Breaking News
July 19, 2018 - Cancer patients receiving anti-PD-1 therapies may experience delayed skin reactions
July 19, 2018 - Scientists study adverse effects of carbon, silicon nanotubes and carbon nanofibers
July 19, 2018 - Keck Hospital of USC receives Magnet recognition for excellence in nursing
July 19, 2018 - Scientists identify hidden signals in RNAs that control protein synthesis
July 19, 2018 - Quadrivalent HPV Vaccine Not Tied to Spontaneous Abortion
July 19, 2018 - FDA OKs first drug made to reduce excessive sweating
July 19, 2018 - New findings do no support caffeine as effective appetite suppressant or weight-loss aid
July 19, 2018 - Prolonged preoperative opioid use linked to adverse outcomes after total knee and hip arthroplasty
July 19, 2018 - Biophysicists use infrared sensor as new method for drug discovery
July 19, 2018 - Rat study shows negative effects of perinatal exposure to phthalates
July 19, 2018 - Children with disabilities endure long waits for life-changing medical equipment
July 19, 2018 - Ways to stay safe while camping and hiking
July 19, 2018 - People with HIV twice as likely to suffer from heart disease
July 19, 2018 - On-the-Job Stress Relief – Drugs.com MedNews
July 19, 2018 - Compounds found in green tea and wine may block formation of toxic metabolites
July 19, 2018 - Gene regulator associated with protein pileup in exfoliation glaucoma
July 19, 2018 - Trump administration summons immigrant infants
July 19, 2018 - FDA grants approval for first breast cancer drug through ‘Real-Time Oncology Review’
July 19, 2018 - Five tips for men seeking plastic surgery
July 19, 2018 - Researchers discover the reasons why some people get dizzy when hearing certain sounds
July 19, 2018 - Research project investigates snake venom treatment as antibiotic alternative for eye infections
July 19, 2018 - Melanoma could soon be detected using a blood test
July 19, 2018 - Exposure to bright light may have big impact on sleep-related behavior in children
July 19, 2018 - Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice
July 19, 2018 - New proteomics studies help gain more insights into Alzheimer’s, cancer and listeriosis
July 19, 2018 - Study finds major discrepancies in prescription drug labeling pregnancy information across four countries
July 19, 2018 - Cellectar’s CLR 131 Receives FDA Orphan Drug Designation for Treatment of Ewing’s Sarcoma
July 19, 2018 - Watching the immune system in action reveals what happens when things goes wrong
July 19, 2018 - Increasing blood sugar levels improves memory and performance in older adults
July 19, 2018 - Connection between self-regulation and obesity appears to be different for girls and boys
July 19, 2018 - Researchers develop new, less destructive method for whitening teeth
July 19, 2018 - Revving up innate control of viral infection requires a three-cell ignition
July 19, 2018 - Inaccurate direct-to-consumer raw genetic data can harm patients, new research suggests
July 19, 2018 - Weight loss surgery is effective under the right situations
July 19, 2018 - BioTek awarded patent for autofocus feature on microplate reader
July 19, 2018 - Low-carb diets reduce stiffness of arteries in women and promote weight loss in men
July 19, 2018 - New review examines cannabinoids’ potential for direct treatment of cancer
July 19, 2018 - Allergic responses may help protect the skin against cancer, research suggests
July 19, 2018 - Inappropriate Prescribing of Abx High in Urgent Care Centers
July 19, 2018 - Many at risk for HIV despite lifesaving pill
July 19, 2018 - Tips for doctors and parents on the harms of marijuana use for teens
July 18, 2018 - Researchers detect presence of IgE antibodies after kidney transplantation
July 18, 2018 - New technique allows researchers to create large scale, personalized bone grafts
July 18, 2018 - Smoking May Boost Atrial Fibrillation Risk
July 18, 2018 - Genome editing method targets AIDS virus
July 18, 2018 - These things matter: Medical complications are not inevitable, a physician writes
July 18, 2018 - Cognitive functions often wilt as water departs the body, shows study
July 18, 2018 - Origins of bread found 14,400 years ago in Jordan
July 18, 2018 - Low-dose ketamine found to be as effective as opioids for treating acute pain
July 18, 2018 - Novel bioengineering technique could help repair bone defects
July 18, 2018 - Researchers identify new potential target protein for colon cancer
July 18, 2018 - Air pollution contributes significantly to diabetes globally
July 18, 2018 - Cell membrane’s importance offers new strategy to fight infections
July 18, 2018 - Researchers identify key protein involved in irregular brain cell activity
July 18, 2018 - 3D modeling of drug resistance could lead to more effective cancer treatment
July 18, 2018 - Hunger hormones could be key to new treatments for drug, alcohol addiction
July 18, 2018 - Nitrate-cured meats may contribute to mania, study finds
July 18, 2018 - Why men may recover more quickly from influenza infections than women
July 18, 2018 - Study finds discharge against medical advice as predictor of readmissions in heart attack patients
July 18, 2018 - KemPharm Announces Top Line Results from KP415.E01 Efficacy and Safety Trial in Children With ADHD
July 18, 2018 - Self-control and obesity: Gender matters in children
July 18, 2018 - Bioengineers, diabetes researchers convene to discuss future concepts for precision medicine
July 18, 2018 - New findings support more conservative use of ED neuroimaging for non-index seizures
July 18, 2018 - Practicing yoga benefits pregnant women, study suggests
July 18, 2018 - New strategy may lead to more accurate breast cancer diagnoses
July 18, 2018 - FDA Approves Symtuza (D/C/F/TAF), the First and Only Complete Darunavir-Based Single-Tablet Regimen for the Treatment of HIV-1 Infection
July 18, 2018 - New guide helps hospitals pick right partner to handle hospitalist services
July 18, 2018 - Deep data dive helps predict cerebral palsy
July 18, 2018 - Stricter firearm legislation associated with reduced murder and suicide rates
July 18, 2018 - Physical and sexual abuse in childhood associated with endometriosis risk
July 18, 2018 - Omega 3 supplements do not reduce risk of heart disease, stroke or death
July 18, 2018 - GSA’s new publication provides support for safe use of OTC analgesics by older adults
July 18, 2018 - Researchers receive grant from U.S. Department of Education to study children with HFASD
July 18, 2018 - Early childhood adversity increases sensitivity of the body’s immune response to cocaine
July 18, 2018 - Parental incarceration affects health behaviors of children in adulthood
July 18, 2018 - Researchers find that yellow fever and Asian tiger mosquitoes can carry new virus
July 18, 2018 - Two Regimens Fail to Stop Declines in β-Cell Function
July 18, 2018 - Researchers apply computing power to track the spread of cancer
July 18, 2018 - Olfactory receptors play pathophysiological role in all organs than merely smell perception
July 18, 2018 - Fish consumption associated with lower risk of early death
Lesser-known CRS-HIPEC treatment for cancers that have spread to abdominal cavity

