Breaking News
September 23, 2018 - HIV and a tale of a few cities
September 23, 2018 - NIH launches clinical trial to test infusions of combination antibodies in people with HIV
September 23, 2018 - Researchers develop new system to detect consumption of synthetic cannabinoids
September 23, 2018 - Vax-Hub to influenze radical change in development and manufacturing of vaccines
September 23, 2018 - People who have slept lesser than seven hours have higher risks of car crashes
September 23, 2018 - an ancient art may work best to prevent falls in old age
September 23, 2018 - Consumption of foods with lower nutritional quality related to increased cancer risk
September 23, 2018 - Patient Health Information Often Shared Electronically
September 23, 2018 - Can machine learning bring more humanity to health care?
September 23, 2018 - Body organs undergo structural changes in response to diet
September 23, 2018 - Genetic polymorphisms linked with muscle injury and stiffness
September 23, 2018 - As states try to rein in drug spending, feds slap down one bold Medicaid move
September 22, 2018 - Why Eczema Is Tougher to Treat for Black Patients
September 22, 2018 - Team reveals that human genome could contain up to 20 percent fewer genes
September 22, 2018 - USC research uncovers previously unknown genetic risk factor for Alzheimer’s disease
September 22, 2018 - Novel method achieves accurate and precise temperature estimation in fat-containing tissues
September 22, 2018 - BSI accredits Oxehealth’s vital signs measurement software as Class IIa medical device
September 22, 2018 - Evolution of psychiatric disorders and human personality traits
September 22, 2018 - Obesity in early puberty doubles asthma risk for boy’s future offspring
September 22, 2018 - World’s most advanced real-time patient monitoring platform receives key US patent
September 22, 2018 - Study explores connection between sexuality and cognitive status in older adults
September 22, 2018 - LSTM partners with TB Alliance to develop novel TB drug regimens
September 22, 2018 - Annual wellness visits improve delivery of preventive services in elderly population
September 22, 2018 - CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma
September 22, 2018 - Hispanic communities with high proportions of Hispanics face more cardiovascular-related death
September 22, 2018 - Vici syndrome – Genetics Home Reference
September 22, 2018 - Single-dose drug can shorten flu symptoms by about a day, studies suggest
September 22, 2018 - AMSBIO launches circulating tumor DNA Reference Standards
September 22, 2018 - Sandalwood mimicking odorant could stimulate hair growth in humans
September 22, 2018 - Overlooked immune cells could play a key role in cancer immunotherapy, claims new study
September 22, 2018 - Study reveals prevalence of diagnosed type 1 and type 2 diabetes among American adults
September 22, 2018 - Researchers develop fast detection strategy to know type of virus acquired by patients
September 22, 2018 - Global Prevalence of Insufficient Activity 27.5 Percent
September 22, 2018 - Strategies to protect bone health in hematologic stem cell transplant recipients
September 22, 2018 - Brigham Genomic Medicine program unravels 30 medical mysteries
September 22, 2018 - New system harnesses power of bubbles to destroy dangerous biofilms
September 22, 2018 - Inflammation plays crucial role in preventing heart attacks and strokes, study reveals
September 22, 2018 - Calorie dense, nutrient deficient meals common across the world
September 22, 2018 - Researchers develop technology to study behavior of implants without animal testing
September 22, 2018 - First gut bacteria in newborns may have lasting effect on ability to ward off chronic diseases
September 22, 2018 - Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species
September 22, 2018 - Insulin treatment shows great potential against chronic bowel inflammation
September 22, 2018 - ‘Liking Gap’ Might Stand in Way of New Friendships
September 22, 2018 - Simple factors that can avoid harmful side effects in type 2 diabetes
September 22, 2018 - ALSAM Foundation invests additional $2 million for drug discovery and development projects
September 22, 2018 - Study findings may advance discussion of how to effectively curb human-wildlife conflict
September 22, 2018 - Dopamine neurons may involve in conditions ranging from Parkinson’s disease to schizophrenia
September 22, 2018 - Protein C and Protein S Tests: MedlinePlus Lab Test Information
September 22, 2018 - Obesity and diabetes—two reasons why we should be worried about the plastics that surround us
September 22, 2018 - Concern over fussy eating prompts parents to use non-responsive feeding practices
September 22, 2018 - Novel mathematical approach uncovers existence of unsuspected biological cycles
September 22, 2018 - Cancer Research UK invests £14 million to transform London into cancer biotherapeutics hub
September 22, 2018 - Scientists predict how well the body will fight lung cancer by analyzing immune cell shapes
September 22, 2018 - New outbreak of rare eye disease identified in contact lens wearers
September 22, 2018 - Iterum Initiates SURE 2 and SURE 3 Phase 3 Clinical Trials of IV and Oral Sulopenem in Complicated Urinary Tract and Complicated Intra-abdominal Infections
September 22, 2018 - Research finds divide in dental health accessibility between city and regional areas
September 22, 2018 - Premature babies show better brain development when fed breast milk, finds study
September 22, 2018 - Novel system uses AI to detect abnormalities in fetal hearts
September 22, 2018 - UNC scientists reveal new approach to prevent obesity and diabetes
September 22, 2018 - CWRU receives NIH grant to learn how non-coding genes contribute to spread of colorectal cancer
September 22, 2018 - Scientists better understand influenza virus and how it spreads
September 22, 2018 - Scientists to focus on length of time when a person is alive and healthy
September 22, 2018 - Study shows positive financial impacts of Medicaid expansion for low-income Michigan residents
September 22, 2018 - Innovative approach for developing vaccine against most prevalent human malaria parasite
September 22, 2018 - Study finds excess emissions from diesel cars produced by major auto manufacturers in Europe
September 22, 2018 - Decision aids for parents of children with minor head injuries help communicate with physicians
September 22, 2018 - Research scientist at Kessler Foundation receives $10,000 grant to study aphasia after stroke
September 22, 2018 - New findings on characteristics of Burning Mouth Syndrome
September 22, 2018 - Study sheds light on molecular mechanisms underlying progression of prion diseases
September 22, 2018 - Innovation Fund Denmark supports research project that aims to fight Clostridium difficile diarrhea
September 22, 2018 - Survey estimates caregiving costs for family members
September 22, 2018 - Inhibiting NF-kB improves heart function in a mouse model of Duchenne muscular dystrophy
September 22, 2018 - Introducing new EMR system may affect several aspects of clinic workflow
September 22, 2018 - Study finds why some human genes are more popular with biomedical researchers
September 22, 2018 - Finding epigenetic signature appears to predict inflammation risk in serious type of IBD
September 22, 2018 - Researchers develop light-based technique to measure very weak magnetic fields
September 22, 2018 - UAB researchers study dysfunction of the immune system associated with NSAID carprofen
September 22, 2018 - QIAGEN and DiaSorin launch automated, CE-marked workflow for high-throughput TB screening
September 22, 2018 - EFS checklist provides user-friendly tool for evaluating feeding skills in preterm infants
September 22, 2018 - Family history in blacks, Latinos associated with higher risk of AFib
New project aims to systematically study connections between different areas of the brain

