Breaking News
April 18, 2019 - Scientists enter research collaboration to find a cure for cancer
April 18, 2019 - Study to compare benefits of tai chi and mindfulness meditation on MS symptoms
April 18, 2019 - Gestational diabetes during pregnancy may increase risk of type 1 diabetes in children
April 18, 2019 - Is a New Remedy for Body Odor on the Horizon?
April 18, 2019 - Orthostatic hypotension – Genetics Home Reference
April 18, 2019 - Healing the heartbreak of stillbirth and newborn death
April 18, 2019 - Conference to highlight advances in human immune monitoring, bioinformatics | News Center
April 18, 2019 - Bacteria use viruses for self-recognition, study reveals
April 18, 2019 - New adhesive patch could help reduce post-heart attack muscle damage
April 18, 2019 - Researchers analyze the effects of dark play in a serious video game
April 18, 2019 - Filial cannibalism and offspring abandonment may be forms of parental care
April 18, 2019 - Two proteins act in concert to maintain a healthy heart in mice, shows study
April 18, 2019 - Scientists create a functioning 3D printed heart
April 18, 2019 - Non-invasive vagus nerve stimulation improves disease symptoms in patients with rheumatoid arthritis
April 18, 2019 - Majority of men struggle to understand diagnosis and treatment of prostate cancer
April 18, 2019 - Researchers create new small molecules that may combat equine encephalitis viruses
April 18, 2019 - Animal-assisted therapy improves social behavior in patients with brain injuries
April 18, 2019 - Some viruses help protect harmful bacteria in CF patients | News Center
April 18, 2019 - Outpatient healthcare providers inappropriately prescribe antibiotics to 40% of patients
April 18, 2019 - Men who have a resting heart rate of 75 bpm are twice as likely to die early
April 18, 2019 - Novel serum biomarkers to detect NAFLD-related fibrosis
April 18, 2019 - New study delves deeper into individual genomic differences than ever before
April 18, 2019 - Gilead and Galapagos Announce Filgotinib Meets Primary Endpoint in the Phase 3 FINCH 3 Study in Methotrexate-Naïve Rheumatoid Arthritis Patients
April 18, 2019 - Emotional mirror neurons found in rats
April 18, 2019 - Sylvia Plevritis appointed chair of biomedical data science | News Center
April 18, 2019 - Yeast strain provides manufacturing boost to low-calorie sweetener derived from lactose
April 18, 2019 - C-Path and CDISC release global Therapeutic Area Standard for HIV research
April 18, 2019 - Integrating AI to analyze imaging data allows early recognition of heart disease
April 18, 2019 - Low-cost, high-speed algorithm may allow animal-free chemical toxicity testing
April 18, 2019 - HPV-negative cervical cancers are more aggressive with worse prognosis
April 18, 2019 - AI detects prostate cancer with same level of accuracy as experienced radiologists
April 18, 2019 - Study resolves sex differences in psychiatric illness risk
April 18, 2019 - Novartis Announces FDA Filing Acceptance and Priority Review of Brolucizumab (RTH258) for Patients with Wet AMD
April 18, 2019 - Cocktail of common antibiotics can fight resistant E. coli
April 18, 2019 - Persis Drell to give keynote address at medical school diploma ceremony | News Center
April 18, 2019 - EpicTogether: Remembering Our Why
April 18, 2019 - Study identifies novel loci contributing to asthma susceptibility in adults
April 18, 2019 - Gut bacteria and pregnancy
April 18, 2019 - New study finds that screening could help prevent rare types of cervical cancer
April 17, 2019 - Spatial orgnization of the genome can be altered using small molecules
April 17, 2019 - AEDs Tied to Higher Pneumonia Risk in Alzheimer Patients
April 17, 2019 - Telemedicine tied to more antibiotics for kids, study finds
April 17, 2019 - Two medical students awarded 2019 Soros Fellowships for New Americans | News Center
April 17, 2019 - Sociologist Constance A. Nathanson Awarded Guggenheim Fellowship
April 17, 2019 - Empathy and hormones could account for aggressive behavior in children, shows study
April 17, 2019 - Researchers develop oral appliance to help sufferers of sleep apnea
April 17, 2019 - Neuronal transport factor detects its target transcripts in more complex manner than previously thought
April 17, 2019 - New drug-delivery system senses high oxidant levels, responds to body chemistry and environment
April 17, 2019 - Health Tip: Horseback Trail Riding Safety
April 17, 2019 - Scientists outline the promises and pitfalls of machine learning in medicine
April 17, 2019 - $12 million grant renewal for flu vaccine research | News Center
April 17, 2019 - Lisa Kachnic, MD, Joins Columbia University as Chair of Radiation Oncology
April 17, 2019 - New study sheds light on how extreme temperature hampers spermatogenesis in insects
April 17, 2019 - Study tests high-tech, non-pharmaceutical way to address ADHD and distractibility
April 17, 2019 - New EZ-2 evaporator for clinical biochemistry sample preparation
April 17, 2019 - Fat shaming celebrities may make women more judgemental about being overweight
April 17, 2019 - Magic mouthwash effectively reduces mouth sore pain caused by radiation therapy
April 17, 2019 - CBD could help slip medications into the brain
April 17, 2019 - Scientists characterize 2017 pneumonic plague outbreak in Madagascar
April 17, 2019 - Human iPSC-derived MSCs from aged individuals acquire a rejuvenation signature
April 17, 2019 - Gun Research Is Suddenly Hot
April 17, 2019 - Employee wellness programs provide little health benefits
April 17, 2019 - Cannabis users could be more tolerant to anesthesia agents
April 17, 2019 - Study suggests new approach to treat renal fibrosis
April 17, 2019 - Green roofs may improve indoor air quality, study shows
April 17, 2019 - Selumetinib Granted U.S. Breakthrough Therapy Designation in Neurofibromatosis Type 1
April 17, 2019 - Fasting-mimicking diet holds promise for treating people with inflammatory bowel disease
April 17, 2019 - Daily cannabis use significantly higher among individuals with serious psychological distress
April 17, 2019 - Victims of bullying have greater chances of mental health problems, unemployment in later life
April 17, 2019 - Strategies to achieve greater vaccination coverage throughout Europe
April 17, 2019 - Online atlas created to identify, classify protein signatures present at AML diagnosis
April 17, 2019 - £1.8 million award to boost Crohn’s disease research
April 17, 2019 - Oxytocin blocks excess drinking in alcohol-dependent rats
April 17, 2019 - Rutgers researchers identify new factor essential for maintaining stem cells in the brain and gut
April 17, 2019 - Universal late pregnancy ultrasound improves health of mothers, babies and could be cost saving
April 17, 2019 - Cosmo Pharmaceuticals Announces Submission of Remimazolam NDA to FDA
April 17, 2019 - Stopping inflammation from becoming chronic
April 17, 2019 - Planned Parenthood’s ‘Risky Strategy’ To Update Its Image
April 17, 2019 - Common sleep myths may pose a significant public health threat
April 17, 2019 - Indicators of despair rising among Americans entering midlife
Chronic opioid users at increased risk of complications after spinal fusion surgery

