Breaking News
January 22, 2018 - Study identifies new loci associated with asthma enriched in epigenetic marks
January 22, 2018 - Specially prepared supplement helps women to run faster, study shows
January 22, 2018 - 3-D Stent Retriever with Aspiration Proves Mettle in AIS
January 22, 2018 - Public health research seeks to understand how natural disasters impact spread of Zika
January 22, 2018 - Research reveals role of nanophenomenon in stimulating bone-repair process
January 22, 2018 - Epilepsy associated with volume and thickness differences in brain matter
January 22, 2018 - Trevena Announces FDA Acceptance for Review of New Drug Application for Olinvo (oliceridine) Injection
January 22, 2018 - A Noteworthy Margin of Error
January 22, 2018 - Firm advances human trials of revolutionary vaccine
January 22, 2018 - Many Indians put away treating orthopedic problems
January 22, 2018 - Cherwell releases new pocket guide to prepared culture media
January 22, 2018 - Huron earns ISO 13485 certification for quality management system
January 22, 2018 - Avion Pharmaceuticals Announces FDA Approval of Balcoltra (levonorgestrel and ethinyl estradiol tablets and ferrous bisglycinate tablets) Oral Contraceptive
January 22, 2018 - Multi-Gene Test For Early CVD; Neighborhood HF Risk; Novel Testosterone Drugs
January 22, 2018 - Skipping breakfast disrupts ‘clock genes’ that regulate body weight
January 22, 2018 - Creativity May Rely on ‘Teamwork’ in the Brain
January 22, 2018 - NeuroBreak: Alzheimer’s Germ Contest; High Salt Diet May Be Bad for Brain
January 22, 2018 - Diabetics may often fare poorly in hospice care
January 22, 2018 - Performance enhancing benefits of caffeine more apparent for infrequent tea, coffee drinkers
January 22, 2018 - HHS Unveils Framework for Interoperability
January 22, 2018 - More dentists to discuss risks of HPV-related cancers with their patients
January 21, 2018 - Research shows how Zika virus damages placenta to cause malformations in babies
January 21, 2018 - Achaogen Announces FDA Acceptance of New Drug Application with Priority Review for Plazomicin for Treatment of Complicated Urinary Tract Infections and Bloodstream Infections
January 21, 2018 - Drug Allergies: Time to Re-Test?
January 21, 2018 - Mitochondrial protein in cardiac muscle cells linked to heart failure, study finds
January 21, 2018 - Women more likely than men to die from a heart attack
January 21, 2018 - Next generation genomic sequencing can help detect pathogens after joint replacement
January 21, 2018 - Gov’t Shutdown Looms as Senate Debates Spending Bill
January 21, 2018 - Emergency Readiness for Older Adults and People with Disabilities
January 21, 2018 - Heart health at risk for Latinas over worries about deportation
January 21, 2018 - Scientists methodically identify genes related to blood feeding and non-biting mosquitoes
January 21, 2018 - Researchers discover potential target genes to halt thyroid cancer progression
January 21, 2018 - Youth with shared residency after parents’ divorce have less mental issues
January 21, 2018 - Sleep Better, Lose Weight? – Drugs.com MedNews
January 21, 2018 - More $$ Needed for Health Emergencies, Senators Told
January 21, 2018 - Gene test to predict breast cancer recurrence less cost effective in real world practice
January 21, 2018 - Study finds rise in number of adolescents receiving psychiatric or neurodevelopmental diagnosis
January 21, 2018 - Reminders can improve immunization rates
January 21, 2018 - A More Personalized Approach to PSA Screening in 2017
January 21, 2018 - T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma
