Breaking News
April 24, 2018 - FDA Approves Intravenous Formulation of Akynzeo (fosnetupitant/palonosetron) for Chemotherapy-Induced Nausea and Vomiting
April 24, 2018 - Is Alzheimer’s caused by disruptions to the brain’s energy supply?
April 24, 2018 - Low concentrations of antibiotics can develop high antibiotic resistance in bacteria
April 24, 2018 - Imagined and real movements have similar brain mechanisms, research suggests
April 24, 2018 - Alcoholic drinks affect oral bacteria tied to diseases
April 24, 2018 - Mechanism in Non-Contact ACL Tears Similar in Men, Women
April 24, 2018 - Buprenorphine may be safer than methadone if treatment duration is longer, study suggests
April 24, 2018 - NF-κB1 gene known to drive cancer development is critical for preventing stomach cancers
April 24, 2018 - New tool helps blind, low-vision users navigate modern webpages more easily
April 24, 2018 - Vegetarian diet and Mediterranean diet close to each other in health benefits
April 24, 2018 - FSU receives $1.5 million federal grant for innovative suicide prevention research
April 24, 2018 - Health Tip: Screening for Cancer in Older Adults
April 24, 2018 - Investigators highlight potential of exercise in addressing substance abuse in teens
April 24, 2018 - Study shows people might develop dementia later and live with it for a shorter period of time
April 24, 2018 - EMBL scientists develop new illumination method to manage neuropathic pain
April 24, 2018 - New compound could offer pain-relieving properties without risk of addiction
April 24, 2018 - New drug treatment could be promising therapeutic approach for millions with asthma
April 24, 2018 - Study provides guidance on using cannabis for treatment of stress, anxiety, and depression
April 24, 2018 - By Royal approval: Queen’s Award success for Elucigene
April 24, 2018 - The role of ‘extra’ DNA in cancer evolution and therapy resistance
April 24, 2018 - Researchers identify tools that caregivers could use to detect delirium in older adults
April 24, 2018 - What to Look Out For
April 24, 2018 - Drugs prescribed for newborns vary widely between NICUs, study finds
April 24, 2018 - FM4200 pressure-resistant mass flow meter from Sensirion
April 24, 2018 - Study links past experiences with bias and avoidance of doctors in women with higher BMI
April 24, 2018 - Role of extrachromosomal pieces of DNA in cancer development and treatment resistance
April 24, 2018 - Rehabilitation technique for stroke appears beneficial for multiple sclerosis patients
April 24, 2018 - Women who find purpose and meaning in life less likely to have anxiety, study shows
April 24, 2018 - Catalyst Pharmaceuticals Announces Submission of New Drug Application for Firdapse for Treatment of Lambert-Eaton Myasthenic Syndrome
April 24, 2018 - Suicide and homicide rates show large racial disparities across US states
April 24, 2018 - Scientists develop tissue-engineered models to better understand cancer metastases
April 24, 2018 - NuProbe to commercialize Wyss Institute’s new technology to facilitate precision medicine
April 24, 2018 - Special series explores pasteurized donor human milk use for hospitalized infants
April 24, 2018 - Slight changes in patient’s position during radiotherapy may impact survival chances
April 24, 2018 - FDA Approves Tagrisso (osimertinib) as First-Line Treatment for EGFR-Mutated Non-Small Cell Lung Cancer
April 24, 2018 - After knee replacement, play on
April 24, 2018 - Contact precautions do not limit spread of drug-resistant bacteria in ICUs
April 24, 2018 - Researchers discover genetic catalysts that accelerate evolution of antibiotic resistance in bacteria
April 24, 2018 - WPI researcher launches mobile app for assessing perinatal depression in women
April 24, 2018 - Researchers identify superior blood-based biomarker for assessing sports-related concussions
April 24, 2018 - Gene Therapy Found to Be Promising for β-Thalassemia
April 24, 2018 - Bariatric surgery can lead to changes in relationship status
April 24, 2018 - GPs must embrace digital technologies to make healthcare access easier for patients
April 24, 2018 - Novel stem cell therapy may transform current paradigms for treating heart failure patients
April 24, 2018 - Maternal depression during and after pregnancy linked to poorer child neurodevelopment
April 24, 2018 - Vitamin D and magnesium supplements provide right nutritional support to athletes
April 24, 2018 - Could a Tattoo Someday Spot Your Cancer?
April 24, 2018 - Throat reflexes differ in people with tetraplegia and sleep apnea
April 24, 2018 - Study shows no increased risk of breast cancer recurrence after DIEP flap reconstruction
April 24, 2018 - Nearly three-quarters of commonly used medical scopes tainted by bacteria
April 24, 2018 - Home-based treatment program offers robust and sustained relief for IBS patients
April 24, 2018 - New IntelliCyt Cy-Clone PLUS streamlines clone ranking and selection for cell line development
April 24, 2018 - Scientists examine how specific eating patterns could help fight cancer and obesity
April 24, 2018 - Study sheds new light on how bilinguals process language
April 24, 2018 - Probiotics can improve liver health, shows study
April 24, 2018 - Study may explain how chemoresistance evolves over time in some triple-negative breast cancers
April 24, 2018 - Role of midbrain in encoding identity errors
April 23, 2018 - Salamander study provides clues for treating spinal cord injuries
April 23, 2018 - Relaxation after work could give better night’s sleep
April 23, 2018 - Loneliness on its way to becoming Britain’s most lethal condition
April 23, 2018 - Low-cost blood test for multiple myeloma can deliver same diagnostic information as bone biopsy
April 23, 2018 - Metabolic differences may contribute to postpartum weight retention in black moms
April 23, 2018 - Time-Related Deployment Factors Predict Suicide Attempt Risk
April 23, 2018 - Are newborns ugly? Research says newborns rated ‘less cute’ than older babies
April 23, 2018 - Prenatal marijuana use linked to increased chance of low birth weights
April 23, 2018 - Researchers identify target gene in P. aeruginosa infection
April 23, 2018 - New studies related to causes of liver degradation and possible treatments
April 23, 2018 - Studies offer leads for new approaches to treat neurological problems
April 23, 2018 - Promising cell study may offer new opportunities for treating Parkinson’s disease
April 23, 2018 - Gene Therapy May Be Cure for Some With Rare Blood Disorder
April 23, 2018 - Obesity impacts liver health in kids as young as eight years old
April 23, 2018 - Frequent cannabis use by young people linked to small reductions in cognitive function
April 23, 2018 - Innovative research could lead to new ways to treat, prevent cancer
April 23, 2018 - Study uncovers possible source of gender differences in migraines
April 23, 2018 - Study proves usefulness of EDX testing in diagnosis, management of neuromuscular disorders
April 23, 2018 - Hacking ‘drug trafficking’ system could increase effectiveness of diabetes treatment
April 23, 2018 - Clinical trial to examine stem cell therapy for treatment, prevention of complications after traumatic injury
April 23, 2018 - Targeted radiotherapy found to be a good option for women with early breast cancer
April 23, 2018 - Eating fish could prevent Parkinson’s disease
April 23, 2018 - Philips showcases dedicated radiation oncology solutions at ESTRO 2018
Researchers discover Tfh cell dysfunction in HIV-infected patients

