Breaking News
August 14, 2018 - American Heart Association Urges Screen Time Limits for Youth
August 14, 2018 - Brief interventions during routine care reduce alcohol use among men with HIV
August 14, 2018 - New genome analysis could identify people at higher risk of common deadly diseases
August 14, 2018 - NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease
August 14, 2018 - Daicel supplies free nanodiamond samples to international researchers
August 14, 2018 - Switching anti-psychotic drugs in first-episode schizophrenia patients does not improve clinical outcomes
August 14, 2018 - Study to examine whether modulating gut bacteria can improve cardiac function in heart failure patients
August 14, 2018 - One out of two children not getting enough nutrients needed for their health
August 14, 2018 - Mono-antiplatelet therapy after aortic heart valve replacements may work as well as two drugs
August 14, 2018 - Aid-in-dying patient chooses his last day
August 14, 2018 - Exercise Really Can Chase Away the Blues, to a Point
August 14, 2018 - Surgical mesh implants may cause autoimmune disorders
August 14, 2018 - Researchers develop revolutionary zebrafish model to gain more insight into bone diseases
August 14, 2018 - Researchers discover secret communication hotline between breast cancers and normal cells
August 14, 2018 - Study examines how a person adapts to visual field loss after stroke
August 14, 2018 - Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells
August 14, 2018 - Reducing opioid prescriptions for one operation can also spill over to other procedures
August 14, 2018 - E-cigarettes not so safe but still better than cigarettes
August 14, 2018 - Researchers find link between common ‘harmless’ virus and cardiovascular damage
August 14, 2018 - Initiation of PIMs associated with higher risk of fracture-specific hospitalizations and mortality
August 14, 2018 - Genetically modified mosquitoes and special bed nets help tackle deadly diseases
August 14, 2018 - Advances in treating hep C lead to new option for transplant patients
August 14, 2018 - Study finds quality of doctor-patient discussions about lung cancer screening to be ‘poor’
August 14, 2018 - MSU researchers uncover the effects of aging on regenerative ability of kidneys
August 14, 2018 - Better conditioning, throwing mechanics can help reduce elbow injuries in young baseball pitchers
August 14, 2018 - Brain game doesn’t offer brain gain
August 14, 2018 - Reproductive choices facing women with disabilities require careful consideration
August 14, 2018 - Scientists pinpoint the cause of a rare childhood seizure disorder
August 14, 2018 - Lumpectomy plus radiation associated with reduced risk of breast cancer death, study finds
August 14, 2018 - UAB study shows how ion channel differentiates newborn and mature neurons in the brain
August 14, 2018 - Experts highlight key knowledge gaps that need to be addressed in Ebola vaccine research
August 14, 2018 - Discovery could lead to new drugs against infection and inflammation
August 14, 2018 - Infection Prevention Differs Between Small, Large Hospitals
August 14, 2018 - Mom still matters—In study, young adults tended to prioritize parents over friends
August 14, 2018 - Deep brain stimulation might benefit those with severe alcoholism, preliminary studies show
August 14, 2018 - Study finds increased rate of repeat pregnancies in women with intellectual and developmental disabilities
August 14, 2018 - Lighter sedation fails to reduce risk of postoperative delirium in older patients
August 13, 2018 - Asking better questions about person’s memory could improve doctors’ understanding of patients
August 13, 2018 - U.S. Trauma Doctors Push for Stricter Gun Controls
August 13, 2018 - Asthma and flu: a double whammy
August 13, 2018 - 5 Questions: Donna Zulman on engaging high-need patients in intensive outpatient programs | News Center
August 13, 2018 - Behavioral Nudges Lead to Drop in Prescriptions of Potent Antipsychotic
August 13, 2018 - Potential New Class of Drugs May Reduce Cardiovascular Risk by Targeting Gut Microbes
August 13, 2018 - How to get your kids to eat better
August 13, 2018 - The importance of hearing your patients
August 13, 2018 - Transmission of F. tularensis unlikely to happen through the food chain
August 13, 2018 - Researchers discover epigenetic mechanism underlying ischemic cardiomyopathy
August 13, 2018 - Adolescent health programs receive only a tiny share of international aid, finds research
August 13, 2018 - Fracture risk increases by 30% after gastric bypass, study shows
August 13, 2018 - Quality-improvement project to standardize feeding practices helps micro preemies gain weight
August 13, 2018 - Long-term cannabinoid exposure impairs memory, study shows
August 13, 2018 - New intervention to reduce risk of HIV in young transgender women
August 13, 2018 - Japan human trial tests iPS cell treatment for Parkinson’s
August 13, 2018 - Altered nitrogen metabolism may contribute to emergence of new cancer mutations
August 13, 2018 - Cycling provides greatest health benefits, study finds
August 13, 2018 - Scientists discover biomarker for kidney cancer
August 13, 2018 - New test predicts the risk of serious disease before symptoms appear
August 13, 2018 - Cianna Medical receives FDA 510(k) clearance to extend indication of SCOUT reflector for use in soft tissue localization
August 13, 2018 - Ground-breaking discovery offers new hope for treatment of Alzheimer’s, other neurological diseases
August 13, 2018 - Medical nutrition therapy provided by RDNs benefits patients with chronic kidney disease
August 13, 2018 - Prenatal Tdap vaccination not linked with increased risk of autism in children, study shows
August 13, 2018 - One-Third of Canadian Patients Get Hip Fx Repair Within 24 Hours
August 13, 2018 - ANA (Antinuclear Antibody) Test: MedlinePlus Lab Test Information
August 13, 2018 - Traffic jams in the brain
August 13, 2018 - NIH awards $6.5 million to establish multi-institution biomedical technology resource center
August 13, 2018 - New marker in the blood could help predict person’s risk of developing kidney cancer
August 13, 2018 - New biomarker may provide clues to create diagnostic tool for hypoglycemia-associated autonomic failure
August 13, 2018 - Oxidative Stress Hampers Blood Vessel Dilation in Men
August 13, 2018 - Parents’ Religious Beliefs May Affect Kids’ Suicide Risk: Study
August 13, 2018 - Measure of belly fat in older adults is linked with cognitive impairment
August 13, 2018 - FDA permits marketing of first mobile medical app for contraceptive use to prevent pregnancy
August 13, 2018 - NUS scientists develop new technology to customize optimal drug ‘cocktail’ for myeloma patients
August 13, 2018 - Disordered eating behaviors up for overweight young adults
August 13, 2018 - Connection between Alzheimer’s disease and degenerative eye diseases
August 13, 2018 - Employer expectation of checking email during nonwork hours affects health of workers and families
August 13, 2018 - Rotavirus vaccination reduces infant diarrhea deaths by 34% in rural Malawi
August 13, 2018 - Approval of drug derived from cannabis not necessarily a win for weed
August 13, 2018 - Study shows COPD risk in women with asthma can be reduced
August 13, 2018 - FIND and genedrive announce study agreement to evaluate HCV ID Kit
August 13, 2018 - One in two people putting their eye health at risk during summer, says eye research charity
Civilians Now Getting Flu-Like Illness Afflicting Troops

