Breaking News
November 18, 2017 - Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy
November 18, 2017 - Mount Sinai researchers identify new therapeutic target for ER+ breast cancer
November 18, 2017 - Age, CRP levels predict success in tapering of biologics in rheumatoid arthritis patients
November 18, 2017 - New dye could be used to observe electrical activity of neurons in the brain
November 18, 2017 - New study further validates use of vaginal progesterone to decrease risk of preterm birth
November 18, 2017 - Russian researcher determined range of reference values for boron in the human body
November 18, 2017 - ‘What the Health?’ Tax bill or health bill?
November 18, 2017 - Could Your Cat Give You ‘Bird Flu?’
November 18, 2017 - Vitamin D Linked to Fertility Outcomes in ART
November 18, 2017 - Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease
November 18, 2017 - Tax reform proposal could impact care for older Americans
November 18, 2017 - PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease
November 18, 2017 - Researchers receive £1.3 million to develop sight-saving imaging technology
November 18, 2017 - Novel buckypaper sensor could pave way for high-performance, affordable wearable technology
November 18, 2017 - Despite ACA cost protections, most adolescents skip regular checkups
November 18, 2017 - Stem cell treatment allows paraplegic rats to walk and regain sensory perception
November 18, 2017 - HTC analytical conference comes to the UK
November 18, 2017 - Face It: Drinking, Smoking Takes Toll on Looks: MedlinePlus Health News
November 18, 2017 - New research shows where in the brain the earliest signs of Alzheimer’s occur
November 18, 2017 - Philips announces launch of global movement to raise awareness for COPD
November 18, 2017 - University of Bristol awarded grant to reduce antibacterial drug resistance in Thailand
November 18, 2017 - New oxytocin chemical sensor could be first step towards early diagnosis of autism
November 18, 2017 - Study finds medical cannabis is effective at reducing opioid addiction
November 18, 2017 - Specially tailored, ultrafast light pulses can trigger neurons to fire in different patterns
November 18, 2017 - Decrease in sunshine linked to rising incidence of Rickets
November 18, 2017 - Harnessing social media big data to fight against prescription drug crisis
November 18, 2017 - Researchers find way to switch tumor cells between 2D and 3D morphology
November 18, 2017 - FDA Approves Hemlibra (emicizumab-kxwh) for Hemophilia A with Inhibitors
November 18, 2017 - Adolescents underreport amphetamine use, likely unaware that adderall is amphetamine
November 18, 2017 - Study reveals a reduced risk of teenage eczema in breastfed babies
November 18, 2017 - Separating side effects could pave way for safe, effective pain medications
November 18, 2017 - Gut bacteria at young age can contribute to MS disease onset and progression, study suggests
November 18, 2017 - Environmental triggers may play role in development of Lupus
November 18, 2017 - Review looks into conventional versus new treatment modalities in orthodontic pain management
November 17, 2017 - FDA Alert: Diphenoxylate Hydrochloride and Atropine Sulfate Tablets by Greenstone: Recall
November 17, 2017 - For older women, every movement matters
November 17, 2017 - Talking-based therapy could transform aftercare for cancer survivors
November 17, 2017 - Olympus IXplore SpinSR10 imaging system enables researchers to observe fine details in live cells
November 17, 2017 - Study explores reasons for underrepresentation of minorities in genetic cancer research
November 17, 2017 - California firm running physician practices is closing down as scrutiny ramps up
November 17, 2017 - BMI not valid measure of obesity in postmenopausal women, study shows
November 17, 2017 - Vaginal progesterone decreases the risk of premature birth in women with short cervix
November 17, 2017 - Pricey ER Tests for Chest Pain Often Unnecessary
November 17, 2017 - ‘Old’ Lungs May Be Good Transplant Options: MedlinePlus Health News
November 17, 2017 - How not to gain weight over the holidays
November 17, 2017 - Researchers map first-ever proteome of healthy human heart
November 17, 2017 - Drug used to prevent and treat malaria may also be effective for Zika virus
November 17, 2017 - One in 20 children still receiving codeine to treat pain despite warning from federal regulators
November 17, 2017 - Improving clinical trials with machine learning
November 17, 2017 - Experts identify mental exercise program that can reduce risk of dementia
November 17, 2017 - Just-in-time 3-D implants set to transform tumor surgery
November 17, 2017 - Skin patch offers hope for people with peanut allergy
November 17, 2017 - Scientists identify biomarkers that predict risk of death in Ebola patients
November 17, 2017 - Heart attack, stroke patients have improved outcomes when statins are prescribed after discharge
November 17, 2017 - Majority of people do not understand link between obesity and cancer, study shows
November 17, 2017 - Deep vein thrombosis accurately diagnosed by GPs trained in compression ultrasonography
November 17, 2017 - New Kevlar-based hydrogel recreates the magic of natural cartilage
November 17, 2017 - FDA approves first adjuvant treatment to reduce risk of kidney cancer recurrence
November 17, 2017 - Foods made with biofortified corn flour and eggs retain vitamin A after cooking
November 17, 2017 - Integrated Care Winning the Day for Healthcare Companies
November 17, 2017 - CPAP may be superior to gastric banding for severe sleep apnea
November 17, 2017 - New pain relievers reduce opiate overdose risk
November 17, 2017 - Brain astrocytes could play key role in pathogenesis of Alzheimer’s disease
November 17, 2017 - Researchers test whether LVAD surgery could reverse frailty in older adults with heart failure
November 17, 2017 - ATS debuts new video to highlight dangers of flavored tobacco
November 17, 2017 - Medicaid expansion under ACA more likely to increase smoking cessation rates among low-income adults
November 17, 2017 - FDA Approves Mepsevii (vestronidase alfa) for Mucopolysaccharidosis Type VII
November 17, 2017 - 1 in 5 Americans Still Uses Tobacco, Gov’t. Reports: MedlinePlus Health News
November 17, 2017 - People with psychotic-like experiences spend less time in healthy brain states
November 17, 2017 - Hospital Readmission Reduction Program linked to increase in death rates, study finds
November 17, 2017 - Study finds rising rates of marijuana use in states where it is legal
November 17, 2017 - Scientists unveil pathology underlying optic nerve hypoplasia in children
November 17, 2017 - Novel device designed to treat diastolic heart failure found safe and effective
November 17, 2017 - Smoking parents may underestimate kid’s exposure to secondhand smoke
November 17, 2017 - FAIMS technology holds potential to be effective screening tool for pancreatic cancer
November 17, 2017 - Applying AFM to study the viscoelastic properties of cells
November 17, 2017 - FDA Alert: Nexterone (amiodarone HCl) 150 mg/100 mL Premixed Injection: Recall
November 17, 2017 - High cognitive ability not a safeguard from conspiracies, paranormal beliefs
November 17, 2017 - Computerized speed of processing training results in decreased risk of dementia
November 17, 2017 - Sexual activity poses exceedingly small risk in causing sudden cardiac arrest
Low-energy ESWT shows promise for managing digital ulcers in patients with systemic sclerosis

