Breaking News
April 21, 2019 - Angry dreams explained by brain waves
April 20, 2019 - Parenteral Antimicrobial Tx at Home Burdens Children’s Caregivers
April 20, 2019 - Diabetes treatment may keep dementia, Alzheimer’s at bay
April 20, 2019 - New bandage-like biosensor collects and analyzes sweat
April 20, 2019 - A comprehensive, centralized database of bovine milk compounds
April 20, 2019 - Two new epigenetic regulators maintain self-renewal of embryonic stem cells
April 20, 2019 - New Evidence That Veggies Beat Steak for Heart Health
April 20, 2019 - Study reveals genes associated with heavy drinking and alcoholism
April 20, 2019 - Texas A&M AgriLife becomes the newest member of NutriRECS international consortium
April 20, 2019 - In most states, insurance won’t cover addiction treatments
April 20, 2019 - Computer-based memory games may be beneficial for individuals with fragile X syndrome
April 20, 2019 - Timing of food intake influences molecular clock in the liver of mice
April 20, 2019 - Precise decoding of breast cancer cells paves way for new treatment option
April 20, 2019 - Scientists use 3D imaging to help model complex processes performed by placenta
April 20, 2019 - MediciNova Announces Plans to Move Forward with a Phase 3 Trial of MN-166 (ibudilast) in ALS
April 20, 2019 - Genetic variants that protect against obesity could aid new weight loss medicines
April 20, 2019 - New technology developed for microscopic imaging in living organisms
April 20, 2019 - when quitting cigarettes, consider using more nicotine, not less
April 20, 2019 - Key proteins can block Listeria without triggering the death of host cells
April 20, 2019 - Researchers create a working model of cerebral tract to study brain function
April 20, 2019 - New study shows that microbes can help break toxic chemical in dust
April 20, 2019 - Scientists use NIR light and injected DNA nanodevice to guide stem cells to injury
April 20, 2019 - Microbial Features ID’d for Pediatric Irritable Bowel Syndrome
April 20, 2019 - Study reveals patterns of drug intoxication deaths, organ donors across the US
April 20, 2019 - Scientists deploy CRISPR gene-editing tool to engineer multiple edits
April 20, 2019 - AHA News: Here’s How Middle-Aged People — Especially Women — Can Avoid a Heart Attack
April 20, 2019 - Charcot foot: MedlinePlus Medical Encyclopedia
April 20, 2019 - France to ban popular breast implants over cancer risk: media
April 20, 2019 - Researchers explore whether time of day can affect the body’s response to physical exertion
April 20, 2019 - CPAP brings longer life for obese people with sleep apnea: Study
April 20, 2019 - New discovery transforms conventional microfluidics into open-space microfluidics
April 20, 2019 - An accurate estimation of the overall cost of bacterial resistance in French hospitals during 2015 and 2016
April 20, 2019 - ‘PRO-cision Medicine’ approach helps personalize care for patients with cancer
April 19, 2019 - TG Therapeutics Receives Orphan Drug Designation for Umbralisib from the U.S. Food and Drug Administration for the Treatment of Marginal Zone Lymphoma
April 19, 2019 - Screen time—even before bed—has little impact on teen well-being: study
April 19, 2019 - Cytosurge’s first FluidFM User Conference
April 19, 2019 - New study finds that previously described differences among endoscopists are not true
April 19, 2019 - Study compares effectiveness and cost of gene therapy and HSCT in major beta-thalassemia
April 19, 2019 - Scientific breakthrough provides new hope for people living with multiple sclerosis
April 19, 2019 - New Virtual Reality Therapy game could offer relief for patients with chronic pain, mobility issues
