Breaking News
April 27, 2018 - Alcohol Intake May Influence Oral Microbiome Composition
April 27, 2018 - What happens to our muscles during spaceflight and when living on Mars?
April 27, 2018 - Abdominal pain should be seen as a warning sign for invasive meningococcal disease
April 26, 2018 - Mediterranean diet enhances good bacteria living in the gut
April 26, 2018 - UA researchers aim to predict and prevent fatal disease in premature babies
April 26, 2018 - Researchers develop new method for early and accurate breast cancer screening
April 26, 2018 - Cytochalasin B-induced membrane vesicles successfully tested as vector for anti-tumor drug delivery
April 26, 2018 - Hospitals lure diabetes patients with self-care courses, but costs can weigh heavily
April 26, 2018 - Common therapy options for psoriasis can help reduce coronary plaque, study shows
April 26, 2018 - Kids Are Naturally as Fit as an ‘Iron Man’
April 26, 2018 - Traditional health claims about India’s ayurvedic foods help make them big business
April 26, 2018 - Maternal binge drinking may make offspring more vulnerable to mood problems and alcohol abuse
April 26, 2018 - VA hospitals provide better quality care than other health providers
April 26, 2018 - Cytosurge develops new 3D printing method that allows scientists to manufacture tiny, complex metal components
April 26, 2018 - Detailed genetic testing of head and neck cancers could lead to more personalized treatments
April 26, 2018 - Study shows new approach to improve survival rates for patients with stage IV Wilms tumors
April 26, 2018 - Nonsurgical technique enables people with spinal cord injuries to regain use of hands
April 26, 2018 - Elective induction of labor at 39 weeks decreases risks of C-section, other complications
April 26, 2018 - Hair products used by Black women contain dozens of hazardous chemicals
April 26, 2018 - Scientists create an atlas of the human genome
April 26, 2018 - New shape of DNA found in human cells
April 26, 2018 - Researchers target telomerase for killing NRAS-mutant melanoma cells
April 26, 2018 - Scientists improve growth of 3d brain models to better understand autism, dementia, schizophrenia
April 26, 2018 - Evox Therapeutics expands into new facilities at The Oxford Science Park
April 26, 2018 - Scientists discover new method for measuring cellular age
April 26, 2018 - UNC-Chapel Hill receives new award to help improve health of North Carolinians
April 26, 2018 - Study finds no evidence of chronic wasting disease transmissibility in macaques
April 26, 2018 - Study highlights impact of early detection on skin cancer survival
April 26, 2018 - Scientists discover culprit in reducing effectiveness of insulin
April 26, 2018 - Exploiting rabies virus machinery to usher Parkinson’s disease drug directly to the brain
April 26, 2018 - ‘Rapid autopsy’ programs seek clues to cancer within hours of death
April 26, 2018 - Personalised prescriptions according to your genetics
April 26, 2018 - ECDC analysis highlights measles vaccination gaps in teenagers and young adults
April 26, 2018 - Study assesses link between cognitive function levels and crash risk among older drivers
April 26, 2018 - Researchers uncover how obesity leads to cancer initiation
April 26, 2018 - Consuming large quantities of sugar during pregnancy can affect child’s cognition, shows study
April 26, 2018 - Researchers create new tool to measure patient uncertainty for predicting hospital readmissions
April 26, 2018 - FDA Alert: Lamictal (lamotrigine): Drug Safety Communication
April 26, 2018 - Massive single-cell survey of kidney cell types reveals new paths to disease
April 26, 2018 - Cognitive behavioral therapy can help children with autism manage emotional challenges
April 26, 2018 - CU Anschutz Medical Campus receives NIH grant to speed up discovery of new treatments
