Breaking News
November 24, 2017 - Video game improves balance in youth with autism
November 24, 2017 - Chromatrap introduces easy-to-use range of DNA kits for molecular biology applications
November 24, 2017 - Bacteria in the intestine can play important pacemaker role in peristalsis
November 24, 2017 - Resistance training promotes environmental quality of life and sense of coherence in older people
November 24, 2017 - Research suggests genome’s spatial organization as important switch for defining cell types
November 24, 2017 - Study highlights need for more clinical trials to improve treatment of children with heart disease
November 24, 2017 - Quickly Treating Mini-Stroke Can Cut Risk for Future Stroke
November 24, 2017 - Inclusion in mainstream school can exacerbate feelings of being ‘different’ in pupils with autism spectrum conditions
November 24, 2017 - Fat-busting ingredients in cinnamon
November 24, 2017 - IMeasureU introduces IMU Step for tracking movements of professional, amateur athletes
November 24, 2017 - Study uncovers key mechanism by which tumors develop resistance to radiation therapy
November 24, 2017 - This Thanksgiving, carve out time for lively discourse on end-of-life wishes
November 24, 2017 - Creutzfeldt-Jakob disease patients harbor infectious prions in their skin
November 24, 2017 - Call for ‘renewed focus’ on deadly threat from antibiotic resistance
November 24, 2017 - 14 signs your daughter may have ADHD
November 24, 2017 - ACA appears to have encouraged more people to use preventive care for heart health
November 23, 2017 - UVA researchers developing new tool to help cancer patients make complex care decisions
November 23, 2017 - SITC releases first consensus recommendations on managing immunotherapy side effects
November 23, 2017 - Research shows major shift in eye surgeries from hospitals to ambulatory surgery centers
November 23, 2017 - Multiple sclerosis drug can beat obstinate bacteria
November 23, 2017 - Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis
November 23, 2017 - Heart disease risk factors linked to walking difficulties in people under age of 78
November 23, 2017 - UVA scientists working to find end-around method to stop triple-negative breast cancer
November 23, 2017 - Researchers develop new tool to share clinico-genomic data
November 23, 2017 - New analysis identifies five distinct patient clusters that may need different approaches to manage asthma
November 23, 2017 - Study shows education and poverty affect outcomes of total knee replacement
November 23, 2017 - Research paves way for development of vaccines against mycoplasma bacteria
November 23, 2017 - Season of festivities can increase opportunities to overindulge in alcohol
November 23, 2017 - Methotrexate drug holiday improves flu vaccine efficacy in rheumatoid arthritis patients
November 23, 2017 - Study identifies signaling pathway essential for growth of new blood vessels
November 23, 2017 - OBD presents results of immunotherapy studies at FNIH Biomarker Consortium Cancer Steering Committee’s annual meeting
November 23, 2017 - New study shows how SNO reaction may contribute to Parkinson’s disease
November 23, 2017 - Study highlights need to improve quality of cardiovascular care for HIV-positive adults
November 23, 2017 - New intelligence tool provides clarity to scientists in booming immuno-oncology field
November 23, 2017 - Cancer Survivors Can Develop PTSD, Too
November 23, 2017 - One step closer toward a treatment for Alzheimer’s disease?
November 23, 2017 - Scientists detect pathological prion protein in skin of CJD patients
November 23, 2017 - Bacterial colonization can function as a pacemaker for the intestine, study reveals
November 23, 2017 - Preclinical study shows clear path toward effective treatment for rare bone disease
November 23, 2017 - Displaced Puerto Ricans face obstacles getting health care
November 23, 2017 - High-intensity exercise improves memory, study finds
November 23, 2017 - Researchers compare shunts and stents to maintain blood flow in infants with heart disease
November 23, 2017 - Gold nanoparticles could potentially help in more effective drug delivery
November 23, 2017 - Moderate coffee consumption more likely to provide beneficial health outcomes
November 23, 2017 - ESMO Consortium Study advocates for equal access to quality cancer treatment across Asia
November 23, 2017 - Gut bacteria at young age can contribute to MS onset and progression, study suggests
November 23, 2017 - Australian government urged to sue tobacco companies
November 23, 2017 - OB/GYN vs PCP: Who Should Handle Sexual Health?
November 23, 2017 - A Teen Mom’s Stress May Harm Her Heart: MedlinePlus Health News
November 23, 2017 - How SORLA protects against Alzheimer’s disease
November 23, 2017 - Newly discovered drug-like compound may revolutionize treatment of autoimmune diseases
November 23, 2017 - Comprehensive review finds increasing number of new heart failure cases in the UK
November 23, 2017 - Leishmania adaptation to environmental changes results from frequent chromosomal amplifications
November 23, 2017 - People who use indoor firing ranges at risk of lead poisoning
November 23, 2017 - Tiny robots could pave way for treating illness in hard-to-reach areas of the body
November 23, 2017 - Study finds smokers wrongly believe Natural American Spirit cigarettes are healthier
November 23, 2017 - Cancer patients willing to swap drug efficacy for reduced risk of adverse events
November 23, 2017 - Oncologists find new biomarker for breast cancer having poor prognosis
November 23, 2017 - Scientists show how diaper phantoms can improve tumor measurements
November 23, 2017 - Metabolites significantly affected in chronic kidney disease, study finds
November 23, 2017 - AR and VR technologies hold potential to increase attractiveness of healthy foods
November 23, 2017 - Amazon Filters offers SupaPore H0P filters for fermentation applications
November 23, 2017 - FDA Approves Genentech’s Gazyva for Previously Untreated Advanced Follicular Lymphoma
November 23, 2017 - Does Sex Really Trigger Cardiac Arrest?: MedlinePlus Health News
November 23, 2017 - Baby-boomers and millennials more afflicted by the opioid epidemic
November 23, 2017 - UNC Lineberger professor receives The Leukemia & Lymphoma Society grant for immunotherapy research
November 23, 2017 - Researchers question exclusion of people with prior cancer history from clinical trials
November 23, 2017 - New mechanism in cancer cells to disarm attacking immune cells, study reveals
November 23, 2017 - Most U.S. Parents Can’t Find Good Childcare: Survey
November 23, 2017 - Alpha-fetoprotein (AFP) Test: MedlinePlus Lab Test Information
November 23, 2017 - Opening windows and doors may improve sleep
November 23, 2017 - Research shows how HLF gene affects blood cell development
November 23, 2017 - Deaths due to diabetes higher than expected in Germany
November 23, 2017 - Study finds improvement in men’s health and negative health trend among women
November 23, 2017 - Study finds specific tumor environment that stimulates cancer cells to metastasize
November 23, 2017 - Problems with your hospital care? Speak up!
November 23, 2017 - Thyroid cancer survivors have higher risk for aging-related diseases
November 23, 2017 - Is a common shoulder surgery useless?
November 23, 2017 - Palliative care services help cancer patients
November 23, 2017 - Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’
Neutrophils found to be helpful, not harmful, after injury