April 19, 2019 - Emergency medicine doctors find better way to treat severe epileptic seizures in children
April 19, 2019 - MedlinePlus: Cholesterol Good and Bad
April 19, 2019 - For busy medical students, two-hour meditation study may be as beneficial as longer course
April 19, 2019 - Music therapy helps young patients feel better
April 19, 2019 - Molecular target UNC45A is essential for cancer cell proliferation and tumor growth
April 19, 2019 - Crackling and wheezing could be the sounds of a progressing lung disease
April 19, 2019 - Key research takeaways from ECCMID 2019
April 19, 2019 - AI Can Identify Model of Cardiac Rhythm Device From Chest X-Ray
April 19, 2019 - New way to combat childhood anxiety: treat the parents
April 19, 2019 - Women getting C-sections best judge of own pain medication needs | News Center
April 19, 2019 - Light-intensity physical activity associated with healthy brain aging
April 19, 2019 - Immune responses that prevent fungal infections may eliminate Trichinella spiralis
April 19, 2019 - Exercising in the morning, rather than at night, may yield better results, shows study
April 19, 2019 - Why eating ‘right’ could cause you to stray from your diet
April 19, 2019 - Health Tip: Antidepressant Precautions – Drugs.com MedNews
April 19, 2019 - Bigger portions lead to preschoolers eating more over time
April 19, 2019 - Specific strains of Staphylococcus aureus linked to wounds that do not heal
April 19, 2019 - Morning exercise may burn more calories
April 19, 2019 - Nominations invited for prestigious awards at Pittcon Conference & Expo 2020
April 19, 2019 - Revolutionary discovery paves new way for treatment of necrotizing enterocolitis
April 19, 2019 - Drug that treats high blood pressure shows promise against neurodegenerative diseases
April 19, 2019 - More care is needed for patients after kidney transplantations, reports research
April 19, 2019 - Virtual reality offers benefits for Parkinson’s disease patients
April 19, 2019 - Liver Illness Strikes Latino Children Like A ‘Silent Tsunami’
April 19, 2019 - Disruptive behaviors in autistic children linked to reduced brain connectivity
April 19, 2019 - New insights into how vitamin D affects immune system
April 19, 2019 - Microfluidic-based drug screening chip identifies antibiotic interactions in eight hours
April 19, 2019 - Research sheds light on how hepatitis B virus establishes chronic infection
April 19, 2019 - New scoring system based on genetic markers predicts obesity risk at birth
April 19, 2019 - Pfizer Announces Presentation of Data from a Phase 2 Study of its 20-Valent Pneumococcal Conjugate Vaccine Candidate Being Investigated for the Prevention of Invasive Disease and Pneumonia in Adults Aged 18 Years and Older
April 19, 2019 - Exercise can improve non-motor symptoms of Parkinson’s disease
April 19, 2019 - Phasefocus to launch new cell imaging system
April 19, 2019 - KZFPs play a key role in the regulation of human genome
April 19, 2019 - DWK Life Sciences offers Workflow Solutions to improve productivity
April 19, 2019 - Bedfont wins 2nd accolade at the South East FSB Awards 2019
April 19, 2019 - Extracts of ginkgo seeds show antibacterial activity on pathogens that cause skin infections
April 19, 2019 - Groundbreaking experiment in pigs challenges the notion about brain damage
April 19, 2019 - Improving the quality of digital pathology imaging
April 19, 2019 - Scientists get closer to injecting artificial lymph nodes into people to fight disease
April 19, 2019 - Exercises and swimming goggles may reduce adverse effects on eye during long spaceflights
Diet During Pregnancy May Cut Offspring Allergy Risk

