Breaking News
July 15, 2018 - Parents who had severe trauma, stresses in childhood more likely to have kids with behavioral health problems
July 15, 2018 - At colloquium, a range of views on value of predictive algorithms | News Center
July 15, 2018 - Pittcon invites oral and poster presentations for 2019 Technical Program
July 15, 2018 - Virtual reality could offer psychotherapy for fear of heights, study shows
July 15, 2018 - Retooled vaccine raises hopes as a lower-cost treatment for Type 1 diabetes
July 15, 2018 - Kolon TissueGene To Start US Phase III Clinical Trial For Invossa
July 15, 2018 - Study finds prenatal marijuana use can affect infant size, behavior
July 15, 2018 - Howard Chang named HHMI investigator | News Center
July 15, 2018 - Study shows tailored mental health services improve wellbeing of emerging adults
July 15, 2018 - A bright future might help teens steer clear of violence
July 15, 2018 - Stanford Medicine magazine explores the art, science of listening and hearing | News Center
July 15, 2018 - New study tracks how the brain turns simple sensory inputs into meaningful categories
July 15, 2018 - Deadlier subtype of metastatic prostate cancer found to be common than previously thought
July 15, 2018 - UZH scientists identify enzyme that controls cell division
July 15, 2018 - Unhealthy Food Behaviors May Signal Eating Disorder in Teen
July 15, 2018 - Study raises doubts on a previous theory of Parkinson’s disease
July 15, 2018 - Grant awarded to study whether stem cells can treat urinary incontinence | News Center
July 15, 2018 - Imaging techniques may help assess immune system recovery in HIV patients
July 15, 2018 - Machine-learning may aid in diagnosis and treatment of mental health disorders
July 15, 2018 - ‘Skin Cancer, Take A Hike!’ program promotes sun safety and skin cancer awareness
July 15, 2018 - Blink Health announces lowest prices for generic prescriptions through Blue Eagle Health
July 15, 2018 - New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model
July 15, 2018 - Georgia State professor receives federal grant to study virus similar to Ebola virus
July 15, 2018 - Quitting Smoking? Even a Little Exercise Can Help You Stay Slim
July 15, 2018 - DBS treatment may slow the progression of Parkinson’s tremor in early-stage patients
July 15, 2018 - 5 Questions: Luby on virus with potential to cause global pandemic | News Center
July 15, 2018 - Corn loses its cancer-fighting phenolic acids when processed into cornflakes
July 15, 2018 - Study uncovers possible link between iron loading, alcohol intake and mortality
July 15, 2018 - Molecular insights of NagA enzyme could help combat TB
July 15, 2018 - The Facts on Tampons—and How to Use Them Safely
July 15, 2018 - Normalisation of ‘plus-size’ risks hidden danger of obesity, study finds
July 15, 2018 - $2.5 million award to support physician-scientist training | News Center
July 15, 2018 - Aeras announces publication of Phase 2 results of two TB vaccines
July 15, 2018 - Public to set research priorities in field of ethnic inequalities and severe mental illness
July 15, 2018 - Eisai and Biogen Announce Positive Topline Results of the Final Analysis for BAN2401 at 18 Months
July 15, 2018 - U.S. obesity rates rising again
July 15, 2018 - Millions could have incorrect statin, aspirin and blood pressure prescriptions | News Center
July 15, 2018 - Researchers identify factors associated with cell phone-related distracted driving in parents
July 15, 2018 - Bioethicists suggest ethical considerations for forensic use of genetic data
July 15, 2018 - Most clinical trial participants find benefits of sharing personal data outweigh risks, Stanford study finds | News Center
July 14, 2018 - Researchers solve protein puzzle that paves way for new cancer therapies
July 14, 2018 - Blood telomeres can help predict risk of disease worsening or death in COPD patients
July 14, 2018 - CDC: Nearly One-Third of Injury Deaths Occur at Home
July 14, 2018 - Injectable electronics offer powerful new tool in understanding how retinal cells work
July 14, 2018 - Human blood cells transformed into functional neurons | News Center
July 14, 2018 - Podcast: KHN’s ‘What the Health?’ ACA under fire. Again.
July 14, 2018 - Small device with motion sensors can predict older adults’ risk of falling
July 14, 2018 - Neurological Fallout From Ebola Infection Worse Than Thought
July 14, 2018 - Screening for impaired vision in older adults: New Canadian guideline
July 14, 2018 - Blood test for pregnant women can predict premature birth, Stanford-led study reports | News Center
July 14, 2018 - Study uncovers process that neutralizes tumor cells
July 14, 2018 - Four-protein biomarker blood test improves lung cancer risk assessment for smokers
July 14, 2018 - Researchers develop novel approach to bridge gap in cell-free systems
July 14, 2018 - Research reveals new gears in the circadian clock
July 14, 2018 - Researchers assess role of physician in preventing intimate partner violence perpetration
July 14, 2018 - Two diabetes medications don’t slow progression of type 2 diabetes in youth
July 14, 2018 - New clues to restoring fertility in women with disabling ovary disorder
July 14, 2018 - Compound in citrus oil could reduce dry mouth in head, neck cancer patients | News Center
July 14, 2018 - Streck ARM-D Kits detect more antibiotic resistance than comparable tests
July 14, 2018 - Study finds wide variations in follow-up imaging for women with non-metastatic breast cancer
July 14, 2018 - FDA expands its support for states to implement FSMA Produce Safety Rule
July 14, 2018 - CTI BioPharma Announces the Continuation without Modification of PAC203 Phase 2 Study of Pacritinib in Patients with Myelofibrosis Previously Treated with Ruxolitinib
July 14, 2018 - First-hand accounts of premature baby loss inspires new resource
July 14, 2018 - Study identifies cellular ‘death code’ | News Center
July 14, 2018 - Federal judge enters consent decree against Minnesota dairy farm for selling adulterated meat
July 14, 2018 - New web-based game motivates people to exercise more
July 14, 2018 - Calcium electrotransfer could be used to target cancer cells, study finds
July 14, 2018 - Researchers identify new region in mouse brain that affects appetite and body weight
July 14, 2018 - Repeated testing produces ‘practice effect’ that obscures true cognitive decline
July 14, 2018 - Amgen And UCB Resubmit Biologics License Application (BLA) For Evenity (romosozumab) To The US FDA
July 14, 2018 - New research detects brain cell that improves learning
July 14, 2018 - Spirit, Inspiring Change award winners announced | News Center
July 14, 2018 - Opioid patients face several barriers to treatment, study finds
July 14, 2018 - Black adults more likely to develop high blood pressure by age of 55
July 14, 2018 - Insurers fall short in catching and reporting Medicaid fraud, inspectors find
July 14, 2018 - Scientists identify structural and functional differences in human immune-surveillance protein
July 14, 2018 - FDA Approves TPOXX (tecovirimat) as the First Drug for the Treatment of Smallpox
July 14, 2018 - Visual perceptual skills are updated by process similar to memory reconsolidation, study finds
July 14, 2018 - Big Data in Precision Health focuses on how to make technology work for patient care | News Center
July 14, 2018 - New technique measures how well cancer drugs reach their targets
Researchers develop self-healing material for bone implants

