Breaking News
July 19, 2018 - Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice
July 19, 2018 - Study finds major discrepancies in prescription drug labeling pregnancy information across four countries
July 19, 2018 - Cellectar’s CLR 131 Receives FDA Orphan Drug Designation for Treatment of Ewing’s Sarcoma
July 19, 2018 - Watching the immune system in action reveals what happens when things goes wrong
July 19, 2018 - Increasing blood sugar levels improves memory and performance in older adults
July 19, 2018 - Connection between self-regulation and obesity appears to be different for girls and boys
July 19, 2018 - Researchers develop new, less destructive method for whitening teeth
July 19, 2018 - Revving up innate control of viral infection requires a three-cell ignition
July 19, 2018 - Inaccurate direct-to-consumer raw genetic data can harm patients, new research suggests
July 19, 2018 - Weight loss surgery is effective under the right situations
July 19, 2018 - BioTek awarded patent for autofocus feature on microplate reader
July 19, 2018 - Low-carb diets reduce stiffness of arteries in women and promote weight loss in men
July 19, 2018 - New review examines cannabinoids’ potential for direct treatment of cancer
July 19, 2018 - Allergic responses may help protect the skin against cancer, research suggests
July 19, 2018 - Inappropriate Prescribing of Abx High in Urgent Care Centers
July 19, 2018 - Many at risk for HIV despite lifesaving pill
July 19, 2018 - Tips for doctors and parents on the harms of marijuana use for teens
July 18, 2018 - Researchers detect presence of IgE antibodies after kidney transplantation
July 18, 2018 - New technique allows researchers to create large scale, personalized bone grafts
July 18, 2018 - Smoking May Boost Atrial Fibrillation Risk
July 18, 2018 - Genome editing method targets AIDS virus
July 18, 2018 - These things matter: Medical complications are not inevitable, a physician writes
July 18, 2018 - Cognitive functions often wilt as water departs the body, shows study
July 18, 2018 - Origins of bread found 14,400 years ago in Jordan
July 18, 2018 - Low-dose ketamine found to be as effective as opioids for treating acute pain
July 18, 2018 - Novel bioengineering technique could help repair bone defects
July 18, 2018 - Researchers identify new potential target protein for colon cancer
July 18, 2018 - Air pollution contributes significantly to diabetes globally
July 18, 2018 - Cell membrane’s importance offers new strategy to fight infections
July 18, 2018 - Researchers identify key protein involved in irregular brain cell activity
July 18, 2018 - 3D modeling of drug resistance could lead to more effective cancer treatment
July 18, 2018 - Hunger hormones could be key to new treatments for drug, alcohol addiction
July 18, 2018 - Nitrate-cured meats may contribute to mania, study finds
July 18, 2018 - Why men may recover more quickly from influenza infections than women
July 18, 2018 - Study finds discharge against medical advice as predictor of readmissions in heart attack patients
July 18, 2018 - KemPharm Announces Top Line Results from KP415.E01 Efficacy and Safety Trial in Children With ADHD
July 18, 2018 - Self-control and obesity: Gender matters in children
July 18, 2018 - Bioengineers, diabetes researchers convene to discuss future concepts for precision medicine
July 18, 2018 - New findings support more conservative use of ED neuroimaging for non-index seizures
July 18, 2018 - Practicing yoga benefits pregnant women, study suggests
July 18, 2018 - New strategy may lead to more accurate breast cancer diagnoses
July 18, 2018 - FDA Approves Symtuza (D/C/F/TAF), the First and Only Complete Darunavir-Based Single-Tablet Regimen for the Treatment of HIV-1 Infection
July 18, 2018 - New guide helps hospitals pick right partner to handle hospitalist services
July 18, 2018 - Deep data dive helps predict cerebral palsy
July 18, 2018 - Stricter firearm legislation associated with reduced murder and suicide rates
July 18, 2018 - Physical and sexual abuse in childhood associated with endometriosis risk
July 18, 2018 - Omega 3 supplements do not reduce risk of heart disease, stroke or death
July 18, 2018 - GSA’s new publication provides support for safe use of OTC analgesics by older adults
July 18, 2018 - Researchers receive grant from U.S. Department of Education to study children with HFASD
July 18, 2018 - Early childhood adversity increases sensitivity of the body’s immune response to cocaine
July 18, 2018 - Parental incarceration affects health behaviors of children in adulthood
July 18, 2018 - Researchers find that yellow fever and Asian tiger mosquitoes can carry new virus
July 18, 2018 - Two Regimens Fail to Stop Declines in β-Cell Function
July 18, 2018 - Researchers apply computing power to track the spread of cancer
July 18, 2018 - Olfactory receptors play pathophysiological role in all organs than merely smell perception
July 18, 2018 - Fish consumption associated with lower risk of early death
July 18, 2018 - MR Solutions’ 7T MRI imaging system installed at University of Hawaii
July 18, 2018 - Humorous ads screened around World Cup game achieve higher biometric response than sporty ads
July 18, 2018 - New study demonstrates little effect of hormone therapy on artery thickness
July 18, 2018 - A 3-Pronged Plan to Cut Type 2 Diabetes Risk
July 18, 2018 - New clues to sepsis may speed diagnosis
July 18, 2018 - Stars of Stanford Medicine: Improving cardiovascular health in Africa and beyond
July 18, 2018 - Heart attack risk continues to increase among pregnant women, study finds
July 18, 2018 - Few tips to help avoid sunburns in summer
July 18, 2018 - High-fat diet and systemic inflammation contribute to progression of prostate cancer
July 18, 2018 - Researchers develop 3D map of gene interactions that play key role in heart disease
July 18, 2018 - Conservative management of lung subsolid nodules reduces overtreatment and unnecessary surgery
July 18, 2018 - Report warns of dog illness that can spread to owners
July 18, 2018 - A winning essayist’s tips for keeping track of scientific facts
July 18, 2018 - Researchers seek to understand role of APOE mutation in Alzheimer’s disease
July 18, 2018 - Animal studies reveal brain changes responsible for appetite effects of cannabis
July 18, 2018 - New ZEISS ZEN Intellesis machine allows segmentation of correlative microscopy
July 18, 2018 - Study findings highlight importance of early detection of SMA through newborn screening
July 18, 2018 - Results of Phase III (PIX306) Trial Evaluating Progression-Free Survival of Pixuvri (pixantrone) Combined with Rituximab in Patients with Aggressive B-cell Non-Hodgkin Lymphoma
July 18, 2018 - Diabetes researchers find switch for fatty liver disease
July 18, 2018 - The future of the microbiome: A conversation
July 18, 2018 - States attacking ACA would hurt most if shield on preexisting conditions were axed
July 18, 2018 - Novel delivery system for bacteriophages could offer new way to battle lung infections
July 18, 2018 - PTSD may increase risk of stroke, heart attack in World Trade Center response crews
July 18, 2018 - Finding the right protective eyewear for young athletes
UB researcher explores link between signals in the brain’s reward system and overeating, drug addiction

