Breaking News
October 21, 2018 - Report reveals growing impact of cannabis on young people
October 21, 2018 - NSF awards $5 million grant to help scientists magnify societal impact of research
October 21, 2018 - Fertility Rates Down for Each Urbanization Level 2007 to 2017
October 21, 2018 - Genetically engineered 3-D human muscle transplant in a murine model
October 21, 2018 - Moms’ tight work schedules may affect their children’s sleep
October 21, 2018 - AHA: No Direct Link Between Preeclampsia and Cognitive Impairment, Study Finds
October 21, 2018 - Weight loss success linked with active self-control regions of the brain
October 21, 2018 - Scripps researchers successfully test potential new smoking-cessation treatment in rodents
October 21, 2018 - More accurate and less stressful way to measure a baby’s heartbeat
October 21, 2018 - Researchers show better cardiorespiratory fitness leads to longer life
October 21, 2018 - Healthy candies for diabetic patients
October 21, 2018 - Environment impact of microplastics remains unclear
October 21, 2018 - Antibiotics for appendicitis? Surgery often not needed
October 21, 2018 - AHA and AMA recognize more than 800 medical practices, health systems for blood pressure control
October 21, 2018 - Scientists obtain clearest ever image of Ebola virus protein
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – Drugs.com MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - High diet quality associated with lower risk of death in colorectal cancer patients
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - Research provides insight into neurobiology of aggression and bullying
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Neuroscientists identify brain region that appears to be related to food preference decisions
October 21, 2018 - Deaths related to air pollution in the U.S. decreased by 47% between 1990 and 2010
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
Delayed word processing could predict patients’ potential to develop Alzheimer’s disease

Delayed word processing could predict patients’ potential to develop Alzheimer’s disease

image_pdfDownload PDFimage_print
Diagram of the brain of a person with Alzheimer’s Disease. Credit: Wikipedia/public domain.

A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.

Using an electroencephalogram (EEG) – a test that detects electrical activity in a person’s brain via electrodes attached to their scalp – researchers studied the brain activity of a group of 25 patients to establish how quickly they processed words shown to them on a computer screen.

The study, published in Neuroimage Clinical, was led by the University of Birmingham’s School of Psychology and Centre for Human Brain Health and was carried out in collaboration with the Universities of Kent and California.

The patients who took part were a mix of healthy elderly people, patients with mild cognitive impairment (MCI), and patients with MCI who had developed Alzheimer’s within three years of diagnosis of MCI.

MCI, a condition in which someone has minor problems with mental abilities such as memory beyond what would normally be expected for a healthy person of their age, is estimated to be suffered by up to 20 per cent of people aged over 65. It is not a type of dementia, but a person with MCI is more likely to go on to develop dementia.

Dr Ali Mazaheri, of the University of Birmingham, said: “A prominent feature of Alzheimer’s is a progressive decline in language, however, the ability to process language in the period between the appearance of initial symptoms of Alzheimer’s to its full development has scarcely previously been investigated.

“We wanted to investigate if there were anomalies in brain activity during language processing in MCI patients which could provide insight into their likelihood of developing Alzheimer’s.

“We focused on language functioning, since it is a crucial aspect of cognition and particularly impacted during the progressive stages of Alzheimer’s.”

Previous research has found that when a person is shown a written word, it takes 250 milliseconds for the brain to process it – activity which can be picked up on an EEG.

Dr Katrien Segaert, of the University of Birmingham, adds: “Crucially, what we found in our study is that this brain response is aberrant in individuals who will go on in the future to develop Alzheimer’s disease, but intact in patients who remained stable.

“Our findings were unexpected as language is usually affected by Alzheimer’s disease in much later stages of the onset of the disease.

“It is possible that this breakdown of the brain network associated with language comprehension in MCI patients could be a crucial biomarker used to identify patients likely to develop Alzheimer’s disease.

“We hope to now test the validity of this biomarker in large population of patients in the UK to see if it’s a specific predictor of Alzheimer’s disease, or a general marker for dementia involving the temporal lobe.

“The verification of this biomarker could lead the way to early pharmacological intervention and the development of a new low cost and non-invasive test using EEG as part of a routine medical evaluation when a patient first presents to their GP with concern over memory issues.”


Explore further:
Being unaware of memory loss predicts Alzheimer’s disease, new study shows

More information:
Ali Mazaheri et al. EEG oscillations during word processing predict MCI conversion to Alzheimer’s disease, NeuroImage: Clinical (2017). DOI: 10.1016/j.nicl.2017.10.009

Journal reference:
NeuroImage: Clinical

Provided by:
University of Birmingham

Tagged with:

About author

Related Articles