Breaking News
October 15, 2018 - Innovative brain tumor operation set to tailor to patients’ needs
October 15, 2018 - Findings offer new insight into early changes that occur during AD pathology
October 15, 2018 - Neurons regulating reproductive hormone release have different activity in epileptic mice
October 15, 2018 - More parents are concerned about taking babies swimming in public pools
October 15, 2018 - Health Tip: Know the Risk Factors for Lower Back Pain
October 15, 2018 - Study shows cigarillo flavors enhanced by high-intensity sweeteners
October 15, 2018 - Study traces hospital-acquired bloodstream infections to patients’ own bodies | News Center
October 15, 2018 - Abnormal vision in childhood can affect development of brain areas responsible for attention
October 15, 2018 - Color-changing contact lens could help doctors to monitor eye disease medications
October 15, 2018 - Tobacco heating products cause less staining to teeth than conventional cigarettes
October 15, 2018 - Young adults who are obese can expect to lose up to 10 years in life expectancy
October 15, 2018 - Scientists uncover how proteins meet on the cell membrane
October 15, 2018 - Affordable housing with supportive social services for senior citizens can reduce hospital use
October 15, 2018 - Following a Tissue Sample
October 15, 2018 - Prisoners need drug and alcohol treatments but AA programs aren’t the answer
October 15, 2018 - Andrea Califano and Jordan Orange Elected to National Academy of Medicine
October 15, 2018 - The impending risk of African Swine Fever Virus
October 15, 2018 - Breastfeeding reduces the number of antibiotic-resistant bacteria in infant gut
October 15, 2018 - Researchers develop comprehensive molecular atlas of postnatal mouse heart development
October 15, 2018 - ObsEva SA Presents Clinical Data from Phase III IMPLANT 2 Trial of Nolasiban in IVF at the American Society of Reproductive Medicine (ASRM) Annual Meeting
October 15, 2018 - Engineering teratoma-derived fibroblasts to enhance osteogenesis
October 15, 2018 - Lab study shows effectiveness of potential therapy for treatment-resistant hypothyroidism
October 15, 2018 - JCU study firms up association between diet and depression
October 15, 2018 - Researchers to study the use of CRISPR on human liver on-a-chip platform
October 15, 2018 - Sub-concussive impacts not associated with decline in neurocognitive function
October 15, 2018 - Researchers find potential treatment to halt premature labor and birth
October 15, 2018 - As U.S. suicides rates rise, Hispanics show relative immunity
October 15, 2018 - FDA Issues a Complete Response Letter to Acacia Pharma for Barhemsys
October 15, 2018 - Photoactive bacteria bait may help in fight against MRSA infections
October 15, 2018 - Increasing vigorous exercise reduces risk factors of type 2 diabetes, cardiovascular disease in children
October 15, 2018 - First-of-its-kind study to test a personalized vaccine in cancer patient
October 15, 2018 - Extension trial assesses benefit of switching from flash monitoring to RT-CGM for hypoglycemia
October 15, 2018 - Half of parents say young children are afraid of doctor’s visits
October 15, 2018 - Study shows how fingerprint-based drug screening works on the living and deceased
October 15, 2018 - Study reveals potential to monitor progression of Alzheimer’s disease by measuring brain antioxidant levels
October 15, 2018 - FDA Approves Xarelto to Reduce the Risk of Major Cardiovascular Events in Patients with Chronic Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD)
October 15, 2018 - Promising new therapeutic approach against Ebola virus identified
October 15, 2018 - Study unravels how cancer stem cells use normal genes in abnormal ways
October 15, 2018 - Healthcare systems fail to deliver at affordable prices finds report
October 15, 2018 - Intensive BP Therapy in Diabetes May Lower Risk for CV Events
October 15, 2018 - Muscle relaxants increase risk of respiratory complications
October 15, 2018 - Female birds become more promiscuous after hatchings fail in the first breeding attempt
October 15, 2018 - Humans occupied Madagascar thousands of years later than previously thought
October 15, 2018 - Is Kidney Dialysis Always Needed When Septic Shock Strikes?
October 15, 2018 - Study shows invasive lung cancer surgery can lead to long-term opioid use
October 15, 2018 - Sugar, a “sweet” tool to understand brain injuries
October 14, 2018 - King’s commemorates activities and research on World Arthritis Day
October 14, 2018 - Humana and VFW NY team up on Stop 22 initiative to increase awareness of veterans committing suicide
October 14, 2018 - Water fluoridation contributes to urinary fluoride levels in pregnant women in Canada
October 14, 2018 - Study of children in Romanian orphanages tells cautionary tale about family separation
October 14, 2018 - Previous Endologix AFX Safety Notice classified by FDA as Class I recall
October 14, 2018 - Legal scholars sound alarm on academies’ report about returning research results to participants
October 14, 2018 - UNIST selects six extraordinary scholars to be induced as ‘Rising-star Distinguished Professor’
October 14, 2018 - Scientists find new way to help asthmatics breathe more easily
October 14, 2018 - New ‘gag rule’ may adversely impact health care of pregnant women
October 14, 2018 - Rosacea – Genetics Home Reference
October 14, 2018 - When the fighting crosses the line
October 14, 2018 - New findings could benefit patients with triple-negative breast cancer
October 14, 2018 - UK Biobank provides wealth of information for further genetic studies
October 14, 2018 - KHN’s ‘What the Health?’ Falling premiums and rising political tensions
October 14, 2018 - Duvelisib Promising for Chronic Lymphocytic Leukemia, SLL
October 14, 2018 - Tailored drug cocktails offer hope to kids with aggressive brain tumors
October 14, 2018 - Common gene variants linked to migraine risk in African-American children
October 14, 2018 - Funding requests are being accepted by BlueCross BlueShield of Tennessee Community Trust
October 14, 2018 - Using pulsed electric fields in cancer therapy
October 14, 2018 - Major Childbirth Complications More Likely for Black Women
October 14, 2018 - Young cancer survivors at greater risk of mental health disorders
October 14, 2018 - Common herbicide compound could help fight hospital-acquired fungal infections
October 14, 2018 - Alterations in genes encoding proteins contribute to ADHD development
October 14, 2018 - New patient-centric website launched in Europe to empower people with chronic conditions
October 14, 2018 - Antimicrobial signaling molecule has lower activity against hepatitis C virus in most humans
October 14, 2018 - Genomic dark matter activity connects Parkinson’s and psychiatric diseases
October 14, 2018 - Cornell dots equipped with antibody fragments offer a new cancer weapon
October 14, 2018 - Addressing social and cultural factors is key to reducing burden of type 2 diabetes
October 14, 2018 - Study reveals why females age more slowly than males
October 14, 2018 - DNA vaccine shown to provide long-term protection from Ebola
October 14, 2018 - Gene therapy shown to remove core component of Parkinson’s disease
October 14, 2018 - Obamacare premiums dip for first time. Some call it a correction
October 14, 2018 - Scientists use haploid stem cells to produce mice with same-sex parents
October 14, 2018 - New transgenic mouse model sheds light on biological causes of Parkinson’s disease
UB researcher explores link between signals in the brain’s reward system and overeating, drug addiction

