Breaking News
April 23, 2018 - CDC seeking $400 million to replace lab for deadliest germs
April 23, 2018 - Sensirion to present single-use liquid flow sensor at COMPAMED 2017
April 23, 2018 - FDA approves contact lenses that shade the sun
April 22, 2018 - Concussion recovery and symptom severity found to vary between men and women
April 22, 2018 - C. Difficile Risk Higher With Stoma Reversal Versus Colectomy
April 22, 2018 - Repeated ranibizumab doesn’t impair macular perfusion
April 22, 2018 - New microscope reveals how cells behave in 3D and real time inside living organisms
April 22, 2018 - Study shows clinical benefit and monetary gains of weight-loss surgery
April 22, 2018 - GNA Biosolutions launches world’s first Laser PCR platform at Medica Trade Fair
April 22, 2018 - Researchers present simulation model to investigate hospital responsiveness to mass casualty incidents
April 22, 2018 - Does Pot Really Dull a Teen’s Brain?
April 22, 2018 - Controversial pregnancy test drug shows deformities in zebrafish embryos within hours of exposure
April 22, 2018 - New research partnership makes childbirth safer in Mozambique
April 22, 2018 - Brief bedside visual art intervention reduces pain, anxiety in cancer patients
April 22, 2018 - The memory part of the brain may also hold clues for anxiety and depression
April 22, 2018 - AYOXXA to develop multiplex immunoassay to support treatment of sepsis patients
April 22, 2018 - New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer
April 22, 2018 - Researchers chart a new way to look at concussion
April 22, 2018 - Every parent needs to know fundamental red flags for autism
April 22, 2018 - Anatotemp expands anatomic dental implant healing abutments with 4Side anti-rotational connection
April 22, 2018 - Gene Twist Can Make Your Blood Pressure Spike From Salt
April 22, 2018 - Study suggests failed osteoarthritis drug could help treat opioid addiction
April 22, 2018 - More Americans aware of growing problem of opioid addiction
April 22, 2018 - KHN’s ‘What the Health?’ Nothing in health care ever goes away
April 22, 2018 - BGS to promote high-quality sterilization services at Health GB in Manchester
April 22, 2018 - New integrated POC tool detects biomarkers of heart failure rapidly and precisely
April 22, 2018 - Direct electrical current can be delivered to nerves for blocking pain signals
April 22, 2018 - Newly Published Phase 2 Study Found Esketamine Demonstrated Significantly Rapid Improvements in Depressive Symptoms and Suicidality
April 22, 2018 - Healthy red blood cells owe their shape to muscle-like structures
April 22, 2018 - Researchers present case study of management of rheumatic mitral regurgitation in woman contemplating pregnancy
April 22, 2018 - New black Porvair Krystal UV Quartz microplates for Circular Dichroism measurements
April 22, 2018 - Advanced flow chemistry modules enhance control of nanoprecipitation
April 22, 2018 - Look! Down in the petri dish! It’s a superplatelet!
April 22, 2018 - Research reveals why people with tetraplegia more likely to suffer from sleep apnea
April 21, 2018 - New non-invasive nerve stimulation may offer relief for people with hand tremor
April 21, 2018 - Smartphone App May Up Medication Adherence in HTN
April 21, 2018 - Western diet depletes artery-protecting immune cells
April 21, 2018 - Excelitas Technologies launches new powerful LED light source for fluorescence microscopy
April 21, 2018 - Academia and high tech companies join forces to increase production capacity for microfluidic systems
April 21, 2018 - Developing cooking skills as young adult may have long-term health benefits
April 21, 2018 - Study compares survival outcomes of different drugs for type 2 diabetes
April 21, 2018 - More Than 40 Percent of Americans Breathe Dirty Air: Report
April 21, 2018 - Obstructive sleep apnea – Genetics Home Reference
April 21, 2018 - More evidence shows exposure to traffic and outdoor air pollution increases risk of asthma
April 21, 2018 - Novel gold nanoparticle technology could guide cancer treatment in real-time
April 21, 2018 - News coverage of Ebola impacted public’s perception on disease and survivors
April 21, 2018 - S.Africa’s DIY battle against HIV
April 21, 2018 - Children with autism have gastrointestinal and immune system deregulation, research finds
April 21, 2018 - Human brain processes sight and sound in the same way, shows study
April 21, 2018 - Evolutionary history of tumor helps predict severity of prostate cancer
April 21, 2018 - Pepper plant metabolizes antibiotic in personal care products
April 21, 2018 - Tradeshow Talks with Integra
April 21, 2018 - EPFL becomes part of Chan Zuckerberg’s project to develop Human Cell Atlas
April 21, 2018 - Pfizer Announces Positive Topline Results From Phase 3 ATTR-ACT Study Of Tafamidis In Patients With Transthyretin Cardiomyopathy
April 21, 2018 - Breaking through the HIV vaccine ‘logjam’
April 21, 2018 - IntelliCyt introduces new QSol buffer to enable robust, consistent sampling
April 21, 2018 - Scientists publish comprehensive lineage tree of whole adult animal in Science journal
April 21, 2018 - Innovative method based on FluidFM technology could revolutionize biological research
April 21, 2018 - Americans world’s biggest TV addicts, watching four hours a day
April 21, 2018 - Investigational drug may help increase protein levels in babies with spinal muscular atrophy
April 21, 2018 - Study shows distinctions between age groups in predicting and responding to stress at home
April 21, 2018 - Aziyo Biologics, BIOTRONIK enter into US co-distribution agreement
April 21, 2018 - Opiate Use Linked to Early Mortality in IBD Patients
April 21, 2018 - Online ads help pregnant smokers quit
April 21, 2018 - Opioid pain medications may not be safe for hemodialysis patients
April 21, 2018 - Rare variants in non-coding DNA inherited from parents heighten autism risk
April 21, 2018 - A needleless glucose monitor for diabetes patients
April 21, 2018 - BD introduces new informatics and automation solutions for clinical laboratories
April 21, 2018 - Turn Chores Into a Fitness Routine
April 21, 2018 - DNA methylation plays key role in stem cell differentiation
April 21, 2018 - Scientists find link between soil metals and cancer mortality
April 21, 2018 - Experts discuss implications of low calcium intake in global population
April 21, 2018 - GNA Biosolutions to display Pharos V8 Laser PCR instrument at Analytica trade fair
April 21, 2018 - People with vitamin D deficiency may be at greater risk of diabetes
April 21, 2018 - Study findings could open new possibilities for treating cancer with adenovirus
April 21, 2018 - People who use medical marijuana have higher rates of prescription drug use, study finds
April 21, 2018 - Study debunks ‘myth’ that strenuous exercise dampens immunity
April 21, 2018 - FDA approves marijuana based medication for epilepsy treatment
April 21, 2018 - Researchers find novel genes for longevity in mammals
April 21, 2018 - GNA Biosolutions and project partners launch new research project to develop TB diagnostic platform for POC applications
New project aims to systematically study connections between different areas of the brain

