Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
PolyU researchers design new self-fitting scaffold to induce bone regeneration

PolyU researchers design new self-fitting scaffold to induce bone regeneration

Researchers from The Hong Kong Polytechnic University (PolyU) have designed and fabricated a high performing self-fitting bone scaffold by combining a shape memory foam and hydroxyapatite (the principal mineral component of bone tissue). It can be safely and conveniently implanted into bone defects and induce bone regeneration, thus enhancing the recovery of bone injuries and fractures. Up to date, no bone scaffold in commercial market possesses such shape memory self-fitting effect.

PolyU researchers have developed a novel self-fitting scaffold which can be safely and conveniently implanted into bone defects and induce bone regeneration. The team is led by Professor Hu Jinlian (centre) and Dr Xie Ruiqi (left) from the Institute of Textiles and Clothing, and Dr Guo Xia (right) from the Department of Rehabilitation Sciences.

Despite the regenerative capacity of bone, for large bone defects due to bone tumor resections or severe fractures, bone grafting surgeries (autografts or allografts) are always required for orchestrating bone regeneration. With bone fracture becoming a rising worldwide health concern, especially for aging societies, how to improve grafting process or induce bone regeneration effectively, thus help relieve suffering and reduce society’s medical expenses, have become a rising challenge for scientists. Taking hip fractures from osteoporosis as an example, a latest study projected that the number of annual new cases in Hong Kong, of  9,590 this year, will be tripled by 2050; while Malaysia and Singapore will reach 3.5 times during the period.

One promising field explored by tissue engineering scientists is to develop a bone scaffold which can act as template for speedy tissue regeneration, and can be used in minimally invasive operation so as to reduce hospitalization stay and infection risk. The novel scaffold developed by the team of PolyU researchers, led by Professor Hu Jinlian (Principal Investigator) and Dr Xie Ruiqi from the Institute of Textiles and Clothing, and Dr Guo Xia from the Department of Rehabilitation Sciences,has offered promising breakthrough. The team has close collaboration with Sichuan University in cell culture and animal modeling for the research.

Characteristics of PolyU’s novel bone scaffold

The novel scaffold made of shape memory polyurethane foam (a type of plastic material) and hydroxyapatite (HA) nano-particles is characterized by its remarkable self-fitting effect. As a shape memory material, the scaffold can be compacted at 0°C, implanted with compact shape at room temperature, and recovered to its original shape completely at 40°C. The scaffold thus can fill up the irregular bone defects perfectly. The transitional temperatures, with range close to human body’s physiological temperatures, also enhance the feasibility of using the scaffold in minimally invasive surgery.

The self-fitting scaffold possesses a highly porous structure with interconnected pores to allow cells migration and formation of new tissues. The average pore size of the scaffold is 670 μm (diameter of a human hair is around 100 μm), which is close to that of trabecular bone (the inner layer of bone) and thus mimics the actual in vivo microenvironment. The optimal structure of the scaffold is around 60% of space voids.

The mechanical strength of the scaffold can neither be too low (may cause deformation or crash) nor too high (may reduce the density of surrounding bone tissue). The compressive strength of the PolyU developed self-fitting scaffold is designed at 13.6MPa (Megapascal), which is comparable to that of trabecular bone. Laboratory tests also show that the self-fitting scaffold is biocompatible and has no cytotoxicity.

Animal study on bone regeneration

“Our research team further examined the performance of the self-fitting scaffold in facilitating bone regeneration through a rabbit femoral defect study. The results show that our scaffold has overcome the disadvantages of traditional polymer scaffolds, and has great potential for bone regeneration,” said Professor Hu.

In the animal study, 18 rabbits with a femoral bone defect in each knee, making up a total of 36 lesions, were divided into experimental group and control group.

The bone defects of the rabbits in the experimental group were implanted with self-fitting scaffolds (with original size around 5% larger than the bone defects) compacted to around 50% of their original size. After triggering with 40°C saline, the scaffolds expanded from the compacted shape to fill the defect in 60 seconds. The bone defects in the control group were left unfilled.

Twelve weeks after the surgery, the experimental group displayed faster bone tissue ingrowth in volume. There was 46% of bone ingrowth, or the proportion of total defects being repaired. On the contrary, the control group had only 24%.

The self-fitting scaffold has been proved inducing the formation of osteoblasts and blood vessels, which are responsible for the synthesis of bone tissue. In the experimental group, 12 weeks after the surgery, the number of neovascular buds grew on the scaffolds was 4 times of that in the control group. Moreover, 5% of bone surface was covered by osteoblasts in the experimental group whereas the control group recorded almost no osteoblast.

In conclusion, the novel shape memory scaffold developed by PolyU has the advantages of:

  • being implanted via minimally invasive operation;
  • self-adaption and self-fitting;
  • optimal structure for bone remodeling;
  • full biocompatibility; and
  • optimal mechanical properties.

Source:

https://www.polyu.edu.hk/web/en/media/media_releases/index_id_6565.html

Tagged with:

About author

Related Articles