Chronic opioid users at increased risk of complications after spinal fusion surgery

image_pdfDownload PDFimage_print

Patients who have been taking opioid pain relievers for several months before spinal fusion surgery are at increased risk of complications after their surgery, reports a study in the journal Spine, published by Wolters Kluwer.

Patients on chronic opioid therapy before spinal fusion are at increased risk of complications and adverse outcomes–including repeated spinal surgery, according to the new research by Safdar N. Khan, MD, of The Ohio State University Wexner Medical Center, and colleagues. They write, “With increasing emphasis on cost containment and quality improvement, our findings are intended to caution providers about chronic opioid therapy as a risk factor for additional interventions and costs after lumbar fusion.”

Increased Risks and Costs after Spinal Fusion in Chronic Opioid Users Using an insurance database, the researchers identified 24,610 patients undergoing spinal fusion in the lower (lumbar) spine. Of these, 5,500 patients–22.3 percent–were taking opioid pain relievers for more than six months before their surgery. Several factors were linked to an increased rate of chronic opioid therapy: tobacco use disorder, drug abuse/dependence, anxiety, depression, and inflammatory arthritis.

A wide range of complications were more frequent for patients taking long-term opioids. In the first 90 days after spinal fusion, the odds of surgical wound complications were 19 percent higher for chronic opioid users, relative to those with no or less than six months of opioid use.

Chronic opioid therapy was also associated with a higher likelihood of emergency department visits and hospitalizations within 90 days. The odds were especially high for issues related to lumbar spine pain: a 31 percent relative increase in emergency visits and an 80 percent increase in hospital admissions. Patients taking chronic opioids before surgery were eight times more likely to still be taking opioids one year afterward. They had a 33 percent relative increase in the likelihood of repeat spinal fusion surgery within one year.

They also had higher odds of other complications–including constipation, a common side effect of opioids–and increased costs for medical care. “All these findings highlight the vicious cycle of unrelieved pain and fusion and increased healthcare costs in long-term opioid users,” Dr. Khan and colleagues write.

With the increased use of opioids for back pain, many patients take these medications for some time before spinal fusion surgery. Previous studies have found various negative effects of opioid use on outcomes after surgery. The new research focused on how chronic opioid therapy affects risks and costs after the most common type of spinal fusion surgery (one- or two-level posterior lumbar fusion).

The results suggest that close to one-fourth of patients are using long-term opioids before spinal fusion. These chronic opioid users have higher complication rates, including wound complications, emergency visits and hospital admissions for back pain, and repeat spinal fusion surgery.

Spine surgeons should be vigilant about the increased complications and higher costs in patients receiving chronic opioid therapy before spinal fusion surgery, Dr. Khan and colleagues believe. They conclude: “As we head toward a value- and outcomes-based reimbursement system, spine surgeons need to incorporate pre-operative opioid use into their surgical decision making.”

Source:

https://wolterskluwer.com/

Tagged with:

About author

Related Articles