Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Oncologists find new biomarker for breast cancer having poor prognosis

Oncologists find new biomarker for breast cancer having poor prognosis

A PROTEIN INDICATING HIGHER BREAST CANCER MORTALITY RISK

With the support of the FWF, an oncologist found a biomarker for breast cancer having a poor prognosis and developed two viable methods to detect it in tissue samples.

Breast cancer is the most frequent malignant tumor in women worldwide. In Austria, about 5,500 women develop it each year and 1,500 die of it despite the availability of an early detection program. When a lump is found in a breast, the next step in clinical practice is a biopsy. Although no remedy exists for the anxious hours faced by the affected women, quick diagnostic procedures and competent information about the results are very helpful. The tissue sample taken is most important for diagnosis and treatment. If the tumor is found to be malignant, the subtype is determined immediately, since, depending on the result, different treatment methods are chosen. “After consultation by the interdisciplinary tumor board, the doctors discuss available treatment options with the patient and also talk about prognosis (chance to be cured), if the patient asks for it”, explains oncologist Thomas Bauernhofer from the University Hospital Graz.

In this context, the oncologist investigated a new biomarker in a project funded by the Austrian Science Fund FWF. This biomarker indicates a poorer prognosis for breast cancer patients. In a five-year research effort in close collaboration with the Institutes for  Biophysics and Pathology , the physician managed to produce evidence: a higher expression of the GIRK1 protein shows a greater relapse rate and mortality among patients with the hormone-dependent (ER+) breast cancer subtype after surgery.

BUILDING BLOCK OF AN ION CHANNEL AS A BIOMARKER

The GIRK1 protein is one of at least two required elements for building functioning potassium ion channels in the cell membrane. Such ion channels are indispensable in the human heart, brain or pancreas and, for instance, ensure that the heart beats regularly. A scientific publication with a small number of cases that found GIRK1 in breast cancer inspired the research team to study this protein as a potential new biomarker. At first, a large quantity of messenger RNA (mRNA), a precursor in the production of the GIRK1 protein, was detected in breast cancer cell lines and tissue. By correlating tissue samples and genetic profiles of breast tumors with women’s survival statistics, it is now possible to identify patients at special risk. “Breast cancer patients with an estrogen-receptive positive tumor (ER+) usually respond well to anti-hormonal treatment. But in case the ER+ tumor express a great amount of GIRK1, such patients have a lower probability of survival”, explains Thomas Bauernhofer. The ER+ tumor subtype is found in about 60% of all breast cancer patients.

Within the FWF project, two methods were developed to detect excessive GIRK1 expression in tissue sections. The team spent many months looking for an appropriate staining method by means of immunohistochemistry. Having thus been established successfully, the new method is of benefit for researchers investigating the GIRK ion channel in other contexts. The second detection method (fluorescence in-situ hybridization) even enables scientists to determine the expression of GIRK1-mRNA in tumor tissue by means of automatic image analysis.

WHICH GENES ARE WORKING IN PARALLEL?

In a gene cluster examination, the team from Graz also proved that apart from the GIRK1 gene, three further genes are very active in a tumor. “Two genes are associated with an estrogen receptor (ER alpha), a third one with the angiotensin II receptor”, reports Thomas Bauernhofer. The higher mortality among women with an estrogen-receptor positive tumor and high GIRK1 expression could be attributed to a diminished effect of antihormonal therapy or an increased ability to form metastases. GIRK1, however, could also become a new target for treatment. Thomas Bauernhofer now wants to gain a more exact idea of the interdependencies: “It is still too early for verifying the biomarker in every biopsy. Our results do not have therapeutic consequences for the time being, but we need to further investigate the relationship between GIRK1 and poor survival rates.”

Source:

http://scilog.fwf.ac.at/en/biology-and-medicine/7027/protein-indicating-higher-breast-cancer-mortality-risk

Tagged with:

About author

Related Articles