Breaking News
December 19, 2018 - Research opens door to development of drug or vaccine for late-onset Alzheimer’s
December 19, 2018 - Single workout can boost metabolism for days
December 19, 2018 - UI study leads to better understanding of signaling capacity between neurons
December 19, 2018 - Gut microbiome plays role in immune system regulation, study finds
December 19, 2018 - How MAPK translocation leads to drug resistance in melanoma
December 19, 2018 - Increasing prevalence of antibiotic resistance in the U.S. linked with occasional use
December 19, 2018 - Mind-body exercises may improve cognition in older adults
December 19, 2018 - Hepatitis C drug can eliminate chikungunya, yellow fever virus
December 19, 2018 - Separating male and female mice changes the way they smell, shows study
December 19, 2018 - FDA Approves Genentech’s Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer
December 19, 2018 - Mediterranean Diet for Osteoarthritis | About OA
December 19, 2018 - Successful bladder repair using silk fibroid scaffolds
December 19, 2018 - Quidel receives CE mark to use Sofia 2 Lyme+ Fluorescent Immunoassay with Sofia 2 analyzer
December 19, 2018 - Horizon Discovery partners with C4XD to validate novel synthetic lethal oncology targets
December 19, 2018 - Research suggests a promising therapeutic target to treat or prevent metabolic disorders
December 19, 2018 - Split liver transplants could save children on wait list finds study
December 19, 2018 - Michigan-based food manufacturer ordered to discontinue operations after recurrent food safety violations
December 19, 2018 - Real-time neurofeedback controls Parkinson’s brainwaves
December 19, 2018 - Incorrect prescribing warnings in electronic prescribing systems
December 19, 2018 - New $1.6 million NIH grant supports study on a gene vital to circadian rhythms
December 19, 2018 - Racial Disparities Seen Among Teens Undergoing Flu Vaccination
December 19, 2018 - To resolve inflammation, location matters
December 19, 2018 - Dancing could help older women to perform their daily tasks
December 19, 2018 - Research identifies new therapeutic target for cancer treatment and tissue regeneration
December 19, 2018 - Energy costs, social isolation contribute to health risk of older adults in extreme weather
December 19, 2018 - Potential combination therapy against rare disease of the bone marrow could improve treatment
December 19, 2018 - Researchers aim to improve cognition, reverse weight gain in schizophrenia
December 19, 2018 - UC San Diego Health offers new DRG stimulation device for phantom limb pain
December 19, 2018 - Study examines relationship between growth restriction and risk of childhood mortality
December 19, 2018 - New study provides insights on increased risk of suicide in young patients visiting ED
December 19, 2018 - AHA: Thyroid Problems Linked to Worsening Heart Failure
December 19, 2018 - World-first coeliac disease vaccine enters Phase 2 trials
December 19, 2018 - RNA sequencing offers novel insights into the microbiome
December 19, 2018 - A promising, effective vaccine for common respiratory disease
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - ‘Little Foot’ endocast reveals a small brain combining ape-like and human-like features
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
Early life epilepsies should be treated with urgency as childhood cancers

Early life epilepsies should be treated with urgency as childhood cancers

image_pdfDownload PDFimage_print

Like childhood cancers, early life epilepsies represent many rare disorders with diverse underlying causes. Unlike childhood cancers, little has changed in the outcomes of early life epilepsies in the past few decades, despite advances in diagnostic technologies and availability of new treatments. Following recommendations in the U.S., specialty treatment for early life epilepsies is often delayed for a year of uncontrolled seizures. “For an infant, it is akin to recommending an oncology consultation only after a cancer has metastasized,” write Anne Berg, PhD, and Stewart Goldman, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, in Neurology.

“Epilepsies in infants and young children should be treated with the urgency that we see in pediatric oncology,” says Dr. Berg, Research Professor in Pediatrics at Northwestern University Feinberg School of Medicine, who specializes in childhood epilepsy. “Right away these children should receive a comprehensive evaluation that includes thorough genetic testing, so that we can match treatment to the precise cause of their epilepsy in order to achieve optimal outcomes. This is the age of precision medicine and we have the tools to make a profound difference for these young patients.”

Early life epilepsies affect approximately 6400 infants and toddlers each year in the U.S. These disorders are some of the most difficult to treat forms of epilepsy, with uncontrolled seizures posing a serious threat to early brain development. Studies also show high early mortality associated with early life epilepsies – 10 to 20 percent in the first few decades of life. Early effective treatment can result in better outcomes.

In addition to the current lack of urgency, treatments for children with early life epilepsies are often inconsistent across institutions and solid evidence for various therapeutic approaches is lacking. To remedy this, the authors call for epilepsy centers to join forces and emulate the cooperative group model that has been so successful for childhood cancers.

The overall survival of childhood cancers is around 80 percent today – up from only 10 percent in the 1950s. This dramatic improvement is largely due to the research conducted through the national cooperative group structure. Over 90 percent of children diagnosed with cancer are treated at a hospital that is part of the cooperative group called Children’s Oncology Group, which is funded by the National Cancer Institute. These children receive evidence-based treatments within days of initial referral and virtually all patients participate in clinical trials.

“The epilepsy community needs to come together and create a large scale, national collaborative structure for early life epilepsies that will allow us to conduct randomized clinical trials and other clinical research to establish evidence-based treatments and protocols for these children. Because these are individually such rare diseases, it is essential that all patients with early life epilepsies are encouraged to enroll in research studies,” says Dr. Berg.

Early efforts to develop collaborative research structures for early life epilepsies include the Neonatal Seizure Registry, the Pediatric Epilepsy Research Consortium and the National Infantile Spasms Consortium.

“We still have a long way to go,” says Dr. Berg. “Ultimately, a successful cooperative effort will need to include everyone involved in the diagnosis, treatment and referral of children at the earliest signs of early life epilepsies. We also need to build partnerships with the many family-run philanthropic organizations focused on specific genetic epilepsies. We need to speak with a unified voice to legislators and funding agencies about the urgency to advance care and improve outcomes of early life epilepsies.”

Source:

http://www.chicagochildrens.org/

Tagged with:

About author

Related Articles