Lesser-known CRS-HIPEC treatment for cancers that have spread to abdominal cavity

image_pdfDownload PDFimage_print

While cancer treatment advances are being made in the areas of precision medicine and immunotherapy, a unique combination of traditional therapies can also provide some cancer patients a treatment option that may provide significant benefit. For instance a lesser-known treatment combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is being increasingly used to treat cancers that have spread to the abdominal cavity – a condition known as peritoneal metastases. This treatment strategy involves the surgical removal of metastatic cancer deposits followed by heated chemotherapy given within the abdominal cavity designed to obliterate the remaining invisible cancer cells that may be present in the tissues.

Rutgers Cancer Institute of New Jersey is one of the few centers in the region whose surgeons have vast expertise in managing patients’ disease through this unique treatment. Having recently expanded its surgical and research focus on cancers of the abdominal cavity, the Institute has named H. Richard Alexander, MD, FACS, as its new chief surgical officer. Dr. Alexander, who is also a professor of surgery at Rutgers Robert Wood Johnson Medical School, has been pioneering the development of CRS-HIPEC through its evolution over the past two decades. He shares more about the procedure.

Q: Tell us more about CRS-HIPEC.

A: CRS and HIPEC are really two complementary components of treatment. CRS is the systematic removal of all visible cancer deposits in the abdominal cavity, but it is ineffective at addressing invisible or microscopic tumor deposits that are present in the abdominal tissues. HIPEC is a strategy of delivering an intensive dose of chemotherapy right to the tissues that are at risk of harboring invisible cancer cells. HIPEC is administered in the operating room right after the CRS is completed. It usually takes about 90 minutes and may be an optimal way of ensuring that the chemotherapy is distributed to all the tissues in the abdomen. It also takes advantage of the fact that many chemotherapy agents have an enhanced effect on killing cancer cells under hyperthermic conditions — when the temperature in the tissues is slightly increased.

Q: What kind of cancers can it treat?

A: The CRS and HIPEC combination has been used to treat patients with a variety of cancers that have the ability to spread diffusely throughout the abdominal cavity such as colorectal cancer, appendiceal cancer, ovarian cancer, mesothelioma, and in some cases gastric or other cancers. There is growing evidence to support the use of CRS and HIPEC for some conditions. However, its use in some settings is more controversial.

Q: Who is the best candidate for this procedure?

A: A surgical oncologist with expertise in CRS and HIPEC is the best person to discuss whether or not this treatment is an option for someone who has abdominal spread of cancer. The decision to proceed with the procedure should be a collaborative one involving the patient, the family, and all the cancer specialists involved. Ideally, it should be considered part of a thoughtful strategy that may include additional treatment before and after the procedure to assist in controlling the cancer. A patient should be in fundamentally good medical condition and not have other medical problems that might make the procedure unacceptably risky. Sometimes, additional testing may be necessary prior to the procedure.

Q: Why is this procedure not widely offered at all hospitals or cancer treatment centers?

A: CRS-HIPEC requires specialized expertise and equipment not available at all treatment centers. It is widely acknowledged that complications and the risk of the procedure are minimized when performed by surgeons and at medical centers with experience in this area, such as Rutgers Cancer Institute of New Jersey.

Q: What is the benefit of receiving CRS-HIPEC at a National Cancer Institute-designated Comprehensive Cancer Center like Rutgers Cancer Institute?

A: The reality is that patients who undergo the CRS-HIPEC procedure, even when it is considered successful, are at a higher risk of experiencing a recurrence at some point during follow-up surveillance. Because of that it is beneficial for a patient to be cared for at a facility where second-line treatment options and access to clinical trials are available. ​

Source:

https://www.cinj.org/turning-heat-chemotherapy

Tagged with:

About author

Related Articles