Breaking News
September 19, 2018 - Inequality issues persist even under new U.S. kidney transplant allocation system
September 19, 2018 - New study reveals mechanisms that lead to cognitive decline in Type 2 diabetes
September 19, 2018 - FDA launches new comprehensive effort to educate kids about dangers of e-cigarettes
September 19, 2018 - Study reveals mechanism underlying plants’ ability to signal defense
September 19, 2018 - Researchers harness Zika virus vaccine under development to target glioblastoma
September 19, 2018 - Novel deep learning drug discovery platform gets £1 million innovation boost
September 19, 2018 - Sensor array may detect de novo Parkinson’s disease in breath
September 19, 2018 - A roadmap for the future of electronic health records
September 19, 2018 - Surprising research showing peptide adaptability may pave way to develop immunotherapies
September 19, 2018 - Amyloid β protein makes comeback as therapeutic target for Alzheimer’s disease
September 19, 2018 - Alcon expands its global support of eye care professionals through Alcon Experience Academy
September 19, 2018 - Study gives new insights into how cells leverage GPCRs to control inflammation
September 19, 2018 - Automatic relevance detection in ophthalmic surgery videos
September 19, 2018 - UNIST to accelerate discovery, development of new medicines for incurable diseases
September 19, 2018 - Novel clinical trial to examine cannabis as potential treatment for essential tremor
September 19, 2018 - Salsa dancers have lower injury rates than Spanish, aerobic or Zumba dancers
September 19, 2018 - Bristol-Myers Squibb’s Novel, Oral, Selective TYK2 Inhibitor Delivered Significant Skin Clearance in Patients with Moderate to Severe Plaque Psoriasis in Phase 2 Trial
September 19, 2018 - Can work stress contribute to Parkinson’s disease risk?
September 19, 2018 - Global Climate Action Summit: A focus on kids and climate
September 19, 2018 - Vitamin D may reduce breast cancer mortality in women with lower BMI
September 19, 2018 - Targeted Lung Denervation procedure significantly reduces COPD problems
September 19, 2018 - FDA-approved ‘safe’ daily BPA exposure may contribute to insulin resistance
September 19, 2018 - Research finds physical connection between the brain’s fluid reservoirs and meningeal lymphatics
September 19, 2018 - UCalgary study could help physicians make better treatment decisions for stroke
September 19, 2018 - Biomedical review finds failure rates in some surgical mesh treatments to be unacceptably high
September 19, 2018 - Researchers develop more accurate measure of body fat
September 19, 2018 - Doctors and students rally to support gun violence research, education
September 19, 2018 - LEO Pharma and MorphoSys announce expansion of strategic alliance to develop peptide-derived drugs
September 19, 2018 - Seniors in pain hop aboard the canna-bus
September 19, 2018 - New compound could prevent malaria parasites from maturing inside mosquito
September 19, 2018 - Scientists find alterations in blood flow in response to body position change
September 19, 2018 - UNC Health Care extends free access to virtual care service in the aftermath of Hurricane Florence
September 19, 2018 - Opioid Refills Rare After Rhinoplasty
September 19, 2018 - Corn, obesity, and navigating healthy eating choices as a parent
September 19, 2018 - Journal editor aims to prompt thoughtful review of ethics in precision health
September 19, 2018 - Researchers identify key step in how plant cells respond to pathogens
September 18, 2018 - Researchers analyze how exposure to silver nanoparticles affects zebrafish
September 18, 2018 - Study shows air pollution may be bad for the fetus
September 18, 2018 - Coffee May Have Another Perk for Kidney Patients
September 18, 2018 - Tongue-in-cheek Nobels honor nutritional analysis of cannibalism, roller-coaster kidney stones treatment
September 18, 2018 - Progress, priorities, challenges are focus of State of Stanford Medicine | News Center
