Breaking News
February 20, 2019 - Over Half of Hip Replacements Expected to Last 25 Years
February 20, 2019 - Microscopic eye movements affect how we see contrast
February 20, 2019 - Computer vs. patient: Fighting for residents’ attention | News Center
February 20, 2019 - New “Smart Drug” Shows Promise for Metastatic Triple-Negative Breast Cancer
February 20, 2019 - Researchers develop large-scale window material for high-efficiency PM2.5 capture
February 20, 2019 - Widespread confusion among consumers on food date labels lead to unnecessary discards
February 20, 2019 - Researchers unlock plant’s secret of producing specialized metabolites
February 20, 2019 - Newly released national framework identifies obstacles to improving EMS systems
February 20, 2019 - Exercise can shift human body clock depending on time when people work out
February 20, 2019 - Female adolescent blood donors more likely to have iron deficiency and related anemia
February 20, 2019 - Rubicon level linked to inhibition of autophagic process
February 20, 2019 - Researchers find potential therapeutic strategy to treat Alzheimer’s
February 20, 2019 - New forms of older anti-cancer agent appear to enhance immune response to fight melanoma
February 20, 2019 - Health Tip: Eat Less Saturated Fat
February 20, 2019 - Sleeping in contact lenses puts you at risk of dangerous infection
February 20, 2019 - “We should study that!”: How a nurse-scientist found her passion
February 20, 2019 - Cervical microbiome may influence HPV infection more than previously thought
February 20, 2019 - Sausage mislabeling in Canada is down, new study finds
February 20, 2019 - Study shows blood pressure benefits of morning exercise for older overweight/obese adults
February 20, 2019 - New screening method could catch organ rejection much earlier without a biopsy needle
February 20, 2019 - Study may have important implications for refining parenting during child’s adolescence
February 20, 2019 - Study sheds new light on how antibiotic resistance genes are transferred between bacteria
February 20, 2019 - Chronic Wasting Disease may soon spread to humans, warns CDC
February 20, 2019 - Scientists identify new genetic causes linked to abnormal pregnancies and miscarriages
February 20, 2019 - Using LyoSpeed technology to avoid residual solvent when drying HPLC fractions
February 20, 2019 - Scientists join forces to identify a new approach to fight African sleeping sickness
February 20, 2019 - New screening tool more likely to identify sexual and labor exploitation of youth
February 20, 2019 - Newly licensed nurses work for long hours, also have a second paid job
February 20, 2019 - Physicists identify simple mechanism used by deadly bacteria to fend off antibiotics
February 20, 2019 - FDA Grants Priority Review to Genentech’s Personalized Medicine Entrectinib
February 20, 2019 - Exposure to chemicals before and after birth is associated with a decrease in lung function
February 20, 2019 - Neuroscientists reveal that simple brain region can guide complex feats of mental activity
February 20, 2019 - Study finds new link between food allergies and multiple sclerosis
February 20, 2019 - First gene therapy operation for macular degeneration is a success
February 20, 2019 - Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs
February 20, 2019 - Study shows therapeutic potential of VEGF-A mRNA for regenerative angiogenesis in humans
February 20, 2019 - FDA Approves Keytruda (pembrolizumab) for the Adjuvant Treatment of Patients with Melanoma with Involvement of Lymph Node(s) Following Complete Resection
February 20, 2019 - Study identifies brain cells that modulate behavioral response to threats
February 20, 2019 - Researchers take closer look at how viruses bind cells and cause infection
February 20, 2019 - Newly developed gene therapy helps decelerate aging process
February 20, 2019 - Study suggests new treatment strategy for deadly brain cancer
February 20, 2019 - Scientists develop unique hybrid implant that imitates bone structure
February 20, 2019 - Push-ups can be tailored to meet specific needs of individuals
February 20, 2019 - Early-career job loss has long term health implications
February 20, 2019 - CVD Does Not Modify Depression-Mortality Link in Elderly
February 20, 2019 - Electrical activity early in fruit flies’ brain development could shed light on how neurons wire the brain
February 20, 2019 - Machine learning technique helps predict which asthma patients respond to corticosteroid therapy
February 20, 2019 - Self-reported sleep duration is a useful tool to measure sleep in children, study suggests
February 20, 2019 - T-cells play key role in how the body fights follicular lymphoma
February 20, 2019 - Study shows how 3D organization of genetic material helps perpetuate the species
February 20, 2019 - Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells
February 20, 2019 - Study reveals major sex differences in management of cardiovascular risk factors among U.S. adults
February 20, 2019 - Health Tip: Get Your Child to School on Time
February 20, 2019 - Shortcut strategy for screening compounds with clinical potentials for drug development
February 20, 2019 - Common acid reflux drugs tied to elevated risk for kidney disease
February 20, 2019 - Microbiome could be culprit when good drugs do harm
February 20, 2019 - Prenatal exposure to forest fires causes stunted growth in children
February 20, 2019 - Gene therapy restores hearing in mice with congenital genetic deafness
February 20, 2019 - First molecular test predicts treatment response for kidney cancer
February 20, 2019 - New method for improved visualization of single-cell RNA- sequencing data
February 20, 2019 - Researchers capture altered brain activity patterns of Parkinson’s in mice
February 20, 2019 - A possible blood test for detecting Alzheimer’s disease before symptoms show
February 20, 2019 - Primary care physicians associated with longevity, new research finds
February 19, 2019 - New study identifies many key lessons to establish sanctioned safe consumption sites
February 19, 2019 - Single CRISPR treatment can safely and stably correct genetic disease
February 19, 2019 - Multinational initiative to study familial primary distal renal tubular acidosis
February 19, 2019 - Breakthrough study highlights the promise of cell therapies for muscular dystrophy
February 19, 2019 - Subsymptom Threshold Exercise Speeds Concussion Recovery
February 19, 2019 - Midline venous catheters – infants: MedlinePlus Medical Encyclopedia
February 19, 2019 - Searching for side effects
February 19, 2019 - Humanity is all right, probably, although human extinction remains quite possible, researcher says
February 19, 2019 - Having Anesthesia Once as a Baby Does Not Cause Learning Disabilities, New Research Shows
February 19, 2019 - Anti-cancer immunotherapy could be used to fight HIV
February 19, 2019 - Customized Micropatterning for Improved Physiological Relevance
February 19, 2019 - Unique gene therapy approach paves new way to tackle rare, inherited diseases
February 19, 2019 - Activating gene that helps excite neurons reverses depression in male mice
February 19, 2019 - Science Puzzling Out Differences in Gut Bacteria Around the World
February 19, 2019 - Cells that destroy the intestine
February 19, 2019 - On recovery, vulnerability and ritual: An exhibit in white
February 19, 2019 - Scientific Duo Gets Back To Basics To Make Childbirth Safer
Researchers develop new approach to assess effectiveness of Men B vaccine