Diet During Pregnancy May Cut Offspring Allergy Risk

image_pdfDownload PDFimage_print

Action Points

  • Probiotics during pregnancy may reduce the risk of eczema in offspring, while fish oil supplementation may reduce the risk of potential egg allergy.
  • Note that, according to the study authors, these findings need to be considered when guidelines for pregnant women are updated.

Probiotics during pregnancy may reduce the risk of eczema in offspring, while fish oil supplementation may reduce the risk of potential egg allergy, a systematic review and meta-analysis found.

Nineteen trials suggested that maternal supplementation with probiotics taken during late pregnancy and lactation was associated with a reduced risk of eczema at ages ≤4 years (RR 0.78, 95% CI 0.68-0.90, I2=61%), reported Vanessa Garcia-Larsen, PhD, of the Johns Hopkins School of Public Health in Baltimore, and colleagues.

Moreover, six trials suggested that fish oil supplementation during pregnancy and lactation may be linked to a reduced risk of allergic sensitization to egg (RR 0.69, 95% CI 0.53-0.90, I2=15%), the authors wrote in PLoS Medicine.

They noted that while there is evidence that early dietary exposures could influence the development of immune-mediated health conditions, such as allergic and autoimmune diseases, “a comprehensive analysis of the relationship between all dietary exposures during pregnancy, lactation, or the first year of life” and risk of these diseases has not been undertaken.

Garcia-Larsen’s group also stated that while a World Allergy Organization guideline recommends prebiotic and probiotic supplements to prevent eczema, European, North American and Australian guidelines “do not support this.” Certain guidelines recommend exclusive breastfeeding for the first 4 to 6 months of life to reduce risk of eczema, food allergy, and wheezing, while recent Australasian guidelines recommended “oily fish or omega-3 fatty acid supplements during pregnancy” to reduce eczema.

“Our research suggests probiotic and fish oil supplements may reduce a child’s risk of developing an allergic condition, and these findings need to be considered when guidelines for pregnant women are updated,” said co-author Robert Boyle, MD, of Imperial College London, in a statement.

This evidence review was conducted to inform U.K. dietary recommendations for infants and their pregnant or lactating mothers, the authors said. They examined 260 studies about milk feeding, including one on breastfeeding promotion, and 173 studies of “other maternal or infant dietary exposures,” which included 80 trials of maternal, infant, or combined interventions.

The researchers found a high risk of bias in nearly half of the milk feeding studies and a quarter of studies on other dietary exposures. They noted this was due to “attrition bias in intervention studies and confounding bias in observational studies.” Findings of these studies were evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system of evidence.

Probiotic and prebiotic supplementation studies evaluated single or multiple organisms, given as capsules, powder, or part of a drink or infant formula milk at a dose of 1 to 10 billion colony-forming units per day. When examining the link between supplementation with probiotics during late pregnancy and lactation and risk of eczema, the absolute risk reduction was 44 cases per 1,000 (95% CI 20-64). The absolute risk reduction was 31 cases per 1,000 (95% CI 10-47) when examining the association between fish oil supplementation during pregnancy and lactation and risk of allergic sensitization to egg. GRADE certainty of these findings was moderate, the authors said.

But GRADE certainty of findings was low for other findings, such as:

  • Breastfeeding promotion reducing risk of eczema during infancy (one intervention trial)
  • Longer exclusive breastfeeding reducing type 1 diabetes mellitus (28 observational studies)
  • Probiotics reducing allergic sensitization to cow’s milk (nine observational studies)

Study limitations included that for many dietary exposures, evidence was inconclusive or inconsistent, so the authors were unable to “exclude the possibility of beneficial or harmful effects.” They also cited that their search date for observational studies was 2013, so this information “may benefit from an update.” They noted that they included abstract publications, since their exclusion can lead to publication bias, but there may be methodological bias due to lack of peer review.

“Despite allergies and eczema being on the rise, and affecting millions of children, we are still hunting for the root causes of these conditions, and how to prevent them,” Garcia-Larsen said in a statement. “This study has provided clues, which we now need to follow with further research.”

This study was supported by grants from the U.K. Food Standards Agency.

Garcia-Larsen disclosed support from the U.K. Food Standards Agency.

Other co-authors disclosed support from the U.K. Food Standards Agency and one co-author was a co-investigator and author of two of the trials included in this systematic review.

  • Reviewed by
    Robert Jasmer, MD Associate Clinical Professor of Medicine, University of California, San Francisco

2018-02-28T16:44:23-0500

Tagged with:

About author

Related Articles