Breaking News
August 17, 2018 - Study shows DNA methylation related to liver disease among obese patients
August 17, 2018 - Life on the border: Back at Stanford, ready to pitch in
August 17, 2018 - New device for accurately placing hemodialysis catheters on kidney patients
August 17, 2018 - New strategy accelerates, automates process of prototype molecule optimization
August 17, 2018 - Study finds role of autoimmunity in development of COPD
August 17, 2018 - Researchers transform research tool to study neuronal function
August 17, 2018 - Cognitive impairment does not equate to unhappiness in older adults
August 17, 2018 - Peer Comparisons Can Decrease Risky Prescribing Patterns
August 17, 2018 - Susceptible genes identified for childhood chronic kidney disease
August 17, 2018 - Research uncovers miscarriage cause, identifies potential targets for treatment
August 17, 2018 - Bacterial armor could be new target for antibiotics | News Center
August 17, 2018 - FDA expands approval of Vertex’ cystic fibrosis medicine to treat children aged 12 to
August 17, 2018 - Give Your Child a Head Start With Math
August 17, 2018 - Ground-breaking study tests whether rejected livers can be made viable for transplantation
August 16, 2018 - New algorithm could improve diagnosis of rare diseases | News Center
August 16, 2018 - SCHILLER introduces latest generation of ECG device, CARDIOVIT AT-102 G2
August 16, 2018 - Proper treatment, refraining from smoking can reduce heart disease risk from type 2 diabetes
August 16, 2018 - Mount Sinai study could transform treatment for patients with retinal degenerative diseases
August 16, 2018 - Penn researchers develop first mouse model of idiopathic pulmonary fibrosis
August 16, 2018 - Four tips to help prevent fall allergy symptoms
August 16, 2018 - Women’s Preventive Services Initiative says screen all women annually for urinary incontinence
August 16, 2018 - At Stanford, patient discovers the source of her headaches, nausea | News Center
August 16, 2018 - To Prevent Injuries in Young Baseball Players, Chris Ahmad Reaches Out to Parents
August 16, 2018 - Restoring blood flow may be linked to longer survival in patients with critical limb ischemia
August 16, 2018 - New model of genetically engineered immune cells may help fight solid tumors
August 16, 2018 - Maternal stress increases anxious and depressive-like behaviors in female offspring
August 16, 2018 - Childhood exposure to secondhand smoke increases risk of COPD death in adulthood
August 16, 2018 - Scientists uncover key control mechanism of DNA replication
August 16, 2018 - NIH begins first-in-human trial of experimental live, attenuated Zika virus vaccine
August 16, 2018 - Two diabetes medications don’t slow progression of type 2 diabetes in youth
August 16, 2018 - 5 Questions: How Stanford research is making MRI scans safer for kids | News Center
August 16, 2018 - Columbia Celebrates 25th Anniversary of White Coat Ceremony
August 16, 2018 - Phonak’s new smallest and most discreet Virto B-Titanium hearing aid
August 16, 2018 - New project aims to study growth of water-based microorganisms
August 16, 2018 - Immune cell found to play important role in photosensitivity
August 16, 2018 - Higher social dominance linked to faster decision-making in men
August 16, 2018 - Blood test in early pregnancy could determine a woman’s later risk for gestational diabetes
August 16, 2018 - New research confirms link between DDT exposure and autism
August 16, 2018 - Neurodevelopmental Anomalies, Birth Defects Linked to Zika ID’d
August 16, 2018 - Risk of heart failure up in ALVSD patients with diabetes
August 16, 2018 - Exercise reduces symptoms and fatigue in patients with chronic kidney disease
August 16, 2018 - Study reveals role of RUNX proteins in DNA repair
August 16, 2018 - New research finds no harm from average salt consumption
August 16, 2018 - Researchers develop new way of testing bacterial resistance to antibiotics
August 16, 2018 - Magnetic gene in aquarium fish could open doors to treatment for epilepsy, Parkinson’s
August 16, 2018 - Five tips for successful long-term breastfeeding
August 16, 2018 - Researchers identify brain networks involved in object naming
August 16, 2018 - Promoting HPV Vaccine Doesn’t Prompt Risky Sex by Teens: Study
August 16, 2018 - Treating Rheumatoid Arthritis: Search for a Cure
August 16, 2018 - Research shows in the long run, charcoal toothpaste likely won’t whiten teeth
August 16, 2018 - Seattle Children’s opens new clinic to provide convenient access to pediatric specialty care services
August 16, 2018 - Curious case of the lost contact lens
August 16, 2018 - GN Hearing unveils world’s first Premium-Plus hearing aid
August 16, 2018 - Parental life span linked with increased longevity and health in daughters
August 16, 2018 - Health leaders reveal ten most important medicines in NHS history
August 16, 2018 - Mobile health devices diagnose hidden heart condition in at-risk populations
August 16, 2018 - When it comes to shedding pounds, it pays to think big
August 16, 2018 - Liva Healthcare announces appointment of Thomas Cooke as clinical services manager in the UK
August 16, 2018 - New digital pharmacy aims to help people living with chronic care conditions
August 16, 2018 - Preventing ACL injuries in high school athletes
August 16, 2018 - Experts provide insight into novel concepts and approaches for stroke rehabilitation
August 16, 2018 - Scientists reverse congenital blindness in mouse model
August 16, 2018 - Study shows link between use of benzodiazepines and increased risk of Alzheimer’s disease
August 16, 2018 - Study provides new insight into how ‘trash bag of the cell’ traps and seals off waste
August 16, 2018 - Trial shows PARP inhibitor as novel treatment option for patients with advanced breast cancers
August 16, 2018 - Prenatal exposure to violence increases toddlers’ aggressive behavior to their mothers
August 16, 2018 - Can manipulating gut microbes improve cardiac function in patients with heart failure?
August 16, 2018 - Hearts of newborn piglets can completely heal after heart attacks
August 16, 2018 - Ablating the mutant p53 gene in mice with colorectal cancer inhibits tumor growth
August 16, 2018 - Higher BMI in people with prediabetes related to evening preference and lack of sufficient sleep
August 16, 2018 - Using peripheral nerve blocks to treat facial pain may produce long-term pain relief
August 16, 2018 - Neural stem cells are the key to tail regeneration
August 16, 2018 - Study compares genetic and neural contributions to ADHD in children with or without TBI
August 16, 2018 - Adding energy drinks to alcohol may exacerbate negative effects of binge drinking
August 16, 2018 - Eye Examination Can Help Detect Abuse in Children
August 16, 2018 - Know the Difference: Rheumatoid Arthritis or Osteoarthritis?
August 16, 2018 - From ‘sea of mutations,’ two possible cancer links rise to the surface
August 16, 2018 - Does medical school take too long?
August 16, 2018 - Brown University researchers reveal key physical properties of ‘giant’ cancer cells
August 16, 2018 - Regular resistance training improves exercise motivation
Allergic responses may help protect the skin against cancer, research suggests