Researchers discover Tfh cell dysfunction in HIV-infected patients

image_pdfDownload PDFimage_print

A team of chemical and biomedical engineers from the Cockrell School of Engineering at The University of Texas at Austin, in collaboration with researchers from the University of Pennsylvania, have discovered that HIV-infected patients experience a dysfunction in a certain type of immune cell: the follicular helper T (Tfh) cell.

In a paper published today in Science Immunology, the authors outline how, through combining a sophisticated sequencing technique with a mass cytometry method (the measurement of cell characteristics), they discovered the Tfh cell dysfunction.

According to the latest figures from the World Health Organization, about 40 million people worldwide are living with HIV/AIDS. In the U.S., about 1 million are living with the virus, and 1 in 7 of those infected don’t know it. Overall, the number of recorded cases has been in steady decline — thanks to medical advances and greater public awareness. Still, major information gaps remain in our understanding of the fundamental nature of HIV, making every new insight important.

The UT Austin research team’s finding is significant because the Tfh cells — which are present in greater numbers in HIV-infected patients than in healthy individuals– typically help fight off infection by communicating with other immune-supporting cells in the lymph nodes (the immune system’s command center) about an impending viral attack. The researchers found that the Tfh cells present in those infected with HIV are not playing their usual part to defend against viral infections.

Led by UT Austin assistant professor Jenny Jiang in the Department of Biomedical Engineering, the research team combined techniques and approaches developed by Jiang and Laura Su, assistant professor of medicine in Penn’s Perelman School of Medicine. Together, these technologies allowed the team to comprehensively profile T cells in the lymph node glands of HIV patients.

“These types of cells play a critical role during viral infections of any kind,” Jiang said. “They communicate with other immune cells and provide instructions to B cells, for example, to produce virus-neutralizing antibodies that not only kill it off but also help prevent future infections.”

Although the CD4+ T cell is notoriously depleted in patients infected with HIV, the population of Tfh cells is actually more elevated in the lymph nodes of those infected with HIV than it is in healthy individuals. This paradox is what makes further analysis of Tfh cell behavior by anyone studying HIV so vital.

Based on their central role in generating protective antibodies, it would be intuitive to assume that the increased presence of Tfh cells should result in greater resistance to infection. However, the researchers found this not to be the case, suggesting that Tfh cells in HIV patients are ineffective at sending signals to B cells to request help to fight off the infection.

“We believe Tfh cells behave differently when fighting chronic infections like HIV versus when fighting off acute infections like the common cold, potentially making them an easy target for HIV,” Jiang said. “Our next step is to determine why the Tfh cell dysfunction occurs in HIV-infected patients, moving us one step closer to better understanding the virus.”

Tagged with:

About author

Related Articles