Breaking News
February 21, 2018 - ‘Grey’s Anatomy’ Traumas Lack Realism
February 21, 2018 - Sleep quality improves with help of incontinence drug
February 21, 2018 - Scientists uncover genetic cause behind typhoid’s antibiotic resistance
February 21, 2018 - Study reveals a significant link between heavy alcohol use and dementia
February 21, 2018 - French scientists develop new wearable laser that eradicates skin conditions
February 21, 2018 - People with major depressive disorder have reduced arginine levels, study shows
February 21, 2018 - National Health Spending at $3.5 Trillion in 2017, CMS Says
February 21, 2018 - Substantial inequalities in cesarean births persist in many countries
February 21, 2018 - Early childhood immune signature predicts risk of developing asthma later on
February 21, 2018 - Stanford researchers explore how gut bacteria respond to common changes in habitat
February 21, 2018 - Household Products May Pollute the Air as Much as Your Car Does: Study
February 21, 2018 - Combo Bests Targeted Agent in mRCC
February 21, 2018 - Researchers discover brain pathway that dissociates opioid addiction from analgesia
February 21, 2018 - Scientists uncover how newly discovered gene helps grow blood vessels
February 21, 2018 - Brain’s quality control process holds clues to obesity’s roots
February 21, 2018 - Researchers to study whether menstrual cups can help prevent vaginal infections
February 21, 2018 - MS patients who feel stigmatized more likely to suffer from depression
February 21, 2018 - Vitamin D supplementation during pregnancy could protect against childhood obesity
February 21, 2018 - Lower-Quality Medical Tx Might Have Skewed Key PCI vs CABG Trials
February 21, 2018 - Love and fear are visible across the brain instead of being restricted to any brain region
February 21, 2018 - Researchers discover potential new antimalarial treatment targets
February 21, 2018 - Adults with congenital heart disease have increased risk for dementia, study finds
February 21, 2018 - Clinical trial studying type 1 diabetes reaches full enrollment
February 21, 2018 - Father’s stress affects the brain development of offspring, mice study shows
February 21, 2018 - ESRD Death Declines in Vasculitis Patients
February 21, 2018 - Taking ibuprofen for long periods found to alter human testicular physiology
February 21, 2018 - Google AI device could predict a person’s risk of a heart attack
February 20, 2018 - FDA Approves Domestic Source for Tc-99m Isotopes
February 20, 2018 - Sanofi rejects refund demand faces Philippine suit over dengue vaccine (Update)
February 20, 2018 - Researchers discover that activation of specific enzyme may help suppress tumor metastasis
February 20, 2018 - Blood or marrow transplantation survivors have higher risk of cognitive impairment
February 20, 2018 - Booze Beats Pot at Being Unhealthy: Oregon Poll
February 20, 2018 - Morning Break: ’20 Years Late’; Drugs in the Dirt; Catching Flu in the Dorm
February 20, 2018 - Another piece to the puzzle in naked mole rats’ long, cancer-free life
February 20, 2018 - Scientists identify four viruses that can produce insulin-like hormones
February 20, 2018 - New e-Health solution developed to prevent cardiovascular disease, dementia in senior citizens
February 20, 2018 - New genetic risk score could help guide screening decisions for prostate cancer
February 20, 2018 - Study finds higher risk of stroke among blacks with atrial fibrillation than whites
February 20, 2018 - Physical activity could be used as strategy for diabetes prevention
February 20, 2018 - Researchers develop sensing method for early detection of cancer and diabetes
