Breaking News
April 26, 2018 - UNC-Chapel Hill receives new award to help improve health of North Carolinians
April 26, 2018 - Study finds no evidence of chronic wasting disease transmissibility in macaques
April 26, 2018 - Study highlights impact of early detection on skin cancer survival
April 26, 2018 - Scientists discover culprit in reducing effectiveness of insulin
April 26, 2018 - Exploiting rabies virus machinery to usher Parkinson’s disease drug directly to the brain
April 26, 2018 - ‘Rapid autopsy’ programs seek clues to cancer within hours of death
April 26, 2018 - Personalised prescriptions according to your genetics
April 26, 2018 - ECDC analysis highlights measles vaccination gaps in teenagers and young adults
April 26, 2018 - Study assesses link between cognitive function levels and crash risk among older drivers
April 26, 2018 - Researchers uncover how obesity leads to cancer initiation
April 26, 2018 - Consuming large quantities of sugar during pregnancy can affect child’s cognition, shows study
April 26, 2018 - Researchers create new tool to measure patient uncertainty for predicting hospital readmissions
April 26, 2018 - FDA Alert: Lamictal (lamotrigine): Drug Safety Communication
April 26, 2018 - Massive single-cell survey of kidney cell types reveals new paths to disease
April 26, 2018 - Cognitive behavioral therapy can help children with autism manage emotional challenges
April 26, 2018 - CU Anschutz Medical Campus receives NIH grant to speed up discovery of new treatments
April 26, 2018 - Researchers discover significant distortions in leading genetics study method
April 26, 2018 - New combination therapy could improve survival in children with high-risk neuroblastoma
April 26, 2018 - Scientists clarify casual role of oxidative stress in metabolically abnormal and healthy obesities
April 26, 2018 - Home-based exercise program found ineffective for patients with peripheral artery disease
April 26, 2018 - New UCLA study could elucidate certain causes of infertility and miscarriage
April 26, 2018 - Choroidal Thickness Changes in Patients With Untreated DM
April 26, 2018 - Medical chemists discover peptic ulcer treatment metallodrug effective in ‘taming’ superbugs
April 26, 2018 - UB researchers build 3D-printed, drug-filled dentures to fight against infections
April 26, 2018 - Researchers find role of iron storage gene in slowing down prostate cancer growth
April 26, 2018 - Study suggests link between regular mid-day naps and neurocognitive function in teens
April 26, 2018 - Researchers gain ground-breaking insights into how inflammatory diseases work
April 26, 2018 - Injured U.S. Vet Receives World’s First Penis/Scrotum Transplant
April 26, 2018 - Researchers find existing drug effective at preventing onset of type 1 diabetes
April 26, 2018 - MGH researchers identify risk factors for drug overdose in youth with substance use disorders
April 26, 2018 - Researchers develop new vaccine to help people overcome bath salts abuse
April 26, 2018 - Genetic signature predicts diabetes diagnosis
April 26, 2018 - Study shows link between restless legs syndrome symptoms and brain structure
April 26, 2018 - MU researchers use new techniques to fight against diabetic retinopathy
April 26, 2018 - AAE’s new practice statements aim at improving patient care
April 26, 2018 - Expression of long non-coding RNAs can result in high levels of specific proteins involved in cancer
April 26, 2018 - FDA re-examining safety of new drug approved for Parkinson’s disease psychosis
April 26, 2018 - Unanimous Positive Result of FDA Advisory Committee Meeting for First Plant-Based Pharmaceutical Cannabidiol Treatment for Seizures in Patients with Two Rare, Severe Forms of Epilepsy
April 26, 2018 - Bacteria boost antifungal drug resistance in severe childhood tooth decay
April 26, 2018 - New study affirms bedtime habits of Americans
April 26, 2018 - Hospital patients are more interested in tracking their health data, research shows
April 26, 2018 - Study shows gene variations associated with malaria risk
April 26, 2018 - Inhealthcare teams up with MSKassist to combat problems related to obesity and aging
April 26, 2018 - Caffeine during pregnancy – babies 66 percent more likely to become overweight
April 26, 2018 - FDA Approves Jynarque (tolvaptan) to Slow Kidney Function Decline in Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease
April 26, 2018 - Pricey dental implants often best but insurance rarely pays
April 26, 2018 - Advion’s Peak Express software now available with the expression compact mass spectrometer
April 25, 2018 - Researchers find link between pneumonia in older people and PPI prescriptions
April 25, 2018 - Alcohol damages microbiome in the mouth
April 25, 2018 - Regular soaking in hot tub improves health outlook in obese women with PCOS
April 25, 2018 - FDA Alert: Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) Devices: Letter to Health Care Providers
April 25, 2018 - Sunshine could hold clues on the timing for a severe form of heart attack, study says
April 25, 2018 - Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system
April 25, 2018 - Biofeedback-assisted relaxation may help children during medical procedures
April 25, 2018 - Key signaling protein in Huntington’s disease found to have deleterious effects on heart function, shows study
April 25, 2018 - Celecoxib Lowers Opioid Use Post Head & Neck Cancer Surgery
April 25, 2018 - New ‘brain health index’ can predict how well patients will do after stroke
April 25, 2018 - Positive interventions in sepsis management raise key questions about E. coli reduction targets
April 25, 2018 - Scientists identify new DNA structure within living human cells
April 25, 2018 - E. coli’s toxin-antitoxin system inhibits bacterial growth
April 25, 2018 - Researchers uncover reason why exercise may be beneficial for the heart
April 25, 2018 - Researcher presents case study of asymptomatic patient with severe mitral regurgitation
April 25, 2018 - Use ‘Proper Form’ When Practicing Yoga
April 25, 2018 - Study reports possible novel method for stopping untreatable pediatric brain cancers
April 25, 2018 - Visually guided walking paves way for better treatment for mobility impairments
April 25, 2018 - Researchers identify novel pathway in development of AML with poor prognosis
April 25, 2018 - Cardiovascular disease may only be a matter of time for people with healthy obesity
April 25, 2018 - Girls with type 2 diabetes have high frequency of menstrual irregularities
April 25, 2018 - Study explains why intense exercise curbs appetite
April 25, 2018 - Experimental drug for rheumatoid arthritis prevents side effect of stem cell transplants
April 25, 2018 - Why are Antibiotics Overprescribed for Meningitis Treatment?
April 25, 2018 - Consuming protein supplements with meals, rather than between meals, may promote weight control
April 25, 2018 - Seeing prostate cancer in a new light
April 25, 2018 - Jacobs Medical Center recognized with Baby Friendly Designation for efforts in mother-baby bonding
April 25, 2018 - Gene related to high fatality could be used as biomarker in patients with P. aeruginosa infection
April 25, 2018 - Study shows patients in major prostate cancer study are more likely to die than real-world patients
April 25, 2018 - HBP researchers develop new tool to examine role of genes in disease-relevant brain regions
April 25, 2018 - Trio’s pioneering silicone ostomy product wins prestigious Queen’s Award for Enterprise
April 25, 2018 - Study highlights potential of stem cells derived from adults in regenerative medicine
April 25, 2018 - A new, emerging procedure burns cancer cells
Cancer risk found to be three times greater after acute thrombosis in the leg