UB researcher explores link between signals in the brain’s reward system and overeating, drug addiction

image_pdfDownload PDFimage_print

Why are some people able to stop after eating just a few potato chips, while others aren’t satisfied until the bag is nothing but crumbs? The answer may lie in the signals acting in the brain’s reward system.

A University at Buffalo public health researcher is investigating these signals and their potential relationship to overeating, with a particular focus on sex differences, through studies in a rodent model. The study outcomes could help provide a better understanding of – and treatment for – obesity.

Elizabeth Mietlicki-Baase, an assistant professor of exercise and nutrition sciences in UB’s School of Public Health and Health Professions, is zeroing in on amylin signaling in the brain. Amylin is a hormone produced in the pancreas and in the brain.

The brain contains numerous amylin receptors. During her postdoctoral research at the University of Pennsylvania, Mietlicki-Baase focused on the brain’s mesolimbic reward system and, in particular, a structure known as the ventral tegmental area, or VTA, which affects food intake, body weight and food reward. Her research identified the VTA as a novel site of action in the brain at which amylin controls energy balance.

At UB, she received a grant from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to further investigate how amylin impacts food intake, with an emphasis on discovering how amylin signaling in the brain differs between male and female rats.

“I’m one of probably a handful of researchers studying amylin’s effects on food reward, especially the sex differences aspect of it,” Mietlicki-Baase says.

For the study, rodents will be given two different diets. One is a bland but nutritionally complete diet, while the other is a sweeter, fattier and tastier food.

“When rats are on this high-fat diet, we see more potent effects of amylin signaling in the VTA to reduce food intake. That could be really important because in humans, if we’re able to identify a therapy that has more potent effects on junk food intake as opposed to healthier foods, it could be very valuable,” Mietlicki-Baase says.

She is collaborating with Stewart Clark, assistant professor of pharmacology and toxicology in the Jacobs School of Medicine and Biomedical Sciences at UB on this project.

Mietlicki-Baase is also interested in understanding the neural underpinnings of drug addiction. She also recently received a NARSAD Young Investigator grant from the Brain & Behavior Research Foundation to continue her previous research in this area. Here, she is focusing on a hormone known as glucagon-like peptide-1 (GLP-1) which, similar to amylin, affects food intake and body weight. GLP-1 has also been shown to reduce cocaine use in rats.

“That’s really interesting because there’s growing literature suggesting that dysregulated energy intake and overconsumption of palatable foods has several physiological parallels with drug addiction,” she said.

The Brain & Behavior Research Foundation grant will examine how GLP-1 signaling in the brain affects drug seeking. “We’re trying to understand if we manipulate GLP-1 receptor signaling in the hindbrain, can that impact a rat’s motivation to seek out cocaine after the rat has gone through a period of drug abstinence?” Mietlicki-Baase said.

The results of these experiments could help lead to pharmacological options for treating addiction in humans. “The study will help improve our understanding of how addiction occurs in humans by identifying new sites of action in the brain that are relevant for these behaviors, and by identifying systems that we can potentially target with pharmacotherapies,” Mietlicki-Baase says.

Source:

http://www.buffalo.edu/news/releases/2017/11/010.html

Tagged with:

About author

Related Articles