Breaking News
December 15, 2017 - For marketplace customers who delay, auto-enrollment could be nasty wake-up
December 15, 2017 - Researchers identify potential alternatives to tackle drug resistant malaria parasites
December 15, 2017 - Scientists unravel mystery of how immune cells remember infections decades later
December 15, 2017 - Outcomes Poorer for Black Patients with Early Breast Ca
December 15, 2017 - Liposuction May Ease Limb Swelling in Cancer Patients
December 15, 2017 - How well can digital assistants answer questions on sex?
December 15, 2017 - NIH-funded study to explore hearing loss risk in Detroit firefighters
December 15, 2017 - Caris Life Sciences reveals identification of new mechanism of action to treat NHL
December 15, 2017 - Loyola Medicine study finds high success rate for diabetic Charcot foot surgery
December 15, 2017 - Bone marrow edema does not increase due to intense physical activity, study finds
December 15, 2017 - Human ‘common cold’ virus kills healthy chimpanzees in Uganda
December 15, 2017 - Experience of reflex walking refines perception of biological motion during early infancy
December 15, 2017 - FDA Approves Admelog (insulin lispro) Rapid-Acting “Follow-On” Insulin Product to Treat Diabetes
December 14, 2017 - Friday Feedback: Good Idea for Ex-Pharma Exec to Run HHS?
December 14, 2017 - More than 200 people sickened onboard Ovation of Seas cruise
December 14, 2017 - FDA announces new approach for sharing updates on antibiotics, antifungal drugs to physicians
December 14, 2017 - Steroid study provides new insights into medicines’ side effects
December 14, 2017 - Government announces plans to include eye test reminder during driving license renewal
December 14, 2017 - Non-ionizing radiation from magnetic fields could have adverse biological impacts on health
December 14, 2017 - Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk
December 14, 2017 - Researchers develop new method for quickly detecting signs of multiple sclerosis
December 14, 2017 - In era of increased competition, hospitals fret over ratings
December 14, 2017 - Female veterans experience improvement in low back pain with course of chiropractic care
December 14, 2017 - Relieving Symptoms of Cystic Fibrosis with Exercise
December 14, 2017 - FDA Alert: Blue Pearl All Natural Male Enhancement Supplement: Recall
December 14, 2017 - CardioBrief: In Defense Of ORBITA
December 14, 2017 - Definition of High Blood Pressure Drops: MedlinePlus Health News
December 14, 2017 - Drug may help surgical patients stop opioids sooner
December 14, 2017 - Researchers develop biosensor that enables development of new health tests
December 14, 2017 - Radiation therapy can be used to treat patients with life-threatening heart rhythm
December 14, 2017 - UVA researchers developing tool to help prostate cancer patients weigh treatment options
December 14, 2017 - Experts tell Congress how to cut drug prices
December 14, 2017 - Researchers use cryptographic techniques to decode activity of motor neurons
December 14, 2017 - Study finds changes in the heart after spinal cord injury
December 14, 2017 - Health Highlights: Dec. 12, 2017
December 14, 2017 - Pelzman’s Picks: How States Can Cut Disparities in Care and Costs
December 14, 2017 - New Hemophilia Treatment Stems Bleeding Episodes: MedlinePlus Health News
December 14, 2017 - Onetime ‘world’s heaviest man’ has second surgery in Mexico
December 14, 2017 - Belgian researchers create transplantable artificial ovary prototype
December 14, 2017 - Using atraumatic needles for lumbar punctures decreases risk of complications
December 14, 2017 - Outpatient total knee replacement surgery linked to higher rates of complications
December 14, 2017 - Social impairments can be corrected by brain stimulation
December 14, 2017 - Studies reveal possibility for memory T cells to serve a dual purpose
December 14, 2017 - Antibody-Drug Conjugate Ups PFS in Untreated Hodgkin’s
December 14, 2017 - Study finds reading information aloud to yourself improves memory
December 14, 2017 - Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies
December 14, 2017 - Living Lyme disease bacteria found months after antibiotic treatment
December 14, 2017 - These annual checkups help seniors not only survive but thrive
December 14, 2017 - Study reveals impact of diabetes during pregnancy on baby’s heart
December 14, 2017 - Hydraulic fracturing is harmful to infants health, study states
December 14, 2017 - Huntington’s disease drug clears initial hurdles
December 14, 2017 - TPU researchers create 3D-printed models of children’s hearts
December 14, 2017 - Brain responses of children with inherited dyslexia risk predict their future reading speed
December 14, 2017 - People diagnosed with schizophrenia or bipolar disorder may actually have treatable condition
December 14, 2017 - Study: New Furosemide Formulation Simplifies Administration for HF
December 14, 2017 - Discrimination harms your health—and your partner’s
December 14, 2017 - Having older brothers may increase the likelihood of being gay
December 14, 2017 - New scientific yardstick released to help early detection of Alzheimer’s disease
December 14, 2017 - New finding demonstrates what happens at cellular level during onset of type2 diabetes
December 14, 2017 - Study identifies potassium as key to circadian rhythms in red blood cells
December 14, 2017 - Good friends might be your best brain booster as you age
December 14, 2017 - NIH expected to award up to $70 million to launch Alzheimer’s Clinical Trials Consortium
December 14, 2017 - Pitting pathogens against each other could prevent drug resistance emerging
December 14, 2017 - Study provides new insights into development of Sonic Hedgehog medulloblastoma
December 14, 2017 - Dr. Reddy’s Announces Approval of Impoyz (clobetasol propionate) Cream for Plaque Psoriasis
December 14, 2017 - Gene Screens Can Alter Perception, Behavior
December 14, 2017 - Can Scrotal Vein Condition Hike Heart Risks?: MedlinePlus Health News
December 14, 2017 - Molecules in spit may be able to diagnose and predict length of concussions
December 14, 2017 - Children’s Colorado and RxRevu partner to help prescribers better meet needs of pediatric patients
December 14, 2017 - Researchers discover new way to attack drug-resistant prostate cancer cells
December 14, 2017 - Scientists develop new, high resolution method for identifying microbial species and strains
December 14, 2017 - Declining trend of salmonellosis cases has leveled off in the EU
December 14, 2017 - Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes
December 14, 2017 - How to Perk Up the Holidays for Hospital Patients
December 14, 2017 - Prolonged Sedation May be Bad for Baby’s Brain
December 14, 2017 - The pediatric submersion score predicts children at low risk for injury following submersions
December 14, 2017 - Video game helps doctors to quickly recognize trauma patients who need high levels of care
December 14, 2017 - Younger persons newly-diagnosed with type 2 diabetes have poorer health than older patients
December 14, 2017 - Clinician re-examines evidence on re-use of catheters and UTIs in people with spinal cord injuries
December 14, 2017 - UK and Russian researchers join forces against AMR