New project aims to systematically study connections between different areas of the brain

image_pdfDownload PDFimage_print

Hosted by Charité – Universitatsmedizin Berlin, the TrueBrainConnect project aims to systematically study connections between different areas of the brain, and hopes to draw conclusions regarding potential disease patterns. A team of researchers, led by Dr. Stefan Haufe – a computer scientist and expert in the field of machine learning – are hoping to produce complex models capable of predicting different mental states. Their research will be based on EEG data. The new working group has secured funding from the European Research Council (ERC) for a duration of five years, and will be based at Charité’s Berlin Center for Advanced Neuroimaging.

The TrueBrainConnect project is based on the premise that many neurological disorders start to manifest themselves even before the onset of symptoms, or before they produce noticeable changes in brain structure or behavior. The project’s hypothesis is that these disorders herald their presence through irregularities in the way different areas of the brain communicate with each other. The new working group, which will be led by Dr. Haufe, will try to develop methods capable of reliably estimating and localizing brain interactions, in the hope of improving the prognosis of pathological conditions affecting the brain. “Electroencephalography (EEG), which records the brain’s electrical activity, is one of the most well-established neuroimaging methods, and allows researchers to study brain activity almost in real time. The data generated by this process are entered into computer models, which allow us to deduce the principles guiding these interactions within the brain,” explains Dr. Haufe.

The methods currently available for the analysis of neuroimaging data are not yet sufficiently developed, and robust conclusions cannot be drawn from them. It is hoped that new signal processing and machine learning techniques will allow researchers to make precise determinations regarding brain signal sources and actual nerve cell interactions. To this end, Dr. Haufe and his team will be working in close collaboration with clinical colleagues: “The new TrueBrainConnect method will be capable of visualizing neuronal patterns that underpin disorders such as dementia and Parkinson’s disease. The primary aims of these endeavors include the identification of the early precursors of disease and the delineation of different types of dementia.” The researchers are hopeful that this will help improve the early diagnosis of these extremely common neurological disorders.

However, numerous challenges will need to be overcome along the way. For instance, for each signal recorded, researchers must determine whether its origins can be clearly traced back to an actual interaction between different areas of the brain, or whether it has a different origin. While EEG offers researchers numerous advantages, the technology also presents technical challenges that need to be resolved, such as poor spatial resolution and a high degree of noise contamination. “To improve the quality of predictions, TrueBrainConnect will use the latest methods from the field of machine learning. One important question the project will be investigating is how to correctly interpret these new models; how to recognize which patterns of brain activity are crucial for a particular prognosis,” explains Dr. Haufe.

“Dr. Haufe’s research fills an important gap, and places EEG research on methodologically sound foundations,” says Prof. Dr. John-Dylan Haynes, Director of the Berlin Center for Advanced Neuroimaging and researcher at Charité’s Bernstein Center for Computational Neuroscience. TrueBrainConnect will be positioned at the interface between two high-profile fields of research: the analysis of functional brain connectivity and the study of age-related neurological disorders. Both the development of improved statistical techniques for the analysis of neuroimaging data, as well as the development of new methods of signal processing and machine learning, will form the heart of these endeavors. Their practical application, and the evaluation of their effectiveness in the investigation of neurological disorders, will form part of the second stage of this project. It is anticipated that these new techniques will be used in the fields of Brain-Computer Interfacing and Mental State Monitoring, as well as in basic and clinical research.

Aimed at early-career scientists, ERC Starting Grants are awarded by the European Research Council as part of the Horizon 2020 Framework Programme for Research and Innovation. A total of €1.5 million has been secured to fund the development of the working group at Charité’s Berlin Center for Advance Neuroimaging.​

Source:

https://www.charite.de/en/service/press_reports/artikel/detail/truebrainconnect_erkrankungen_des_gehirns_vorhersagen/

Tagged with:

About author

Related Articles