Breaking News
September 19, 2018 - FDA-approved ‘safe’ daily BPA exposure may contribute to insulin resistance
September 19, 2018 - Research finds physical connection between the brain’s fluid reservoirs and meningeal lymphatics
September 19, 2018 - Biomedical review finds failure rates in some surgical mesh treatments to be unacceptably high
September 19, 2018 - Researchers develop more accurate measure of body fat
September 19, 2018 - Doctors and students rally to support gun violence research, education
September 19, 2018 - LEO Pharma and MorphoSys announce expansion of strategic alliance to develop peptide-derived drugs
September 19, 2018 - Seniors in pain hop aboard the canna-bus
September 19, 2018 - New compound could prevent malaria parasites from maturing inside mosquito
September 19, 2018 - Scientists find alterations in blood flow in response to body position change
September 19, 2018 - UNC Health Care extends free access to virtual care service in the aftermath of Hurricane Florence
September 19, 2018 - Opioid Refills Rare After Rhinoplasty
September 19, 2018 - Corn, obesity, and navigating healthy eating choices as a parent
September 19, 2018 - Journal editor aims to prompt thoughtful review of ethics in precision health
September 19, 2018 - Researchers identify key step in how plant cells respond to pathogens
September 18, 2018 - Researchers analyze how exposure to silver nanoparticles affects zebrafish
September 18, 2018 - Study shows air pollution may be bad for the fetus
September 18, 2018 - Coffee May Have Another Perk for Kidney Patients
September 18, 2018 - Tongue-in-cheek Nobels honor nutritional analysis of cannibalism, roller-coaster kidney stones treatment
September 18, 2018 - Progress, priorities, challenges are focus of State of Stanford Medicine | News Center
September 18, 2018 - Established Alzheimer’s Risk Gene Has a New Role
September 18, 2018 - Hospitalization after antibiotic initiation found to be higher for people with Alzheimer’s disease
September 18, 2018 - Many children with special healthcare needs do not have access to ‘PCMH-concordant’ care
September 18, 2018 - Investigational nasal influenza vaccine tested in children and teens
September 18, 2018 - Lymphatic vessels surrounding the brain play crucial role in multiple sclerosis, research suggests
September 18, 2018 - New fiber laser-based ultrasound sensor may have potential applications in medical diagnostics
September 18, 2018 - Protect your heart and health during ‘dog days’ of summer
September 18, 2018 - Faculty receive awards for promise in biomedical research, clinical care | News Center
September 18, 2018 - Digital games for CVD-related self-management improve exercise capacity and energy expenditure
September 18, 2018 - Aluminum inclusions help enhance adsorption of chemo drugs onto active carbon delivery capsule
September 18, 2018 - Adding PET scans to CT imaging can change treatment for women with cervical cancer
September 18, 2018 - UCSF awarded $20 million grant to study impacts of new, emerging tobacco products
September 18, 2018 - Human brains may be wired to prefer lying on the couch, suggests research
September 18, 2018 - Zika virus vaccine shows promise for treatment of fatal glioblastoma
September 18, 2018 - Theravance Biopharma and Mylan to Report New Data from Phase 3 Studies of Yupelri (revefenacin) in Oral Presentation at European Respiratory Society International Congress 2018
September 18, 2018 - INSiGHT identifies unique retinal regulatory genes
September 18, 2018 - Diversity, science leadership grants awarded to student-faculty pairs | News Center
September 18, 2018 - Many parents blame electronics for sleep problems among teens
September 18, 2018 - Researchers study neuronal activity in brain that prevents individuals from doing physical activity
September 18, 2018 - Purifying Proteins from Mammalian Cell Culture
September 18, 2018 - Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection
September 18, 2018 - Outcome of ACL reconstruction related to the way you move post-surgery
September 18, 2018 - Study aims to investigate risk factors for PPCs in surgical patients with gastric cancer
September 18, 2018 - Ardelyx Submits New Drug Application for Tenapanor for IBS-C
September 18, 2018 - Sociodemographic disparities in eyeglass use among elderly
September 18, 2018 - New Drug Shows Promise for Progressive Form of MS
September 18, 2018 - Babies exposed to higher levels of organochlorine compounds in womb may have worse lung function
September 18, 2018 - Women exposed to trauma in their lives gave birth to underweight male infants
September 18, 2018 - Probiotic supplementation may reduce use of antibiotics, scientific analysis shows
September 18, 2018 - Resveratrol decreases pain severity and levels of inflammatory biomarkers in osteoarthritis patients
September 18, 2018 - Research shows pollution is reaching the placenta
September 18, 2018 - KAIST researchers develop heart-targeting drug delivery technology using tannin acid
September 18, 2018 - Muscle relaxants used during general anesthesia can increase risk of pulmonary complications
September 18, 2018 - Silicone breast implants may increase risk of rare adverse outcomes in women
September 18, 2018 - Pediatricians Have a Role in Encouraging Play Among Children
September 18, 2018 - California’s Medicaid program hits ‘print’ when the feds need info
September 18, 2018 - Genes, environment and schizophrenia—new study finds the placenta is the missing link
September 18, 2018 - Boehringer Ingelheim announces study results of COPD patients treated with Spiolto Respimat
September 18, 2018 - PAREXEL launches Patient Innovation Center to improve drug development process
September 18, 2018 - Children’s National and NIAID launch pediatric clinical research partnership
September 18, 2018 - Researchers may be overlooking complexities in social relations of primates
September 18, 2018 - Key signaling molecule that helps stem cells make healthy bone declines as we age
September 18, 2018 - More women veterans with chronic pain use CIH therapies than men
September 18, 2018 - As Earth Warms, Heat-Related Deaths Will Multiply
September 18, 2018 - Labetalol use up for patients with preeclampsia and asthma
September 18, 2018 - MoreGrasp project shows significant results in field of thought-controlled grasp neuroprosthetics
September 18, 2018 - Drumming can benefit school children with autism
September 18, 2018 - Busyness can help people to make virtuous choices, research shows
September 18, 2018 - Two-minute bursts of in-class exercise breaks do not disrupt learning and teaching
September 18, 2018 - New online tools aid surgeons and specialists who care for older people
September 18, 2018 - Researchers use CRISPR to identify gene that helps cells resist flavivirus infection
September 18, 2018 - Brain’s support cells may play a central role in repetitive behaviors related to OCD
September 18, 2018 - Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell
September 18, 2018 - Easy and rapid test for viral infections can cut antibiotic use, hospitalizations
September 18, 2018 - Gunshot victims more likely to require blood transfusions and die than other trauma patients
September 18, 2018 - Cyclacel Pharmaceuticals Announces Initiation of Phase 1b/2 Clinical Trial of Sapacitabine With Olaparib in BRCA Mutant Breast Cancer
September 18, 2018 - Older adults fitted with cochlear implants exhibit poor brain function
September 18, 2018 - Inexpensive testing spurs cancer patients’ relatives to assess own disease risk | News Center
September 18, 2018 - Aging may have originated at the very beginning of life, says study
September 18, 2018 - New research on sperm quality updates advice for couples trying to conceive
September 18, 2018 - Paracetamol use in infancy may increase risk of developing asthma by the age of 18
Cancer risk found to be three times greater after acute thrombosis in the leg