September 18, 2018 - Established Alzheimer’s Risk Gene Has a New Role
September 18, 2018 - Hospitalization after antibiotic initiation found to be higher for people with Alzheimer’s disease
September 18, 2018 - Many children with special healthcare needs do not have access to ‘PCMH-concordant’ care
September 18, 2018 - Investigational nasal influenza vaccine tested in children and teens
September 18, 2018 - Lymphatic vessels surrounding the brain play crucial role in multiple sclerosis, research suggests
September 18, 2018 - New fiber laser-based ultrasound sensor may have potential applications in medical diagnostics
September 18, 2018 - Protect your heart and health during ‘dog days’ of summer
September 18, 2018 - Faculty receive awards for promise in biomedical research, clinical care | News Center
September 18, 2018 - Digital games for CVD-related self-management improve exercise capacity and energy expenditure
September 18, 2018 - Aluminum inclusions help enhance adsorption of chemo drugs onto active carbon delivery capsule
September 18, 2018 - Adding PET scans to CT imaging can change treatment for women with cervical cancer
September 18, 2018 - UCSF awarded $20 million grant to study impacts of new, emerging tobacco products
September 18, 2018 - Human brains may be wired to prefer lying on the couch, suggests research
September 18, 2018 - Zika virus vaccine shows promise for treatment of fatal glioblastoma
September 18, 2018 - Theravance Biopharma and Mylan to Report New Data from Phase 3 Studies of Yupelri (revefenacin) in Oral Presentation at European Respiratory Society International Congress 2018
September 18, 2018 - INSiGHT identifies unique retinal regulatory genes
September 18, 2018 - Diversity, science leadership grants awarded to student-faculty pairs | News Center
September 18, 2018 - Many parents blame electronics for sleep problems among teens
September 18, 2018 - Researchers study neuronal activity in brain that prevents individuals from doing physical activity
September 18, 2018 - Purifying Proteins from Mammalian Cell Culture
September 18, 2018 - Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection
September 18, 2018 - Outcome of ACL reconstruction related to the way you move post-surgery
September 18, 2018 - Study aims to investigate risk factors for PPCs in surgical patients with gastric cancer
September 18, 2018 - Ardelyx Submits New Drug Application for Tenapanor for IBS-C
September 18, 2018 - Sociodemographic disparities in eyeglass use among elderly
September 18, 2018 - New Drug Shows Promise for Progressive Form of MS
September 18, 2018 - Babies exposed to higher levels of organochlorine compounds in womb may have worse lung function
September 18, 2018 - Women exposed to trauma in their lives gave birth to underweight male infants
September 18, 2018 - Probiotic supplementation may reduce use of antibiotics, scientific analysis shows
September 18, 2018 - Resveratrol decreases pain severity and levels of inflammatory biomarkers in osteoarthritis patients
September 18, 2018 - Research shows pollution is reaching the placenta
September 18, 2018 - KAIST researchers develop heart-targeting drug delivery technology using tannin acid
September 18, 2018 - Muscle relaxants used during general anesthesia can increase risk of pulmonary complications
September 18, 2018 - Silicone breast implants may increase risk of rare adverse outcomes in women
September 18, 2018 - Pediatricians Have a Role in Encouraging Play Among Children
September 18, 2018 - California’s Medicaid program hits ‘print’ when the feds need info
September 18, 2018 - Genes, environment and schizophrenia—new study finds the placenta is the missing link
September 18, 2018 - Boehringer Ingelheim announces study results of COPD patients treated with Spiolto Respimat
September 18, 2018 - PAREXEL launches Patient Innovation Center to improve drug development process
Smartphone ‘scores’ can reliably reflect symptom severity in Parkinson’s patients