February 20, 2018 - New wearable electronics could be game-changer for stroke rehabilitation
February 20, 2018 - Immune history influences person’s response to flu vaccine
February 20, 2018 - Research findings could help develop new drugs to prevent, treat dry eye disease
February 20, 2018 - Serenity Now! Learn to Have Patience with Patients
February 20, 2018 - Computer simulation addresses the problem of blood clotting
February 20, 2018 - Women with type 1 diabetes not protected against coronary artery disease
February 20, 2018 - Persistent bloating can be a sign of ovarian cancer, warns charity
February 20, 2018 - Trump administration proposes rule to loosen curbs on short-term health plans
February 20, 2018 - Key protein involved in epigenetic regulation of gene expression guides skin cell renewal
February 20, 2018 - Heart attack symptoms often missed in women
February 20, 2018 - Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptoms
February 20, 2018 - Study reveals functional dynamics of ion channels
February 20, 2018 - Study explores link between mortality risk and combustible tobacco use
February 20, 2018 - ‘She Trusted Me, and I’d Turned Her Away’
February 20, 2018 - AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies
February 20, 2018 - Fast food makes the immune system more aggressive in the long term
February 20, 2018 - Therapeutic target for glaucoma could have treatment ramifications for Alzheimer’s and Parkinson’s
February 20, 2018 - Overcoming Negative Reviews | Medpage Today
February 20, 2018 - MyD88—villain of allergies and asthma
February 20, 2018 - Food scientists develop rapid screening technique to detect pesticide residue in vegetables
February 20, 2018 - Lab-grown cerebellar cells may help explain how ASD develops at molecular level
February 20, 2018 - Scientists explore connection between bad sleep habits and stiff blood vessels
February 20, 2018 - New Treatment Apalutamide (Erleada) Approved for Prostate Cancer That Resists Hormone Therapy
February 20, 2018 - Do You Really Need My Signature on That?
February 20, 2018 - HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection
February 20, 2018 - Diabetes does not increase work-loss years due to early retirement
February 20, 2018 - Researchers aim to find out how PTSD affects decisions of police
February 20, 2018 - UH Cleveland Medical Center explores novel treatments for uterine fibroids
February 20, 2018 - Flu Vax Efficacy 25% Against Predominant H3N2 Strain So Far
February 20, 2018 - HIV screening most optimal at 25 years of age if no risk factors
February 20, 2018 - Loyola Medicine primary care physician offers advice to minimize risk of flu
February 20, 2018 - Safe sleep recommendations for parents that may help reduce child’s risk of SUID
February 20, 2018 - Why Do So Few Docs Have Buprenorphine Waivers?
February 20, 2018 - Low levels of alcohol good for the brain
February 20, 2018 - Experimental treatment improves invisible symptoms of a man with spinal cord injury
February 20, 2018 - Myriad’s EndoPredict offers better prediction of breast cancer recurrence, analysis shows
February 20, 2018 - Researchers identify fifteen genes that determine our facial features
February 20, 2018 - Morning Break: New Health IT Player; Luxturna No Bargain; Nuclear Freakout
February 20, 2018 - How does it compare? Hospice care at home, at assisted living facility, at nursing home
February 19, 2018 - Scientists develop water-soluble warped nanographene for bioimaging
Novel hip resurfacing implant may give higher quality of life, greater mobility to patients