January 21, 2018 - Tetraphase Pharmaceuticals Announces Submission of New Drug Application to FDA for Eravacycline for the Treatment of Complicated Intra-Abdominal Infections (cIAI)
January 21, 2018 - Have Robotics Had a Detrimental Effect on Surgical Residency?
January 21, 2018 - Being bilingual may help autistic children
January 21, 2018 - Metrics Are Not Widespread in Rheumatoid Care
January 21, 2018 - Neuroanatomic abnormalities ID’d in those at risk for autism
January 21, 2018 - Children born with Down’s syndrome have superior genome that compensates for disability
January 21, 2018 - Study finds higher risks for asymptomatic paroxysmal AF patients
January 21, 2018 - The Second Stage of Diet Resolutions
January 21, 2018 - CT Scans Reduce Lung Cancer Deaths … But Among Whom?
January 21, 2018 - ADHD drug use soars among young women
January 21, 2018 - Researchers propose new regulation mechanism linked to action of SirT6 on chromatin
January 21, 2018 - Statins appear to reduce risk of repeated surgery in patients who undergo vitrectomy
January 21, 2018 - Morning Break: Hep A Outbreak Spreads; Tide Pod Challenge; Keeping Lobsters Out of Hot Water
January 21, 2018 - EULAR and ACR present SLE classification criteria at the 2017 ACR/ARHP Annual Meeting
January 21, 2018 - Progenics Pharmaceuticals Announces FDA Acceptance of New Drug Application for Azedra (iobenguane I 131) in Pheochromocytoma and Paraganglioma
January 21, 2018 - House Passes Funding Bill with 6-Year CHIP Renewal
January 21, 2018 - DASH ranked Best Diet Overall for eighth year in a row by U.S. News and World Report
January 21, 2018 - Dementia study sheds light on how damage spreads through brain
January 20, 2018 - Morning Break: Missing Maria Deaths; N.J. Doc Charged in Wife’s Murder; Viva Vaseline!
January 20, 2018 - No interventions proven to prevent late-life dementia
January 20, 2018 - Judge orders new Olympus trial over superbug death
January 20, 2018 - Don’t Rely on Just One Blood Pressure Test for Kids: Study
January 20, 2018 - Going Off the Deep End About Water
January 20, 2018 - Parental attention can reduce risk of drug abuse in adolescence
January 20, 2018 - Mast Uri System offers efficient and cost-friendly diagnostic solution
January 20, 2018 - International SOS, Chatham House sign partnership agreement to further advance Global Health Security Agenda
January 20, 2018 - Study offers way to predict onset of lung disease in children with cystic fibrosis
January 20, 2018 - C-Suite Must Lead in Ending Sexual Harassment
January 20, 2018 - Researchers find a way to ‘starve’ cancer
January 20, 2018 - Applied math can help predict genesis and evolution of different cancers
January 20, 2018 - UCLA researchers describe herpes virus structure associated with Kaposi’s sarcoma
January 20, 2018 - New study enrolls first patient to evaluate potential of WaveCrest LAAO System
January 20, 2018 - New review explores effects of exposing developing brains to general anesthesia
January 20, 2018 - GW Pharmaceuticals Announces Acceptance of NDA Filing for Epidiolex (cannabidiol) in the treatment of Lennox-Gastaut syndrome and Dravet syndrome
January 20, 2018 - Weight-Loss Surgery Approaches Offer Similar Results
January 20, 2018 - Free online access to millions of documents on chemical toxicity
January 20, 2018 - CE marked MAST Toxoreagent kit for detection of Toxoplasma antibodies
January 20, 2018 - DNA study sheds light on longstanding puzzle of cell division
January 20, 2018 - Montefiore provides specialized medical care to parents of adopted children
January 20, 2018 - Enzyme discovery provides new horizon of therapeutic opportunities across disease spectrum
Two immunotherapy approaches for multiple myeloma show hope