Allergic responses may help protect the skin against cancer, research suggests

image_pdfDownload PDFimage_print

The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings.

The research, led by Imperial College London, highlights previously unknown skin defenses – and could open avenues for developing new skin cancer treatments.

The early-stage study, published in the journal Nature Immunology, may also provide clues into why allergies are on the rise. Estimates suggest 44 per cent of Britons now suffer from at least one allergy – but the reasons behind the increase are unknown.

The team behind the latest research suggest their findings support the so-called ‘Toxin Hypothesis’, which proposes that exposure to environmental toxins and chemicals foreign to our body may trigger allergic responses.

The new research focuses on a type of antibody called Immunoglobulin E, or IgE. This protein, which is part of the immune system, triggers allergic reactions by mistakenly recognizing a harmless substance – such as peanuts – as a danger. A full-blown attack is launched by the body, under instruction from IgE, resulting in skin rashes, and swelling of face, mouth – and in severe cases – the airway.

However, despite the actions of IgE having such serious consequences in the body, scientists are still puzzled by its original role – and whether it serves any useful purpose.

The latest research suggests the antibody may have a crucial role in defending against the damage caused by environmental chemicals – and thereby protects against cancer. The IgE (triggered by the skin exposure to toxic agents) accumulates at the skin site, and prevents damaged cells from turning into cancerous tumors.

Dr Jessica Strid, lead author of the study from the Department of Medicine at Imperial, explained: “IgE must have some important role in the body – but at the moment scientists are still unclear what it is. We used to think it protects us against parasites – such as intestinal worms – and the lack of worm infections is causing the allergy rise. However, after previous work suggested the body can still fight parasites without IgE, we don’t now believe this to be the only purpose.

“Our new work suggests IgE could protect against the damage caused by skin exposure to tumor-promoting chemicals or UV irradiation – and help fight against skin cancer.”

In the research, the team found that placing a toxic chemical on mouse skin caused IgE to be induced and travel to the site of damage. Once there, IgE lowered the risk of cancer development in the skin.

They also studied skin tumors from 12 patients with squamous cell carcinoma – the second most common type of skin cancer.

Results showed all tumors, some of which were more aggressive than others, had IgE present. Further analysis of a larger cohort of patients showed that less dangerous or ‘low risk’ tumors had more IgE-carrying cells, while more serious tumors had less, suggesting IgE may be offering some kind of protective effect against the progression of the cancer.

Dr Strid added: “This is just the beginning of the story – our next step is to find out how exactly IgE may stop skin cells turning cancerous, and to see if we can somehow manipulate the allergic response to either protect against, or treat skin cancer.”

She added that the findings also hint that allergies could be linked to chemicals in our modern environment.

“Our work raises a lot of questions – and we now have to set about answering them. But the initial results support the so-called Toxin Hypothesis, which suggests that chemicals in the environment, such as those in air pollution, arising from industrial combustion and car emissions, as well as from tobacco smoke, could damage the skin and cause a rise in IgE. The theory suggests this rise in IgE may play a role in the alarming increase in allergies over the last decades.”

She explained IgE may have evolved to kick into action when the skin touched something toxic. “It may be that the IgE would trigger a rash, or a stronger unpleasant response, when the skin contacts something potentially poisonous. This would send a clear message to the body saying this is harmful – don’t touch that again.”

Source:

https://www.imperial.ac.uk/news/187266/allergic-responses-linked-skin-cancer-protection/

Tagged with:

About author

Related Articles