Breaking News
December 17, 2017 - Teens Acting Badly? Smog Could Be to Blame
December 17, 2017 - FDA Says ‘Yes’ to Short-Acting Insulin Admelog
December 17, 2017 - Vaping popular among teens; opioid misuse at historic lows
December 17, 2017 - Lower Urinary Symptoms Occur in Almost All Patients with SSc
December 17, 2017 - Genetic mutation in extended Amish family in Indiana protects against aging and increases longevity (Update)
December 16, 2017 - Butler Hospital launches international Alzheimer’s disease prevention study
December 16, 2017 - iMedicalApps: Virtual Reality Boosts Self-Confidence for Med Students
December 16, 2017 - Researchers validate five new genes responsible for Amyotrophic Lateral Sclerosis
December 16, 2017 - New genetic analysis of candidiasis reveals surprising fungal sex secrets
December 16, 2017 - New high precision machine-learning model could help accelerate drug discovery
December 16, 2017 - Groundbreaking gene therapy trial brings cure for hemophilia closer
December 16, 2017 - Racial Differences Seen in IgG4 Disease
December 16, 2017 - Treacher Collins Syndrome
December 16, 2017 - New approach to tracking how deadly ‘superbugs’ travel could slow their spread
December 16, 2017 - Muscle paralysis may promote breakdown of bones
December 16, 2017 - WSU scientists create injectable dye to track progression of diseases
December 16, 2017 - Kaiser Permanente delivers clot-busting drugs to stroke patients more than twice as fast as national rates
December 16, 2017 - Some Great Holiday Foods for Weight Loss
December 16, 2017 - Shared Decision-Making Strategies for Lung Ca Screening Get High Marks
December 16, 2017 - Lactic acid bacteria can protect against Influenza A virus, study finds
December 16, 2017 - Cancer immunotherapy’s effectiveness may depend on patient’s genetic makeup
December 16, 2017 - Researchers explore patient-doctor conversations, best practices linked to opioid tapering
December 16, 2017 - ‘Virtual child’ to help professionals learn key techniques to treat children with autism
December 16, 2017 - IU scientists discover way to make drug treatment more successful against malaria
December 16, 2017 - Prostate cancer researchers find significant disparities between two liquid biopsy providers
December 16, 2017 - ED-Diagnosed Lung Ca Patients Worse Off: Clin Onc News Report
December 16, 2017 - Calcium in Urine Test: MedlinePlus Lab Test Information
December 16, 2017 - Pregnancy-related conditions taken together leave moms—and dads—at risk
December 16, 2017 - Research uncovers mechanism implicated in defective function of tumor-associated dendritic cells
December 16, 2017 - OncoBreak: Stubborn Racial Disparities; Paid Medical Leave & Chemo; DIY Gene Tests
December 16, 2017 - Critical link between obesity and diabetes has been identified
December 16, 2017 - Transfusion dependence reduces access to high-quality end-of-life care for leukemia patients
December 16, 2017 - Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies
December 16, 2017 - FDA Approves Ixifi (infliximab-qbtx), a Biosimilar to Remicade
December 16, 2017 - Morning Break: Trump to Get Check-Up; Cancerous Transplant; Death Knell for MIPS?
December 16, 2017 - First transcatheter implant for diastolic heart failure successful
December 16, 2017 - ‘Sushi-like’ nanodiscs provide structural snapshots of misfolding proteins
December 16, 2017 - Inherited gene variation may be to blame for poor survival of patients with early-onset breast cancer
December 16, 2017 - Sign-up deadline is Friday, but some people may get extra time
December 16, 2017 - Higher Booze Taxes Might Pay Off for Public Health
December 16, 2017 - Regular Activity in Midlife Spares Joints in Women
December 16, 2017 - Rain May Not Cause Achy Joints After All: MedlinePlus Health News
December 16, 2017 - MedDiet adherence doesn’t affect acute heart failure mortality
December 16, 2017 - HKBU experts develop new generation of smart anti-cancer drug molecules
December 16, 2017 - Chronic Kidney Disease Audit finds wide variations in coding of CKD patients in primary care
December 16, 2017 - Scientists use nanoparticles to fight Mucoviscidosis
December 16, 2017 - Increasing physical activity decreases risk of death from lymphoma
December 16, 2017 - Fear compromises the health, well-being of immigrant families, survey finds
December 16, 2017 - Rejected antibiotic candidate could be worth a second look, research finds
December 16, 2017 - Is Nation on the Right Track to Combat Opioid Crisis?
December 16, 2017 - Arthritis No Longer Just a Disease of the Old: MedlinePlus Health News
December 16, 2017 - Study reveals biology behind why muscle stem cells respond differently to aging or injury
December 16, 2017 - Family members without inherited mutation have increased risk of melanoma
December 16, 2017 - Researchers reveal previously unknown mechanism that inhibits cells’ ability to develop into tumors
December 16, 2017 - Studies highlight potential of fMRI applications to detect, treat epilepsy in children
December 16, 2017 - Active surveillance proposed as first-line approach to manage patients with low-risk PMC of the thyroid
December 16, 2017 - Patients’ life values affect their attendance at medical treatment for pelvic-floor dysfunction
December 16, 2017 - Experts consider hazards of antibiotic resistances to be high
December 16, 2017 - Study finds erectile dysfunction as risk factor for early cardiovascular disease
December 16, 2017 - Amber-tinted glasses may reduce insomnia severity
December 16, 2017 - Arthritis Drug Seen Lowering GvHD Risk
December 16, 2017 - Atoh1, a potential Achilles’ heel of Sonic Hedgehog medulloblastoma
December 15, 2017 - Cornell engineers develop new method to measure vital signs using radio waves
December 15, 2017 - Rutgers studies highlight need for salon clients, workers to protect themselves from health risks
December 15, 2017 - FDA Approves Nucala (mepolizumab) for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
December 15, 2017 - Morning Break: CVS Buying Aetna; Uterus Transplant Baby; Your Brain on Drugs, Redux
December 15, 2017 - Social phobia linked to autism and schizophrenia
December 15, 2017 - Timestrip technology helping to prevent missed vaccinations
December 15, 2017 - Researchers win NIH grants for Alzheimer’s research on Amish resilience and rapid onset
December 15, 2017 - Mitochondrial error-correction mechanism essential for energy production of cells
December 15, 2017 - New report reveals steep rise in lung disease admissions to emergency departments during winter
December 15, 2017 - Study finds social stigma as barrier to successful treatment of children with HIV in Ethiopia
December 15, 2017 - Health Tip: Keep Gift-Giving Stress Under Wraps
December 15, 2017 - Long Stoppage of Bisphosphonates Tied to More Fractures
December 15, 2017 - Triglycerides Test: MedlinePlus Lab Test Information
December 15, 2017 - Study shows interventions, though few, can be effective for students with high-functioning autism
December 15, 2017 - Higher blood sugar during first trimester of pregnancy increases child’s risk of congenital heart defect
December 15, 2017 - Study tests accuracy of laboratory-developed cancer tests and FDA-approved companion diagnostics
December 15, 2017 - Extracellular vesicles can be used to effectively delay progression of kidney damage
December 15, 2017 - Targeted lung cancer treatments may benefit smokers and non-smokers alike
New therapy lessens impact of mistreatment at a young age

