Breaking News
August 14, 2018 - Wearable devices and ‘mhealth’ technology emerge as promising tools for better health
August 14, 2018 - Phase 2 Clinical Data Published Showing Summit’s Ridinilazole Preserved Gut Microbiome of Patients with CDI
August 14, 2018 - Cardiac progenitor cells undergo a cell fate switch to build coronary arteries
August 14, 2018 - Revealed: The molecular mechanism underlying hypertrophic cardiomyopathy, or “workaholic heart”
August 14, 2018 - New technology shows potential to streamline the analysis of proteins
August 14, 2018 - Rethinking the stroke rule ‘time is brain’
August 14, 2018 - Incidence of coronary artery compression in children may be more common than previously thought
August 14, 2018 - Study helps to better understand disease caused by Alpha-1 antitrypsin deficiency
August 14, 2018 - AI platform identifies acute neurological illnesses faster than human diagnosis
August 14, 2018 - American College of Rheumatology receives grants to support development of lupus clinical trials
August 14, 2018 - New study explains why women get more migraines than men
August 14, 2018 - American Heart Association Urges Screen Time Limits for Youth
August 14, 2018 - Brief interventions during routine care reduce alcohol use among men with HIV
August 14, 2018 - New genome analysis could identify people at higher risk of common deadly diseases
August 14, 2018 - NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease
August 14, 2018 - Daicel supplies free nanodiamond samples to international researchers
August 14, 2018 - Switching anti-psychotic drugs in first-episode schizophrenia patients does not improve clinical outcomes
August 14, 2018 - Study to examine whether modulating gut bacteria can improve cardiac function in heart failure patients
August 14, 2018 - AI technology could hold key to improving health services
August 14, 2018 - One out of two children not getting enough nutrients needed for their health
August 14, 2018 - Mono-antiplatelet therapy after aortic heart valve replacements may work as well as two drugs
August 14, 2018 - Aid-in-dying patient chooses his last day
August 14, 2018 - Exercise Really Can Chase Away the Blues, to a Point
August 14, 2018 - Surgical mesh implants may cause autoimmune disorders
August 14, 2018 - Researchers develop revolutionary zebrafish model to gain more insight into bone diseases
August 14, 2018 - Researchers discover secret communication hotline between breast cancers and normal cells
August 14, 2018 - Study examines how a person adapts to visual field loss after stroke
August 14, 2018 - Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells
August 14, 2018 - Reducing opioid prescriptions for one operation can also spill over to other procedures
August 14, 2018 - E-cigarettes not so safe but still better than cigarettes
August 14, 2018 - Researchers find link between common ‘harmless’ virus and cardiovascular damage
August 14, 2018 - Initiation of PIMs associated with higher risk of fracture-specific hospitalizations and mortality
August 14, 2018 - Genetically modified mosquitoes and special bed nets help tackle deadly diseases
August 14, 2018 - Advances in treating hep C lead to new option for transplant patients
August 14, 2018 - Study finds quality of doctor-patient discussions about lung cancer screening to be ‘poor’
August 14, 2018 - MSU researchers uncover the effects of aging on regenerative ability of kidneys
August 14, 2018 - Better conditioning, throwing mechanics can help reduce elbow injuries in young baseball pitchers
August 14, 2018 - Brain game doesn’t offer brain gain
August 14, 2018 - Reproductive choices facing women with disabilities require careful consideration
August 14, 2018 - Scientists pinpoint the cause of a rare childhood seizure disorder
August 14, 2018 - Lumpectomy plus radiation associated with reduced risk of breast cancer death, study finds
August 14, 2018 - UAB study shows how ion channel differentiates newborn and mature neurons in the brain
August 14, 2018 - Experts highlight key knowledge gaps that need to be addressed in Ebola vaccine research
August 14, 2018 - Discovery could lead to new drugs against infection and inflammation
August 14, 2018 - Infection Prevention Differs Between Small, Large Hospitals
August 14, 2018 - Mom still matters—In study, young adults tended to prioritize parents over friends
August 14, 2018 - Deep brain stimulation might benefit those with severe alcoholism, preliminary studies show
August 14, 2018 - Study finds increased rate of repeat pregnancies in women with intellectual and developmental disabilities
August 14, 2018 - Lighter sedation fails to reduce risk of postoperative delirium in older patients
August 13, 2018 - Asking better questions about person’s memory could improve doctors’ understanding of patients
August 13, 2018 - U.S. Trauma Doctors Push for Stricter Gun Controls
August 13, 2018 - Asthma and flu: a double whammy
August 13, 2018 - 5 Questions: Donna Zulman on engaging high-need patients in intensive outpatient programs | News Center
August 13, 2018 - Behavioral Nudges Lead to Drop in Prescriptions of Potent Antipsychotic
August 13, 2018 - Potential New Class of Drugs May Reduce Cardiovascular Risk by Targeting Gut Microbes
August 13, 2018 - How to get your kids to eat better
August 13, 2018 - The importance of hearing your patients
August 13, 2018 - Transmission of F. tularensis unlikely to happen through the food chain
August 13, 2018 - Researchers discover epigenetic mechanism underlying ischemic cardiomyopathy
August 13, 2018 - Adolescent health programs receive only a tiny share of international aid, finds research
August 13, 2018 - Fracture risk increases by 30% after gastric bypass, study shows
August 13, 2018 - Quality-improvement project to standardize feeding practices helps micro preemies gain weight
August 13, 2018 - Long-term cannabinoid exposure impairs memory, study shows
August 13, 2018 - New intervention to reduce risk of HIV in young transgender women
August 13, 2018 - Japan human trial tests iPS cell treatment for Parkinson’s
August 13, 2018 - Altered nitrogen metabolism may contribute to emergence of new cancer mutations
August 13, 2018 - Cycling provides greatest health benefits, study finds
August 13, 2018 - Scientists discover biomarker for kidney cancer
August 13, 2018 - New test predicts the risk of serious disease before symptoms appear
August 13, 2018 - Cianna Medical receives FDA 510(k) clearance to extend indication of SCOUT reflector for use in soft tissue localization
August 13, 2018 - Ground-breaking discovery offers new hope for treatment of Alzheimer’s, other neurological diseases
August 13, 2018 - Medical nutrition therapy provided by RDNs benefits patients with chronic kidney disease
August 13, 2018 - Prenatal Tdap vaccination not linked with increased risk of autism in children, study shows
August 13, 2018 - One-Third of Canadian Patients Get Hip Fx Repair Within 24 Hours
August 13, 2018 - ANA (Antinuclear Antibody) Test: MedlinePlus Lab Test Information
August 13, 2018 - Traffic jams in the brain
August 13, 2018 - NIH awards $6.5 million to establish multi-institution biomedical technology resource center
August 13, 2018 - New marker in the blood could help predict person’s risk of developing kidney cancer
August 13, 2018 - New biomarker may provide clues to create diagnostic tool for hypoglycemia-associated autonomic failure
August 13, 2018 - Oxidative Stress Hampers Blood Vessel Dilation in Men
Robust Pipeline for Atopic Dermatitis