Researchers develop self-healing material for bone implants

image_pdfDownload PDFimage_print

Researchers from the Center for Composite Materials at the National University of Science and Technology MISiS (NUST MISIS) have recently developed a self-healing material for bone implants. The material was based on a shape memory polymer, which can be restored to its original structure upon the local application of heat. The findings of this research were presented during the Healthcare of the Future: The Latest Promising Innovations Moscow-Delhi video conference, which was held at Rossiya Segodnya International Multimedia Press Center.

The discussion centers around the possibility of replacing parts of fractured bones of small and large sizes, as well as surgically removing bone tissue fragments that are affected by malignant tumors. The human body lacks the required resources for self-healing large amounts of bone tissue and hence the need for implants arises.

If the implanted material is subject to cyclic loading (which commonly happens upon the replacement of bone fragments in limbs, especially in legs), cracks may form in the material. These cracks are very hard to manage and impossible to prevent, but it is possible to create an implant made from self-healing material.

“We are currently developing an approach toward using shape memory materials,” said Fyodor Senatov, Candidate of physical and mathematical sciences and a research assistant at NUST MISIS’ Center for Composite Materials. “Initially, the implant has its own defined shape. When a deformation appears caused by a crack, we can apply heat and the material returns to its original structure. In order to possess this shape memory effect, the polymer must contain both a fixed phase (either chemical or physical crosslinks, molecular entanglements or intermolecular interactions) and a soft phase, which is responsible for the entropic elasticity of macromolecules and allows the material to be temporarily deformed. Imagine the polymeric material, from which an implant is made, as being a spring placed inside gelatin. As you deform this piece of plastic, the spring gets stretched out inside. Thick gelatin will prevent the spring from recoiling. But if we heat the gelatin up, it will become soft, and the spring will be able to return to its original shape,” Senatov added.

The driving force behind the material’s ability to restore its shape is the change in the polymer’s molecular mobility and its switch from a more structured temporary configuration, following the deformation, to a thermodynamically favored configuration with higher entropy and less internal energy.

Today, researchers from various laboratories all over the world are carrying out tests on animals to study the possibility of applying heat to such implants locally, without damaging the neighboring tissues. In order to heat up the implant, researchers conduct minimally invasive surgery by making a small incision to bring the waveguide directly to the replaced bone fragment. The main problem is that the implant’s shape can only be restored at temperatures above 50ºC, a temperature that can cause serious damage to living cells. Moreover, the temperature activating the shape memory effect is way too high for the polymers that are used in bone implants.

If we decide to make implants more similar to bones, to make them able to withstand great cyclic loads, the heating temperature will be even higher – about 60-70ºC. These temperatures, without a doubt, will simply destroy the neighboring tissues.

“Unfortunately, so far humans have not developed a material, which is both solid and strong and able to change its structure under acceptable temperatures,” Senatov explained. “I think we will have to keep experimenting with careful heating technology or optimize implants by creating composite materials and altering their internal structure. We have already “fumble” for materials like this, but so far they can self-heal only at 50ºC.”

Now the researchers from the NUST MISIS’s Center for Composite Materials are using various polymers, mainly those which are bioresorbable, or biodegradable, as a foundation for the production of implants. Implants from these materials can be used to replace smaller bone fragments – one of the most in-demand operations in oral and maxillofacial surgery. For replacing larger bone fragments, medical professionals use implants made from ultra-high molecular weight polyethylene.

The polymer’s density can be increased via the introduction of other particles, such as hydroxyapatite – the mineral base of bones and teeth. To obtain the necessary temperature, researchers can use direct heat, electric current, ultrasound or an alternating magnetic field. In order to achieve heating by using a magnetic field, they introduce special magnetic nanoparticles into the polymer. Upon the application of an alternating magnetic field, these particles start warming up and begin transferring heat to the surrounding material. Now researchers are experimenting with the composition of these materials, trying to increase their density and reduce the temperature required to heat them up.

Tagged with:

About author

Related Articles