Researchers tackling deadly TB discuss the way forward in treatment and prevention

image_pdfDownload PDFimage_print

Researchers from across the world who are tacking the deadly bacterial disease tuberculosis (TB) attended a symposium at St George’s, University of London to discuss the way forward in treatment and prevention.

TB is one of the top 10 causes of death worldwide and in 2016, 10.4 million people fell ill with the disease and another 1.7 million died. Many of the deaths – 95% according to the World Health Organization – are among people have immune systems damaged by HIV.

The International Consortium for Trials of Chemotherapeutic Agents in Tuberculosis (INTERTB) group of experts meeting at St George’s was organized by Dr Amina Jindani, an Honorary Senior Lecturer.

So INTERTB is a consortium of all the groups in the world who carry out trials to improve treatment for drug-sensitive TB, and they have met annually at St George’s since 2009.

Dr Jindani was involved in some of the first TB drugs trials 50 years ago.

She explained: “When I started working in TB, the treatment was 18 months, and although the regimen was very effective, 18 months was just too long, and very few people completed the treatment.

“When two new drugs became available in the 1960s, rifampicin and pyrazinamide, from preclinical studies, it was thought that they would be able to shorten the treatment duration. The very first short course study that was ever done using these two drugs was done by the MRC, and I coordinated it in 42 centers in Kenya, Tanzania, Uganda and Zambia.”

Dr Jindani explained: “In spite of having a very effective six month treatment, the annual incidence is not decreasing; and the annual mortality remains at nearly 2 million in this is a curable disease. Why should 5000 people globally a day die of a curable disease? In any other situation it would be an outrage.”

“We have a safe, well-tolerated, highly effective treatment regimen but six months is still too long. After the first two months they feel well again, and so they stop taking their treatment.

“Then they relapse – if they relapse with drug-sensitive organisms that’s fine, but sometimes they relapse with drug-resistant organisms.  What we need is an effective vaccine, but in the absence of that, the only thing we can do to encourage compliance and completion of treatment, and increase the cure rates, is to reduce treatment duration.”

Rather than use new drugs, Dr Jindani’s main efforts are going into making one of the existing drugs – rifampicin – more effective by increasing its dose in the hope that treatment can come down to four months.

She is leading a new trial, RIFASHORT, to test using higher doses of rifampicin, and to have just four months of treatment.

She said: “In one arm we’re doubling the dose of rifampicin, in another we’re tripling the dose of rifampicin for four months”, she said, “because we have some pre-clinical evidence that that might kill off the persisting bacteria, and that’s the aim now, to eliminate the persistent bacteria”.

Another St George’s expert, Professor Julia Critchley is Professor of Epidemiology in the Population Health Research Institute, spoke to the delegates at the INTERTB meeting about her concerns regarding the concern that people with diabetes are three-times more likely to get TB than people without diabetes, possibly because their immune system is less effective in a way that the TB bacteria exploit.

Genetic factors and diet changes are considered the most probable causes of the rise in diabetes in Africa and Asia.

Dr Jindani said, “So Indians have a genetic disposition to developing diabetes. In the other countries, diets are changing. For example in the past I never saw a fat person in Africa, and now I do, because they’re all eating junk food. There again the levels of diabetes are going up exponentially, and they risk getting TB.”

Source:

https://sgul.ac.uk/news/news-archive/experts-tackling-deadly-tuberculosis-say-thousands-are-dying-of-the-curable-disease-each-day

Tagged with:

About author

Related Articles