Civilians Now Getting Flu-Like Illness Afflicting Troops

image_pdfDownload PDFimage_print

Action Points

  • Human adenovirus type 4, an influenza-like illness usually found in isolated military settings, was detected among the general population, such as college students, other young adults, and residents of long-term care facilities.
  • Note that HAdV-4 plays a leading role in the etiology of outbreaks of febrile respiratory illness and ocular disease in military recruit training facilities, and a vaccine against this virus was exclusively licensed for military use.

Human adenovirus type 4, an influenza-like illness usually found in isolated military settings, was detected among the general population, such as college students, residents of long-term care facilities and other young adults, researchers found.

Thirty-six isolates of human adenovirus type 4, or HAdV-4, were found in adults outside of military facilities, reported Adriana E. Kajon, PhD, of Lovelace Respiratory Research Institute in Albuquerque, New Mexico, and colleagues.

While most of these were the most common genome types found among military recruits, certain novel variants were identified among college students and young adults from upstate New York, the authors wrote in Emerging Infectious Diseases.

HAdV-4 is one cause of acute respiratory disease and ocular disease, the authors said. They noted that a vaccine against this virus was exclusively licensed for military use, although HAdV-4 vaccination protocols were discontinued for 15 years, until they were reinstated in 2011. But the authors said there is no surveillance for the disease outside of the military, which makes it difficult to figure out the burden of disease linked to it among civilians.

“The apparent increased frequency of detection of cases and case clusters of HAdV-4 respiratory infection in the northeastern United States … caught our attention,” they wrote.

Researchers obtained specimens that were positive for HAdV-4. Patients had acute respiratory disease or influenza-like illness characterized by a fever, cough, sore throat and other respiratory symptoms. These cases were identified by the New York State Department of Health as part of the CDC’s influenza-like illness surveillance network or “special HAdv cases” referred to the CDC for investigation.

Identified cases came from an outbreak at a long-term care facility in Boston, adults with severe pneumonia in Connecticut and New York, college students in New York, and additional cases among other adults, including a nursing home patient, a fatal case of a patient at a cancer care center, and acute respiratory disease in a teenager at a pediatric clinic.

Among these 36 cases, authors identified five genomic variants — some of which were associated with outbreaks and others that were “epidemiologically unlinked” cases of acute respiratory disease. Of these, genomic variant 4a1 was isolated from 18 of 36 specimens, while genomic variant 4a2 was isolated from 12 of 36 specimens. Both variants were highly prevalent in basic training facilities prior to the reinstatement of vaccination protocols in 2011, the authors said.

But they also found two previously unreported variants described as “closely related” to 4a1 and 4a2 among certain college students in upstate New York, and one strain that was similar to a vaccine-like strain of the virus in an 18 year-old at a physician’s office.

They speculated on the potential reasons for this virus in the civilian population, either that the public could have been exposed to non-attenuated vaccine strains through fecal shedding from military personnel who were vaccinated from 1971 to 1997, or that these variants were circulating at low prevalence among civilian communities since the 1950s, when they were first identified, the authors said.

They added that due to the severity of clinical presentation in some of these cases, the vaccine licensed for military use against HAdV-4 should be considered “a potentially valuable resource” to prevent disease in closed communities, like college, summer camps, and long-term care facilities.

“Our data and reports of cases of severe [acute respiratory disease] associated with HAdV-4 infection in Italy and Singapore suggest that the role of this HAdV type in the etiology of adult civilian ARD might have been underestimated in the absence of access to molecular…typing resources,” they wrote.

They recommended including human adenovirus in differential diagnostic panels to ensure that patients with influenza-like symptoms, but who test negative for the flu, are not treated with anti-influenza agents.

The study was supported by the CDC.

Kajon disclosed no relevant relationships with industry. One co-author disclosed support from the NIH.

2018-01-11T12:00:00-0500

Tagged with:

About author

Related Articles