April 26, 2018 - Researchers discover significant distortions in leading genetics study method
April 26, 2018 - New combination therapy could improve survival in children with high-risk neuroblastoma
April 26, 2018 - Scientists clarify casual role of oxidative stress in metabolically abnormal and healthy obesities
April 26, 2018 - Home-based exercise program found ineffective for patients with peripheral artery disease
April 26, 2018 - Surgeries performed by older surgeons have lower patient mortality rates, study reveals
April 26, 2018 - New UCLA study could elucidate certain causes of infertility and miscarriage
April 26, 2018 - Choroidal Thickness Changes in Patients With Untreated DM
April 26, 2018 - Medical chemists discover peptic ulcer treatment metallodrug effective in ‘taming’ superbugs
April 26, 2018 - UB researchers build 3D-printed, drug-filled dentures to fight against infections
April 26, 2018 - Researchers find role of iron storage gene in slowing down prostate cancer growth
April 26, 2018 - Study suggests link between regular mid-day naps and neurocognitive function in teens
April 26, 2018 - Researchers gain ground-breaking insights into how inflammatory diseases work
April 26, 2018 - Injured U.S. Vet Receives World’s First Penis/Scrotum Transplant
April 26, 2018 - Researchers find existing drug effective at preventing onset of type 1 diabetes
April 26, 2018 - MGH researchers identify risk factors for drug overdose in youth with substance use disorders
April 26, 2018 - Researchers develop new vaccine to help people overcome bath salts abuse
April 26, 2018 - Genetic signature predicts diabetes diagnosis
April 26, 2018 - Study shows link between restless legs syndrome symptoms and brain structure
April 26, 2018 - MU researchers use new techniques to fight against diabetic retinopathy
April 26, 2018 - AAE’s new practice statements aim at improving patient care
April 26, 2018 - Expression of long non-coding RNAs can result in high levels of specific proteins involved in cancer
April 26, 2018 - FDA re-examining safety of new drug approved for Parkinson’s disease psychosis
April 26, 2018 - Unanimous Positive Result of FDA Advisory Committee Meeting for First Plant-Based Pharmaceutical Cannabidiol Treatment for Seizures in Patients with Two Rare, Severe Forms of Epilepsy
April 26, 2018 - Bacteria boost antifungal drug resistance in severe childhood tooth decay
April 26, 2018 - New study affirms bedtime habits of Americans
April 26, 2018 - Hospital patients are more interested in tracking their health data, research shows
April 26, 2018 - Study shows gene variations associated with malaria risk
April 26, 2018 - Inhealthcare teams up with MSKassist to combat problems related to obesity and aging
April 26, 2018 - Caffeine during pregnancy – babies 66 percent more likely to become overweight
April 26, 2018 - FDA Approves Jynarque (tolvaptan) to Slow Kidney Function Decline in Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease
April 26, 2018 - Pricey dental implants often best but insurance rarely pays
April 26, 2018 - Advion’s Peak Express software now available with the expression compact mass spectrometer
April 25, 2018 - Researchers find link between pneumonia in older people and PPI prescriptions
April 25, 2018 - Alcohol damages microbiome in the mouth
April 25, 2018 - Regular soaking in hot tub improves health outlook in obese women with PCOS
April 25, 2018 - FDA Alert: Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) Devices: Letter to Health Care Providers
April 25, 2018 - Sunshine could hold clues on the timing for a severe form of heart attack, study says
April 25, 2018 - Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system
April 25, 2018 - Biofeedback-assisted relaxation may help children during medical procedures
Diet During Pregnancy May Cut Offspring Allergy Risk

