Breaking News
September 22, 2018 - Cardiac MR With Contrast Feasible in Developing World
September 22, 2018 - Daily low-dose aspirin doesn’t reduce heart-attack risk in healthy people
September 21, 2018 - Children with asthma found to be disadvantaged in education and future occupation
September 21, 2018 - Interaction of chemical slurry and ancient shale in fracking wastewater causes radioactivity
September 21, 2018 - Researchers find that sample size is key factor determining accuracy of study results
September 21, 2018 - Study shows how the drive to eat overpowers the brain’s signal to stop
September 21, 2018 - 30 Million Americans Now Have Diabetes
September 21, 2018 - Thousands of breast cancer gene variants engineered and analyzed
September 21, 2018 - The current fellowship interview process is cumbersome — Stanford researchers have a better idea
September 21, 2018 - Progenitor cells for human bone and cartilage have been identified
September 21, 2018 - Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy
September 21, 2018 - SLU’s College professor receives NIH grant to develop I-TEST project
September 21, 2018 - DermTech completes enrollment in clinical study to assess DNA damage and reversal
September 21, 2018 - Grieving patients treated with talk therapy have lower risk of suicide and psychiatric illness
September 21, 2018 - NIH and FDA call for eliminating involvement of RAC in human gene therapy experiments
September 21, 2018 - New system uses algorithm to convert 2D videos into 3D printed ‘motion sculptures’
September 21, 2018 - Sea squirt model reveals key molecules in dopaminergic neuron differentiation
September 21, 2018 - Effective management of neonatal abstinence syndrome requires coordinated ‘cascade of care’
September 21, 2018 - Refugees seek care for wounds of war
September 21, 2018 - Under the sea, in an octopus’ garden on ecstacy
September 21, 2018 - Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort
September 21, 2018 - Giving kids honest information about water consumption may help them make healthy choices
September 21, 2018 - Horwitz Prize Awarded for Work on Hormones
September 21, 2018 - CHMP issues positive opinion supporting use of Trelegy Ellipta in broader group of COPD patients
September 21, 2018 - Scientists discover new molecules that work together to remove unwanted DNA
September 21, 2018 - Dr. Fenella France to deliver 2019 Plenary Lecture
September 21, 2018 - New research finds that MHC-II molecules have more influence on tumors than MHC-I
September 21, 2018 - Researchers study effects of cardiac cycle in simple learning task
September 21, 2018 - FDA takes new steps to address opioid crisis by approving Opioid Analgesic Risk Evaluation and Mitigation Strategy
September 21, 2018 - Positive Barhemsys Phase 3 Treatment Data Published in Anesthesia & Analgesia
September 21, 2018 - Celiac Disease Screening: MedlinePlus Lab Test Information
September 21, 2018 - Autism linked to egg cells’ difficulty creating large proteins
September 21, 2018 - Tweaking nuclear pores could provide new avenue to battle against cancer
September 21, 2018 - Experts warn health care providers to slow down in allowing smart pill in patient care settings
September 21, 2018 - MoreGrasp reports breakthrough development of grasp neuroprosthetics activated by thought control
September 21, 2018 - Study reveals new way to target HER2-negative metastatic breast cancer
September 21, 2018 - CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL
September 21, 2018 - Study offers solid link between visceral organs and brain’s reward, motivation system
September 21, 2018 - First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute
September 21, 2018 - New study shows how Ethiopia has managed to achieve extraordinary progress
September 21, 2018 - Choroidal Detachment – The American Society of Retina Specialists
September 21, 2018 - New clinical trial evaluates aesthetic results of conservative surgery in breast cancer
September 21, 2018 - Discovery of a key protein involved in the development of autism
September 21, 2018 - Air pollution appears to be linked to increased risk of developing dementia
September 21, 2018 - Henry Ford Health System receives $600k grant to study genetic makeup of gliomas
September 21, 2018 - Arthritis common in individuals with varying degrees of depression, finds study
September 21, 2018 - Scientist intends to fight pathogenic bacteria with viruses
September 21, 2018 - New research suggests link between PFAS chemicals and hyperthyroidism in pet cats
September 21, 2018 - Multi-year study data shows impact of new soft contact lens to slow myopia progression in children
September 21, 2018 - Neuroscientists identify circuit for brain’s statistical inference about motion
September 21, 2018 - MILabs’ VECTor6 system wins Commercial Innovation Award at WMIC 2018
September 21, 2018 - Scientists find wild African monkeys infected with bacterium that causes syphilis, yaws in humans
September 21, 2018 - 2006 to 2015 Saw Increase in Severe Maternal Morbidity
September 21, 2018 - Similar changes in the brains of patients with ADHD and emotional instability
September 21, 2018 - Cobalt mining in DR Congo takes a high toll on both creuseurs and environment
September 21, 2018 - Eating fatty fish during pregnancy may boost unborn child’s brain development
September 21, 2018 - Study reveals promising new drug candidate to treat acute renal failure
September 21, 2018 - Neural signal that urges to eat overpowers the one that says to stop
September 21, 2018 - Scientists achieve breakthrough in accelerated diagnosis of multi-resistant hospital pathogens
September 21, 2018 - Researchers simulate how different breast tissues respond to heat from MRIs
September 21, 2018 - Despite red flags at surgery centers, overseers award gold seals
September 21, 2018 - Zapping Airway Nerves May Help COPD Patients Breathe
September 21, 2018 - Researchers find answers as to why some people are at risk of gout
September 21, 2018 - Stars of Stanford Medicine: Genetic counseling and compassion
September 21, 2018 - Researchers use reinforcement learning to train gliders to soar like birds
September 21, 2018 - New federally-funded research project could lead to treatments that extend human lifespan
September 21, 2018 - Health insurance ads have shifted over time due to health plans offered via ACA
September 21, 2018 - Use of transcranial electrical stimulation to bolster creativity has far-reaching implications
September 21, 2018 - Scientists find way to boost efficacy of powerful antimalarial drug with anti-cancer medicines
September 21, 2018 - Weighing the risks and benefits of drug tapering—two patients, two perspectives
September 21, 2018 - The “exposome” revealed: a barrage of bacteria, chemicals, microscopic animals and more
September 21, 2018 - Top three immune boosting recommendations to ward off freshers’ flu
September 21, 2018 - Young children’s oral microbiota could serve as early indicator for obesity
September 21, 2018 - Older individuals with multiple sclerosis report higher quality of life than younger counterparts
September 21, 2018 - LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines
September 21, 2018 - AbbVie Presents Upadacitinib Longer-Term (32-Week) and Patient-Reported Outcomes Data from Phase 2b Atopic Dermatitis Study at 27th European Academy of Dermatology and Venereology (EADV) Congress
September 21, 2018 - Alzheimer’s drug may stop disease if used before symptoms develop
September 21, 2018 - Human skeletal stem cell can generate cartilage, bone
September 21, 2018 - UK and European research collaborations receive vote of confidence by three major cancer charities
September 21, 2018 - Microbiota in the intestines and cell stress cause colon cancer
Pitt researcher secures nearly $5 million NIH funding for ‘Tic-Tac-Toe’ RF coil system