Two immunotherapy approaches for multiple myeloma show hope

image_pdfDownload PDFimage_print

Researchers from the University of Pennsylvania’s Abramson Cancer Center have developed two experimental immunotherapy methods that include one chimeric antigen receptor (CAR) T cell therapy for the treatment of multiple myeloma patients who were not responding to other treatments.

Multiple myeloma is a cancer of the bone marrow. healthy plasma cells in the bone marrow mutate and multiply uncontrollably. malignant plasma cells produce a paraprotein. Image Credit: Designua / Shutterstock

Multiple myeloma is a cancer of the bone marrow. healthy plasma cells in the bone marrow mutate and multiply uncontrollably. malignant plasma cells produce a paraprotein. Image Credit: Designua / Shutterstock

The other study used a monoclonal antibody in treatment of multiple myeloma. Both of the studies would be presented as oral abstracts at the 59th Annual American Society of Hematology Meeting and Exposition in Atlanta.

The team of researchers administered CAR T cells to the multiple myeloma patients after they had undergone chemotherapy and found that 64 percent of the patients responded favorably after the therapy. In the other study an experimental monoclonal antibody was infused into patients with resistant multiple myeloma and an overall response rate of 60 percent was noted. According to the researchers that receptor targeted in both these immunotherapy approaches is called the B-Cell Maturation Antigen (BCMA). BCMA occurs in high abundance in patients with myeloma and thus can be used as a target for these drugs in multiple myeloma.

Multiple myeloma affects thousands of patients every year. According to the American Cancer Society the estimated number of new cases this year is around 30,200 and these patients are usually treated with chemotherapy, radiation therapy and stem cell transplant. Multiple myeloma affects particular immune cells called the plasma cells that become cancerous and multiply uncontrollably.

Study 1

The first study is presented as Abstract #505 which involves the use of CART-BCMA. Here the CAR T cells are developed specially by the researchers in collaboration with Novartis over the past five years. Patient’s own immune cells are collected and they are modified in such a manner so that they can find and destroy the cancer cells specifically. These are termed “hunter” cells that can target the BCMA receptor that is present over the cancer cells and can multiply within the body to kill the cancer cells. The normal white blood cells are suppressed first using a chemotherapy cycle before infusing these CAR-T cells. The patients included in the experimental clinical trial had all failed with traditional treatment before being enrolled for the study. On an average they had received some seven lines of therapy before this study and failed to respond adequately.

The group was divided into two dose groups of the CART-BCMA therapy – the lower dose included 5 patients and the higher dosage group had 10 patients. The lower dosage group showed minor response in at least 2 patients. Minor response was defined as 25 percent or more reduction in the levels of myeloma protein. In the higher dosage group, minor response was seen in eight patients (80 percent) and one patient showed complete response. The clinical trial is not yet concluded and more patients are being treated with the higher dose level. Of the 15 patients, side effects such as cytokine-release syndrome which manifests as flu like syndrome, nausea, fever, muscle pain etc. was noted in 12 patients. For this side effect one patient received tocilizumab and another received siltuximab as therapy. No deaths were seen during the study and three patients developed some nerve toxicity that did not persist. Study’s lead author Adam D. Cohen, assistant professor of Hematology and Oncology at Penn and the director of Myeloma Immunotherapy in Penn’s Abramson Cancer Center emphasized the importance of BCMA as an important target in treating multiple myeloma. The study was supported by the Penn-Novartis alliance.

Study 2

The second study presented as Abstract #741 used an experimental drug called GSK2857916. Dr. Cohen led this study as well. This new experimental drug was given breakthrough therapy designation by the US FDA this November so that it could be developed in an expedited fashion. This drug is combination of a chemotherapy drug called MMAF and a monoclonal antibody that targets the BCMA.

For the trial, 35 patients were given 16 treatment cycles with this experimental drug every three weeks. At the end of the study, 21 out of 35 (60 percent) showed some response to the drug. Around 51 percent showed a good partial response which meant that their myeloma protein levels reduced by over 90 percent. Media time that the patient spent without the disease progressing was around eight months.

Significant side effects in this study included eye toxicities such as dry eyes and blurry vision that was seen in 63 percent patients. Cohen added that there was a high response rate which had never been seen among these cases which were unresponsive to routine treatments.

Tagged with:

About author

Related Articles