Breaking News
January 24, 2019 - FDA authorizes marketing of new test to aid in the diagnosis of M. gen. infections
January 24, 2019 - Health Tip: Simple CPR – Drugs.com MedNews
January 24, 2019 - Diabetes in America, 3rd Edition
January 24, 2019 - Bangladesh ‘Tree Man’ returns to hospital as condition worsens
January 24, 2019 - Costs of gun-related hospitalizations, readmissions examined in study
January 24, 2019 - Good health literacy linked to better adherence to blood pressure medications among Hispanics
January 24, 2019 - Only a minority of patients in the U.S. with type 1 diabetes achieve treatment goals
January 24, 2019 - High fat reduces efficiency of the immune system to fight infectious disease
January 24, 2019 - FDA grants clearance to Hologic’s assay for detection of common sexually transmitted infections
January 24, 2019 - Study highlights need for reliable therapeutic targets for prevention, treatment of cardiovascular diseases
January 24, 2019 - Next step toward replacement therapy in type 1 diabetes
January 24, 2019 - “Scientific serendipity” identifies link between type of RNA and autism
January 24, 2019 - Trump Zeroes In On Surprise Medical Bills In White House Chat With Patients, Experts
January 24, 2019 - Unique form of chronic sinusitis found in older patients
January 24, 2019 - NUS researchers make muscle recovery easier for patients with ingenious medical device
January 24, 2019 - Specific cognitive deficits found in individuals with spinal cord injury
January 24, 2019 - An essential reference for diagnostic ultrasonography and biopsy of the thyroid gland
January 24, 2019 - Proteus Digital Health Launches Digital Oncology Medicines to Improve Patient Outcomes
January 24, 2019 - Study looking to prevent type 1 diabetes follows children into adolescence
January 24, 2019 - Nice doctors make a difference
January 23, 2019 - Blood vessel discovery could advance our knowledge of osteoporosis
January 23, 2019 - New esophageal cancer test uses genetic biomarkers to detect changes in esophagal cells
January 23, 2019 - Study evaluates first-ever Robotic Visualization System for neurosurgery
January 23, 2019 - Scientists reveal new mechanism that could lead to specific treatment of strokes and seizures
January 23, 2019 - Both educational level and occupational orientation predict mother’s smoking during pregnancy
January 23, 2019 - How to (gently) get your child to brush their teeth
January 23, 2019 - Short-term hospital readmissions for gun injuries cost $86 million a year | News Center
January 23, 2019 - New certified reference material for testing residual solvents in cannabis
January 23, 2019 - Gene-edited chickens could prevent future flu pandemic
January 23, 2019 - Cardiovascular disease risk begins even before birth
January 23, 2019 - Younger patients receiving kidney transplant more likely to live longer, shows data
January 23, 2019 - Skin samples hold early signs of prion disease, research suggests
January 23, 2019 - Researchers discover how body initiates repair mechanisms that limits damage to myelin sheath
January 23, 2019 - Fecal transplant from certain donors better than others
January 23, 2019 - Risk for Uninsurance in AMI Patients Reduced With Medicaid Expansion
January 23, 2019 - Readmissions reduction program may be associated with increase in patient-level mortality
January 23, 2019 - Fostering translation and communication in medicine and beyond
January 23, 2019 - To Fight Fatty Liver, Avoid Sugary Foods and Drinks
January 23, 2019 - TPU scientists develop new implants that double the rate of bone lengthening in kids
January 23, 2019 - New sessions at Pittcon 2019
January 23, 2019 - Insilico to present latest findings in AI for Drug Discovery at 3rd Annual SABPA FTD Forum
January 23, 2019 - Opioid overdose patients can be safely discharged an hour after administration of naloxone