Cancer risk found to be three times greater after acute thrombosis in the leg

image_pdfDownload PDFimage_print

Patients with the most acute type of thrombosis in the leg – known as an arterial thrombosis – risk developing diseases that are far worse than the blood clot itself. The risk of developing cancer during the first six months after the blood clot is three times greater than normal.

This is shown by a register-based study that medical doctor and PhD Jens Sundbøll has recently published in the journal Circulation. Jens Sundbøll is employed at the Department of Clinical Epidemiology, which is part of the Department of Clinical Medicine at Aarhus University and Aarhus University Hospital.

“It is especially, but not only, the smoking-related forms of cancer that show up after the arterial thrombosis. The risk is highest for lung and pancreatic cancer, both of which are related to smoking. However, other forms of cancer such as colon cancer and leukemia are also overrepresented,” says Jens Sundbøll about the research results.

In the study, Jens Sundbøll observes that the cancer risk is continuously increased but decreases in strength over time. After the first six months with 3-fold increased risk compared with a control group without blood clots, it falls during the next six months to ‘only’ a forty percent increased risk. Once the first year after the blood clot has passed, the risk of cancer is continuously 15 percent increased.

“With the high relative figures, one should bear in mind that arterial thromboses are relatively rare with 1.5 cases per 10,000 persons annually, compared to 5-10 cases per 10,000 annually for deep venous thrombosis,” says Jens Sundbøll.

Whereas an ordinary venous blood clot causes the leg to swell, contract and become warm and red, the characteristics of the arterial blood clot are almost the opposite. Namely that the leg becomes pale and cold. As Jens Sundbøll puts it, cases where doctors come across an arterial blood clot are those where they need to remember the five p’s: pallor, pulselessness, pain, paresis/paralysis as well as paraesthesia:

“If the arterial thrombosis is not correctly treated within a short period of time, the patient typically loses a leg.”

Jens Sundbøll points out that hospitalization in connection with the arterial blood clot is an obvious opportunity to question patients about early signs of the various cancers that the arterial blood clots are now shown to be markers for:

“It is well known that early treatment is crucial for the prognosis of many types of cancer, and our findings show that an arterial thrombosis in the leg is associated with an increased risk of cancer to the same degree as a deep venous thrombosis – both absolutely and relatively speaking. This is an important finding, which clinicians should integrate into their deliberations. Hospitalisation for an arterial thrombosis in the leg is an obvious opportunity to carry out an opportunistic screening for cancer, which I believe should be considered, just as for patients presenting with a deep venous thrombosis, “says Jens Sundbøll.

The study “Risk and Prognosis of Cancer after Lower Limb Arterial Thrombosis” is based on the 6,600 Danes who were diagnosed with an arterial blood clot in the leg during the period 1994-2013. Of them, 772 were diagnosed with cancer during the twenty-year period.

The study was carried out by comparing the number of cancer cases in patients with arterial blood clots in the leg with the number of cancer cases in the general population. Data from the Danish National Patient Registry were used to identify patients with blood clots, and the Danish Cancer Registry was used to follow the patients for cancer.

“6,600 patients might not sound like much, but it is in fact among the largest data materials for lower limb arterial thrombosis in the world. This is also the first time that the association with cancer has been examined,” says Jens Sundbøll.

In a research context, the fact that cancer patients have a significantly increased risk of blood clots is well-established, and it can therefore be asked whether it is the active, yet undiagnosed, cancer that causes the arterial blood clot in the leg, or whether the blood clot facilitate the formation of a latent cancer. The answer is that we do not know. The study does not clarify the underlying causal mechanisms, but Jens Sundbøll still has a reasoned suggestion for the classical ‘chicken and egg’ dilemma.

“We know that blood platelets and coagulation factors change in cancer patients and that the blood has an increased tendency to form blood clots in cancer patients. It is therefore likely that an undetected cancer discloses itself through a lower limb arterial thrombosis. Similarly, one can imagine that an undetected cancer located in the close proximity of the arteries supplying the leg grows into the arteries and sends off thrombi via the bloodstream down into the leg,” says Jens Sundbøll.

Tagged with:

About author

Related Articles