Pitt researcher secures nearly $5 million NIH funding for ‘Tic-Tac-Toe’ RF coil system

image_pdfDownload PDFimage_print

The University of Pittsburgh houses a whole-body 7 Tesla magnetic resonance imager (7T MRI), one of the strongest human MRI devices in the world and a powerful imaging tool that allows researchers to gain a far better understanding of brain structure and function. Tamer Ibrahim, associate professor of bioengineering in Pitt’s Swanson School of Engineering, runs the Radiofrequency (RF) Research Facility and conducts experimental and human studies with this device – one of only five dozen 7T MRI machines in the world.

Over the past two years, in collaboration with Pitt’s Departments of Psychiatry and Epidemiology, Ibrahim’s lab has received close to $5 million from multiple NIH grants that total more than $18 million and extend through 2022. These awards fund the development and use of innovative 7T human imaging technologies.

Ibrahim and his team of bioengineering graduate students constructed and optimized the “Tic-Tac-Toe” RF coil system for 7T human MRI devices. This system is a collection of transmit antennas and receive antennas that are tightly arranged to fit the human head. It was designed through many hours of computer simulations using full-wave electromagnetic software developed in his lab.

Though advancements have been made, several major obstacles still face neuro 7T imaging such as considerable scanning and preparation time for every subject; significant RF excitation intensity losses; potential RF heating; and concerns regarding the unclear RF safety assurance between different subjects.

“The Tic-Tac-Toe RF coil system is a novel design that addresses many of the technical difficulties associated with ultrahigh field human MRI,” said Ibrahim. “Our system provides highly consistent and homogenous excitation across different patients, which in turn provides improved images.”

In collaboration with Howard Aizenstein (MPI), Charles F. Reynolds III and Ellen G. Detlefsen Endowed Chair of Geriatric Psychiatry at Pitt, Ibrahim recently became PI/PD on an NIH R01 grant where he will use the technology developed in his lab to investigate small vessel disease in older adults with depression. This disease affects a large amount of the American population, but research has been hindered in part due to the inadequacies of traditional imaging.

In this $3.1 million project, Ibrahim uses the “Tic-Tac-Toe” RF coil system and develops a new 7T RF coil system to better understand the neurological issues, treatment, and management of depression.

“White matter hyperintensities (WMH) in the brain are a hallmark symptom of small vessel disease, which has been associated with depression in older adults,” explained Ibrahim. “Traditional MR imaging does not provide enough detail; thus, researchers cannot determine the specific mechanisms that contribute to depression. Ultrahigh-field MR imaging allows for greater specificity of the WMH lesions and other components of small vessel disease, which will give us a better understanding of depression as a whole.”

In addition to their work with depression, Ibrahim’s developed technology has contributed to research in a variety of other neurological diseases such as Alzheimer’s disease, schizophrenia, sickle cell disease, and major depressive disorder.

Ibrahim’s lab is composed entirely of graduate and undergraduate students who aim to develop highly technical RF devices, which they typically get to implement into clinical studies. “We have applied our work to several patient and disease studies at Pitt,” said Ibrahim. “Our lab’s research is unique because its roots are in engineering and physics, but it has now matured to extensive patient-level studies.”

“It has been interesting to see our work go from engineering and physics concepts to real-world applications,” Ibrahim continued. “This is a great example of how engineering innovation done in the Swanson School of Engineering translates into medicine.”

Source:

http://www.engineering.pitt.edu/News/2018/Ibrahim-Tic-Tac-Toe/

Tagged with:

About author

Related Articles