Low-energy ESWT shows promise for managing digital ulcers in patients with systemic sclerosis

image_pdfDownload PDFimage_print

Extracorporeal shock-wave therapy at low energy levels showed promise as a new treatment for digital ulcers in patients with systemic sclerosis, or scleroderma, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego.

Systemic sclerosis, also called scleroderma, is a serious and rare autoimmune disease that affects the skin and other organs. Severe complications may include kidney disease, pulmonary arterial hypertension (PAH), lung inflammation or gastrointestinal problems.

Systemic sclerosis (SSc) patients often have Raynaud’s phenomenon as a complication, which can cause digital skin ulcers. Treatments like immunosuppressants, vasodilators or anticoagulants are often ineffective for digital ulcers and are associated with high costs and significant side effects. Low-energy, extracorporeal shock-wave therapy (ESWT) is effective at stimulating growth factors and the formation of new blood vessels, and healing these skin wounds, so a group of researchers in Japan conducted a study to test the effectiveness of this therapy.

“Digital ulcers are a severe complication of SSc caused by microvascular impairment and persistent vasospasm associated with Raynaud’s phenomenon. Several studies have shown that approximately 50 percent of SSc patients experience digital ulcers. Ten percent require continuous therapy, and one percent exhibit severe symptoms such as gangrene,” said Tomonori Ishii, MD, a researcher at Tohoku University Hospital in Sendai, Japan and a lead author of this study. “In some cases, digital ulcers cause severe scarring and lead to amputation. Although most of the small ulcers are localized to the fingertips, some large ulcers spread throughout the finger and lead to necrosis or progressive digital shortening. Even a small fingertip ulcer causes severe pain and restricts activities of daily living.”

The study included 60 SSc patients with refractory digital ulcers who had no response to intravenous prostaglandin E1 therapy for at least four weeks. Thirty patients were treated with ESWT, while the other 30 patients were treated with currently available therapies. Patients in the ESWT group were allowed to continue their pre-study treatments as well. Patients were evaluated after eight weeks of therapy.

Results of the study showed a significant decrease in the number of ulcers in the ESWT group compared with the conventional treatment group (a mean of 4.47 versus 0.83, respectively) after eight weeks. In addition, 70 percent of the patients in the ESWT group experienced a decrease in the total number of their digital ulcers after eight weeks, compared to 26.7 percent of the patients in the conventional treatment group.

During the follow-up period, an average of 1.57 new ulcers formed in patients from the conventional treatment group, compared with 0.23 new ulcers for those treated with ESWT. The patients in the ESWT group reported no serious adverse events in association with the therapy during the eight-week study.

The researchers concluded treatment with ESWT is minimally invasive, well tolerated, does not require anesthesia and can result in clinically meaningful improvement for SSc patients with refractory digital ulcers.

“Low-energy ESWT may be a new approach to managing digital ulcers associated with SSc. ESWT has a strong and rapid effect for ulcer healing. It also has potential and unexpected benefits. First, ESWT may be effective in treating the pathology. It aims to stimulate neovascularization and is not intended to dilate damaged vessels,” said Dr. Ishii. “It is a non-pharmacological treatment that may avoid the adverse effects that are inevitable with medication. It can be used in patients with severe disease, including renal, cardiac, and respiratory failure, as well as gastrointestinal tract disturbances. Moreover, its safety may enable treatment repetition with efficacy. In addition to treating ulcers, ESWT may help eliminate pain, which is the most severe and persistent complaint of these patients.”​

Source:

https://www.rheumatology.org/About-Us/Newsroom/Press-Releases/ID/843/Shock-Wave-Therapy-Successfully-Treats-Finger-Ulcers-in-Scleroderma-Patients

Tagged with:

About author

Related Articles