Breaking News
September 25, 2018 - Hybrid theranostic complex shows high therapeutic efficacy against tumor cells
September 25, 2018 - FDA Issues Statement Reaffirming the Positive Benefit-Risk Profile of Nuplazid (pimavanserin) for Patients with Hallucinations and Delusions Associated with Parkinson’s Disease Psychosis
September 25, 2018 - 5 obstacles parents commonly face in child obesity treatment and how to overcome them
September 25, 2018 - Immunologist to study how Chikungunya causes devastating effects in older adults
September 25, 2018 - Rural borderland communities vulnerable to high stress impacting mental and physical health
September 25, 2018 - SNMMI announces recipients of 2018-2020 Wagner-Torizuka Fellowship
September 25, 2018 - Common painkiller not effective in controlling chronic pain after traumatic nerve injury
September 25, 2018 - New therapeutic vaccine helps immune cells fight HPV-related head and neck cancer
September 25, 2018 - Environmentally-induced gene activity influences IQ test performance
September 25, 2018 - Biogen and Eisai announce results of LTE Phase 1b study of aducanumab for treating MCI
September 25, 2018 - FDA Approves Copiktra (duvelisib) Capsules for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma
September 25, 2018 - Medical device company settles US case over false claims
September 25, 2018 - Trying to get answers: One woman’s quest for a diagnosis
September 25, 2018 - Lung cancer patients treated with invasive surgery more likely to become chronic opioid users
September 25, 2018 - Oxford VR raises £3.2m to boost innovation in VR for mental health problems
September 25, 2018 - Gene therapy approach could help treat mitochondrial diseases
September 25, 2018 - Few Yogurt Products Qualify As Low-Sugar
September 25, 2018 - Eye disease can cause blindness, and it’s on the rise
September 25, 2018 - Pawnshop density linked to gun-related suicides, Stanford study finds
September 25, 2018 - Pioneering procedure for common prostate condition offered by The London Clinic
September 25, 2018 - Number of people with respiratory diseases likely to increase if UK air pollution remains unchecked
September 25, 2018 - FARXIGA receives positive results in Phase III DECLARE-TIMI 58 cardiovascular outcomes trial
September 25, 2018 - New program to reduce harmful stress effectively improves mood in cancer patients
September 24, 2018 - Florence’s Lingering Threat: Mold – Drugs.com MedNews
September 24, 2018 - For professional baseball players, faster hand-eye coordination linked to batting performance
September 24, 2018 - Bill for later school start times is defeated, but Stanford sleep specialist isn’t
September 24, 2018 - For Heart Failure Patients, Mitral Valve Procedure Improved Outcomes
September 24, 2018 - Successful recovery from addiction means more than achieving abstinence
September 24, 2018 - New nanoplatform technology may reverse drug-resistance in renal cell carcinoma
September 24, 2018 - October 1918 marks the centenary of Spanish Flu that claimed more lives than World War I
September 24, 2018 - LGBT community reports more number of poor mental health days than general population
September 24, 2018 - New research suggests power of zebrafish as tool for cancer drug discovery
September 24, 2018 - New study finds height as possible risk factor for developing varicose veins
September 24, 2018 - Researchers compare weight loss results of online and in-person diabetes prevention program
September 24, 2018 - New HER2 PET Study Uses Affibody’s ABY-025 Tracer to Individualize Breast Cancer Treatment
September 24, 2018 - Drug combination offers more effective care for patients suffering miscarriage
September 24, 2018 - Tallness linked to varicose veins, Stanford study says
September 24, 2018 - For Heart Failure Patients, Mitral Valve Procedure Improved Outcomes
September 24, 2018 - Ecstasy drug makes octopuses more social
September 24, 2018 - Immediate compression therapy could cut risk of complications after deep-vein thrombosis
September 24, 2018 - Transcatheter mitral valve repair reduces mortality for patients with mitral regurgitation
September 24, 2018 - First intracranial aneurysm patients treated with BRAVO Flow Diverter after CE mark approval
September 24, 2018 - ‘Physicians of the mouth’? Dentists absorb the medical billing drill
September 24, 2018 - People more likely to believe those with confident tone of voice than with accent
September 24, 2018 - Harmony Biosciences Presents 5-Year Data On Pitolisant At International Narcolepsy Symposium
September 24, 2018 - Blood test may identify gestational diabetes risk in first trimester
September 24, 2018 - Height may be risk factor for varicose veins | News Center
September 24, 2018 - King’s commemorates opening of new NMR facility with one-day symposium
September 24, 2018 - Eisai receives approval for partial label change of DC Bead device for transcatheter arterial embolization
September 24, 2018 - Using multi-level approach to reduce underage drinking among youths on rural reservations
September 24, 2018 - High-resolution genomic map gives scientists unprecedented view of brain development
September 24, 2018 - Researchers find impact of neurobehavioral symptoms on employment in adults with TBI
September 24, 2018 - Alexion announces positive results from Phase 3 PREVENT study of Soliris in patients with NMOSD
September 24, 2018 - First evaluation of benefits, harms of Alzheimer’s screening for family members of older adults
September 24, 2018 - Ancora Heart announces positive data of study evaluating AccuCinch Ventricular Repair System
September 24, 2018 - Children of mothers using cannabis may start using it at an earlier age, finds study
September 24, 2018 - Gilead Sciences plans to launch authorized generic versions of Epclusa and Harvoni in the US
September 24, 2018 - Most patients who underwent transcatheter valve replacement experience prosthesis-patient mismatch
September 24, 2018 - Lumos acquires license for LUM-201 drug that promotes secretion of growth hormone
September 24, 2018 - New study provides basis for Air Canada to change its facial hair policy for aircrew
September 24, 2018 - Infant walkers lead to thousands of emergency visits for babies
September 24, 2018 - Genes predicting person’s height may provide clues about causes of varicose veins
September 24, 2018 - EPA Plan Will Maintain Carbon Emissions From Power Plants
September 24, 2018 - Characterizing pig hippocampus could improve translational neuroscience
September 24, 2018 - Element3 Health reports social and mental engagement play key role in overall health
September 24, 2018 - Paralympic medalists support Fight for Sight’s unique virtual event
September 24, 2018 - ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma
September 24, 2018 - Public awareness of urological conditions found to be alarmingly low across Europe
September 24, 2018 - Fitter Folks Suffer Milder Strokes: Study
September 24, 2018 - Novel botulinum toxin compound relieves chronic pain
September 24, 2018 - CHMP recommends approval of Gilenya for treatment of multiple sclerosis in children, adolescents
September 24, 2018 - National Friendly’s private medical insurance is a hit with women living in the South East
September 24, 2018 - Academics receive prestigious awards for achievements in blood pressure research
September 24, 2018 - Obese pregnant women can restrict weight gain safely with proper nutrition guidance
September 24, 2018 - CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer
September 24, 2018 - China NMPA approves LENVIMA for treatment of unresectable hepatocellular carcinoma
September 24, 2018 - A new approach for finding Alzheimer’s treatments
September 24, 2018 - USC research uncovers previously unknown genetic risk factor for dementia
September 24, 2018 - Study examining mental health among students finds significant disparities in treatment across race
September 24, 2018 - Breakthrough discovery paves way for future test to identify drowsy drivers
With E-Cigs, Flavorings May Pose the Greatest Danger