Diet During Pregnancy May Cut Offspring Allergy Risk

image_pdfDownload PDFimage_print

Action Points

  • Probiotics during pregnancy may reduce the risk of eczema in offspring, while fish oil supplementation may reduce the risk of potential egg allergy.
  • Note that, according to the study authors, these findings need to be considered when guidelines for pregnant women are updated.

Probiotics during pregnancy may reduce the risk of eczema in offspring, while fish oil supplementation may reduce the risk of potential egg allergy, a systematic review and meta-analysis found.

Nineteen trials suggested that maternal supplementation with probiotics taken during late pregnancy and lactation was associated with a reduced risk of eczema at ages ≤4 years (RR 0.78, 95% CI 0.68-0.90, I2=61%), reported Vanessa Garcia-Larsen, PhD, of the Johns Hopkins School of Public Health in Baltimore, and colleagues.

Moreover, six trials suggested that fish oil supplementation during pregnancy and lactation may be linked to a reduced risk of allergic sensitization to egg (RR 0.69, 95% CI 0.53-0.90, I2=15%), the authors wrote in PLoS Medicine.

They noted that while there is evidence that early dietary exposures could influence the development of immune-mediated health conditions, such as allergic and autoimmune diseases, “a comprehensive analysis of the relationship between all dietary exposures during pregnancy, lactation, or the first year of life” and risk of these diseases has not been undertaken.

Garcia-Larsen’s group also stated that while a World Allergy Organization guideline recommends prebiotic and probiotic supplements to prevent eczema, European, North American and Australian guidelines “do not support this.” Certain guidelines recommend exclusive breastfeeding for the first 4 to 6 months of life to reduce risk of eczema, food allergy, and wheezing, while recent Australasian guidelines recommended “oily fish or omega-3 fatty acid supplements during pregnancy” to reduce eczema.

“Our research suggests probiotic and fish oil supplements may reduce a child’s risk of developing an allergic condition, and these findings need to be considered when guidelines for pregnant women are updated,” said co-author Robert Boyle, MD, of Imperial College London, in a statement.

This evidence review was conducted to inform U.K. dietary recommendations for infants and their pregnant or lactating mothers, the authors said. They examined 260 studies about milk feeding, including one on breastfeeding promotion, and 173 studies of “other maternal or infant dietary exposures,” which included 80 trials of maternal, infant, or combined interventions.

The researchers found a high risk of bias in nearly half of the milk feeding studies and a quarter of studies on other dietary exposures. They noted this was due to “attrition bias in intervention studies and confounding bias in observational studies.” Findings of these studies were evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system of evidence.

Probiotic and prebiotic supplementation studies evaluated single or multiple organisms, given as capsules, powder, or part of a drink or infant formula milk at a dose of 1 to 10 billion colony-forming units per day. When examining the link between supplementation with probiotics during late pregnancy and lactation and risk of eczema, the absolute risk reduction was 44 cases per 1,000 (95% CI 20-64). The absolute risk reduction was 31 cases per 1,000 (95% CI 10-47) when examining the association between fish oil supplementation during pregnancy and lactation and risk of allergic sensitization to egg. GRADE certainty of these findings was moderate, the authors said.

But GRADE certainty of findings was low for other findings, such as:

  • Breastfeeding promotion reducing risk of eczema during infancy (one intervention trial)
  • Longer exclusive breastfeeding reducing type 1 diabetes mellitus (28 observational studies)
  • Probiotics reducing allergic sensitization to cow’s milk (nine observational studies)

Study limitations included that for many dietary exposures, evidence was inconclusive or inconsistent, so the authors were unable to “exclude the possibility of beneficial or harmful effects.” They also cited that their search date for observational studies was 2013, so this information “may benefit from an update.” They noted that they included abstract publications, since their exclusion can lead to publication bias, but there may be methodological bias due to lack of peer review.

“Despite allergies and eczema being on the rise, and affecting millions of children, we are still hunting for the root causes of these conditions, and how to prevent them,” Garcia-Larsen said in a statement. “This study has provided clues, which we now need to follow with further research.”

This study was supported by grants from the U.K. Food Standards Agency.

Garcia-Larsen disclosed support from the U.K. Food Standards Agency.

Other co-authors disclosed support from the U.K. Food Standards Agency and one co-author was a co-investigator and author of two of the trials included in this systematic review.

  • Reviewed by
    Robert Jasmer, MD Associate Clinical Professor of Medicine, University of California, San Francisco

2018-02-28T16:44:23-0500

Tagged with:

About author

Related Articles