Breaking News
October 15, 2018 - Innovative brain tumor operation set to tailor to patients’ needs
October 15, 2018 - Findings offer new insight into early changes that occur during AD pathology
October 15, 2018 - Neurons regulating reproductive hormone release have different activity in epileptic mice
October 15, 2018 - More parents are concerned about taking babies swimming in public pools
October 15, 2018 - Health Tip: Know the Risk Factors for Lower Back Pain
October 15, 2018 - Study shows cigarillo flavors enhanced by high-intensity sweeteners
October 15, 2018 - Study traces hospital-acquired bloodstream infections to patients’ own bodies | News Center
October 15, 2018 - Abnormal vision in childhood can affect development of brain areas responsible for attention
October 15, 2018 - Color-changing contact lens could help doctors to monitor eye disease medications
October 15, 2018 - Tobacco heating products cause less staining to teeth than conventional cigarettes
October 15, 2018 - Young adults who are obese can expect to lose up to 10 years in life expectancy
October 15, 2018 - Scientists uncover how proteins meet on the cell membrane
October 15, 2018 - Affordable housing with supportive social services for senior citizens can reduce hospital use
October 15, 2018 - Following a Tissue Sample
October 15, 2018 - Prisoners need drug and alcohol treatments but AA programs aren’t the answer
October 15, 2018 - Andrea Califano and Jordan Orange Elected to National Academy of Medicine
October 15, 2018 - The impending risk of African Swine Fever Virus
October 15, 2018 - Breastfeeding reduces the number of antibiotic-resistant bacteria in infant gut
October 15, 2018 - Researchers develop comprehensive molecular atlas of postnatal mouse heart development
October 15, 2018 - ObsEva SA Presents Clinical Data from Phase III IMPLANT 2 Trial of Nolasiban in IVF at the American Society of Reproductive Medicine (ASRM) Annual Meeting
October 15, 2018 - Engineering teratoma-derived fibroblasts to enhance osteogenesis
October 15, 2018 - Lab study shows effectiveness of potential therapy for treatment-resistant hypothyroidism
October 15, 2018 - JCU study firms up association between diet and depression
October 15, 2018 - Researchers to study the use of CRISPR on human liver on-a-chip platform
October 15, 2018 - Sub-concussive impacts not associated with decline in neurocognitive function
October 15, 2018 - Researchers find potential treatment to halt premature labor and birth
October 15, 2018 - As U.S. suicides rates rise, Hispanics show relative immunity
October 15, 2018 - FDA Issues a Complete Response Letter to Acacia Pharma for Barhemsys
October 15, 2018 - Photoactive bacteria bait may help in fight against MRSA infections
October 15, 2018 - Increasing vigorous exercise reduces risk factors of type 2 diabetes, cardiovascular disease in children
October 15, 2018 - First-of-its-kind study to test a personalized vaccine in cancer patient
October 15, 2018 - Extension trial assesses benefit of switching from flash monitoring to RT-CGM for hypoglycemia
October 15, 2018 - Half of parents say young children are afraid of doctor’s visits
October 15, 2018 - Study shows how fingerprint-based drug screening works on the living and deceased
October 15, 2018 - Study reveals potential to monitor progression of Alzheimer’s disease by measuring brain antioxidant levels
October 15, 2018 - FDA Approves Xarelto to Reduce the Risk of Major Cardiovascular Events in Patients with Chronic Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD)
October 15, 2018 - Promising new therapeutic approach against Ebola virus identified
October 15, 2018 - Study unravels how cancer stem cells use normal genes in abnormal ways
October 15, 2018 - Healthcare systems fail to deliver at affordable prices finds report
October 15, 2018 - Intensive BP Therapy in Diabetes May Lower Risk for CV Events
October 15, 2018 - Muscle relaxants increase risk of respiratory complications
October 15, 2018 - Female birds become more promiscuous after hatchings fail in the first breeding attempt
October 15, 2018 - Humans occupied Madagascar thousands of years later than previously thought
October 15, 2018 - Is Kidney Dialysis Always Needed When Septic Shock Strikes?
October 15, 2018 - Study shows invasive lung cancer surgery can lead to long-term opioid use
October 15, 2018 - Sugar, a “sweet” tool to understand brain injuries
October 14, 2018 - King’s commemorates activities and research on World Arthritis Day
October 14, 2018 - Humana and VFW NY team up on Stop 22 initiative to increase awareness of veterans committing suicide
October 14, 2018 - Water fluoridation contributes to urinary fluoride levels in pregnant women in Canada
October 14, 2018 - Study of children in Romanian orphanages tells cautionary tale about family separation
October 14, 2018 - Previous Endologix AFX Safety Notice classified by FDA as Class I recall
October 14, 2018 - Legal scholars sound alarm on academies’ report about returning research results to participants
October 14, 2018 - UNIST selects six extraordinary scholars to be induced as ‘Rising-star Distinguished Professor’
October 14, 2018 - Scientists find new way to help asthmatics breathe more easily
October 14, 2018 - New ‘gag rule’ may adversely impact health care of pregnant women
October 14, 2018 - Rosacea – Genetics Home Reference
October 14, 2018 - When the fighting crosses the line
October 14, 2018 - New findings could benefit patients with triple-negative breast cancer
October 14, 2018 - UK Biobank provides wealth of information for further genetic studies
October 14, 2018 - KHN’s ‘What the Health?’ Falling premiums and rising political tensions
October 14, 2018 - Duvelisib Promising for Chronic Lymphocytic Leukemia, SLL
October 14, 2018 - Tailored drug cocktails offer hope to kids with aggressive brain tumors
October 14, 2018 - Common gene variants linked to migraine risk in African-American children
October 14, 2018 - Funding requests are being accepted by BlueCross BlueShield of Tennessee Community Trust
October 14, 2018 - Using pulsed electric fields in cancer therapy
October 14, 2018 - Major Childbirth Complications More Likely for Black Women
October 14, 2018 - Young cancer survivors at greater risk of mental health disorders
October 14, 2018 - Common herbicide compound could help fight hospital-acquired fungal infections
October 14, 2018 - Alterations in genes encoding proteins contribute to ADHD development
October 14, 2018 - New patient-centric website launched in Europe to empower people with chronic conditions
October 14, 2018 - Antimicrobial signaling molecule has lower activity against hepatitis C virus in most humans
October 14, 2018 - Genomic dark matter activity connects Parkinson’s and psychiatric diseases
October 14, 2018 - Cornell dots equipped with antibody fragments offer a new cancer weapon
October 14, 2018 - Addressing social and cultural factors is key to reducing burden of type 2 diabetes
October 14, 2018 - Study reveals why females age more slowly than males
October 14, 2018 - DNA vaccine shown to provide long-term protection from Ebola
October 14, 2018 - Gene therapy shown to remove core component of Parkinson’s disease
October 14, 2018 - Obamacare premiums dip for first time. Some call it a correction
October 14, 2018 - Scientists use haploid stem cells to produce mice with same-sex parents
October 14, 2018 - New transgenic mouse model sheds light on biological causes of Parkinson’s disease
Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetes

Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetes

image_pdfDownload PDFimage_print

A wearable medical patch measuring the beat-to-beat variation in heart rate is a promising device for the early detection of hypoglycemia, or low blood sugar, in type 1 diabetes, according to the researchers who tested the new monitor. Results of their preliminary study will be presented Saturday at ENDO 2018, the Endocrine Society’s 100th annual meeting in Chicago.

Hypoglycemia is common in children and adults with type 1 diabetes. When untreated, severe hypoglycemia can lead to seizures, loss of consciousness or even death. Sometimes people with diabetes do not recognize symptoms of low blood sugar, a problem called impaired awareness of hypoglycemia. Although wearing a continuous glucose meter can help identify hypoglycemia, the glucose sensor, inserted under the skin, typically has a delay.

“This delay can compromise the accuracy of measuring low glucose values,” said the study’s principal investigator, Marleen Olde Bekkink, M.D., Ph.D., an endocrinology fellow at Radboud University Medical Center in Nijmegen, Netherlands. “People with impaired awareness of hypoglycemia may need to wear an additional monitor.”

Past research found that hypoglycemia speeds one’s heart rate and alters heart rate variability, which is the normal beat-to-beat variation in heartbeats. Olde Bekkink and her colleagues tested the feasibility detecting hypoglycemia using a commercially available biosensor called the HealthPatch (from VitalConnect, San Jose, Calif.) that measures heart rate and a single-lead electrocardiogram, or ECG. The patch continuously measured the heart rate of 27 men and women with type 1 diabetes and self-reported frequent impaired awareness of hypoglycemia. All study subjects wore the adhesive patch on their chest, plus a continuous glucose meter, for five days at home. In a diary, they recorded any low blood sugar level (below 70 milligrams per deciliter), verified by fingerstick measurement.

Wireless technology transmitted the heart rate data to a mobile Apple device, either an iPhone or iPod. Then the investigators used an algorithm they developed to determine various parameters of heart rate variability. They conducted their primary analysis on 39 hypoglycemic events that occurred in 10 subjects.

In 28, or 72 percent, of the low blood sugar events, the algorithm detected clear patterns of change in heart rate variability at the start of hypoglycemia, Olde Bekkink reported. She said these changes correspond with what occurs at the beginning of low blood sugar: an activated sympathetic nervous system and suppressed activity of the parasympathetic nervous system.

“Timely detection of impending hypoglycemia is critical to avoid severe, potentially life-threatening hypoglycemia,” Olde Bekkink said. “Our proof-of-principle study found that measuring heart rate variability using a wearable device in an outpatient setting seems promising for alerting to upcoming hypoglycemia.”

Because 11 hypoglycemic events displayed no detectable changes, Olde Bekkink said they must further refine the algorithm to increase its accuracy and precision before being able to use the biosensor in daily practice for patients with type 1 diabetes. Then the researchers would translate the data into an audiovisual hypoglycemia alert sent to a mobile device, she noted.

Source:

https://www.endocrine.org/

Tagged with:

About author

Related Articles