Breaking News
March 26, 2019 - Finding the elusive drinking ‘brake’
March 26, 2019 - Using the Mastermind strategy in brain research
March 26, 2019 - Synthetic biological logic gate could one day be used to modify cellular function
March 26, 2019 - Researchers uncover large-scale brain patterns and networks which control sleep
March 26, 2019 - Scientific Symposium at LABVOLUTION focuses on key issues in life sciences
March 26, 2019 - Screen time plus snacking could increase risk for metabolic syndrome in teens
March 26, 2019 - Attention, Seniors: Drink More Water and Head Off Disease
March 26, 2019 - Peptide shows promise for protecting kidneys from nephritis
March 26, 2019 - Causes of diabetes decline or disappear when ‘zombie cells’ are removed, shows study
March 26, 2019 - Scientists identify common genetic variants associated with post-stroke recovery
March 26, 2019 - Study finds link between menopause and changes in body composition
March 26, 2019 - Higher levels of sex hormones in older men related to lower biological age
March 26, 2019 - Research links participation in team sports to larger hippocampal volumes in children
March 26, 2019 - Cerveau announces research collaboration agreement with Eisai for novel tau imaging agent
March 26, 2019 - New technique measures frequency of sounds emitted from biological structures
March 26, 2019 - Removal of ‘zombie cells’ alleviates causes of diabetes in obese mice
March 26, 2019 - Women exposed to deepwater horizon oil spill continue to experience PTSD symptoms
March 26, 2019 - Shaping new treatments for tuberculosis
March 26, 2019 - Understanding genetic interactions holds key to new personalized therapies
March 26, 2019 - Nervous system relies on guidance cues for neuronal axons to reach destinations
March 26, 2019 - Altering gut microbiome may be potential treatment option for PCOS
March 26, 2019 - Moleculin Files with FDA for Expedited Approval Pathway for Annamycin
March 26, 2019 - GPs play pivotal role in ensuring success of new Faster Diagnosis Standard for Cancer
March 26, 2019 - New clues discovered to lung transplant rejection
March 26, 2019 - New study offers insight into development of delusions
March 26, 2019 - Children’s ball pits full of pathogenic microbes
March 26, 2019 - Exploring pathophysiological factors that link sleep problems and Alzheimer’s disease
March 26, 2019 - Walking downhill after meals can reduce bone resorption in postmenopausal women with diabetes
March 26, 2019 - USA LESS Issues Voluntary Nationwide Recall of LEOPARD Miracle Honey Due to Presence of Undeclared Sildenafil
March 26, 2019 - CT scan prior to spine fusion finds almost half of patients had undiagnosed osteoporosis
March 26, 2019 - After 2 Apparent Student Suicides, Parkland Grieves Again
March 25, 2019 - Inherited form of rickets improves more with new injectable medicine than conventional therapy
March 25, 2019 - Trastuzumab Tied to Higher Long-Term Risk for Heart Failure
March 25, 2019 - Personal context directly affects CPAP use
March 25, 2019 - Mosquito tracking key to preventing disease outbreaks
March 25, 2019 - Scientists Detect Hidden Signals from Beneficial Bacteria
March 25, 2019 - Treating women with thyroid antibodies with Levothyroxine do not increase live birth rate
March 25, 2019 - Brain area that only processes spoken, not written words identified
March 25, 2019 - Race and ethnicity influence fracture risk in diabetic patients
March 25, 2019 - Researchers report new regenerative medicine approach for treating osteoarthritis of the knee
March 25, 2019 - Exposure to dim light at night may contribute to spread of breast cancer to bones
March 25, 2019 - Benefits of osteoporosis treatment in postmenopausal women outweigh the perceived risks
March 25, 2019 - Researchers find evidence of Cryptosporidium parasite in Minnesota’s public water systems
March 25, 2019 - Three Clues to Raised Risk of Miscarriage
March 25, 2019 - Structured play helps toddlers self-regulate, altering their life course
March 25, 2019 - Translating horror into justice: Stanford psychiatrist advocates for human rights
March 25, 2019 - HORIBA Medical introduces D-Dimer reagent for Yumizen G hemostasis range
March 25, 2019 - Recurrent pregnancy loss may be caused by sperm DNA damage, finds study
March 25, 2019 - Special Collection tracks development of new diagnostic tests for tuberculosis
March 25, 2019 - Air Force develops genetic test to predict mental performance
March 25, 2019 - To abort or not to abort—making difficult choices alone
March 25, 2019 - Computer vision technology could aid ICU care by spotting movement
March 25, 2019 - IONTAS wins ‘Small Business of the Year’ category at Cambridge News Business Excellence Awards 2019
March 25, 2019 - First postpartum depression drug gets FDA nod
March 25, 2019 - Research Recognition Award will help improve lives of young people with absence epilepsy
March 25, 2019 - Bisphosphonates to treat osteoporosis appears to be beneficial for all women
March 25, 2019 - Time-restricted eating may prove to be a dietary intervention against breast cancer
March 25, 2019 - Researchers develop new augmented reality app to assess spatial memory
March 25, 2019 - Dolomite Bio releases new Drop-seq datasets for single-cell RNA sequencing
March 25, 2019 - Hemoglobin A1c blood test may underestimate prevalence of diabetes
March 25, 2019 - Immune system errors linked to development of childhood leukemia
March 25, 2019 - Eating leafy green vegetables may help maintain muscle strength and mobility
March 25, 2019 - BMA secures state-backed clinical negligence indemnity scheme for GP trainees
March 25, 2019 - Biohaven Announces Completion of Pre-NDA Meeting With FDA for Oral CGRP Receptor Antagonist Rimegepant
March 25, 2019 - Adding breakfast to classrooms may have a health downside
March 25, 2019 - She Was Dancing On The Roof And Talking Gibberish. A Special Kind Of ER Helped Her.
March 25, 2019 - KNAUER introduces new Sepapure FPLC columns and media for protein purification tasks
March 25, 2019 - Weight loss in obese migraine sufferers can improve their quality of life
March 25, 2019 - Exposure to particulate air pollution may lead to reduced sperm production
March 25, 2019 - Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis
March 25, 2019 - New guideline focuses on strategies to improve health of older adults with diabetes
March 25, 2019 - Study evaluates prescribing of preventive drugs at the end of life in older adults with cancer
March 25, 2019 - Radial or femoral approaches for PCI are equal in terms of survival in heart attack patients
March 25, 2019 - Study shows how some autoimmune diseases are more closely related than others
March 25, 2019 - Long term opioid medications impacts production of important hormones
March 25, 2019 - FDA Issues Complete Response Letter for Zynquista (sotagliflozin)
March 25, 2019 - CDC researchers report on trends in hospital breastfeeding policies
March 25, 2019 - States Push For Caregiver Tax Credits
March 25, 2019 - Females on ketogenic diet fail to show metabolic benefits in animal model
March 25, 2019 - Modulating stiffness of blood-forming stem cells could facilitate mobilization procedures
Meningitis vaccination strategy in Africa found to be effective, economical

