Breaking News
September 24, 2018 - New nanoplatform technology may reverse drug-resistance in renal cell carcinoma
September 24, 2018 - October 1918 marks the centenary of Spanish Flu that claimed more lives than World War I
September 24, 2018 - LGBT community reports more number of poor mental health days than general population
September 24, 2018 - New research suggests power of zebrafish as tool for cancer drug discovery
September 24, 2018 - New study finds height as possible risk factor for developing varicose veins
September 24, 2018 - Researchers compare weight loss results of online and in-person diabetes prevention program
September 24, 2018 - New HER2 PET Study Uses Affibody’s ABY-025 Tracer to Individualize Breast Cancer Treatment
September 24, 2018 - Drug combination offers more effective care for patients suffering miscarriage
September 24, 2018 - Tallness linked to varicose veins, Stanford study says
September 24, 2018 - For Heart Failure Patients, Mitral Valve Procedure Improved Outcomes
September 24, 2018 - Ecstasy drug makes octopuses more social
September 24, 2018 - Immediate compression therapy could cut risk of complications after deep-vein thrombosis
September 24, 2018 - Transcatheter mitral valve repair reduces mortality for patients with mitral regurgitation
September 24, 2018 - First intracranial aneurysm patients treated with BRAVO Flow Diverter after CE mark approval
September 24, 2018 - ‘Physicians of the mouth’? Dentists absorb the medical billing drill
September 24, 2018 - People more likely to believe those with confident tone of voice than with accent
September 24, 2018 - Harmony Biosciences Presents 5-Year Data On Pitolisant At International Narcolepsy Symposium
September 24, 2018 - Blood test may identify gestational diabetes risk in first trimester
September 24, 2018 - Height may be risk factor for varicose veins | News Center
September 24, 2018 - King’s commemorates opening of new NMR facility with one-day symposium
September 24, 2018 - Eisai receives approval for partial label change of DC Bead device for transcatheter arterial embolization
September 24, 2018 - High-resolution genomic map gives scientists unprecedented view of brain development
September 24, 2018 - Alexion announces positive results from Phase 3 PREVENT study of Soliris in patients with NMOSD
September 24, 2018 - First evaluation of benefits, harms of Alzheimer’s screening for family members of older adults
September 24, 2018 - Children of mothers using cannabis may start using it at an earlier age, finds study
September 24, 2018 - Gilead Sciences plans to launch authorized generic versions of Epclusa and Harvoni in the US
September 24, 2018 - Most patients who underwent transcatheter valve replacement experience prosthesis-patient mismatch
September 24, 2018 - Lumos acquires license for LUM-201 drug that promotes secretion of growth hormone
September 24, 2018 - New study provides basis for Air Canada to change its facial hair policy for aircrew
September 24, 2018 - Infant walkers lead to thousands of emergency visits for babies
September 24, 2018 - Genes predicting person’s height may provide clues about causes of varicose veins
September 24, 2018 - EPA Plan Will Maintain Carbon Emissions From Power Plants
September 24, 2018 - Characterizing pig hippocampus could improve translational neuroscience
September 24, 2018 - Element3 Health reports social and mental engagement play key role in overall health
September 24, 2018 - Paralympic medalists support Fight for Sight’s unique virtual event
September 24, 2018 - ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma
September 24, 2018 - Public awareness of urological conditions found to be alarmingly low across Europe
September 24, 2018 - Fitter Folks Suffer Milder Strokes: Study
September 24, 2018 - Novel botulinum toxin compound relieves chronic pain
September 24, 2018 - CHMP recommends approval of Gilenya for treatment of multiple sclerosis in children, adolescents
September 24, 2018 - National Friendly’s private medical insurance is a hit with women living in the South East
September 24, 2018 - Academics receive prestigious awards for achievements in blood pressure research
September 24, 2018 - Obese pregnant women can restrict weight gain safely with proper nutrition guidance
September 24, 2018 - CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer
September 24, 2018 - China NMPA approves LENVIMA for treatment of unresectable hepatocellular carcinoma
September 24, 2018 - A new approach for finding Alzheimer’s treatments
September 24, 2018 - USC research uncovers previously unknown genetic risk factor for dementia
September 24, 2018 - Study examining mental health among students finds significant disparities in treatment across race
September 24, 2018 - Breakthrough discovery paves way for future test to identify drowsy drivers
September 24, 2018 - Transcatheter mitral-valve repair in patients with heart failure
September 24, 2018 - Study opens new avenues for treatment of Laing distal myopathy
September 24, 2018 - Stroke Facts | cdc.gov
September 24, 2018 - Sarcolipin tricks muscle cells into using more energy, burning fat
September 24, 2018 - Enrollment in opioid controlled substance agreement reduces primary care visits
September 24, 2018 - UTA researchers patent new smart seat cushion technology that helps prevent painful ulcers
September 24, 2018 - Second HPV-Related Primary Cancers Common in Survivors
September 24, 2018 - How a virus destabilizes the genome
September 24, 2018 - Old letters provide insight into Spanish flu pandemic horror
September 23, 2018 - Smart textile-based soft robotic exosuit helps wearers save energy and traverse difficult terrain
September 23, 2018 - New research hub to drive radical change in development and manufacturing of vaccines
September 23, 2018 - AHA: For Hispanics, Neighborhood May Be Key Factor in Heart Disease Risk
September 23, 2018 - Excessive airway nerves tied to more severe asthma symptoms, study finds
September 23, 2018 - Study highlights need to remain vigilant in maintaining key infection control processes
September 23, 2018 - Novel therapeutic strategy for blood vessel related disorders, such as cancer and retinopathy
September 23, 2018 - New naturally occurring antibiotic found effective against Mycobacterium tuberculosis
September 23, 2018 - First-in-human phase 0 study shows clinically-relevant activity of new drug in glioblastoma
September 23, 2018 - Removing tobacco product display from shops reduced number of children buying cigarettes
September 23, 2018 - Random fraction of specialized immune cells leads the charge in battling invaders
September 23, 2018 - Few minutes of sprinting exercise may be as effective as longer exercise sessions
September 23, 2018 - Researchers use neutrons to make first direct observations of water in lipid bilayers
September 23, 2018 - Researchers demonstrate pre-clinical success for universal flu vaccine in new paper
September 23, 2018 - Study reveals surprising gaps in some HIV medical providers’ knowledge of ACA
September 23, 2018 - Oxehealth secures European medical device accreditation for vital signs measurement software
September 23, 2018 - HTN Tx Intensification Common Upon Discharge in U.S. Vets
September 23, 2018 - Fibre can strengthen the intestinal barrier
September 23, 2018 - New platform examines infectious pathogens that may spread from animals to humans
September 23, 2018 - Demographers create detailed color map of population aging in Europe
September 23, 2018 - New type of fatty acid can slow down overreactive immune system
September 23, 2018 - Innovative procedure could provide breakthrough in treating early-stage lung cancer
September 23, 2018 - Research finds drop in number of measles cases in the EU/EEA since March 2018
Researchers find enzyme responsible for aircraft noise-related vascular damage