Researchers develop new approach to assess effectiveness of Men B vaccine

image_pdfDownload PDFimage_print

Researchers at the University of Leicester and Meningococcal Reference Unit have developed a new approach to assess the effectiveness of the Men B vaccine, Bexsero®, against different strains that cause meningococcal meningitis and septicemia.

The new approach allows direct testing of blood samples from patients with meningococcal disease to find out if the strain they are infected with might have been prevented by the vaccine. Currently, it is estimated that the vaccine offers protection against 73-88% of strains responsible for meningococcal disease in England and Wales.

The approach is being assessed by Public Health England for its potential to routinely test all meningococcal disease cases.

The research was based on looking at one of the four antigens that make up the vaccine. More work is needed to look at the remaining three antigens.

Dr Chris Bayliss, from the University of Leicester’s Department of Genetics and Genome Biology, said: “This new research fills a gap in current testing capabilities that determine whether a disease-causing meningococcal strain is expected to be covered by the vaccine.

“We are currently unable to obtain and grow live bacteria from up to half of patients to determine whether the vaccine might have prevented the type of meningococcal disease they have, often because treatment with antibiotics has already killed them. There is a need for new tests to identify and measure the amount of antigen by obtaining meningococcal DNA directly from patient samples.”

Bexsero® is a vaccine that helps protect against group B meningococcal disease (MenB), developed by GSK. It was introduced into the UK infant immunization schedule in September 2015 and has been shown to be highly effective in preventing MenB disease in vaccinated infants.

One of the protective components of Bexsero® is an antigen called factor H binding protein (fHbp). Infants vaccinated with MenB vaccines produce antibodies against this protein, so that if they are exposed to meningococcal bacteria that possess this protein, these antibodies will kill the bacteria.

In a study published in the academic journal PLOS ONE, funded by Meningitis Research Foundation (MRF), the researchers show how a combination of DNA sequences and statistical testing can be used to measure the amounts of fHbp present in disease-causing meningococcal bacteria.

Researchers and Mathematicians at the University of Leicester studied more than 2,000 disease-causing meningococcal isolates to measure how much antigen each strain produces.

They used their results to categorize each strain into three classes: ‘covered’; ‘not covered’; and ‘at risk’. The ‘not covered’ groups included the ~12% of strains that will not be covered by the vaccine while the ‘at risk’ groups contains strains that are more likely to cause illness in vaccinated individuals.

Dr Bayliss said: “Detailed molecular analyses of clinical samples are essential for understanding how efficient the new vaccines against meningococcal disease are at protecting people against different meningococcal strains.

“This novel approach has the potential to help measure the effectiveness of Bexsero® more accurately.

“The detailed information collected on the fHbp protein could be important in helping to improve the next generation of MenB vaccines.”

Linda Glennie, Director of Research at MRF, said: “Introducing the MenB vaccine into the UK immunization schedule in 2015 was a major step forward. Vaccines are the only way to prevent bacterial meningitis and septicemia. The MenB vaccine has already been proven to be safe and effective and rates of MenB have been reducing since the introduction of the vaccine. Now that we have a vaccine in the schedule that gives good protection against MenB, these new testing techniques that the scientists have developed will give us crucial insights. Over the years, the strains that circulate in the UK have changed, and it is important to be certain about how much coverage the current MenB vaccines can provide, both now and in the future.”

“We are very encouraged by the results of the study , though measuring the attribution of only one antigen, fHbp, alone, without taking the effect of the other three components of Bexsero into consideration, may underestimate its protective effect,” said Rafik Bekkat-Berkani,MD. Global Medical Affairs Lead from GSK. “Bexsero’s 4 distinct components target different mechanisms in MenB survival and disease development and offer the potential to protect against invasive MenB strains even when the expression of one component is low or antigenically different. We agree with the study’s authors that more research is needed on Bexsero’s additional three antigens potentially providing multiple targets for vaccine-induced antibodies.”

Shamez Ladhani, Paediatric Infectious Disease Consultant, Public Health England, said: “Since the introduction of the MenB vaccine program in 2015, cases of Meningococcal B disease have nearly halved in infants under 1 year and in one and two year olds, who became eligible for the 12-month booster in May 2016. However, any case of meningococcal disease is tragic and, unfortunately, not all cases of meningitis and septicemia are preventable through vaccines. This research is important in helping us understand how we can best protect those who are most at risk from a very serious disease.”

Source:

https://www2.le.ac.uk/news/blog/2018-archive/june/new-way-to-determine-protection-of-men-b-vaccine-against-different-strains

About author

Related Articles