Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Innovative platform developed to destroy cancer cells

Innovative platform developed to destroy cancer cells

The new treatment will serve as both diagnosis and treatment of malignant tumors. This breakthrough in the technologies of cancer diagnosis and treatment was made by an interdisciplinary Russian-German collaboration of chemists, physicists, and biologists from NUST MISIS, Lomonosov Moscow State University, Pirogov Russian National Research Medical University (RNRMU), and the University of Duisburg-Essen (Germany).

For the first time ever, scientists have shown that a hybrid nanomaterial based on magnetite-gold particles can serve as a universal platform to both detect cancer cells anywhere in the body and to complete targeted deliveries of drugs to these cells. The discovery makes it possible to create and implement a completely new generation of cancer treatments in the coming years.

The results of this fundamental research conducted at the intersection of physics, chemistry, biology and medicine have been published in Scientific Reports, one of the most prestigious scientific journals.

“The interdisciplinary collaboration of scientists led by Maxim Abakumov, a Candidate of Chemical Sciences and the Head of the NUST MISIS Biomedical Nanomaterials Laboratory, has managed to develop a platform for simultaneous diagnosis and treatment of cancer. The aggregation of diagnosis and therapy at the cellular level — so-called theranostics — is now considered one of the most promising areas in modern medicine. Scientists now [have] to learn how to detect pathogenic cells at the earliest stage of the disease”, said Alevtina Chernikova, Rector of NUST MISIS.

If these pathogenic cells are tagged with magnetic nanoparticles, they can be diagnosed with the help of magnetic resonance imaging (MRI) and subsequently destroyed by either a drug or a magnetic field that heats and kills cancer cells.

“We have managed to combine gold (Au) and magnetite (Fe3O4) nanoparticles into a hybrid that has both magnetic properties and is capable of carrying the drug [to a tumor]. It turned out as a kind of ‘nanodumbbell’ which could become a platform — a universal base — of future theranostics, and we have shown that in our research”, said Maxim Abakumov, one of the project participants, assistant professor at RNRMU, and Head of the NUST MISIS Biomedical Nanomaterials Laboratory.

This manmade nanohybrid has been tested both in vitro and in vivo. Laboratory tests on mice with grafted tumors have already been completed.

“The article considers a model of a mouse breast tumor and shows the possibility to deliver the hybrid Fe3O4-Au particles to the tumor, loaded with the anti-tumor drug doxorubicin. The drug is released inside the tumor and has a therapeutic influence”, added Mariya Efremova, the project`s co-worker, junior research assistant at the Laboratory for Chemical Design of Bionanomaterials for Medical Applications at Lomonosov Moscow State University, and an engineer at the NUST MISIS Biomedical Nanomaterials Laboratory.

It is possible to place almost any drug (in place of doxorubicin) into the “nanodumbbell”, and this makes this hybrid an ideal platform to detect tumor cells and deliver drugs; previously proposed methods were only suitable for certain types of drugs and only worked on certain types of cancer cells. Such versatility allows us to hope for the emergence of a new generation of treatments for malignant tumors in the coming years.

According to the most optimistic researchers on the project, it will be possible to proceed to pre-clinical trials in just two to three years time, as there is a few years’ of work remaining to be completed before clinical trials on real patients. However, the concept of theranostics has still not been applied in clinical practice anywhere in the world, although Russian scientists are on the front lines of this area.

“As a scientific discipline, theranostics is now developing very quickly. The proposed platform demonstrates impressive and diverse effectiveness in lab conditions, however, it still has a long way [to go before getting] to patients”, said Marina Sekacheva, Head of the Center for Personalized Oncology “OncoTarget” at Sechenov University. Sekacheva believes that doctors should provide maximum practical support to fundamental scientists and continuously work with them on potentially groundbreaking projects such as this one.

Source:

http://en.misis.ru/university/news/science/2018-08/5504/

Tagged with:

About author

Related Articles