Neutrophils found to be helpful, not harmful, after injury

image_pdfDownload PDFimage_print
Dynamic behavior of neutrophils inside sterile injury lesions. (A) Representative images of rapid accumulation of neutrophils in response to focal hepatic injury. Dashed lines highlight injury borders. Scale bars, 230 μm. (B) Representative images of collapsed vessels (arrows) inside the injury area. Scale bar, 10 μm. (C) Quantification of blood vessel diameters inside the injury lesion and in the healthy area (outside injury). Data pooled from three independent experiments. (D) Representative image of neutrophils inside the focal lesion at 12 hours post injury. Higher magnification of the indicated area (white dashed line box) is shown on the right. Scale bar, 30 μm. ****P Science (2017). DOI: 10.1126/science.aam9690

(Medical Xpress)—An international team of researchers has found that neutrophils play an important role in wound cleanup rather than causing unnecessary inflammation. In their paper published in the journal Science, the group describes studying the activities of neutrophils in real time with injured mice. Hannah Garner and Karin de Visser with the Netherlands Cancer Institute offer a Perspective piece on the work done by the team in the same journal issue.

For some time, medical researchers have known that neutrophils offer benefits in responding to injury, but they also believed that neutrophils were detrimental in some patients—immune cells were thought to contribute to unnecessary inflammation, making it more difficult for patients to recover from injuries. As a result, researchers have sought to reduce the actions of neutrophils to speed recovery in traumatized patients. Now, it appears such work may actually have been in vain, as this new effort shows that rather than causing problems, neutrophils actually only help in wound repair.

To learn about the true role of neutrophils as the body reacts to injury, the researchers inflicted burn injuries on test mice and then watched what happened using intravital imaging. They found that rather than causing unnecessary inflammation, the cells initially took apart blood vessels that had collapsed. Several hours later, they were seen picking up damaged DNA fragments. Furthermore, all of the cells moved out and away from the site of the injury within 14 to 16 hours. The team also observed that when they killed the neutrophils, the site of injury contained more debris than sites that with active neutrophils. The researchers continued monitoring the neutrophils and found that a day after an injury had occurred, most of the cells had migrated to bone marrow and were in the process of apoptosis—those few that had not migrated to bone marrow were found in the lungs, but were not causing any problems.

With these new findings, as Garner and de Visser note, more research will likely be conducted regarding the role that neutrophils play in injury repair and suggest that they might lead researchers to new ways of improving treatment of injured patients.


Explore further:
Team discovers how to train damaging inflammatory cells to promote repair after stroke

More information:
Jing Wang et al. Visualizing the function and fate of neutrophils in sterile injury and repair, Science (2017). DOI: 10.1126/science.aam9690

Abstract

Neutrophils have been implicated as harmful cells in a variety of inappropriate inflammatory conditions where they injure the host, leading to the death of the neutrophils and their subsequent phagocytosis by monocytes and macrophages. Here we show that in a fully repairing sterile thermal hepatic injury, neutrophils also penetrate the injury site and perform the critical tasks of dismantling injured vessels and creating channels for new vascular regrowth. Upon completion of these tasks, they neither die at the injury site nor are phagocytosed. Instead, many of these neutrophils reenter the vasculature and have a preprogrammed journey that entails a sojourn in the lungs to up-regulate CXCR4 (C-X-C motif chemokine receptor 4) before entering the bone marrow, where they undergo apoptosis.

Journal reference:
Science

Tagged with:

About author

Related Articles