New project aims to systematically study connections between different areas of the brain

image_pdfDownload PDFimage_print

Hosted by Charité – Universitatsmedizin Berlin, the TrueBrainConnect project aims to systematically study connections between different areas of the brain, and hopes to draw conclusions regarding potential disease patterns. A team of researchers, led by Dr. Stefan Haufe – a computer scientist and expert in the field of machine learning – are hoping to produce complex models capable of predicting different mental states. Their research will be based on EEG data. The new working group has secured funding from the European Research Council (ERC) for a duration of five years, and will be based at Charité’s Berlin Center for Advanced Neuroimaging.

The TrueBrainConnect project is based on the premise that many neurological disorders start to manifest themselves even before the onset of symptoms, or before they produce noticeable changes in brain structure or behavior. The project’s hypothesis is that these disorders herald their presence through irregularities in the way different areas of the brain communicate with each other. The new working group, which will be led by Dr. Haufe, will try to develop methods capable of reliably estimating and localizing brain interactions, in the hope of improving the prognosis of pathological conditions affecting the brain. “Electroencephalography (EEG), which records the brain’s electrical activity, is one of the most well-established neuroimaging methods, and allows researchers to study brain activity almost in real time. The data generated by this process are entered into computer models, which allow us to deduce the principles guiding these interactions within the brain,” explains Dr. Haufe.

The methods currently available for the analysis of neuroimaging data are not yet sufficiently developed, and robust conclusions cannot be drawn from them. It is hoped that new signal processing and machine learning techniques will allow researchers to make precise determinations regarding brain signal sources and actual nerve cell interactions. To this end, Dr. Haufe and his team will be working in close collaboration with clinical colleagues: “The new TrueBrainConnect method will be capable of visualizing neuronal patterns that underpin disorders such as dementia and Parkinson’s disease. The primary aims of these endeavors include the identification of the early precursors of disease and the delineation of different types of dementia.” The researchers are hopeful that this will help improve the early diagnosis of these extremely common neurological disorders.

However, numerous challenges will need to be overcome along the way. For instance, for each signal recorded, researchers must determine whether its origins can be clearly traced back to an actual interaction between different areas of the brain, or whether it has a different origin. While EEG offers researchers numerous advantages, the technology also presents technical challenges that need to be resolved, such as poor spatial resolution and a high degree of noise contamination. “To improve the quality of predictions, TrueBrainConnect will use the latest methods from the field of machine learning. One important question the project will be investigating is how to correctly interpret these new models; how to recognize which patterns of brain activity are crucial for a particular prognosis,” explains Dr. Haufe.

“Dr. Haufe’s research fills an important gap, and places EEG research on methodologically sound foundations,” says Prof. Dr. John-Dylan Haynes, Director of the Berlin Center for Advanced Neuroimaging and researcher at Charité’s Bernstein Center for Computational Neuroscience. TrueBrainConnect will be positioned at the interface between two high-profile fields of research: the analysis of functional brain connectivity and the study of age-related neurological disorders. Both the development of improved statistical techniques for the analysis of neuroimaging data, as well as the development of new methods of signal processing and machine learning, will form the heart of these endeavors. Their practical application, and the evaluation of their effectiveness in the investigation of neurological disorders, will form part of the second stage of this project. It is anticipated that these new techniques will be used in the fields of Brain-Computer Interfacing and Mental State Monitoring, as well as in basic and clinical research.

Aimed at early-career scientists, ERC Starting Grants are awarded by the European Research Council as part of the Horizon 2020 Framework Programme for Research and Innovation. A total of €1.5 million has been secured to fund the development of the working group at Charité’s Berlin Center for Advance Neuroimaging.​

Source:

https://www.charite.de/en/service/press_reports/artikel/detail/truebrainconnect_erkrankungen_des_gehirns_vorhersagen/

Tagged with:

About author

Related Articles