Novel hip resurfacing implant may give higher quality of life, greater mobility to patients

image_pdfDownload PDFimage_print

Surgeons are treating patients with a new type of hip implant that could lead to better outcomes for younger, more active people requiring surgery.

Fifteen patients have so far been treated with a novel ceramic hip resurfacing implant in a new trial at Imperial College London. Early results suggest patients can return to physical activities such as swimming and cycling within six weeks of their operation.

The investigation, whose lead site is Charing Cross Hospital, part of Imperial College Healthcare NHS Trust, is the first in the world to resurface patients’ hips without using metal implants.

The clinical trial is designed to show that the ceramic implant is suitable for both men and women, as conventional hip resurfacing techniques are currently unsuitable for female patients,

The team hopes that the results of the investigation will lead to more treatment options for patients who require surgical replacement of a hip, and enable them to lead fuller, more active lives.

They suggest that the new device, called ‘H1’, could also reduce the risks of hip surgery, as well as save the NHS £10m a year. The technique may also give patients a higher quality of life than conventional hip replacement surgery.

Every year around 100,000 people undergo primary hip replacements in the UK, at an estimated cost of £600 million per year. Most patients have a total hip replacement (THR) where a damaged hip joint is completely replaced with an artificial one. This is typically carried out on people between the ages of 60 and 80. However, this procedure has been reported to fail in younger patients with more active lifestyles -the stiff metal stem in the thigh bone can cause trouble.

There is an alternative type of surgery known as hip resurfacing, which is carried out on younger patients. Unlike THR, the surgeon only removes the diseased cartilage of the hip joint and resurfaces the joint – until now with a metal-on-metal implant. This approach is less invasive and leaves the patient with greater mobility after surgery.

More of the bone is left in the hip joint, so the patient feels more normal, and can be more active. For young active patients, metal hip resurfacing already lasts longer than total hip replacement. However, in some patients, metal particles are released by the implant, causing tissue reactions around this such as swelling and soreness. This can lead to resurfacing implants failing and patients requiring further surgery.

Furthermore, women are unable to have hip resurfacing surgery, as the metal implant doesn’t fit their hips bones properly leading to higher failure rates. As a result, women can’t have this surgery and their only option is a total hip replacement, whatever their age.

Professor Justin Cobb, Chief Investigator, said: “In this safety study, we are ensuring that the H1 hip resurfacing implant can be used safely on patients needing hip replacement surgery. Hip resurfacing is an alternative, more conservative type of surgery that enables a higher level of physical activity than total hip replacement. The metal hip resurfacing implants developed 20 years ago have been highly successful, but some patients have had problems with tissue reactions around the hip owing to the release of metal ions.”

Unlike other hip resurfacings, the H1 implant is made of ceramic that is strong, low wearing and non-toxic. The researchers believe that by swapping the metal material with ceramic, the advantages of hip resurfacing surgery are kept, while the possibility of problems arising from the metal ions released is removed.

Professor Cobb added: “The H1 hip resurfacing implant is made from ceramic and designed to fit the contours of both male and female hips, so may avoid the problems seen with metal hip resurfacing. The ceramic used in the H1 is the same material used for the ball head in most hip replacements in the world today. The early results are promising. We hope to move from the safety study into a full scale efficacy study in the spring, involving more patients in centres around the UK and Europe. The trial is designed to demonstrate that total hip replacement can be postponed or avoided for younger and more active patients, enabling them to lead fuller more active lives.”

In the video above, David Brewer and Krystyna Plater, two implant recipients, talk about why they took part in the clinical investigation and the impact of their new implants. The video also features an interview with Professor Justin Cobb, Head of academic orthopedic surgery at Imperial College London. He explains more about how the implant works and the results of the investigation so far. The video also includes an interview with Brogan Keane, Physician Associate at the MSk Lab, Imperial College London.

The first fifteen patients with degenerative hip joint diseases such as osteoarthritis were recruited to the investigation between September and December 2017. Scans were taken of each patient’s hip before and after surgery, as well as post-operatively at six weeks to evaluate hip function. A blood sample was also taken before and after surgery to monitor the levels of metal ions following the operation.

The team has found that patients were able to return to physical activities such as swimming, cycling and walking within six weeks of their operation. By three months, patients were able to return to those activities they couldn’t do before, including dancing, yoga and gym work, like total hip patients, but a little quicker. Full recovery will take longer.

The researchers will recruit a total of 250 patients to the clinical investigation from hospitals across the UK and the rest of Europe. The patients will be followed up over ten years to assess how the implant is performing.

The team will apply for CE marking, a symbol shown on devices demonstrating that they conform with relevant EU medical devices directives, so that the implant can be used across hospitals outside of the clinical investigation, across Europe and beyond.

The clinical investigation is funded by Embody Orthopaedic – a spin-out from Imperial Innovations, based around intellectual property developed by a PhD student at Imperial. It is an example of the work carried out by Imperial College Academic Health Science Centre, a joint initiative between Imperial College London and three NHS hospital trusts. It aims to transform healthcare by turning scientific discoveries into medical advances to benefit local, national and global populations in as fast a timeframe as possible.

Source:

http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_7-2-2018-10-24-18

Tagged with:

About author

Related Articles