Breaking News
August 17, 2018 - Team explores diabetes drug’s ability to treat RSV infection
August 17, 2018 - New imaging technique can spot tuberculosis infection in an hour | News Center
August 17, 2018 - PolyU researchers design new self-fitting scaffold to induce bone regeneration
August 17, 2018 - CartiHeal and LSU Health successfully enroll first two patients in Agili-C IDE pivotal study
August 17, 2018 - Less-invasive options are slowing disease progression in glaucoma patients
August 17, 2018 - Researchers discover new promising target point for cancer and diabetes therapies
August 17, 2018 - Podcast: KHN’s ‘What the Health?’ See you in court!
August 17, 2018 - New mobile phone application enables early detection of cerebral ictus
August 17, 2018 - UK’s leading sight loss charity invites applications from brightest minds in ophthalmic research
August 17, 2018 - Researchers produce artificial placenta model that closely resembles natural organ
August 17, 2018 - FDA Alert: Temporary Total Artificial Heart Companion 2 Driver System by SynCardia Systems: Letter to Health Care Providers
August 17, 2018 - Researchers discover why sepsis from a staph infection causes organ failure
August 17, 2018 - Revealed: The molecular mechanism underlying hypertrophic cardiomyopathy | News Center
August 17, 2018 - Research explores relationship between personal history of infectious fever and cancer risk
August 17, 2018 - Study finds rise in cases of progressive massive fibrosis among U.S. coal miners
August 17, 2018 - NEDBELS project examines impact of neurodiversity concept on legal systems
August 17, 2018 - Seeking solutions to treat scleroderma
August 17, 2018 - Statins may improve conditions of people with rare lung disease
August 17, 2018 - Study finds why some people with brain markers of Alzheimer’s never develop dementia
August 17, 2018 - Life Biosciences contributes $100,000 to fund its biomedical innovation course on aging
August 17, 2018 - Researchers develop a set of health outcome measures for children with complex medical situations
August 17, 2018 - Many Americans Not Being Assessed for Depression
August 17, 2018 - Scientists report setbacks in quest for AIDS cure
August 17, 2018 - Christopher Gardner busts myths about milk | News Center
August 17, 2018 - Bacterial activity in child’s mouth may serve as biomarkers for autism spectrum disorder
August 17, 2018 - Scripps Research scientists uncover new approach for treating thrombocytopenia
August 17, 2018 - Mathematical model shows the influence of human behavior on spread of infectious diseases
August 17, 2018 - Valley Hospital achieves Magnet recognition for fourth consecutive time
August 17, 2018 - Researchers describe link between poor oocyte development and oxidative stress in obese mice
August 17, 2018 - Hospitals battle for control over fast-growing heart-valve procedure
August 17, 2018 - AHA: Home-Delivered Meals Keep Heart Failure Patients Out of Hospital
August 17, 2018 - In Southern Mozambique, only half of people diagnosed with HIV enroll in medical care
August 17, 2018 - Researchers discuss techniques to help combat growing epidemic of obesity
August 17, 2018 - Researchers develop novel statistical method to evaluate gene-to-gene interactions linked with cancer
August 17, 2018 - Island Fertility joins Stony Brook Community Medical to provide comprehensive fertility care
August 17, 2018 - Study shows link between thinning of the retina and early sign of Parkinson’s disease
August 17, 2018 - Digital birth control app gets FDA nod
August 17, 2018 - FDA grants approval for first generic version of epinephrine auto-injector
August 17, 2018 - Federal advisory group publishes recommendations on prevention of acute, chronic pain
August 17, 2018 - 3D-printed human body parts to be used as teaching aids for surgical training
August 17, 2018 - U.S. murder, suicide rates climbing again
August 17, 2018 - This is your brain on… roller coasters?
August 17, 2018 - Report discusses whether all newborns should undergo genetic sequencing
August 17, 2018 - UCR receives 2018 Inspiring Programs in STEM Award from INSIGHT Into Diversity magazine
August 17, 2018 - Researchers publish new paper on developing vaccine candidates for Helminthic parasites
August 17, 2018 - Researchers develop new method to diagnose broad range of cancers using malaria protein
August 17, 2018 - Female mosquitoes quickly evolve selective mating behavior when faced with threats
August 17, 2018 - FDA Grants Breakthrough Therapy Designation to Daiichi Sankyo’s FLT3 Inhibitor Quizartinib for Relapsed/Refractory FLT3-ITD AML
August 17, 2018 - Resistance training and exercise motivation go hand-in-hand
August 17, 2018 - A lesson for future doctors: Listen to and learn from your patients
August 17, 2018 - NUS study discovers a bidirectional regulator and shines light on A-to-I RNA editing in cancer cells
August 17, 2018 - Research shows link between high blood levels of omega-3s and better brain function in children
August 17, 2018 - Researchers propose new theory for how rare gene mutations cause Alzheimer’s disease
August 17, 2018 - New project to combat DMD-related fibrosis receives major funding boost
August 17, 2018 - Digital psychiatric therapy can ‘rewire’ the brain in children with ADHD, study shows
August 17, 2018 - Psychologist to assess how the brain maintains precise short-term and long-term memories
August 17, 2018 - Eating white button mushrooms could improve regulation of glucose in the liver
August 17, 2018 - Scientists identify mutational signatures in ovarian cancer
August 17, 2018 - Sun Pharma receives U.S. FDA approval for CEQUA to treat patients with dry eye disease
August 17, 2018 - Teva Announces Updated Indication and Vial Presentation for Granix (tbo-filgrastim) Injection in United States
August 17, 2018 - Study shows DNA methylation related to liver disease among obese patients
August 17, 2018 - Life on the border: Back at Stanford, ready to pitch in
August 17, 2018 - New device for accurately placing hemodialysis catheters on kidney patients
August 17, 2018 - New strategy accelerates, automates process of prototype molecule optimization
August 17, 2018 - Study finds role of autoimmunity in development of COPD
August 17, 2018 - Researchers transform research tool to study neuronal function
August 17, 2018 - Cognitive impairment does not equate to unhappiness in older adults
August 17, 2018 - Peer Comparisons Can Decrease Risky Prescribing Patterns
August 17, 2018 - Susceptible genes identified for childhood chronic kidney disease
August 17, 2018 - Research uncovers miscarriage cause, identifies potential targets for treatment
August 17, 2018 - Bacterial armor could be new target for antibiotics | News Center
August 17, 2018 - FDA expands approval of Vertex’ cystic fibrosis medicine to treat children aged 12 to
August 17, 2018 - Give Your Child a Head Start With Math
August 17, 2018 - Ground-breaking study tests whether rejected livers can be made viable for transplantation
August 16, 2018 - New algorithm could improve diagnosis of rare diseases | News Center
August 16, 2018 - SCHILLER introduces latest generation of ECG device, CARDIOVIT AT-102 G2
August 16, 2018 - Proper treatment, refraining from smoking can reduce heart disease risk from type 2 diabetes
August 16, 2018 - Mount Sinai study could transform treatment for patients with retinal degenerative diseases
August 16, 2018 - Penn researchers develop first mouse model of idiopathic pulmonary fibrosis
August 16, 2018 - Four tips to help prevent fall allergy symptoms
Roswell Park researchers identify driver of cancer-promoting metabolic changes