UB researcher explores link between signals in the brain’s reward system and overeating, drug addiction

image_pdfDownload PDFimage_print

Why are some people able to stop after eating just a few potato chips, while others aren’t satisfied until the bag is nothing but crumbs? The answer may lie in the signals acting in the brain’s reward system.

A University at Buffalo public health researcher is investigating these signals and their potential relationship to overeating, with a particular focus on sex differences, through studies in a rodent model. The study outcomes could help provide a better understanding of – and treatment for – obesity.

Elizabeth Mietlicki-Baase, an assistant professor of exercise and nutrition sciences in UB’s School of Public Health and Health Professions, is zeroing in on amylin signaling in the brain. Amylin is a hormone produced in the pancreas and in the brain.

The brain contains numerous amylin receptors. During her postdoctoral research at the University of Pennsylvania, Mietlicki-Baase focused on the brain’s mesolimbic reward system and, in particular, a structure known as the ventral tegmental area, or VTA, which affects food intake, body weight and food reward. Her research identified the VTA as a novel site of action in the brain at which amylin controls energy balance.

At UB, she received a grant from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to further investigate how amylin impacts food intake, with an emphasis on discovering how amylin signaling in the brain differs between male and female rats.

“I’m one of probably a handful of researchers studying amylin’s effects on food reward, especially the sex differences aspect of it,” Mietlicki-Baase says.

For the study, rodents will be given two different diets. One is a bland but nutritionally complete diet, while the other is a sweeter, fattier and tastier food.

“When rats are on this high-fat diet, we see more potent effects of amylin signaling in the VTA to reduce food intake. That could be really important because in humans, if we’re able to identify a therapy that has more potent effects on junk food intake as opposed to healthier foods, it could be very valuable,” Mietlicki-Baase says.

She is collaborating with Stewart Clark, assistant professor of pharmacology and toxicology in the Jacobs School of Medicine and Biomedical Sciences at UB on this project.

Mietlicki-Baase is also interested in understanding the neural underpinnings of drug addiction. She also recently received a NARSAD Young Investigator grant from the Brain & Behavior Research Foundation to continue her previous research in this area. Here, she is focusing on a hormone known as glucagon-like peptide-1 (GLP-1) which, similar to amylin, affects food intake and body weight. GLP-1 has also been shown to reduce cocaine use in rats.

“That’s really interesting because there’s growing literature suggesting that dysregulated energy intake and overconsumption of palatable foods has several physiological parallels with drug addiction,” she said.

The Brain & Behavior Research Foundation grant will examine how GLP-1 signaling in the brain affects drug seeking. “We’re trying to understand if we manipulate GLP-1 receptor signaling in the hindbrain, can that impact a rat’s motivation to seek out cocaine after the rat has gone through a period of drug abstinence?” Mietlicki-Baase said.

The results of these experiments could help lead to pharmacological options for treating addiction in humans. “The study will help improve our understanding of how addiction occurs in humans by identifying new sites of action in the brain that are relevant for these behaviors, and by identifying systems that we can potentially target with pharmacotherapies,” Mietlicki-Baase says.

Source:

http://www.buffalo.edu/news/releases/2017/11/010.html

Tagged with:

About author

Related Articles