Robust Pipeline for Atopic Dermatitis

image_pdfDownload PDFimage_print

Until recently, atopic dermatitis treatments were limited primarily to topical corticosteroids and systemic immunosuppressants.

Now, however, two new therapies have reached clinical practice, and by one recent account there are at least 19 more topicals and biologics in development for atopic dermatitis.

“Our improved understanding about the mechanism for development of atopic dermatitis is leading to an expanding pipeline of new and more targeted treatment interventions,” Amy S. Paller, MD, chair of dermatology and director of the Northwestern University Skin Disease Research Center in Chicago, and colleagues wrote in a review in the Journal of Allergy and Clinical Immunology.

The emerging agents in atopic dermatitis include interleukin (IL)-4, IL-13, IgE, B-cells, IL-5, IL-31, JAK-STAT, SYK, IL-6, phosphodiesterase (PDE)-4, IL-12, IL-17, IL-23, IL-22, H4R, NKR1, κOR, TSLP, PPAR-γ, and diomogammalinolenic acid, the authors noted. In some cases, clinical trials have shown statistically significant improvements in clinical severity scores and patient-reported outcomes. In other cases, safety profiles are good, but many of these agents are in early trials.

Most Promising Atopic Dermatitis Treatments

Among the most promising new atopic dermatitis treatments are crisaborole (Eucrisa), from Pfizer, and dupilumab (Dupixent), from Regeneron, Paller et al noted. Crisaborole is a non-steroidal topical PDE-4 inhibitor approved by the FDA in 2016 for mild to moderate eczema (atopic dermatitis) in patients age 2 or older. Dupilumab is the first highly effective monoclonal antibody to be approved by the FDA. The agent targets IL-4/IL-13 and was approved early this year for adults with moderate-to-severe atopic dermatitis.

There are 12 other biologic agents under development, including nemolizumab, an anti-IL-31 receptor that specifically targets a cytokine that causes itch, which, if successful in clinical trials, would be the first biologic agent designed to control itch, the authors said.

There are six orally administered small-molecule inhibitors that have reached at least phase II trials, including baricitinib, an oral JAK1/2 inhibitor that is under study in the United States for rheumatoid arthritis. Researchers reporting at the European Academy of Dermatology and Venereology Congress earlier this year found that baricitinib improved atopic dermatitis symptoms in combination with a topical corticosteroid and serlopitant, the NK1R inhibitor being studied specifically for pruritus in atopic dermatitis.

These emerging therapies have the potential to revolutionize care, although there could be barriers to optimal clinical practice, including cost, Paller and colleagues wrote. “The extent of their effect on patient care will depend on their affordability and accessibility to patients with atopic dermatitis from a broad range of socioeconomic groups and with different insurance status.”

Long-term safety of target therapy is also an open question that requires further research, according to the authors of a review of novel therapeutic approaches to atopic dermatitis, published in August in Archivum Immunologiae et Therapiae Experimentalis.

And in another review, in the Journal of Dermatological Treatment, Vivian Shi, MD, and co-authors said that atopic dermatitis is entering a new era of target-specific treatments: “While these agents have demonstrated efficacy and potential, only dupilumab has been approved to date for adults with atopic dermatitis. Further large-scale, randomized, placebo-controlled, double-blind, multicenter trials are needed to fully evaluate the clinical benefit, safety, and cost effectiveness of these emerging therapies.”

A clear gap in the data right now is the role of novel atopic dermatitis treatments in children, which is especially important since atopic dermatitis is more prevalent in pediatric populations, the authors stated.

Further research in novel targeted atopic dermatitis therapies may be advanced by the development of the International Treatment of Atopic Eczema (TREAT) Registry Taskforce, which was started in 2017 and is designed to integrate data on systemic immunomodulatory therapies and phototherapy from dermatology communities around the world, Shi and colleagues wrote.

“The completion and continuous update of this task force will reduce heterogeneity among international clinical trial registries, allow direct comparison of data sets, and facilitate drug efficacy and safety monitoring.”

This article originally appeared on the website of our partner Dermatology Times, which is a part of UBM Medica. (Free registration is required.)

2017-11-26T11:00:00-0500

Tagged with:

About author

Related Articles