With E-Cigs, Flavorings May Pose the Greatest Danger

image_pdfDownload PDFimage_print

TUESDAY, March 27, 2018 — The flavorings used in e-cigarettes might potentially be the most toxic part of the vapor inhaled by users, a new study suggests.

E-cigarette liquid contains dozens of different chemicals, and these vary widely from product to product, said lead author Flori Sassano. She is a research project manager with the University of North Carolina School of Medicine.

Many of these chemicals are toxic to human cells in the laboratory, but the most toxic appear to be those related to the flavorings contained in e-liquids, Sassano said.

These chemicals include vanillin and cinnamaldehyde, which respectively produce the flavors of vanilla and cinnamon.

The flavorings have been approved by the U.S. Food and Drug Administration for consumption, but that doesn’t mean they are safe to inhale as vapor from an e-cigarette, Sassano explained.

The FDA’s list of safe flavorings “is based upon studies that have been done of these chemicals when ingested, but not when inhaled,” she said.

There are more than 7,700 e-liquid flavors on the market from more than 1,200 different vendors, and most have not been tested for their potential toxicity, the study authors said in background notes.

For their research, Sassano and her colleagues tested about 150 commercially available e-liquids, and out of those identified 143 unique chemical compounds.

“What this tells us is these e-liquids are very diverse, and because they are diverse they are very hard to study as a group,” Sassano said.

To test toxicity, the researchers developed a system by which lab-grown human cells are exposed to e-liquid chemicals. The more toxic a chemical, the more it will reduce the growth rates of these cells, according to the report.

Most of the liquid in an e-cigarette is made up of propylene glycol and vegetable glycerin, and those chemicals on their own are toxic to lab-grown human cells, the researchers said.

But the flavorings added to e-cigarettes can be even more toxic, the investigators discovered.

The toxic effects of these liquids proved harmful to cells from human lungs and upper airways. And, overall, the more ingredients included in an e-liquid, the greater the toxicity, the findings showed.

The study was published online March 28 in the journal PLOS Biology.

Sassano said the process they’ve developed provides a fast and reliable way to evaluate the toxicity of the chemicals in e-liquids.

However, it’s too soon to tell whether this means regular e-cigarette use will have long-term health consequences, said Sassano and Dr. Norman Edelman, senior scientific advisor to the American Lung Association.

“These are cell cultures,” Edelman explained, “so it’s a little bit of a leap of faith to translate that into human disease.”

At the same time, this process is regularly used by the pharmaceutical industry to test the effects of new drug compounds, Sassano and Edelman noted.

In fact, Sassano said, “This approach is one of the most popular approaches in pharmaceutical companies. When you have a drug that you think might make it to the market, most of the time they go through these same kind of tests to identify the molecules that will be effective on the disease you are studying.”

Gregory Conley, president of the American Vaping Association, said the “next steps in this process must not only include testing cigarette smoke in their systems, but validating the system to determine if what happens in cell dishes actually takes place in animals and humans.”

According to Conley, “Had the authors compared the effects of cigarette smoke against the referenced vaping products, the results would demonstrate that cigarettes are magnitudes more toxic than the tested products. Regrettably, this was not done, and as a result the study sends the reckless and incorrect message to adult smokers that vaping may confer dangers similar to continued smoking.”

But, Edelman said, these study results show that e-cigarettes are not harmless.

“You certainly can’t say e-cigarettes are safe,” Edelman said. “You always look at a risk/benefit analysis. If we were delivering lifesaving drugs using those liquids, you might say the risk is worth the benefit. But we’re not delivering anything worthwhile. We’re delivering nicotine that hooks kids.”

More information

The U.S. National Institute on Drug Abuse has more about e-cigarettes.

© 2018 HealthDay. All rights reserved.

Posted: March 2018

Tagged with:

About author

Related Articles