Breaking News
October 21, 2018 - More accurate and less stressful way to measure a baby’s heartbeat
October 21, 2018 - Researchers show better cardiorespiratory fitness leads to longer life
October 21, 2018 - Healthy candies for diabetic patients
October 21, 2018 - Environment impact of microplastics remains unclear
October 21, 2018 - Antibiotics for appendicitis? Surgery often not needed
October 21, 2018 - AHA and AMA recognize more than 800 medical practices, health systems for blood pressure control
October 21, 2018 - Scientists obtain clearest ever image of Ebola virus protein
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – Drugs.com MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Neuroscientists identify brain region that appears to be related to food preference decisions
October 21, 2018 - Deaths related to air pollution in the U.S. decreased by 47% between 1990 and 2010
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
Heart Failure Incidence Falls in U.K., but Absolute Number Rises

Heart Failure Incidence Falls in U.K., but Absolute Number Rises

image_pdfDownload PDFimage_print

Action Points

  • Note that this observational study using U.K. data found that the incidence of heart failure, as expressed in terms of person-years, has declined modestly over time.
  • Paradoxically, the absolute number of new heart failure cases has risen, due primarily to aging and expansion of the population.

The number of heart failure patients in the U.K. now rivals the total number of patients with the four most common causes of cancer, a new study finds.

More than 920,000 people were living with heart failure in the U.K. in 2014. While overall decreases in heart failure incidence were documented, heart failure cases increased between 2002 and 2014 due to several factors including the aging of the population, population growth, and increased longevity, researchers found.

They speculated that this increase may be partly due to better survival following myocardial infarction.

The study was published online Nov. 21 in The Lancet.

“Despite a modest decline in standardized incidence, there has been a 12% increase in the total number of new cases of heart failure,” wrote researcher Kazem Rahimi, DM, MSc, of the George Institute for Global Health UK and the University of Oxford, and colleagues. “This is substantial, and by comparison is now similar to the total number of new cases of breast, prostate, lung, and bowel cancer combined.”

The population-based study represents the largest investigation of heart failure incidence linking primary and secondary health records to capture the full burden of heart disease and distinguish between new and existing cases of heart failure, the researchers wrote.

The study, which included data on 4 million adults in the U.K., documented a 7% overall reduction in heart failure incidence between 2002 through the end of 2014: from 358 cases to 332 cases per 100,000 person years, with an adjusted incidence rate ratio of 0.93 (95% CI, 0.91-0.94).

Notable heart failure increases were seen in the very elderly — people older than 85 years old — who have traditionally been excluded from randomized trials examining treatments for heart failure.

The reported 12% increase in the estimated absolute number of newly diagnosed heart failure cases and the 23% increase in the number of prevalent heart failure cases during the 12-year period were called “concerning” in an editorial published with the study.

“Although new heart failure cases can be viewed as an ironic success if they arise from more patients surviving myocardial infarction because of advances in acute coronary syndrome management, these cases should be viewed as failures when they originate from poor adherence to heart failure prevention strategies — for example, inadequate hypertension control,” wrote Faiez Zannad, MD, PhD, of the French National Institute of Health and Medical Research.

Zannad noted that the modest downward trend in heart failure incidence has been accompanied by a much more robust decline in myocardial infarction incidence, “suggesting that heart failure prevention strategies have been less successful than have strategies to prevent coronary artery disease.”

The data used in the study came from the Clinical Practice Research Datalink (CPRD), a cohort that is representative of the population of the U.K. in terms of age and sex. Eligible patients included people age 16 years and older for whom data were collected between Jan. 1, 2002 and Dec. 31, 2014.

Among the secondary findings from the study:

  • Patient age and multi-morbidity at first presentation of heart failure increased during the study period (mean age 76·5 years [SD 12·0] to 77·0 years [12·9], adjusted difference, 0·79 years, 95% CI, 0·37–1·20;
  • The mean number of comorbidities also increased from 3·4 [SD 1·9] to 5·4 [2·5]; adjusted difference 2·0, 95% CI, 1·9–2·1).
  • Socioeconomically deprived people had a higher rate of heart failure than affluent people (incidence rate ratio 1·61, 95% CI, 1·58–1·64), and they tended to be diagnosed earlier (adjusted difference –3·51 years, 95% CI, –3·77 to –3·25).
  • Socioeconomically deprived individuals also had more comorbidities, despite their younger age.

“The disparities we have identified in the U.K. point to a potentially preventable nature of heart failure that still needs to be tackled, and to potential opportunities for more targeted and equitable prevention strategies,” Rahimi noted in a written press release. “Achieving equal access and use of healthcare is an important goal, and in this instance could help tackle the biological, environmental and behavioral risk factors that put people from more deprived backgrounds at greater risk of heart failure.”

Study limitations cited by the researchers included the introduction of a national care monitoring program during the study period, which may be responsible for some of the variation seen in specific years, and the lack of data on specific heart failure type.

The large, representative, heterogeneous cohort was cited as a major study strength.

“This population-based approach increases the generalizability of the findings compared with surveys that select participants,” the researcher wrote. “Moreover, in view of the similarity of trends in cardiovascular disease and population aging from the U.K. with other European countries, North America and Australia, our findings are likely to be broadly applicable to much of the rest of the developed world.”

Funding for the study was provided by the British Heart Foundation and the National Institute for Health Research.

The researchers declared no relevant relationships with industry related to this study.

  • Reviewed by
    F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine and Dorothy Caputo, MA, BSN, RN, Nurse Planner

2017-11-22T13:00:00-0500

Tagged with:

About author

Related Articles