January 23, 2019 - Scientists find bacterial extracellular vesicles in human blood
January 23, 2019 - Researchers use modified type of flu virus to develop new therapies for prostate cancer
January 23, 2019 - Researchers gain new insights into development of necrotizing enterocolitis in preemies
January 23, 2019 - Medical expert advises people with epilepsy not to stockpile medicines
January 23, 2019 - CDC study explores link between smoking and clinical outcomes of assisted reproductive technology
January 23, 2019 - Study outlines research priorities for improving pediatric patient care and safety
January 23, 2019 - Bedfont to exhibit NObreath FeNO monitor at Arab Health 2019
January 23, 2019 - Nicotinamide riboside supplementation confers significant physiological benefits to mothers and offspring
January 23, 2019 - Increasing temperatures may help preserve crop nutrition
January 23, 2019 - Many Oncologists in the Dark About LGBTQ Health Needs
January 23, 2019 - Epigenetic change causes fruit fly babies to inherit diet-induced heart disease
January 23, 2019 - Erasing memories could reduce relapse rates among drug addicts
January 23, 2019 - African Americans who smoke cigarettes are more likely to develop peripheral artery disease
January 23, 2019 - Unique data combination helps FinnGen researchers to fund links between genetic factors and health
January 23, 2019 - Parents’ mental health problems associated with reactive attachment disorder in children
January 23, 2019 - Graphene Flagship project studies impact of graphene and related materials on our health
January 23, 2019 - The connection between the Pope and contraceptive pills
January 23, 2019 - Prior dengue infection could protect children from symptomatic Zika
January 23, 2019 - Previous dengue virus infection associated with protection from symptomatic Zika
January 23, 2019 - VISTA checkpoint implicated in pancreatic cancer immunotherapy resistance
January 23, 2019 - The Tiny Camera That Could Revolutionize Cardiovascular Surgery
January 23, 2019 - Peptide isolated from soil fungi has antitumor and antibacterial properties
January 23, 2019 - TGen identifies polio-like virus as potential cause of Acute Flaccid Myelitis outbreak
January 23, 2019 - Migrants and refugees do not bring disease and are at greater health risk themselves says WHO
January 23, 2019 - Examing the effects of menopause in workplace
January 23, 2019 - Enemy number 1 – Air pollution and climate change top of WHO agenda
January 23, 2019 - Two Positive Phase III studies of Tafenoquine for the Radical Cure of Plasmodium vivax Malaria Published in The New England Journal of Medicine
January 23, 2019 - World Trade Center responders at increased risk for head and neck cancers
January 23, 2019 - Low-sugar diet leads to significant improvement in nonalcoholic fatty liver disease in boys
January 23, 2019 - Chaos in bodily regulation can optimize our immune system, finds study
January 23, 2019 - Short, text-based exercises can increase happiness for adults recovering from substance use disorders
January 23, 2019 - Body size may have greater influence on women’s lifespan than men
January 23, 2019 - Groundbreaking tool helps visualize neuronal activity with near-infrared light
January 23, 2019 - Prior dengue immunity in children may be protective against symptomatic Zika
January 23, 2019 - Holocaust survivors with PTSD and their offspring exhibit more unhealthy behavior patterns
January 23, 2019 - Scientists discover new genetic mutations causing inherited deaf-blindness
January 23, 2019 - UC team designs new naloxone-dispensing smart device
January 23, 2019 - Torrent Pharmaceuticals Limited Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium and Hydrochlorothiazide Tablets, USP
New studies related to causes of liver degradation and possible treatments