New therapy lessens impact of mistreatment at a young age

image_pdfDownload PDFimage_print
New therapy lessens impact of mistreatment at a young age
University of Delaware Associate Prof. Tania Roth (left) and graduate student Tiffany Doherty are finding evidence that certain drugs could address epigenetic brain dysfunction caused by early-life adversity. Credit: University of Delaware/ Evan Krape

Everyone has challenges of one kind or another. But research shows that mistreatment at an early age can have long-lasting and life-altering repercussions that could be passed to future generations.

Work underway in the laboratory of University of Delaware neuroscientist Tania Roth suggests new ways to help mitigate that damage.

The research was highlighted as a “hot topic” by the Society for Neuroscience in its literature for the world’s largest gathering of those in the field – Neuroscience 2017 – a five-day event that started Saturday in Washington D.C. Organizers expected more than 30,000 participants from 80 countries.

Roth and graduate student Tiffany Doherty are onsite to present details of the research at a poster session Tuesday, Nov. 14. Undergraduates Johanna Chajes and Lauren Reich also contributed to this work.

Roth and her team already have shown that mistreatment early in life can leave epigenetic marks in the brain and increase the risk of aberrant behaviors – changes that have been documented in rodents and humans, including changes that sometimes do not emerge until adulthood.

But recent findings in Roth’s lab have shown that certain drugs – when delivered at the time mistreatment is experienced – can prevent and/or reduce those marks – so far, only in males. Females have not shared the benefit from the same drug, Doherty said, a result that underlines the importance of recognizing sex-specific differences in research.

“We definitely think we can do the same thing in females,” Roth said. “It may take a different drug or a higher dose, but we have a hint that we’re on to something.”

The work is part of a larger effort by Roth’s lab to establish a causal link between exposure to early adversity, epigenetic marks and behavior.

The findings and the potential for effective treatment could have significant implications for millions of people. According to the Centers for Disease Control, 683,000 reports of child abuse or neglect were reported in the United States in 2015 alone.

Such adversity has been linked in Roth’s research to DNA methylation – an epigenetic process that can reduce the ability of some genes to function properly and increase the risk for psychiatric disorders. Epigenetics are changes in genetic activity that are caused by something outside the genetic code – things such as viruses, bacteria, exposure to toxins, dietary practices and other factors including psychosocial stress.

Recent research has shown that such marks can be seen at a gene known as the brain-derived neurotrophic factor gene (Bdnf).

Roth’s lab first found these results in rodent models. When females had inadequate nesting materials, the stress caused them to mistreat their young. Those young rodents exhibited epigenetic changes and associated behavioral dysfunction, but sometimes not until reaching adulthood.

In collaboration with UD Prof. Mary Dozier, Unidel Amy Elizabeth du Pont Chair in Child Development, who studies the impact of adversity on young children, Roth and her team are analyzing these same DNA markers in those cases and the efficacy of intervention to change those epigenetic marks.

Roth is a pioneer in the field of behavioral epigenetics and has contributed a great deal to the knowledge scientists are developing on this emerging discipline.


Explore further:
Epigenetic changes and disease – what is the connection?

Provided by:
University of Delaware

Tagged with:

About author

Related Articles