Researchers find enzyme responsible for aircraft noise-related vascular damage

image_pdfDownload PDFimage_print

In a recent study, scientists at the Department of Cardiology at the University Medical Center of Johannes Gutenberg University Mainz (JGU) have identified an enzyme responsible for aircraft-related vascular damage. The researchers were also able to show that night-time noise has a particularly harmful effect and thus demand that night-time sleep be protected from noise. With the current study, the scientists around Professor Thomas Münzel, Director of Cardiology I at the Department of Cardiology, and Professor Andreas Daiber, Head of Molecular Cardiology at the Department of Cardiology, consistently pursue the field of noise research and can announce another breakthrough. The new study is published in the European Heart Journal, the world’s most renowned cardiology journal.

Aircraft noise leads to an increased development of cardiovascular diseases in the long term, as a series of precursor studies has now shown unequivocally. In 2013, the research group of Professor Thomas Münzel succeeded in demonstrating that simulated nocturnal noise increases the stress hormone epinephrine, reduces sleep quality, and damages the vascular system, called endothelial dysfunction. Further studies on a newly developed animal model showed last year that aircraft noise leads to a significant increase in stress hormones, a vascular dysfunction, increased oxidative stress, and inflammatory processes in the vessels as well as a marked change in the expression of genes in the vessel wall.

“With this new study, we can demonstrate for the first time that ‘night-time noise’, i.e., noise during the sleep phase of the mice, and not the noise during the waking phase is responsible for vascular dysfunction,” stated Münzel and Daiber. “We can also show that the elimination of the enzyme phagocytic NADPH oxidase, which is located mainly in inflammatory cells, completely avoids aircraft noise-induced negative effects on vessels and brain.” This enzyme was also in the focus of the scientists in the last study. The current investigations finally prove its central role and provide also proof that the negative aircraft noise effects are mediated by this enzyme.

The scientists now also examined the effects of aircraft noise on the brain. The focus was on neuronal nitric oxide (NO) synthase, an important enzyme in the brain. Responsible for learning and memory, this enzyme is down-regulated by aircraft noise and its function is impaired. This new finding may explain the described cognitive developmental disorders in children after exposure to aircraft noise.

Another finding is that the transcription factor FoxO3 plays a central role in noise-induced vascular and brain damage. The consequence of the observed down-regulation of this transcription factor by night-time noise leads to a defective gene expression network that controls cellular events as a function of circadian rhythm. Disturbance of the circadian rhythm can lead to sleep disorders and subsequently to more cardiovascular, mental, and metabolic disorders. To this end, the scientists came to this recognition through extensive genetic analysis by means of Next Generation Sequencing (NGS) and by demonstrating a prevention of the aforementioned vascular damage by treatment with the FoxO3 activator Bepridil.

According to the study initiators, these results represent a further breakthrough in noise research. “With our findings, especially with regard to night-time noise, we can now explain clinical results, e.g., according to the so-called HYENA study, where night-time noise in particular can trigger high blood pressure. The finding that the elimination of the enzyme phagocytic NADPH oxidase completely prevents vascular damage may enable us to develop drug strategies to reduce the negative effects of aircraft noise for our body,” both scientists commented.

The authors conclude from their findings that it must be an important goal to protect the night’s sleep from noise and in particular to implement the legally defined night’s sleep from 10 o’clock at night to 6 o’clock in the morning.

Source:

http://www.unimedizin-mainz.de/presse/press-releases/press-releases/newsdatail/article/mainz-scientists-identify-enzyme-responsible-for-vascular-damage-caused-by-aircraft-noise.html?L=1&cHash=f5a6fa6d8fbbc0febfbc4f2f0e047496

Tagged with:

About author

Related Articles