New studies related to causes of liver degradation and possible treatments

image_pdfDownload PDFimage_print

A treatment gap remains for many conditions involving damage to the liver, the body’s main organ for removing toxins, among other functions. The Experimental Biology 2018 meeting (EB 2018) will feature important research announcements related to the causes of liver degradation and possible treatments.

Receptor for sleep hormone melatonin may play a role in liver cirrhosis

Texas A&M University College of Medicine and Central Texas Veterans Health Care System researchers have discovered a potential new lead for treating chronic liver diseases. The research focuses on melatonin, a hormone associated with maintaining circadian rhythms. Receptors for this hormone can be found in the liver, as well as elsewhere in the body, and previous experiments using mice have shown that melatonin helps reduce the processes that cause liver fibrosis (scarring that ultimately leads to cirrhosis). When the researchers bred mice that were incapable of expressing different kinds of melatonin receptors, the mice showed different rates of liver fibrosis. Fibrosis was significantly decreased in mice incapable of expressing one receptor in particular, known as MT1. This suggests that drugs designed to block MT1 activity could potentially help slow liver disease progression.

Nan Wu will present this research at the American Society for Investigative Pathology annual meeting at EB on Saturday, April 21, from 8:35–8:45 a.m. in Room 2 (abstract) and on Tuesday, April 24, from 4:15–4:30 p.m. in Room 5A.

Deciphering the links between alcoholism and liver cancer

Steatohepatitis is a type of fatty liver disease that can lead to cirrhosis and liver cancer. While it can occur in people who drink little or no alcohol, it is far more common-;and more likely to progress to liver cancer-;in people with alcoholism. A new study by researchers at Harbor–UCLA Medical Center reveals how the expression of certain proteins in the liver differs between patients with non-alcoholic steatohepatitis and alcoholic steatohepatitis. The researchers investigated 10 proteins that are known to play a role in cancer development. Both patient groups showed increased levels of most of the proteins compared to healthy people, but the protein levels were much higher in those with alcoholic steatohepatitis, which helps explain why these patients face such a high risk of liver cancer.

Jiajie Lu will present this research at the American Society for Investigative Pathology annual meeting at EB on Sunday, April 22, from 11:45 a.m.–12:45 p.m. in the Exhibit Hall (poster D31) (abstract) and on Tuesday, April 24, from 5:30–7:30 p.m. in Ballroom 20BC.

Potential therapeutic target for liver damage from acetaminophen

Taking too much acetaminophen (the active ingredient in Tylenol®) can cause serious liver damage and even death. In a new study, researchers at the Central Texas Veterans Health Care System and Texas A&M University Health Science Center identify a possible new way to interfere with the process by which acetaminophen damages liver cells. The research focuses on the role a protein, transforming growth factor beta 1 (TGFβ1), plays in the cascade of events that leads to cell death. Scientists discovered that the damage caused by acetaminophen was reversed in mice bred without the ability to produce TGFβ1 and in genetically normal mice that were treated with a TGFβ1-disabling agent. The results suggest that interrupting TGFβ1’s activity could be one way to prevent or treat acetaminophen-related liver injury. This work was supported by Central Texas Veterans Health Care System and Texas A&M University Health Science Center, Temple, Texas.

Matthew McMillin will present this research at the American Society for Investigative Pathology annual meeting at EB on Tuesday, April 24, from 2:15–2:30 p.m. in Room 5A (abstract) and on Tuesday, April 24 from 5:30–7:30 p.m. in Ballroom 20BC (poster 415.2).

New insights on non-coding RNA in alcoholic liver disease

A tiny segment of RNA known as microRNA-21 has been found to play a role in cancer and heart disease. New research from the University of Connecticut suggests the molecule also influences the processes involved in alcoholic liver disease, a leading cause of cirrhosis. While microRNA-21 does not itself code for cellular functions the way DNA does, it can interfere with how other genes are expressed. In the study, mice fed a diet spiked with alcohol produced significantly higher amounts of microRNA-21 in the liver compared to mice on a normal diet. Tissue samples from human volunteers also found microRNA-21 levels were markedly increased in people with alcohol-related cirrhosis compared to healthy individuals. The researchers gained additional insights about the ways microRNA-21 affects liver health by breeding mice that were incapable of producing microRNA-21 in their livers.

Yulan Zhao will present this research at the American Society for Investigative Pathology annual meeting at EB on Sunday, April 22, from 4:15–5:15 p.m. in Room 4 (abstract) and on Tuesday, April 24, from 5:30–7:30 p.m. in Ballrooms 20BC (poster 150.10).

EB 2018 is the premier annual meeting of five scientific societies to be held April 21–25 at the San Diego Convention Center. Contact the media team for abstracts, images and interviews, or to obtain a free press pass to attend the meeting.

Source:

http://experimentalbiology.org/2018/Home.aspx

Tagged with:

About author

Related Articles