Smartphone ‘scores’ can reliably reflect symptom severity in Parkinson’s patients

image_pdfDownload PDFimage_print

Parkinson’s disease, a progressive brain disorder, is often tough to treat effectively because symptoms, such as tremors and walking difficulties, can vary dramatically over a period of days, or even hours.

To address this challenge, Johns Hopkins University computer scientists, working with an interdisciplinary team of experts from two other institutions, have developed a new approach that uses sensors on a smartphone to generate a score that reliably reflects symptom severity in patients with Parkinson’s disease.

In a study published recently online in the journal JAMA Neurology, researchers from Johns Hopkins’ Whiting School of Engineering, the University of Rochester Medical Center, and Aston University in the United Kingdom reported that the severity of symptoms among Parkinson’s patients seen by neurologists aligned closely with those generated by their smartphone app.

Typically, patients with Parkinson’s disease are evaluated by medical specialists during three or four clinic visits annually, with subjective assessments capturing only a brief snapshot of a patient’s fluctuating symptoms. In their homes, patients may also be asked to fill out a cumbersome 24-hour “motor diary” in which they keep a written record of their mobility, involuntary twisting movements and other Parkinson’s symptoms. The doctor then uses this self-reported or imprecise data to guide treatment.

In the new study, the researchers say patients could use a smartphone app to objectively monitor symptoms in the home and share this data to help doctors fine-tune their treatment.

E. Ray Dorsey, a University of Rochester Medical Center neurologist and a co-author of the research paper, said he welcomes the validation of Parkinson’s patient severity scores produced by the smartphone tests.

“If you think about it, it sounds crazy,” he said, “but until these types of studies, we had very limited data on how these people function on Saturdays and Sundays because patients don’t come to the clinic on Saturdays or Sundays. We also had very limited data about how people with Parkinson’s do at two o’clock in the morning or 11 o’clock at night because, unless they’re hospitalized, they’re generally not being seen in clinics at those times.”

About six years ago, while doing medical research at Johns Hopkins, Dorsey was introduced to Suchi Saria, an assistant professor of computer science at the university. Saria, the corresponding author of the study and an expert in a computing technique called machine learning, had been using it to extract useful information from health-related data that was routinely being collected at hospitals. The two researchers, along with some of Saria’s students, teamed up to find a way to monitor the health of Parkinson’s patients as easily as people with diabetes can check their glucose levels with a pinprick blood test.

The team members knew that neurologists evaluated their Parkinson’s patients by gathering information about how they moved, spoke and completed certain daily tasks. “Can we do this with a cellphone?” Saria wondered at the time. “We asked, ‘What are the tricks we can use to make that happen?’ “

Using existing smartphone components such as its microphone, touch screen and accelerometer, the team members devised five simple tasks involving voice sensing, finger tapping, gait measurement, balance and reaction time. They turned this into a smartphone app called ‘HopkinsPD.’ Next, using a machine learning technique that the team devised, they were able to convert the data collected with these tests and turn that into an objective Parkinson’s disease severity score–a score that better reflected the overall severity of patients’ symptoms and how well they were responding to medication.

The researchers say this smartphone evaluation should be particularly useful because it does not rely on the subjective observations of a medical staff member. Moreover, it can be administered any time or day in a clinic or within the patient’s home, where the patient is less likely to be as nervous as in a medical setting.

“The day-to-day variability of Parkinson’s symptoms is so high,” Saria said. “If you happen to measure a patient at 5 p.m. today and then three months later, again at 5 p.m., how do you know that you didn’t catch him at a good time the first time and at a bad time the second time?”

Collecting more frequent smartphone test data in a medical setting as well as in the home, could give doctors a clearer picture of their patients’ overall heath and how well their medications are working, Saria and her colleagues suggested.

Summarizing the importance of their finding in the JAMA Neurology report, the researchers said, “A smartphone-derived severity score for Parkinson’s disease is feasible and provides an objective measure of motor symptoms inside and outside the clinic that could be valuable for clinical care and therapeutic development.”

Patients in the research project used Android smartphones to download the software, available through the Parkinson’s Voice Initiative website. The team has now partnered with Apple and Sage Bionetworks to develop mPower, an iPhone version that is available at Apple’s App Store.

The study’s three co-lead authors included two of Saria’s students from the Department of Computer Science at Johns Hopkins: doctoral candidate Andong Zhan and third-year undergraduate Srihari Mohan.

Zahn, who is from Qujing, Yunnan, in China, described the project as “a unique experience of extracting data from the physical world to a digital world and finally seeing it become meaningful clinical information.”

Mohan, who is from Redmond, Washington, added, “While not all research gets integrated tangibly into people’s lives, what excites me most is the potential for the methods we developed to be deployed seamlessly into a patient’s lifestyle and improve the quality of care.”

Source:

Smartphone ‘Scores’ Can Help Doctors Track Severity of Parkinson’s Disease Symptoms

About author

Related Articles