Breaking News
December 15, 2017 - For marketplace customers who delay, auto-enrollment could be nasty wake-up
December 15, 2017 - Researchers identify potential alternatives to tackle drug resistant malaria parasites
December 15, 2017 - Scientists unravel mystery of how immune cells remember infections decades later
December 15, 2017 - Outcomes Poorer for Black Patients with Early Breast Ca
December 15, 2017 - Liposuction May Ease Limb Swelling in Cancer Patients
December 15, 2017 - How well can digital assistants answer questions on sex?
December 15, 2017 - NIH-funded study to explore hearing loss risk in Detroit firefighters
December 15, 2017 - Caris Life Sciences reveals identification of new mechanism of action to treat NHL
December 15, 2017 - Loyola Medicine study finds high success rate for diabetic Charcot foot surgery
December 15, 2017 - Bone marrow edema does not increase due to intense physical activity, study finds
December 15, 2017 - Human ‘common cold’ virus kills healthy chimpanzees in Uganda
December 15, 2017 - Experience of reflex walking refines perception of biological motion during early infancy
December 15, 2017 - FDA Approves Admelog (insulin lispro) Rapid-Acting “Follow-On” Insulin Product to Treat Diabetes
December 14, 2017 - Friday Feedback: Good Idea for Ex-Pharma Exec to Run HHS?
December 14, 2017 - More than 200 people sickened onboard Ovation of Seas cruise
December 14, 2017 - FDA announces new approach for sharing updates on antibiotics, antifungal drugs to physicians
December 14, 2017 - Steroid study provides new insights into medicines’ side effects
December 14, 2017 - Government announces plans to include eye test reminder during driving license renewal
December 14, 2017 - Non-ionizing radiation from magnetic fields could have adverse biological impacts on health
December 14, 2017 - Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk
December 14, 2017 - Researchers develop new method for quickly detecting signs of multiple sclerosis
December 14, 2017 - In era of increased competition, hospitals fret over ratings
December 14, 2017 - Female veterans experience improvement in low back pain with course of chiropractic care
December 14, 2017 - Relieving Symptoms of Cystic Fibrosis with Exercise
December 14, 2017 - FDA Alert: Blue Pearl All Natural Male Enhancement Supplement: Recall
December 14, 2017 - CardioBrief: In Defense Of ORBITA
December 14, 2017 - Definition of High Blood Pressure Drops: MedlinePlus Health News
December 14, 2017 - Drug may help surgical patients stop opioids sooner
December 14, 2017 - Researchers develop biosensor that enables development of new health tests
December 14, 2017 - Radiation therapy can be used to treat patients with life-threatening heart rhythm
December 14, 2017 - UVA researchers developing tool to help prostate cancer patients weigh treatment options
December 14, 2017 - Experts tell Congress how to cut drug prices
December 14, 2017 - Researchers use cryptographic techniques to decode activity of motor neurons
December 14, 2017 - Study finds changes in the heart after spinal cord injury
December 14, 2017 - Health Highlights: Dec. 12, 2017
December 14, 2017 - Pelzman’s Picks: How States Can Cut Disparities in Care and Costs
December 14, 2017 - New Hemophilia Treatment Stems Bleeding Episodes: MedlinePlus Health News
December 14, 2017 - Onetime ‘world’s heaviest man’ has second surgery in Mexico
December 14, 2017 - Belgian researchers create transplantable artificial ovary prototype
December 14, 2017 - Using atraumatic needles for lumbar punctures decreases risk of complications
December 14, 2017 - Outpatient total knee replacement surgery linked to higher rates of complications
December 14, 2017 - Social impairments can be corrected by brain stimulation
December 14, 2017 - Studies reveal possibility for memory T cells to serve a dual purpose
December 14, 2017 - Antibody-Drug Conjugate Ups PFS in Untreated Hodgkin’s
December 14, 2017 - Study finds reading information aloud to yourself improves memory
December 14, 2017 - Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies
December 14, 2017 - Living Lyme disease bacteria found months after antibiotic treatment
December 14, 2017 - These annual checkups help seniors not only survive but thrive
December 14, 2017 - Study reveals impact of diabetes during pregnancy on baby’s heart
December 14, 2017 - Hydraulic fracturing is harmful to infants health, study states
December 14, 2017 - Huntington’s disease drug clears initial hurdles
December 14, 2017 - TPU researchers create 3D-printed models of children’s hearts
December 14, 2017 - Brain responses of children with inherited dyslexia risk predict their future reading speed
December 14, 2017 - People diagnosed with schizophrenia or bipolar disorder may actually have treatable condition
December 14, 2017 - Study: New Furosemide Formulation Simplifies Administration for HF
December 14, 2017 - Discrimination harms your health—and your partner’s
December 14, 2017 - Having older brothers may increase the likelihood of being gay
December 14, 2017 - New scientific yardstick released to help early detection of Alzheimer’s disease
December 14, 2017 - New finding demonstrates what happens at cellular level during onset of type2 diabetes
December 14, 2017 - Study identifies potassium as key to circadian rhythms in red blood cells
December 14, 2017 - Good friends might be your best brain booster as you age
December 14, 2017 - NIH expected to award up to $70 million to launch Alzheimer’s Clinical Trials Consortium
December 14, 2017 - Pitting pathogens against each other could prevent drug resistance emerging
December 14, 2017 - Study provides new insights into development of Sonic Hedgehog medulloblastoma
December 14, 2017 - Dr. Reddy’s Announces Approval of Impoyz (clobetasol propionate) Cream for Plaque Psoriasis
December 14, 2017 - Gene Screens Can Alter Perception, Behavior
December 14, 2017 - Can Scrotal Vein Condition Hike Heart Risks?: MedlinePlus Health News
December 14, 2017 - Molecules in spit may be able to diagnose and predict length of concussions
December 14, 2017 - Children’s Colorado and RxRevu partner to help prescribers better meet needs of pediatric patients
December 14, 2017 - Researchers discover new way to attack drug-resistant prostate cancer cells
December 14, 2017 - Scientists develop new, high resolution method for identifying microbial species and strains
December 14, 2017 - Declining trend of salmonellosis cases has leveled off in the EU
December 14, 2017 - Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes
December 14, 2017 - How to Perk Up the Holidays for Hospital Patients
December 14, 2017 - Prolonged Sedation May be Bad for Baby’s Brain
December 14, 2017 - The pediatric submersion score predicts children at low risk for injury following submersions
December 14, 2017 - Video game helps doctors to quickly recognize trauma patients who need high levels of care
December 14, 2017 - Younger persons newly-diagnosed with type 2 diabetes have poorer health than older patients
December 14, 2017 - Clinician re-examines evidence on re-use of catheters and UTIs in people with spinal cord injuries
December 14, 2017 - UK and Russian researchers join forces against AMR
Low levels of miR-29 could reduce susceptibility to cardiac fibrosis

