist creates dramatic teaching tool using power of VR
March 23, 2018 - Grilled meat could be raising the risk of hypertension finds study
March 23, 2018 - Mutations found in bassoon gene may help explain cause of rare brain disorder
March 23, 2018 - Childhood Brain Injuries May be Linked to ADHD Years Later
March 23, 2018 - Why treating addiction with medication should be carefully considered
March 23, 2018 - Researchers make key discovery about cellular pathway linked to myriad of diseases
March 23, 2018 - Researchers uncover cause of rare childhood neurodegenerative disease
March 23, 2018 - Measles infection in early childhood could contribute to later COPD
March 23, 2018 - Opioid painkiller is top prescription in 11 states
March 23, 2018 - Sienna Biopharmaceuticals Announces First Patient Dosed In Proof-of-Concept Trial of Topical By Design™ JAK Inhibitor SNA-125 for Atopic Dermatitis
March 23, 2018 - In Teen Girls, Neural Patterns May Drive Emotional Resilience
March 23, 2018 - Gene-based test for urine detects, monitors bladder cancer
March 23, 2018 - BD to introduce new digital solution for IV chemotherapy administration process at EAHP 2018
March 23, 2018 - New computational method helps to identify tumor cell mutations with greater accuracy
March 23, 2018 - Researchers identify potential obesity treatment in freezing hunger-signaling nerve
March 23, 2018 - Wales participates in the 100,000 Genomes Project
March 23, 2018 - 24-Hr Paging Cuts ED Visits for Kids with Endocrine Issues
March 23, 2018 - The brain learns completely differently than we’ve assumed since the 20th century
March 23, 2018 - Less nutritious diet mainly contributes to Type 2 diabetes among U.S.-based South Asians
March 23, 2018 - Stony Brook Medicine expert provides tips for healthy diet to decrease cancer risk
March 23, 2018 - New findings could have revolutionary impact on quality of life of older people
March 23, 2018 - Restoring enzyme may help reverse effects of vascular aging, study shows
March 23, 2018 - Protein profiling reveals new prostate cancer mechanisms
March 23, 2018 - Depression may be linked to increased risk of atrial fibrillation
March 23, 2018 - FDA Takes Aim at Flavored Tobacco
March 23, 2018 - SMART Strategy Lowers Asthma Exacerbation Risk
March 23, 2018 - Cold open water plunge provides instant pain relief
March 23, 2018 - Portable and wearable technology supports future of military medical devices
March 23, 2018 - Patients with vascular malformations have poor health-related quality of life
March 23, 2018 - Researchers develop unique technology to overcome global antibiotic resistance crisis
March 23, 2018 - New DOD grant to support testing of promising therapy for triple-negative breast cancer
March 23, 2018 - Novel vaccine technologies can help better prepare for future infectious disease threats
March 23, 2018 - OncoBreak: Colonoscopy TV; Coverage for Genomic Testing; Care for Caregivers
March 23, 2018 - For some surgeries, nerve blocks mean better outcomes, fewer opioids
March 23, 2018 - Maternal obesity and androgen excess induce sex-specific anxiety in offspring, study suggests
March 23, 2018 - The tale of Theranos and the mysterious fire alarm
March 23, 2018 - USC researchers create algorithm to optimize substance abuse intervention groups
March 23, 2018 - Impulsivity may be associated with greater weight loss during treatment in obese children
March 23, 2018 - CTI BioPharma Announces Publication of Pacritinib Phase 3 PERSIST-2 Clinical Trial in JAMA Oncology
March 23, 2018 - Senate Panel Addresses Native Americans’ Opioid Troubles
March 23, 2018 - Brain connections in schizophrenia
March 23, 2018 - Mental health assessment in health checks can help detect psychologically vulnerable people
March 23, 2018 - New test for urothelial cancers offers less invasive, more accurate detection
March 23, 2018 - Groundbreaking 100,000 Genomes Project achieves important milestone to transform NHS care
March 23, 2018 - Mice getting a new lease of life with anti-aging pills
March 23, 2018 - Obesity kills taste buds and dulls taste sensation finds study
March 23, 2018 - Medical students get less formal education in radiation oncology, study finds
March 23, 2018 - Researchers find investigational compound to treat triple negative breast cancer after brain metastasis
March 23, 2018 - Researchers develop wearable system to monitor electrical activity in the stomach over 24 hours
March 23, 2018 - A Different Opioid Crisis | Medpage Today
March 23, 2018 - PTSD an ongoing fight for generation of Iraq War vets
March 23, 2018 - Researchers uncover specific gene region in hypertension
March 23, 2018 - Specific immune cells may help slow progression of ALS, research shows
March 23, 2018 - Biosense Webster launches new ‘Power to Heal’ campaign to alleviate AF burden
March 23, 2018 - FDA could curb or ban tobacco in menthol or fruit flavoured cigarettes soon
March 23, 2018 - Mom’s Pre-Pregnancy Waist Size Tied to Autism Risk
March 23, 2018 - AMD Treat-and-Extend Regimens OK: Ophthalmology Times
March 23, 2018 - Safe-sleep recommendations for infants have not reduced sudden deaths in newborns
March 23, 2018 - Survey finds inappropriate prescribing of antibiotics for hospitalized children
March 23, 2018 - Researchers propose alternative treatment to target lymphoma signaling at its root
March 22, 2018 - Compound found in beet extract could help slow progression of Alzheimer’s disease
March 22, 2018 - Lower temperatures can trigger the body’s ‘good’ fat formation at cellular level
March 22, 2018 - Sentinel lymph node biopsies could be safely avoided for some breast cancer patients
March 22, 2018 - Combined Preeclampsia Test Superior to U.K. Standards
March 22, 2018 - Exclusive breastfeeding in hospital associated with longer breastfeeding duration
Why do some obese people have ‘healthier’ fat tissue than others?