Roswell Park researchers identify driver of cancer-promoting metabolic changes

image_pdfDownload PDFimage_print

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis. They are presenting the results of this research at the American Association for Cancer Research (AACR) Annual Meeting 2018, which continues through April 18 in Chicago, Ill.

Marc S. Ernstoff, MD, The Katherine Anne Gioia Chair of Medicine, is the senior author and Shin La Shu, PhD, a clinical researcher with the Department of Medicine, is the first author of “Human melanoma exosomes induce metabolic reprogramming in human adult dermal fibroblasts” (abstract 5087), to be presented Wednesday, April 18, from 8 a.m. to noon CDT during the “Carcinoma-Associated Fibroblasts in Tumor Progression” poster session.

Metastasis -; the spread of cancer cells from the site where cancer first appears to other, more distant organs of the body, where new tumors form and then rapidly grow -; is often the turning point in the disease process, marking a stage at which cancer becomes difficult or impossible to treat or control.

According to the “seed and soil” theory of cancer metastasis, cancer cells that spread from the primary tumor site to other areas must find or create an environment similar to the one they came from in order to survive. To examine more closely the ability of tumor cells to influence and potentially change the healthy environment of normal cells, the researchers focused on exosomes -; small fluid-filled sacs that play important roles in cell metabolism and transport as well as communication between cells.

The research team took exosomes from human melanoma cell lines and introduced them to human dermal fibroblasts, a type of skin cell. The healthy cells rapidly absorbed the tumor-derived exosomes and displayed metabolic changes conducive to tumor growth and metastasis, including acidification through increased glycolysis and decreased oxidative phosphorylation. These changes occurred within less than 24 hours, and exosomes from human melanoma cell lines could effectively “reprogram” healthy skin cells.

“The tumor microenvironment plays a critical role in tumor metastasis, and we show -; for the first time -; that melanoma-derived exosomes can reprogram the metabolism of healthy skin cells, creating a microenvironment that is conducive to cancer progression and metastasis,” says Dr. Ernstoff.

To conduct this research, the team developed an immuno-biochip that first captures exosomes and then searches them for microRNAs -; tiny molecules that influence how genes are expressed. Using this immuno-biochip, the researchers detected the microRNAs miR-155 and miR-210, both of which are known to promote the cancer-promoting metabolic changes observed.

“Our findings identify new therapeutic opportunities to study both exosomes and exosomal microRNAs as targets of interventions that reduce the likelihood of metastasis in cancer patients,” adds Dr. Shu.

More than 20 teams from Roswell Park Comprehensive Cancer Center have been invited to present their research at AACR 2018. In addition, Dr. Ernstoff led the roundtable discussion “Practicing immunotherapy in the clinic” on April 14 and Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, Chair of Gynecologic Oncology and Executive Director of the Center for Immunotherapy, was lead discussant for the session “Multimodality Immuno-oncology Approaches” on April 15. Dr. Odunsi will also be the featured presenter at an April 18 Meet the Experts session, “Reprogramming the Tumor Microenvironment to Enhance ‘Next-Generation’ Adoptive Cellular Therapy.”​

Source:

https://www.roswellpark.org/media/news/cancer-cells-actively-fuel-growth-and-metastasis-reprogramming-healthy-cells-roswell-park

Tagged with:

About author

Related Articles