Cancer risk found to be three times greater after acute thrombosis in the leg

image_pdfDownload PDFimage_print

Patients with the most acute type of thrombosis in the leg – known as an arterial thrombosis – risk developing diseases that are far worse than the blood clot itself. The risk of developing cancer during the first six months after the blood clot is three times greater than normal.

This is shown by a register-based study that medical doctor and PhD Jens Sundbøll has recently published in the journal Circulation. Jens Sundbøll is employed at the Department of Clinical Epidemiology, which is part of the Department of Clinical Medicine at Aarhus University and Aarhus University Hospital.

“It is especially, but not only, the smoking-related forms of cancer that show up after the arterial thrombosis. The risk is highest for lung and pancreatic cancer, both of which are related to smoking. However, other forms of cancer such as colon cancer and leukemia are also overrepresented,” says Jens Sundbøll about the research results.

In the study, Jens Sundbøll observes that the cancer risk is continuously increased but decreases in strength over time. After the first six months with 3-fold increased risk compared with a control group without blood clots, it falls during the next six months to ‘only’ a forty percent increased risk. Once the first year after the blood clot has passed, the risk of cancer is continuously 15 percent increased.

“With the high relative figures, one should bear in mind that arterial thromboses are relatively rare with 1.5 cases per 10,000 persons annually, compared to 5-10 cases per 10,000 annually for deep venous thrombosis,” says Jens Sundbøll.

Whereas an ordinary venous blood clot causes the leg to swell, contract and become warm and red, the characteristics of the arterial blood clot are almost the opposite. Namely that the leg becomes pale and cold. As Jens Sundbøll puts it, cases where doctors come across an arterial blood clot are those where they need to remember the five p’s: pallor, pulselessness, pain, paresis/paralysis as well as paraesthesia:

“If the arterial thrombosis is not correctly treated within a short period of time, the patient typically loses a leg.”

Jens Sundbøll points out that hospitalization in connection with the arterial blood clot is an obvious opportunity to question patients about early signs of the various cancers that the arterial blood clots are now shown to be markers for:

“It is well known that early treatment is crucial for the prognosis of many types of cancer, and our findings show that an arterial thrombosis in the leg is associated with an increased risk of cancer to the same degree as a deep venous thrombosis – both absolutely and relatively speaking. This is an important finding, which clinicians should integrate into their deliberations. Hospitalisation for an arterial thrombosis in the leg is an obvious opportunity to carry out an opportunistic screening for cancer, which I believe should be considered, just as for patients presenting with a deep venous thrombosis, “says Jens Sundbøll.

The study “Risk and Prognosis of Cancer after Lower Limb Arterial Thrombosis” is based on the 6,600 Danes who were diagnosed with an arterial blood clot in the leg during the period 1994-2013. Of them, 772 were diagnosed with cancer during the twenty-year period.

The study was carried out by comparing the number of cancer cases in patients with arterial blood clots in the leg with the number of cancer cases in the general population. Data from the Danish National Patient Registry were used to identify patients with blood clots, and the Danish Cancer Registry was used to follow the patients for cancer.

“6,600 patients might not sound like much, but it is in fact among the largest data materials for lower limb arterial thrombosis in the world. This is also the first time that the association with cancer has been examined,” says Jens Sundbøll.

In a research context, the fact that cancer patients have a significantly increased risk of blood clots is well-established, and it can therefore be asked whether it is the active, yet undiagnosed, cancer that causes the arterial blood clot in the leg, or whether the blood clot facilitate the formation of a latent cancer. The answer is that we do not know. The study does not clarify the underlying causal mechanisms, but Jens Sundbøll still has a reasoned suggestion for the classical ‘chicken and egg’ dilemma.

“We know that blood platelets and coagulation factors change in cancer patients and that the blood has an increased tendency to form blood clots in cancer patients. It is therefore likely that an undetected cancer discloses itself through a lower limb arterial thrombosis. Similarly, one can imagine that an undetected cancer located in the close proximity of the arteries supplying the leg grows into the arteries and sends off thrombi via the bloodstream down into the leg,” says Jens Sundbøll.

Tagged with:

About author

Related Articles