Low levels of miR-29 could reduce susceptibility to cardiac fibrosis

image_pdfDownload PDFimage_print

Cardiac fibrosis involves an increase of connective tissue in the cardiac muscle, causing a loss of function. A team of researchers at the Technical University of Munich (TUM) has now discovered that microRNA 29 (miR-29) plays an important role in the formation of tissue fibrosis. They occur less frequently when miR-29 is suppressed in cardiac muscle cells. Older studies had suggested that it was in fact low levels of miR-29 that caused fibrosis. The new insights point to potential new approaches for developing drugs against fibrotic diseases.

Not long ago, microRNAs were not even known to exist. In recent years, however, it has become increasingly clear that these molecules play an important role in the function of our cells. For example, they determine whether certain proteins are formed. One reason why they are seen as potentially useful in the development of new drugs is that they are relatively easy to synthesize. Moreover, for every microRNA molecule, a corresponding anti-microRNA can be produced that binds and thereby neutralizes it. Universities and research institutes all over the world are currently studying which microRNAs have major effects in the body along with the underlying mechanisms.

Protecting against pathological changes

The team headed by Stefan Engelhardt, Professor of Pharmacology and Toxicology at TUM, is studying the function of microRNAs in the heart. In an earlier study, the scientists identified miR-29 as a molecule possibly associated with pathological changes in the cardiac muscle. Using a mouse model, they have now shown that animals with extremely low levels of miR-29 in their cells from birth are significantly less susceptible to cardiac fibroses and hypertrophy, i.e. pathological growth of the cardiac muscle.

A similar effect was seen when miR-29 was inhibited with drugs, namely a specific anti-miR. “In further experiments we were also able to show that miR-29 was responsible for this effect in particular in cardiac muscle cells, the myocytes,” explains Yassine Sassi, first author of the study along with Petros Avramopoulos. The authors believe that miR-29 controls the activity of a certain chain of molecular signals in organs known as the Wnt signalling pathway. In healthy cells, this signalling pathway is largely silenced. But if Wnt signalling is activated by stress, the effects include the production of excess connective tissue.

Differences compared with earlier studies

“Another interesting result of our study was that we were unable to identify negative effects on the body in the absence of miR-29,” says Petros Avramopoulos. Studies by other teams had suggested that it was not a higher, but rather a lower, miR-29 level that may lead to fibroses in such organs as the liver, lungs and kidneys. “A possible reason for this discrepancy is that, in our experiments, we assessed the function of endogenous miR-29 and conducted part of our studies in an intact organism,” explains Stefan Engelhardt. “Other teams relied mainly on bioinformation analysis and cell cultures or the effects of an artificially elevated miR-29 level.”

He now plans to use the results of his team’s research as a starting point to investigate further effects of miR-29. “Cardiac fibrosss is dangerous and has so far been very difficult to treat,” says Engelhardt. “We are currently looking into whether anti-miR-29, the synthetic counterpart of miR-29, can help not only to prevent this process, but also to reverse it if cardiac fibrosis has already established.” Another challenge is to develop methods for the targeted delivery of future miR-29-based drugs to the cardiac muscle cells.

Source:

https://www.tum.de/en/about-tum/news/press-releases/detail/article/34317/

Tagged with:

About author

Related Articles