Why do some obese people have ‘healthier’ fat tissue than others?

image_pdfDownload PDFimage_print
Credit: CC0 Public Domain

One little understood paradox in the study of obesity is that overweight people who break down fat at a high rate are less healthy than peers who store their fat more effectively.

That’s because when fat breaks down, many of the fatty acids released from the adipose tissue (body fat) can take up residence elsewhere. Too much of this and fat can accumulate to harmful levels in other tissues and organs, which can fuel insulin resistance, a hallmark of type 2 diabetes and heart disease.

A pair of studies from the University of Michigan identifies key characteristics in fat tissue that may allow some obese adults to store their body fat more healthily and suggests that aerobic exercise may lead to healthier fat storage, said principal investigator Jeffrey Horowitz, professor of movement science at the U-M School of Kinesiology.

Most obese people develop insulin resistance, which can lead to type 2 diabetes and other chronic diseases. However, Horowitz and his team found that about one-third of the 30 obese adults in their study did not develop insulin resistance.

This begged the question: What protected these people?

Adipose tissue samples revealed that the healthier group broke down fat at slower rates, and they had fewer proteins involved in fat breakdown and more involved in fat-storing. They also had fewer fibrotic cells in the adipose tissue, which allows tissue to be more flexible, and lower activation of certain inflammatory pathways.

“It sounds counterintuitive, but if we can better understand how to store fat more effectively, and why some people are better at this than others, perhaps we can design therapies and preventions that will improve some of these obesity-related metabolic conditions,” Horowitz said.

In the second study, researchers collected fat tissue after a session of aerobic exercise from two groups of overweight people: one group exercised regularly, and the other group didn’t. For both groups, just one session of exercise triggered signals that led to the growth of new blood vessels in fat tissue.

Researchers also found indications that the regular exercisers had more blood vessels in their fat tissue than non-exercisers.

That’s important because the health of most tissues hinges, in large part, on blood flow and nutrients, Horowitz said. When we gain weight, our fat cells expand, but if blood flow to fat tissue doesn’t increase in parallel, it could become unhealthy or even necrotic.

Horowitz stressed that the two studies are relevant mainly to obese people at risk for metabolic disease. However, there’s a takeaway here for everyone.

“We believe that the regular exercise we do now may create a healthier fat-storing environment for those times when we do overeat and gain weight,” Horowitz said.

Taken together, the studies also support the notion that clinicians must redefine their view of fat, said Horowitz.

“Adipose tissue is scorned because most people see it as causing disease and obesity, but in general adipose tissue doesn’t cause people to gain weight and become obese, it’s just where we store our extra energy when we do overeat,” Horowitz said. “Our studies aren’t suggesting it is healthy to be obese or to overeat—but when we do overeat, it is important to have a safe place to store that extra energy.

“When people gain the same amount of body fat, those with adaptations to their fat tissue that can more healthfully accommodate the extra fat may be protected from developing insulin resistance and obesity-related diseases. We have identified some of these adaptations.”

Doug Van Pelt, a former doctoral student in the Horowitz lab, conducted this work as part of his dissertation. Van Pelt is currently a postdoctoral fellow at the University of Kentucky’s College of Health Sciences.

The two studies are: “Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults” and “Aerobic exercise elevates markers of angiogenesis and macrophage IL6 gene expression in the subcutaneous adipose tissue of overweight to obese adults.”

The study is published in the Journal of Applied Physiology.

Explore further:
Exosomes are the missing link to insulin resistance in diabetes

Journal reference:
Journal of Applied Physiology

Provided by:
University of Michigan

Tagged with:

About author

Related Articles