Meningitis vaccination strategy in Africa found to be effective, economical

image_pdfDownload PDFimage_print
Meningitis vaccination strategy in Africa found to be effective, economical
Alternative Vaccination Strategy for Meningitis in Africa. Credit: Yale University

In sub-Saharan Africa, meningococcal meningitis continues to pose a serious health threat, with sporadic epidemics resulting in some 30,000 cases each year. While all people are susceptible, young children are at the highest risk, and over 50 percent of those infected will die if not diagnosed and treated.

An international team of scientists led by Reza Yaesoubi, Ph.D., assistant professor at the Yale School of Public Health, created a novel mathematical model of meningococcal epidemics in Burkina Faso that allowed them to compare several different meningococcal vaccination strategies in terms of their estimated costs and expected health outcomes.

The model revealed that the introduction of newer polyvalent conjugate vaccines into the routine immunization schedule—in combination with a catch-up campaign during which children and young adults were also given the polyvalent conjugate vaccine—was both cost-effective and potentially cost-saving compared to the current public health strategy that uses the meningococcal serogroup A conjugate vaccine for routine immunization of children and polysaccharide vaccines during outbreaks.

These results suggest that new strategies which incorporate polyvalent conjugate vaccines can have substantial health benefits over current practice in Burkina Faso and elsewhere in Africa’s “meningitis belt,” which stretches across the center of the continent. The findings are published in the journal PLOS Medicine.

“Our findings suggest that instead of waiting for the next meningococcal epidemic to occur, start the immunization of impacted districts, it is more cost-effective, and potentially cost-saving, to immunize children and young adults though a nationwide catch-up vaccination campaign,” said Yaesoubi, the study’s lead author. “The population immunity against the meningococcal disease could then be maintained for years by immunizing babies before they turn 1 year old through the routine immunization program.”

Since the late 1970s, control of meningitis epidemics has relied on the use of polysaccharide vaccines to blunt the magnitude of these outbreaks after they have started. This reactive vaccination approach is limited as its effectiveness requires a very rapid scale of a vaccine campaign after recognition of an outbreak, and the polysaccharide vaccines used are not protective for infants under 2 years old and do not induce long-term protection.

More recently, conjugate vaccines which can be used in younger children and offer longer term immunity have been developed and been successfully used in routine vaccination programs to prevent the occurrence of meningococcal outbreaks. The introduction of a meningococcal serogroup A conjugate vaccine into routine immunization programs has been associated with a massive decline in serogroup A associated disease. However, other meningococcal serogroups still circulate widely in the region, and the continuing threat of sporadic epidemics require maintenance of capacity for reactive vaccination campaigns.

The development of newer polyvalent conjugate meningococcal vaccines effective against nearly all circulating serogroups offers the promise of more effective prevention of meningococcal epidemics in this region. This study offers insight on the best way to use these novel polyvalent conjugate vaccines to control meningococcal epidemics in Burkina Faso.


Explore further:
Recommendations updated for meningococcal vaccine in HIV

More information:
Reza Yaesoubi et al. The cost-effectiveness of alternative vaccination strategies for polyvalent meningococcal vaccines in Burkina Faso: A transmission dynamic modeling study, PLOS Medicine (2018). DOI: 10.1371/journal.pmed.1002495

Journal reference:
PLoS Medicine

Provided by:
Yale University

Tagged with:

About author

Related Articles